Aim: To evaluate the aphrodisiac potential of Terminalia catappa Linn. seeds using a suspension of its kernel (SS)in 1% methyl cellulose in rats. Methods: Male rots were orally treated with 1500 mg/kg or 3000 mg/kg SS...Aim: To evaluate the aphrodisiac potential of Terminalia catappa Linn. seeds using a suspension of its kernel (SS)in 1% methyl cellulose in rats. Methods: Male rots were orally treated with 1500 mg/kg or 3000 mg/kg SS or ve-hicle, and their sexual behaviour was monitored 3 h later using a receptive female. Another group of rats was orallytreated with either 3000 mg/kg SS or vehicle for 7 consecutive days. Their sexual behaviour and fertility were evaluatedon days 1, 4 and 7 of treatment and day 7 post-treatment by pairing overnight with a pro-oestrous female. Results:The 1500 mg/kg dose, had a marked aphrodisiac action (prolongation of ejaculation latency) but no effect on libido(% mounting, % intromission and % ejaculation), sexual vigour (mounting-and-intromission frequency), or sexualperformance (intercopulatory interval). In contrast, the higher dose (3000 mg/kg) reversibly inhibited all the para?e-ten of sexual behaviour other than mounting-and-intromission frequency and copulatory efficiency. The effects of highdose SS were not due to general toxicity, liver toxicity, haemotoxicity, stress, muscle deficiency, muscle incoordina-fion, analgesia, hypoglycaemia or reduction in blood testosterone level. They were due to marked sedation. Conclu-sion: The kernel of T. catappa seeds has aphrodisiac activity and may be useful in the treatment of certain forms ofsexual inadequacies, such as premature ejaculation.展开更多
Aim: To examine the effect of L-arginine, the substrate of nitric oxide (NO) synthase, on reproductive function ofmale rats. Methods: Male rats were gavaged with either L-arginine (100 or 200 mg·kg^(-1)·d^(-...Aim: To examine the effect of L-arginine, the substrate of nitric oxide (NO) synthase, on reproductive function ofmale rats. Methods: Male rats were gavaged with either L-arginine (100 or 200 mg·kg^(-1)·d^(-1)), D-arginine (200mg·kg^(-1)·d^(-1)) or vehicle (0.9% NaCl) for seven consecutive days. Their sexual behaviour and fertility were evaluat-ed using receptive females. Results: L-arginine (200 mg/kg) had no significant effect on sexual competence (interms of sexual arousal, libido, sexual vigour and sexual performance). In mating experiments, the higher dose of L-arginine effectively and reversibly inhibited fertility, whilst the lower dose and the inactive stereoisomer D-arginine hadno significant effect. The antifertility effect caused by L-arginine was due to a profound elevation in the preimplantationloss mediated possibly by impairment in epididymal sperm maturation, hyperactivated sperm motility and sperm capaci-tation. Conclusion: Elevated NO production may be detrimental to male fertility.展开更多
文摘Aim: To evaluate the aphrodisiac potential of Terminalia catappa Linn. seeds using a suspension of its kernel (SS)in 1% methyl cellulose in rats. Methods: Male rots were orally treated with 1500 mg/kg or 3000 mg/kg SS or ve-hicle, and their sexual behaviour was monitored 3 h later using a receptive female. Another group of rats was orallytreated with either 3000 mg/kg SS or vehicle for 7 consecutive days. Their sexual behaviour and fertility were evaluatedon days 1, 4 and 7 of treatment and day 7 post-treatment by pairing overnight with a pro-oestrous female. Results:The 1500 mg/kg dose, had a marked aphrodisiac action (prolongation of ejaculation latency) but no effect on libido(% mounting, % intromission and % ejaculation), sexual vigour (mounting-and-intromission frequency), or sexualperformance (intercopulatory interval). In contrast, the higher dose (3000 mg/kg) reversibly inhibited all the para?e-ten of sexual behaviour other than mounting-and-intromission frequency and copulatory efficiency. The effects of highdose SS were not due to general toxicity, liver toxicity, haemotoxicity, stress, muscle deficiency, muscle incoordina-fion, analgesia, hypoglycaemia or reduction in blood testosterone level. They were due to marked sedation. Conclu-sion: The kernel of T. catappa seeds has aphrodisiac activity and may be useful in the treatment of certain forms ofsexual inadequacies, such as premature ejaculation.
文摘Aim: To examine the effect of L-arginine, the substrate of nitric oxide (NO) synthase, on reproductive function ofmale rats. Methods: Male rats were gavaged with either L-arginine (100 or 200 mg·kg^(-1)·d^(-1)), D-arginine (200mg·kg^(-1)·d^(-1)) or vehicle (0.9% NaCl) for seven consecutive days. Their sexual behaviour and fertility were evaluat-ed using receptive females. Results: L-arginine (200 mg/kg) had no significant effect on sexual competence (interms of sexual arousal, libido, sexual vigour and sexual performance). In mating experiments, the higher dose of L-arginine effectively and reversibly inhibited fertility, whilst the lower dose and the inactive stereoisomer D-arginine hadno significant effect. The antifertility effect caused by L-arginine was due to a profound elevation in the preimplantationloss mediated possibly by impairment in epididymal sperm maturation, hyperactivated sperm motility and sperm capaci-tation. Conclusion: Elevated NO production may be detrimental to male fertility.
