Hemolysis in ED （emergency department） patients is common due to difficult blood draws. Values of serum potassium （K＋） become falsely elevated secondary to release of intracellular contents. Objective： The aim o...Hemolysis in ED （emergency department） patients is common due to difficult blood draws. Values of serum potassium （K＋） become falsely elevated secondary to release of intracellular contents. Objective： The aim of the study was to establish a correction factor for factitious elevated K＋ in samples for de adult ED. Methods： We used samples from 125 adult ED patients, in which the 2nd sample was drawn due to hemolysis of the first tube. Results： Firstly, we derived a correction factor expressing an increase in potassium concentration in 0.21 mmol/L （95% confidence interval, 0.17-0.24 mmol/L with p 〈 0.01） for each hemolysis index increment. Conclusions： A reliable correction factor for factitious hyperkalemia in a clinical relevant range exists.展开更多
Background： DIIHA （Drug-induced immune hemolytic anemia） is rare, and a specialized laboratory is often required to provide optimal serological tests to confirm diagnosis. There have been few cases reported of etor...Background： DIIHA （Drug-induced immune hemolytic anemia） is rare, and a specialized laboratory is often required to provide optimal serological tests to confirm diagnosis. There have been few cases reported of etoricoxib-induced immune hemolytic anemia. Immune complexes formed between some drugs and their respective antibodies attach weakly or strongly in a nonspecific way to RBCs （red blood cells）. The bound immune complex activates complement, which may lead to hemolysis in vivo. Aims： Demonstration of immune complex formation involving etoricoxib in vitro. Methods： A 46-year-old woman developed acute severe anemia one day after a single dose of etoricoxib 90 mgper os with a strong positive DAT （direct anti-globulin test） and a weak positive IAT （indirect anti-globuline test）. For investigation diagnosis, we used the American Association of Blood Banks Technical Manual protocol using patient serum collected in three different moments （at patient admission, one month after and one month after stopping steroids）. Results： The authors found strong positive IAT reactions when the patient serum was tested with the drug. Conclusions： The strong agglutination that occurred in the mixture of the drug and the patient serum indicates a drug/antidrug interaction and may lead to DIIHA. This was the first case reported in Portugal of DIIHA induced by etoricoxib.展开更多
文摘Hemolysis in ED （emergency department） patients is common due to difficult blood draws. Values of serum potassium （K＋） become falsely elevated secondary to release of intracellular contents. Objective： The aim of the study was to establish a correction factor for factitious elevated K＋ in samples for de adult ED. Methods： We used samples from 125 adult ED patients, in which the 2nd sample was drawn due to hemolysis of the first tube. Results： Firstly, we derived a correction factor expressing an increase in potassium concentration in 0.21 mmol/L （95% confidence interval, 0.17-0.24 mmol/L with p 〈 0.01） for each hemolysis index increment. Conclusions： A reliable correction factor for factitious hyperkalemia in a clinical relevant range exists.
文摘Background： DIIHA （Drug-induced immune hemolytic anemia） is rare, and a specialized laboratory is often required to provide optimal serological tests to confirm diagnosis. There have been few cases reported of etoricoxib-induced immune hemolytic anemia. Immune complexes formed between some drugs and their respective antibodies attach weakly or strongly in a nonspecific way to RBCs （red blood cells）. The bound immune complex activates complement, which may lead to hemolysis in vivo. Aims： Demonstration of immune complex formation involving etoricoxib in vitro. Methods： A 46-year-old woman developed acute severe anemia one day after a single dose of etoricoxib 90 mgper os with a strong positive DAT （direct anti-globulin test） and a weak positive IAT （indirect anti-globuline test）. For investigation diagnosis, we used the American Association of Blood Banks Technical Manual protocol using patient serum collected in three different moments （at patient admission, one month after and one month after stopping steroids）. Results： The authors found strong positive IAT reactions when the patient serum was tested with the drug. Conclusions： The strong agglutination that occurred in the mixture of the drug and the patient serum indicates a drug/antidrug interaction and may lead to DIIHA. This was the first case reported in Portugal of DIIHA induced by etoricoxib.
