We are interested in investigating whether cancer therapy may alter the mitochondrial redox state in cancer cells to inhibit their growth and survival.The redox state can be imaged by the redox scanner that collects t...We are interested in investigating whether cancer therapy may alter the mitochondrial redox state in cancer cells to inhibit their growth and survival.The redox state can be imaged by the redox scanner that collects the fuorescence signals from both the oxidized-fAavoproteins(Fp)and the reduced form of nicotinamide adenine dinucleotide(NADH)in snap frozen tissues and has been previously employed to study tumor aggressiveness and treatment responses.Here,with the redox scanner we investigated the effects of chemotherapy on mouse xenografts of a human diffuse large B.cell lymphoma cell line(DLCL2).The mice were treated with CHOP therapy,i.e,cyclophosphamide(C)+hydroxydoxorubicin(H)+Oncovin(O)+prednisone(P)with CHO administration on day 1 and prednisone administration on days 1-5.The Fp content of the treated group was significantly decreased(p=0.033)on day 5,and the mitochondrial redox state of the treated group was slightly more reduced than that of the control group(p=0.048).The decrease of the Fp heterogeneity(measured by the mean st andard deviation)had a border-line statistical significance(p=0.071).The result suggests that the mitochondrial metabolism of lymphoma cells was slightly suppressed and the lymphomas became less aggressive after the CHOP therapy.展开更多
We achieve the robust nonadiabatic holonomic two-qubit controlled gate in one step based on the groundstate blockade mechanism between two Rydberg atoms. By using the Rydberg-blockade effect and the Raman transition m...We achieve the robust nonadiabatic holonomic two-qubit controlled gate in one step based on the groundstate blockade mechanism between two Rydberg atoms. By using the Rydberg-blockade effect and the Raman transition mechanism, we can produce the blockade effect of double occupation of the corresponding ground state,i.e., ground-state blockade, to encode the computational subspace into the ground state, thus effectively avoiding the spontaneous emission of the excited Rydberg state. On the other hand, the feature of geometric quantum computation independent of the evolutionary details makes the scheme robust to control errors. In this way,the controlled quantum gate constructed by our scheme not only greatly reduces the gate infidelity caused by spontaneous emission but is also robust to control errors.展开更多
Heat engines are essential devices in modern industry,converting heat energy into useful mechanical work via their working substances.Here we experimentally simulate the conventional heat engine by employing the vibra...Heat engines are essential devices in modern industry,converting heat energy into useful mechanical work via their working substances.Here we experimentally simulate the conventional heat engine by employing the vibra-tional mode of a single trapped ion as the working substance.In contrast to simply employing the ion in thermal motion,we consider coherently stimulating the ion’s vibrational motion as the phonon laser,which helps acquire clearer results by effectively suppressing the thermal fluctuation.As such,we demonstrate in an exact and high signal-to-noise way the standard steps of both the Otto and Carnot cycles in a single ion,and compare their maxi-mum efficiencies by monitoring the amplitude and frequency of the vibration.Our work witnesses an interesting single-atom thermal engine using coherently controlled phonons.It would be the smallest platform for simulating or demonstrating classical thermodynamic laws and phenomena at a single ion scale via optical manipulation techniques for phonon lasers.展开更多
The reaction between the 2-{TTF-fused-1H-benzimidazol-2-yl}pyridine alkylated with either the di-(pyrazol-1-yl)-4-pyridyl(L^(1))or dimethyl-2,2’-bipyridine(L^(2))moiety and 1 equiv.
