Galectins are sticky molecules that bind toβ-galactoside.Their interactions render them essential players in many cellular processes.The imbalance of galectin expression was reported in many diseases.In cancer,galect...Galectins are sticky molecules that bind toβ-galactoside.Their interactions render them essential players in many cellular processes.The imbalance of galectin expression was reported in many diseases.In cancer,galectins interact with the extracellular matrix,evade the immune system,and potentially have broad interactions with blood components.In the last ten years,since 2010,we did focus on galectin research in different cancer types.Ourfindings showed an interaction between cancer cells and erythrocytes via galectin-4.Moreover,we found that upregulation of galectins was associated with lymph node metastasis in ovarian cancers.Hence,with this,we shortly review some important aspects of galectins and their potential importance in more profound understanding of cancer progression and thefield of cancer biomarkers.展开更多
文摘Galectins are sticky molecules that bind toβ-galactoside.Their interactions render them essential players in many cellular processes.The imbalance of galectin expression was reported in many diseases.In cancer,galectins interact with the extracellular matrix,evade the immune system,and potentially have broad interactions with blood components.In the last ten years,since 2010,we did focus on galectin research in different cancer types.Ourfindings showed an interaction between cancer cells and erythrocytes via galectin-4.Moreover,we found that upregulation of galectins was associated with lymph node metastasis in ovarian cancers.Hence,with this,we shortly review some important aspects of galectins and their potential importance in more profound understanding of cancer progression and thefield of cancer biomarkers.
