Lung cancer(LC)is still one of the most frequent cancers with a high related mortality.Their prognosis is directly proportional to the stage at the time of diagnosis.Seventy percent are currently diagnosed in advanced...Lung cancer(LC)is still one of the most frequent cancers with a high related mortality.Their prognosis is directly proportional to the stage at the time of diagnosis.Seventy percent are currently diagnosed in advanced or locally advanced stage(higher than stage III),making a cure unlikely for the majority of patients.Developments in LC treatment are significant however they do not seem to be enough to reverse the current situation,at least,in a short period of time.Despite recent advances in treatment,primary prevention and early diagnosis appear to be the key to reduce the incidence and mortality of this disease.Many countries have developed LC screening programs based on the results of clinical trials published in recent years.The aim of this paper is to review the latest results of the NEderlands Leuvens Longkanker Screenings Onderzoek and compare them with the findings of the National Lung Screening Trial.We address the question whether it is necessary to continue discussing the evidence regarding LC screening.In both trials,there is a clear impact on LC mortality but,with a modest reduction in over all mortality.Undoubtedly,the benefit of screening can be expected to grow as low-dose computed tomographys are performed over longer periods of time.展开更多
It has always been a spectroscopist’s dream to correlate a material’s luminescence properties with its microscopic structure,based on reliable structure–property relationships.Electronic structure methods are promi...It has always been a spectroscopist’s dream to correlate a material’s luminescence properties with its microscopic structure,based on reliable structure–property relationships.Electronic structure methods are promising to achieve this goal;yet they are especially challenging in the case of Eu-based materials which are known to feature exceptionally high density of excited states,large spins and severe electron correlation.展开更多
文摘Lung cancer(LC)is still one of the most frequent cancers with a high related mortality.Their prognosis is directly proportional to the stage at the time of diagnosis.Seventy percent are currently diagnosed in advanced or locally advanced stage(higher than stage III),making a cure unlikely for the majority of patients.Developments in LC treatment are significant however they do not seem to be enough to reverse the current situation,at least,in a short period of time.Despite recent advances in treatment,primary prevention and early diagnosis appear to be the key to reduce the incidence and mortality of this disease.Many countries have developed LC screening programs based on the results of clinical trials published in recent years.The aim of this paper is to review the latest results of the NEderlands Leuvens Longkanker Screenings Onderzoek and compare them with the findings of the National Lung Screening Trial.We address the question whether it is necessary to continue discussing the evidence regarding LC screening.In both trials,there is a clear impact on LC mortality but,with a modest reduction in over all mortality.Undoubtedly,the benefit of screening can be expected to grow as low-dose computed tomographys are performed over longer periods of time.
基金the UGent Special Research Fund(BOF/PDO/2017/002101)the Fund for Scientific Research-Flanders(FWO)for a travel grant(V416818N)This work was partially supported by Ministerio de Economía y Competitividad,Spain(Dirección General de Investigación y Gestión del Plan Nacional de I+D+i,MAT2017-83553-P).
文摘It has always been a spectroscopist’s dream to correlate a material’s luminescence properties with its microscopic structure,based on reliable structure–property relationships.Electronic structure methods are promising to achieve this goal;yet they are especially challenging in the case of Eu-based materials which are known to feature exceptionally high density of excited states,large spins and severe electron correlation.
