Objectives:Sleep loss decreases working memory(WM)performance in young adults.The mechanisms that regulate WM performance during sleep loss are integrative and likely depend on the duration of perturbed sleep.The aim ...Objectives:Sleep loss decreases working memory(WM)performance in young adults.The mechanisms that regulate WM performance during sleep loss are integrative and likely depend on the duration of perturbed sleep.The aim of this research was to investigate the impact of a single night of partial sleep restriction(PSR)on WM,and the extent to which factors such as cardiorespiratory fitness and brainderived neurotrophic factor(BDNF)influence WM performance following one night of PSR.Methods:We measured WM performance after one night of PSR in twenty-two young adults(n=13 females)with otherwise normal sleep habits.Participants completed an N-back test following one night of normal sleep(6–9 h sleep duration)and after one night of PSR(3 h sleep duration).To account for learning effects due to repeated cognitive testing,a time-matched normal sleep control group was also collected(n=22).Plasma BDNF was measured after normal sleep and PSR.Cardiorespiratory fitness was assessed via an incremental test to exhaustion on a cycle ergometer.Results:3-back reaction time was slightly slower after PSR compared to the control group(P_(Interaction)=0.038;η_(p)^(2)=0.10).No changes in BDNF were observed between sleep conditions(p=0.720;Cohen’s d=−0.04).WMperformance after acute PSR was inversely related to cardiorespiratory fitness(p=0.025;Pearson’s r=-0.48);and these associations were observed without changes in plasma BDNF.Conclusions:Our data suggest that a single night of PSR may acutely impair WM in young adults and contribute to an understanding about the incipient cognitive consequences of shortened sleep.展开更多
基金supported by an Ontario Graduate Scholarship(OGS)funded by the Natural Engineering and Sciences Research Council of Canada(NSERC DG:#20011033)+1 种基金funded by the Natural Engineering and Sciences Research Council of Canada(NSERC DG:RGPIN-2021-03522)Canada Foundation for Innovation(CFI John R.Evans Leader’s Fund).
文摘Objectives:Sleep loss decreases working memory(WM)performance in young adults.The mechanisms that regulate WM performance during sleep loss are integrative and likely depend on the duration of perturbed sleep.The aim of this research was to investigate the impact of a single night of partial sleep restriction(PSR)on WM,and the extent to which factors such as cardiorespiratory fitness and brainderived neurotrophic factor(BDNF)influence WM performance following one night of PSR.Methods:We measured WM performance after one night of PSR in twenty-two young adults(n=13 females)with otherwise normal sleep habits.Participants completed an N-back test following one night of normal sleep(6–9 h sleep duration)and after one night of PSR(3 h sleep duration).To account for learning effects due to repeated cognitive testing,a time-matched normal sleep control group was also collected(n=22).Plasma BDNF was measured after normal sleep and PSR.Cardiorespiratory fitness was assessed via an incremental test to exhaustion on a cycle ergometer.Results:3-back reaction time was slightly slower after PSR compared to the control group(P_(Interaction)=0.038;η_(p)^(2)=0.10).No changes in BDNF were observed between sleep conditions(p=0.720;Cohen’s d=−0.04).WMperformance after acute PSR was inversely related to cardiorespiratory fitness(p=0.025;Pearson’s r=-0.48);and these associations were observed without changes in plasma BDNF.Conclusions:Our data suggest that a single night of PSR may acutely impair WM in young adults and contribute to an understanding about the incipient cognitive consequences of shortened sleep.
