目的探讨甲状腺癌组织中Janus激酶2(janus kinase 2,JAK2)及信号转导因子和转录激活因子3(signal transducer and activator of transcription 3,STAT3)的表达与临床病理特点的关系以及对患者预后的影响。方法选择2018年8月—2020年8月...目的探讨甲状腺癌组织中Janus激酶2(janus kinase 2,JAK2)及信号转导因子和转录激活因子3(signal transducer and activator of transcription 3,STAT3)的表达与临床病理特点的关系以及对患者预后的影响。方法选择2018年8月—2020年8月广西医科大学第一附属医院术后确诊为甲状腺癌的72例患者,取患者的癌组织(癌组织组)和癌旁组织(癌旁组织组)标本。通过免疫组化法对比两组的JAK2和STAT3的阳性表达率,观察甲状腺癌组织中JAK2、STAT3的表达与临床病理特点的关系,比较JAK2、STAT3表达的患者的生存期。结果癌组织组的JAK2、STAT3阳性率明显高于癌旁组织组,差异有统计学意义(χ^(2)=55.125、48.347,P<0.05);JAK2的表达与患者的临床分期、肿瘤大小和淋巴结转移显著相关(r=23.590、16.470、12.710,P<0.05);而STAT3的表达与患者的临床分期、淋巴结转移和包膜侵犯显著相关(r=15.460、13.950、10.860,P<0.05);生存分析显示JAK2和STAT3阳性患者的存活率比阴性患者低。结论JAK2/STAT3信号通路在甲状腺癌组织中高表达,STAT3和JAK2的表达与癌组织的恶性程度有关,与甲状腺癌的发生发展关系密切,有望成为治疗甲状腺癌新靶点。展开更多
A new calculating method of the running in procedure of W-N gear drives according to the criterion of frictional work consumed in meshing cycles is presented.Combining with the amount of clearances between two teeth f...A new calculating method of the running in procedure of W-N gear drives according to the criterion of frictional work consumed in meshing cycles is presented.Combining with the amount of clearances between two teeth flanks,the running-in procedure of W-N gear drives is reappeared more authentically. The erroneous conclusion that considering that the contact pressure uniformly distribute along the tooth depth after full running-in is corrected. So a foundation for the calculation of the contact pressure of W-N gear drives is provided.展开更多
文摘目的探讨甲状腺癌组织中Janus激酶2(janus kinase 2,JAK2)及信号转导因子和转录激活因子3(signal transducer and activator of transcription 3,STAT3)的表达与临床病理特点的关系以及对患者预后的影响。方法选择2018年8月—2020年8月广西医科大学第一附属医院术后确诊为甲状腺癌的72例患者,取患者的癌组织(癌组织组)和癌旁组织(癌旁组织组)标本。通过免疫组化法对比两组的JAK2和STAT3的阳性表达率,观察甲状腺癌组织中JAK2、STAT3的表达与临床病理特点的关系,比较JAK2、STAT3表达的患者的生存期。结果癌组织组的JAK2、STAT3阳性率明显高于癌旁组织组,差异有统计学意义(χ^(2)=55.125、48.347,P<0.05);JAK2的表达与患者的临床分期、肿瘤大小和淋巴结转移显著相关(r=23.590、16.470、12.710,P<0.05);而STAT3的表达与患者的临床分期、淋巴结转移和包膜侵犯显著相关(r=15.460、13.950、10.860,P<0.05);生存分析显示JAK2和STAT3阳性患者的存活率比阴性患者低。结论JAK2/STAT3信号通路在甲状腺癌组织中高表达,STAT3和JAK2的表达与癌组织的恶性程度有关,与甲状腺癌的发生发展关系密切,有望成为治疗甲状腺癌新靶点。
文摘A new calculating method of the running in procedure of W-N gear drives according to the criterion of frictional work consumed in meshing cycles is presented.Combining with the amount of clearances between two teeth flanks,the running-in procedure of W-N gear drives is reappeared more authentically. The erroneous conclusion that considering that the contact pressure uniformly distribute along the tooth depth after full running-in is corrected. So a foundation for the calculation of the contact pressure of W-N gear drives is provided.
