The epithelial to mesenchymal transition(EMT)is a cellular program that drives de-differentiation of cells in both physiological and pathological processes.One of the characteristics of cells describing an EMT is the(...The epithelial to mesenchymal transition(EMT)is a cellular program that drives de-differentiation of cells in both physiological and pathological processes.One of the characteristics of cells describing an EMT is the(re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the organism.The molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with a high demand of extracellular components.展开更多
基金This work was partially supported by Fondo Clemente Estable(ANII)and PEDECIBA from Uruguay.T.Fernández-Calero received fellowships from CAP-Universidad de la República,ANII and the Embassy of France in Uruguay.M.Davyt received a fellowship from CSIC-Universidad de la República.
文摘The epithelial to mesenchymal transition(EMT)is a cellular program that drives de-differentiation of cells in both physiological and pathological processes.One of the characteristics of cells describing an EMT is the(re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the organism.The molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with a high demand of extracellular components.
