目的探讨左室射血分数(left ventricular ejection fraction,LVEF)降低的扩张型心肌病(dilated cardiomyopathy,DCM)治疗后生存的影响因素。方法选取2020年6月至2023年6月于湖州市第一人民医院治疗的158例LVEF降低的DCM患者,根据生存状...目的探讨左室射血分数(left ventricular ejection fraction,LVEF)降低的扩张型心肌病(dilated cardiomyopathy,DCM)治疗后生存的影响因素。方法选取2020年6月至2023年6月于湖州市第一人民医院治疗的158例LVEF降低的DCM患者,根据生存状况将其分为死亡组(n=40)和生存组(n=118)。统计两组患者的临床资料,采用Cox比例风险回归模型分析影响LVEF降低的DCM患者治疗后生存的因素。结果死亡组患者的年龄显著大于生存组,合并高血压、纽约心脏病协会(New York Heart Association,NYHA)心功能分级Ⅳ级、室性心律失常占比、左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左室收缩末期内径(left ventricular end systolic diameter,LVESD)、脑钠肽(brain natriuretic peptide,BNP)水平均显著高于生存组,左室整体纵向应变(global longitudinal strain,GLS)、RR间期标准差(standard deviation of RR interval,SDNN)、RR间期平均值标准差(standard deviation of the average RR interval,SDANN)、RR间期标准差平均值(the average standard deviation of RR interval,SDNNindex)、RR间期差值均方根(root mean square of RR interval difference,rMSSD)、相邻RR间期>50ms总数占总心跳数的百分比(the percentage of total number of adjacent RR intervals>50ms to total heart rate,pNN50)、舒张末期室间隔厚度(end diastolic interventricular septal thickness,IVSd)、左心室后壁舒张期厚度(left ventricular posterior wall diastolic thickness,LVPWD)、每搏输出量(stroke volume,SV)、心输出量(cardiac output,CO)均显著低于生存组(P<0.05)。Cox回归分析显示,年龄、合并高血压、NYHA心功能分级、室性心律失常、GLS、SDNN、SDANN、SDNNindex、rMSSD、pNN50、LVEDD、LVESD、BNP是影响LVEF降低的DCM患者治疗后生存率的危险因素,IVSd、LVPWD是保护因素(P<0.05)。结论LVEF降低的DCM患者死亡率较高,且受年龄、高血压、NYHA心功能分级、室性心律失常、GLS、心率变异性、LVEDD、LVESD、BNP、IVSd、LVPWD等多种因素的影响,临床应早期给予针对性干预以提高患者治疗后生存率。展开更多
Objective Our objective was to investigate the occurrence of opportunistic pathogens and characterize the bacterial community structures in the water system of a pulmonary hospital.Methods The water samples were colle...Objective Our objective was to investigate the occurrence of opportunistic pathogens and characterize the bacterial community structures in the water system of a pulmonary hospital.Methods The water samples were collected from automatic and manual faucets in the consulting room,treatment room,dressing room,respiratory ward,and other non-medical rooms in three buildings of the hospital.Quantitative polymerase chain reaction was used to quantify the load of several waterborne opportunistic pathogens and related microorganisms,including Legionella spp.,Mycobacterium spp.,and M.avium.Illumina sequencing targeting 16 S r RNA genes was performed to profile bacterial communities.Results The occurrence rates of Legionella spp.,Mycobacterium spp.,and M.avium were 100%,100%,and 76%,respectively in all samples.Higher occurrence rates of M.avium were observed in the outpatient service building(building 1,91.7%)and respiration department and wards(building 2,80%)than in the office building(building 3),where no M.avium was found.M.avium were more abundant in automatic faucets(average 2.21×10~4 gene copies/L)than in manual faucets(average 1.03×10~4 gene copies/m L)(P<0.01).Proteobacteria,Actinobacteria,Bacteroidetes,Cyanobacteria,Firmicutes,and Acidobacteria were the dominant bacterial phyla.Disinfectant residuals,nitrate,and temperature were found to be the key environmental factors driving microbial community structure shifts in water systems.Conclusion This study revealed a high level of colonization of water faucets by opportunistic pathogens and provided insight into the characteristics of microbial communities in a hospital water system and approaches to reduce risks of microbial contamination.展开更多
[目的/意义]间歇性中辍是社交网络用户消极使用行为的内容之一,通过分析国内外代表性研究成果,对该领域研究的知识体系和关键问题进行系统梳理,并据此展望未来研究趋势,为后续学术研究提供一定的借鉴作用。[方法/过程]基于中国知网和Web...[目的/意义]间歇性中辍是社交网络用户消极使用行为的内容之一,通过分析国内外代表性研究成果,对该领域研究的知识体系和关键问题进行系统梳理,并据此展望未来研究趋势,为后续学术研究提供一定的借鉴作用。[方法/过程]基于中国知网和Web of Science等数据源,通过关键词检索、追溯检索和主题分析等步骤筛选出54篇重要文献,对研究主题、研究理论、研究方法3个关键问题进行系统综述,并据此构建规范性研究流程的框架。[结果/结论]社交网络情境下的用户间歇性中辍行为研究尚处于起步阶段,在研究主题的细分程度、理论模型的丰富度和研究方法的多样性等方面还有较大的研究空间。基于信息科学、心理学、社会学、新闻传播学等交叉学科视角,从促进因素和抑制因素双向博弈、外部社会环境和心理情感体验综合作用角度来深入探究社交网络用户间歇性中辍行为的影响因素和形成机理将成为未来该领域研究的趋势。展开更多
