Obesity represents a major health issue linked to various dysfunctions within adipose tissue.The equilibrium between energy storage and expenditure is vital for appropriate fat accumulation and lipid metabolism.A comp...Obesity represents a major health issue linked to various dysfunctions within adipose tissue.The equilibrium between energy storage and expenditure is vital for appropriate fat accumulation and lipid metabolism.A comprehensive understanding of the molecular mechanisms underlying adipogenesis(the formation of fat cells)and thermogenesis(the production of heat)is crucial for sustaining lipid homeostasis and managing fat development.Increasing evidence indicates that long noncoding RNAs(lncRNAs),a category of nonprotein-coding RNAs that are several hundred nucleotides long,play substantial roles in biological processes related to obesity through various regulatory pathways.The increasing incidence of obesity has increased interest in the specific mechanisms that govern adipocyte development.Although numerous mRNAs and microRNAs are recognized for their influences on adipogenesis,the overall expression patterns and functional roles of lncRNAs in this context remain inadequately studied.Adipose tissue is rich in various lncRNAs that have different expression patterns during adipogenesis and are regulated by key transcription factors such as PPARγ(peroxisome proliferator-activated receptorγ)and CEBPα(CCAAT/enhancer binding proteinα).For example,ADINR(adipogenic differentiation inducing noncoding RNA)promotes adipogenesis by activating PPARγ,whereas GATA6-AS(GATA6 antisense RNA)affects preadipocyte differentiation through GATA proteins.TUG1(taurine up-regulated gene 1)regulates the TGFβ(transforming growth factorβ)/SMAD pathway,which affects the development of white and brown fat,whereas DLK1/PREF1(delta-like 1/preadipocyte factor 1)inhibits adipocyte maturation.Functional screens utilizing RNA interference(RNAi)and CRISPR-SpCas9 genome editing have revealed critical lncRNAs that exert diverse effects on adipogenesis.This review focuses on recent research concerning the functions of lncRNAs in the regulation of white and brown adipogenesis,emphasizing their roles in adipocyte differentiation.展开更多
文摘Obesity represents a major health issue linked to various dysfunctions within adipose tissue.The equilibrium between energy storage and expenditure is vital for appropriate fat accumulation and lipid metabolism.A comprehensive understanding of the molecular mechanisms underlying adipogenesis(the formation of fat cells)and thermogenesis(the production of heat)is crucial for sustaining lipid homeostasis and managing fat development.Increasing evidence indicates that long noncoding RNAs(lncRNAs),a category of nonprotein-coding RNAs that are several hundred nucleotides long,play substantial roles in biological processes related to obesity through various regulatory pathways.The increasing incidence of obesity has increased interest in the specific mechanisms that govern adipocyte development.Although numerous mRNAs and microRNAs are recognized for their influences on adipogenesis,the overall expression patterns and functional roles of lncRNAs in this context remain inadequately studied.Adipose tissue is rich in various lncRNAs that have different expression patterns during adipogenesis and are regulated by key transcription factors such as PPARγ(peroxisome proliferator-activated receptorγ)and CEBPα(CCAAT/enhancer binding proteinα).For example,ADINR(adipogenic differentiation inducing noncoding RNA)promotes adipogenesis by activating PPARγ,whereas GATA6-AS(GATA6 antisense RNA)affects preadipocyte differentiation through GATA proteins.TUG1(taurine up-regulated gene 1)regulates the TGFβ(transforming growth factorβ)/SMAD pathway,which affects the development of white and brown fat,whereas DLK1/PREF1(delta-like 1/preadipocyte factor 1)inhibits adipocyte maturation.Functional screens utilizing RNA interference(RNAi)and CRISPR-SpCas9 genome editing have revealed critical lncRNAs that exert diverse effects on adipogenesis.This review focuses on recent research concerning the functions of lncRNAs in the regulation of white and brown adipogenesis,emphasizing their roles in adipocyte differentiation.
