Glaucoma is a term encompassing a variety of diseases that culminate in the death of retinal ganglion cells (RGC). Although a variety of factors can initiate the disease onset, increased intraocular pressure (IOP) is ...Glaucoma is a term encompassing a variety of diseases that culminate in the death of retinal ganglion cells (RGC). Although a variety of factors can initiate the disease onset, increased intraocular pressure (IOP) is one of the major risk factors. In our previous study we found that semaphorins were causally involved in RGC death following axotomy. Since a common feature of展开更多
Damage to the optic nerve in mammals induces retrograde degeneration and apoptosis of the retinal ganglion cell (RGC) bodies. We have previously shown that semaphorins, axon guidance molecules with repulsive cues, are...Damage to the optic nerve in mammals induces retrograde degeneration and apoptosis of the retinal ganglion cell (RGC) bodies. We have previously shown that semaphorins, axon guidance molecules with repulsive cues, are capable of mediating apopto-展开更多
文摘Glaucoma is a term encompassing a variety of diseases that culminate in the death of retinal ganglion cells (RGC). Although a variety of factors can initiate the disease onset, increased intraocular pressure (IOP) is one of the major risk factors. In our previous study we found that semaphorins were causally involved in RGC death following axotomy. Since a common feature of
文摘Damage to the optic nerve in mammals induces retrograde degeneration and apoptosis of the retinal ganglion cell (RGC) bodies. We have previously shown that semaphorins, axon guidance molecules with repulsive cues, are capable of mediating apopto-
