Surface functionalization of iron oxide nanoparticles(Fe_(2)O_(3) NPs)with antibiotics is a novel approach that opens the door to drug delivery applications.In the present work,we report iron oxide nanoparticles synth...Surface functionalization of iron oxide nanoparticles(Fe_(2)O_(3) NPs)with antibiotics is a novel approach that opens the door to drug delivery applications.In the present work,we report iron oxide nanoparticles synthesized by chemical co-precipitation method.As-synthesized nanoparticles were characterized using field emission scanning electron microscopy(FESEM),energy dispersive X-ray(EDX),X-ray diffraction(XRD),ultraviolet(UV)-visible(Vis)spectroscopy,Fourier transform infrared(FTIR),and vibrating sample magnetometer(VSM).The poly-shaped Fe_(2)O_(3) NPs of size(34±10)nm with hematite(α-Fe_(2)O_(3))phase were synthesized.The antibacterial activity of chloramphenicol and gentamicin and their formulation with encapsulated iron oxide nanoparticles was investigated by the agar well diffusion technique.Drug-encapsulated Fe_(2)O_(3) NPs showed antibacterial activity against Escherichia coli and Staphylococcus aureus strains,possibly in a dose-dependent manner.Significant effectiveness was confirmed by the increase in the single range of inhibition against the tested microorganisms.Furthermore,the effect of iron oxide nanoparticle concentrations ranging from 1 to 9μg/μL on bacterial growth was examined.展开更多
文摘Surface functionalization of iron oxide nanoparticles(Fe_(2)O_(3) NPs)with antibiotics is a novel approach that opens the door to drug delivery applications.In the present work,we report iron oxide nanoparticles synthesized by chemical co-precipitation method.As-synthesized nanoparticles were characterized using field emission scanning electron microscopy(FESEM),energy dispersive X-ray(EDX),X-ray diffraction(XRD),ultraviolet(UV)-visible(Vis)spectroscopy,Fourier transform infrared(FTIR),and vibrating sample magnetometer(VSM).The poly-shaped Fe_(2)O_(3) NPs of size(34±10)nm with hematite(α-Fe_(2)O_(3))phase were synthesized.The antibacterial activity of chloramphenicol and gentamicin and their formulation with encapsulated iron oxide nanoparticles was investigated by the agar well diffusion technique.Drug-encapsulated Fe_(2)O_(3) NPs showed antibacterial activity against Escherichia coli and Staphylococcus aureus strains,possibly in a dose-dependent manner.Significant effectiveness was confirmed by the increase in the single range of inhibition against the tested microorganisms.Furthermore,the effect of iron oxide nanoparticle concentrations ranging from 1 to 9μg/μL on bacterial growth was examined.
