目的研究接受胰岛素治疗效果欠佳的2型糖尿病(type 2 diabetes mellitus,T2DM)患者短期内联用达格列净片后的血糖波动及安全性。方法纳入2018年3月至2019年12月于徐州医科大学附属医院内分泌科就诊的、接受四针胰岛素联合二甲双胍缓释...目的研究接受胰岛素治疗效果欠佳的2型糖尿病(type 2 diabetes mellitus,T2DM)患者短期内联用达格列净片后的血糖波动及安全性。方法纳入2018年3月至2019年12月于徐州医科大学附属医院内分泌科就诊的、接受四针胰岛素联合二甲双胍缓释片后血糖仍未较好改善的T2DM患者100例为研究对象,随机分为5 mg组和10 mg组,每组50例。两组均在胰岛素治疗基础上加用达格列净片口服,剂量分别为每次5 mg和10 mg,一日1次,疗程均为1周。比较两组患者治疗前、后空腹血糖(fasting plasma glucose,FPG)及餐后2 h血糖(2 h postprandial blood glucose,2hPG)变化,以及两组治疗前、后及治疗后组间相应血糖波动情况,如最大血糖波动幅度(maximum fluctuation range of blood glucose,LAGE)、日内血糖标准差(standard deviation of intra day blood glucose,SDBG)、平均血糖值(mean blood glucose,MBG)、餐后血糖平均波动幅度(average fluctuation range of postprandial blood glucose,PPGE)、日内血糖平均波动幅度(average fluctuation range of blood glucose within a day,MAGE)、日间血糖平均绝对差(mean absolute difference in daytime blood glucose,MODD)及血糖变异系数(coefficient of variation of blood glucose,CV)等,同时记录患者不良事件发生情况。结果两组患者FPG及2hPG均较治疗前下降(P<0.05),且10 mg组FPG及2hPG低于5 mg组(P<0.05)。治疗后,两组LAGE、SDBG、MAGE、PPGE、MODD、MBG及CV较治疗前均改善(P<0.05),且10 mg组上述指标低于5 mg组(P<0.05)。两组患者均未发生严重低血糖事件。结论短期内应用达格列净联合胰岛素可快速且稳定地降糖、改善血糖波动,且低血糖等不良反应较少。展开更多
Vein traits influence photosynthesis and drought resistance and are sensitive to climate change.It is unclear whether vein traits,similar to other leaf traits,have obvious regional characteristics and covariance with ...Vein traits influence photosynthesis and drought resistance and are sensitive to climate change.It is unclear whether vein traits,similar to other leaf traits,have obvious regional characteristics and covariance with other leaf traits,especially in Tibetan Plateau grasslands.We collected 66 species from 37 sites in late July of 2012 and early August of 2013 to investigate leaf vein traits and their relationships with other leaf traits in comparison with the available global database data and to elucidate vein investment of plants with different vein types.The average vein length per area(VLA)of plants in the Tibetan Plateau was within the range of the global dataset,and the relationships among vein traits and other leaf traits of alpine plants were consistent with the global models.The VLAs of parallel-veined grasses and pinnateveined forbs were significantly lower and higher than the global mean value,respectively.The leaf mass perarea and total nitrogen content of parallel-veined grasses were significantly lower and higher,respectively,than the global mean values;the opposite was observed in pinnate-veined forbs.The parallel-veined grasses exhibited almost a four-fold higher vein biomass investment(i.e.,vein mass per leaf mass)than pinnate-veined forbs in the same region.The average VLA and its relationships with other leaf traits of the alpine grassland plants on the Tibetan Plateau had no regional characteristics,suggesting a convergence in plant leaf functioning.Plants with different leaf types differ in their adaptation strategies to plateau environments,and this may relate to biomass investment into leaf veins.Our study fills the gap with regard to vein density in alpine grassland species and provides a new perspective for understanding plant physiology and ecology by calculating and comparing the proportion of vein investment among different vein types.展开更多
文摘目的研究接受胰岛素治疗效果欠佳的2型糖尿病(type 2 diabetes mellitus,T2DM)患者短期内联用达格列净片后的血糖波动及安全性。方法纳入2018年3月至2019年12月于徐州医科大学附属医院内分泌科就诊的、接受四针胰岛素联合二甲双胍缓释片后血糖仍未较好改善的T2DM患者100例为研究对象,随机分为5 mg组和10 mg组,每组50例。两组均在胰岛素治疗基础上加用达格列净片口服,剂量分别为每次5 mg和10 mg,一日1次,疗程均为1周。比较两组患者治疗前、后空腹血糖(fasting plasma glucose,FPG)及餐后2 h血糖(2 h postprandial blood glucose,2hPG)变化,以及两组治疗前、后及治疗后组间相应血糖波动情况,如最大血糖波动幅度(maximum fluctuation range of blood glucose,LAGE)、日内血糖标准差(standard deviation of intra day blood glucose,SDBG)、平均血糖值(mean blood glucose,MBG)、餐后血糖平均波动幅度(average fluctuation range of postprandial blood glucose,PPGE)、日内血糖平均波动幅度(average fluctuation range of blood glucose within a day,MAGE)、日间血糖平均绝对差(mean absolute difference in daytime blood glucose,MODD)及血糖变异系数(coefficient of variation of blood glucose,CV)等,同时记录患者不良事件发生情况。结果两组患者FPG及2hPG均较治疗前下降(P<0.05),且10 mg组FPG及2hPG低于5 mg组(P<0.05)。治疗后,两组LAGE、SDBG、MAGE、PPGE、MODD、MBG及CV较治疗前均改善(P<0.05),且10 mg组上述指标低于5 mg组(P<0.05)。两组患者均未发生严重低血糖事件。结论短期内应用达格列净联合胰岛素可快速且稳定地降糖、改善血糖波动,且低血糖等不良反应较少。
基金supported by the National Natural Science Foundation of China(grant numbers 41731175,31700410 and 41988101)the Strategic Priority Research Program A of the Chinese Academy of Sciences(grant number XDA20050101)。
文摘Vein traits influence photosynthesis and drought resistance and are sensitive to climate change.It is unclear whether vein traits,similar to other leaf traits,have obvious regional characteristics and covariance with other leaf traits,especially in Tibetan Plateau grasslands.We collected 66 species from 37 sites in late July of 2012 and early August of 2013 to investigate leaf vein traits and their relationships with other leaf traits in comparison with the available global database data and to elucidate vein investment of plants with different vein types.The average vein length per area(VLA)of plants in the Tibetan Plateau was within the range of the global dataset,and the relationships among vein traits and other leaf traits of alpine plants were consistent with the global models.The VLAs of parallel-veined grasses and pinnateveined forbs were significantly lower and higher than the global mean value,respectively.The leaf mass perarea and total nitrogen content of parallel-veined grasses were significantly lower and higher,respectively,than the global mean values;the opposite was observed in pinnate-veined forbs.The parallel-veined grasses exhibited almost a four-fold higher vein biomass investment(i.e.,vein mass per leaf mass)than pinnate-veined forbs in the same region.The average VLA and its relationships with other leaf traits of the alpine grassland plants on the Tibetan Plateau had no regional characteristics,suggesting a convergence in plant leaf functioning.Plants with different leaf types differ in their adaptation strategies to plateau environments,and this may relate to biomass investment into leaf veins.Our study fills the gap with regard to vein density in alpine grassland species and provides a new perspective for understanding plant physiology and ecology by calculating and comparing the proportion of vein investment among different vein types.