文摘目的探讨左室射血分数(left ventricular ejection fraction,LVEF)降低的扩张型心肌病(dilated cardiomyopathy,DCM)治疗后生存的影响因素。方法选取2020年6月至2023年6月于湖州市第一人民医院治疗的158例LVEF降低的DCM患者,根据生存状况将其分为死亡组(n=40)和生存组(n=118)。统计两组患者的临床资料,采用Cox比例风险回归模型分析影响LVEF降低的DCM患者治疗后生存的因素。结果死亡组患者的年龄显著大于生存组,合并高血压、纽约心脏病协会(New York Heart Association,NYHA)心功能分级Ⅳ级、室性心律失常占比、左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左室收缩末期内径(left ventricular end systolic diameter,LVESD)、脑钠肽(brain natriuretic peptide,BNP)水平均显著高于生存组,左室整体纵向应变(global longitudinal strain,GLS)、RR间期标准差(standard deviation of RR interval,SDNN)、RR间期平均值标准差(standard deviation of the average RR interval,SDANN)、RR间期标准差平均值(the average standard deviation of RR interval,SDNNindex)、RR间期差值均方根(root mean square of RR interval difference,rMSSD)、相邻RR间期>50ms总数占总心跳数的百分比(the percentage of total number of adjacent RR intervals>50ms to total heart rate,pNN50)、舒张末期室间隔厚度(end diastolic interventricular septal thickness,IVSd)、左心室后壁舒张期厚度(left ventricular posterior wall diastolic thickness,LVPWD)、每搏输出量(stroke volume,SV)、心输出量(cardiac output,CO)均显著低于生存组(P<0.05)。Cox回归分析显示,年龄、合并高血压、NYHA心功能分级、室性心律失常、GLS、SDNN、SDANN、SDNNindex、rMSSD、pNN50、LVEDD、LVESD、BNP是影响LVEF降低的DCM患者治疗后生存率的危险因素,IVSd、LVPWD是保护因素(P<0.05)。结论LVEF降低的DCM患者死亡率较高,且受年龄、高血压、NYHA心功能分级、室性心律失常、GLS、心率变异性、LVEDD、LVESD、BNP、IVSd、LVPWD等多种因素的影响,临床应早期给予针对性干预以提高患者治疗后生存率。
基金supported by the National Natural Science Foundation of China[No.51878468 and No.51508397]the Hospital Management Research Fund of Shanghai Medical Association[No.Q1902037]+1 种基金the Fundamental Research Funds for the Central Universitiesthe National Major Science and Technology Project for Water Pollution Control and Treatment[No.2017ZX07201002]。
文摘Objective Our objective was to investigate the occurrence of opportunistic pathogens and characterize the bacterial community structures in the water system of a pulmonary hospital.Methods The water samples were collected from automatic and manual faucets in the consulting room,treatment room,dressing room,respiratory ward,and other non-medical rooms in three buildings of the hospital.Quantitative polymerase chain reaction was used to quantify the load of several waterborne opportunistic pathogens and related microorganisms,including Legionella spp.,Mycobacterium spp.,and M.avium.Illumina sequencing targeting 16 S r RNA genes was performed to profile bacterial communities.Results The occurrence rates of Legionella spp.,Mycobacterium spp.,and M.avium were 100%,100%,and 76%,respectively in all samples.Higher occurrence rates of M.avium were observed in the outpatient service building(building 1,91.7%)and respiration department and wards(building 2,80%)than in the office building(building 3),where no M.avium was found.M.avium were more abundant in automatic faucets(average 2.21×10~4 gene copies/L)than in manual faucets(average 1.03×10~4 gene copies/m L)(P<0.01).Proteobacteria,Actinobacteria,Bacteroidetes,Cyanobacteria,Firmicutes,and Acidobacteria were the dominant bacterial phyla.Disinfectant residuals,nitrate,and temperature were found to be the key environmental factors driving microbial community structure shifts in water systems.Conclusion This study revealed a high level of colonization of water faucets by opportunistic pathogens and provided insight into the characteristics of microbial communities in a hospital water system and approaches to reduce risks of microbial contamination.
文摘[目的/意义]间歇性中辍是社交网络用户消极使用行为的内容之一,通过分析国内外代表性研究成果,对该领域研究的知识体系和关键问题进行系统梳理,并据此展望未来研究趋势,为后续学术研究提供一定的借鉴作用。[方法/过程]基于中国知网和Web of Science等数据源,通过关键词检索、追溯检索和主题分析等步骤筛选出54篇重要文献,对研究主题、研究理论、研究方法3个关键问题进行系统综述,并据此构建规范性研究流程的框架。[结果/结论]社交网络情境下的用户间歇性中辍行为研究尚处于起步阶段,在研究主题的细分程度、理论模型的丰富度和研究方法的多样性等方面还有较大的研究空间。基于信息科学、心理学、社会学、新闻传播学等交叉学科视角,从促进因素和抑制因素双向博弈、外部社会环境和心理情感体验综合作用角度来深入探究社交网络用户间歇性中辍行为的影响因素和形成机理将成为未来该领域研究的趋势。