基金The grant support to this work incude the Center of Magnetic Resonance and Optical Imaging(CMROI)-an NIH-supported research resource P41RR02305(R.Reddy)the Small A nimal Imaging Resources Program(SAIR)2U24-CA083105(J.D.Glickson and L.Chodosh)+1 种基金2R01-CA101700(J.D.Glickson)NIH K99/R00-CA 126187(R.Choe)。
文摘We are interested in investigating whether cancer therapy may alter the mitochondrial redox state in cancer cells to inhibit their growth and survival.The redox state can be imaged by the redox scanner that collects the fuorescence signals from both the oxidized-fAavoproteins(Fp)and the reduced form of nicotinamide adenine dinucleotide(NADH)in snap frozen tissues and has been previously employed to study tumor aggressiveness and treatment responses.Here,with the redox scanner we investigated the effects of chemotherapy on mouse xenografts of a human diffuse large B.cell lymphoma cell line(DLCL2).The mice were treated with CHOP therapy,i.e,cyclophosphamide(C)+hydroxydoxorubicin(H)+Oncovin(O)+prednisone(P)with CHO administration on day 1 and prednisone administration on days 1-5.The Fp content of the treated group was significantly decreased(p=0.033)on day 5,and the mitochondrial redox state of the treated group was slightly more reduced than that of the control group(p=0.048).The decrease of the Fp heterogeneity(measured by the mean st andard deviation)had a border-line statistical significance(p=0.071).The result suggests that the mitochondrial metabolism of lymphoma cells was slightly suppressed and the lymphomas became less aggressive after the CHOP therapy.
基金supported by the Special Project for Research and Development in Key Areas of Guangdong Province(Grant No.2020B0303300001)the National Natural Science Foundation of China(Grant Nos.U21A20434 and 12074346)the Natural Science Foundation of Henan Province(Grant No.212300410085)。
文摘We achieve the robust nonadiabatic holonomic two-qubit controlled gate in one step based on the groundstate blockade mechanism between two Rydberg atoms. By using the Rydberg-blockade effect and the Raman transition mechanism, we can produce the blockade effect of double occupation of the corresponding ground state,i.e., ground-state blockade, to encode the computational subspace into the ground state, thus effectively avoiding the spontaneous emission of the excited Rydberg state. On the other hand, the feature of geometric quantum computation independent of the evolutionary details makes the scheme robust to control errors. In this way,the controlled quantum gate constructed by our scheme not only greatly reduces the gate infidelity caused by spontaneous emission but is also robust to control errors.
基金supported by Special Project for Research and Devel-opment in Key Areas of Guangdong Province(2020B0303300001)by National Natural Science Foundation of China(U21A20434,12074390,12074346,11835011,11734018)+3 种基金by Key Lab of Guangzhou for Quan-tum Precision Measurement(202201000010)by Guangzhou Funding for Science and Technology(202201011727)by Postdoctoral Science Foundation of China(2022MT10881)by Nansha Senior Leading Talent Team Technology Project(2021CXTD02).
文摘Heat engines are essential devices in modern industry,converting heat energy into useful mechanical work via their working substances.Here we experimentally simulate the conventional heat engine by employing the vibra-tional mode of a single trapped ion as the working substance.In contrast to simply employing the ion in thermal motion,we consider coherently stimulating the ion’s vibrational motion as the phonon laser,which helps acquire clearer results by effectively suppressing the thermal fluctuation.As such,we demonstrate in an exact and high signal-to-noise way the standard steps of both the Otto and Carnot cycles in a single ion,and compare their maxi-mum efficiencies by monitoring the amplitude and frequency of the vibration.Our work witnesses an interesting single-atom thermal engine using coherently controlled phonons.It would be the smallest platform for simulating or demonstrating classical thermodynamic laws and phenomena at a single ion scale via optical manipulation techniques for phonon lasers.
基金supported by Région Bretagne,Rennes Métropole,CNRS,Universitéde Rennes 1 and FEDER.G.F.G.gratefully acknowledges the European Commission through the ERC-AdG 267746 MolNanoMas(project no.267746)the ANR(ANR-13-BS07-0022-01)for financial support.B.L.G.and G.F.G.thank the French GENCI/IDRIS-CINES centre for high-performance computing resources.
文摘The reaction between the 2-{TTF-fused-1H-benzimidazol-2-yl}pyridine alkylated with either the di-(pyrazol-1-yl)-4-pyridyl(L^(1))or dimethyl-2,2’-bipyridine(L^(2))moiety and 1 equiv.
