Integration of green chemistry principles to nanotechnology is one of the key issues in nanoscience research. The development of the concept of green nanoparticle preparation has been growingly needed for environmenta...Integration of green chemistry principles to nanotechnology is one of the key issues in nanoscience research. The development of the concept of green nanoparticle preparation has been growingly needed for environmentally benign metal nanoparticle synthesis protocols to avoid adverse effects in medical applications. Keep this in mind, in the present study, silver nanoparticles were synthesized using Solanum lycopersicums fruit extract. The prepared silver nanoparticles were characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and transmission electron microscopy techniques. The surface plasmon resonance peak was found at 445 nm. The synthesized silver nanoparticles were spherical in shape with the average size of 10 nm. The citric acid present in S. lycopersicums fruit extract acted as reducing agent and malic acid was responsible for capping of the bioreduced silver nanoparticles.展开更多
Objective:There is a paucity of real-world evidence in the Indian context to address the outcome of primary brain tumors(PBTs)in children.This study aimed to describe the demographic profile,clinical characteristics,a...Objective:There is a paucity of real-world evidence in the Indian context to address the outcome of primary brain tumors(PBTs)in children.This study aimed to describe the demographic profile,clinical characteristics,and histological features of PBTs based on the 2016 World Health Organization classification,assess the efficacy of treatment methods,and identify the factors that influence the outcome.Methodology:This is a single-institution,hospital-based study.Data were collected for pediatric patients aged 0−19 years,from September 2001 to May 2023(22 years),who were diagnosed with malignant PBTs.Patients with radiologically or histologically proven tumors were included.Those with metastatic disease to the central nervous system were excluded.The overall survival(OS)and recurrence-free survival(RFS)were estimated using the Kaplan–Meier method.Results:A total of 251 patients with pediatric brain tumors were included in this analysis.The mean age was 9.10±5.54 years.The male-to-female ratio was 1.20:1.In this cohort,the most common histologies were medulloblastoma and astrocytoma.The mean survival of all patients with PBTs was 141.00±7.90 months with 1-,3-,and 8-year OS rates of 79.00%,67.00%,and 60.00%,respectively.Medulloblastoma had 1-,3-,and 8-year OS rates of 81.00%,72.00%,and 65.00%,respectively.The 1-year OS rates for glioblastoma and brainstem glioma were 46.00%and 45.00%,respectively.Complete tumoral resection showed longer survival than lesser degrees of resection(p=0.001).Embryonal tumors(ETs)had a better RFS of 133.60±12.70 months(p≤0.001).Conclusion:ETs have a better prognosis than glial tumors.With an improved OS,the surgical resection extent has a favorable outcome.As a chemosensitive tumor,medulloblastoma benefits most from systemic treatment and responds well to a multimodal approach.展开更多
文摘Integration of green chemistry principles to nanotechnology is one of the key issues in nanoscience research. The development of the concept of green nanoparticle preparation has been growingly needed for environmentally benign metal nanoparticle synthesis protocols to avoid adverse effects in medical applications. Keep this in mind, in the present study, silver nanoparticles were synthesized using Solanum lycopersicums fruit extract. The prepared silver nanoparticles were characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and transmission electron microscopy techniques. The surface plasmon resonance peak was found at 445 nm. The synthesized silver nanoparticles were spherical in shape with the average size of 10 nm. The citric acid present in S. lycopersicums fruit extract acted as reducing agent and malic acid was responsible for capping of the bioreduced silver nanoparticles.
文摘Objective:There is a paucity of real-world evidence in the Indian context to address the outcome of primary brain tumors(PBTs)in children.This study aimed to describe the demographic profile,clinical characteristics,and histological features of PBTs based on the 2016 World Health Organization classification,assess the efficacy of treatment methods,and identify the factors that influence the outcome.Methodology:This is a single-institution,hospital-based study.Data were collected for pediatric patients aged 0−19 years,from September 2001 to May 2023(22 years),who were diagnosed with malignant PBTs.Patients with radiologically or histologically proven tumors were included.Those with metastatic disease to the central nervous system were excluded.The overall survival(OS)and recurrence-free survival(RFS)were estimated using the Kaplan–Meier method.Results:A total of 251 patients with pediatric brain tumors were included in this analysis.The mean age was 9.10±5.54 years.The male-to-female ratio was 1.20:1.In this cohort,the most common histologies were medulloblastoma and astrocytoma.The mean survival of all patients with PBTs was 141.00±7.90 months with 1-,3-,and 8-year OS rates of 79.00%,67.00%,and 60.00%,respectively.Medulloblastoma had 1-,3-,and 8-year OS rates of 81.00%,72.00%,and 65.00%,respectively.The 1-year OS rates for glioblastoma and brainstem glioma were 46.00%and 45.00%,respectively.Complete tumoral resection showed longer survival than lesser degrees of resection(p=0.001).Embryonal tumors(ETs)had a better RFS of 133.60±12.70 months(p≤0.001).Conclusion:ETs have a better prognosis than glial tumors.With an improved OS,the surgical resection extent has a favorable outcome.As a chemosensitive tumor,medulloblastoma benefits most from systemic treatment and responds well to a multimodal approach.
