Purpose: This study aims to compare adolescents' cardiometabolic risk score through an integrative classification of physical activity(PA),which involves the combination of moderate-to-vigorous physical activity(M...Purpose: This study aims to compare adolescents' cardiometabolic risk score through an integrative classification of physical activity(PA),which involves the combination of moderate-to-vigorous physical activity(MVPA) and sedentary behavior(SB).Methods: A cross-sectional study derived from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study database(2006-2008) was conducted in adolescents(n = 548; boys, 47.3%; 14.7 ± 1.2 years) from 10 European cities. MVPA and SB were objectively measured using accelerometry. Adolescents were divided into 4 categories according to MVPA(meeting or not meeting the international recommendations) and the median of SB time(above or below sex-and age-specific median) as follows: High-SB & Inactive, Low-SB & Inactive,High-SB & Active, and Low-SB & Active. A clustered cardiometabolic risk score was computed using the homeostatic model assessment, systolic blood pressure, triglycerides, total cholesterol/high-density lipoprotein cholesterol, sum 4 skinfolds, and cardiorespiratory fitness(CRF).Analyses of covariance were performed to discern differences on cardiometabolic risk scores among PA categories and each health component.Results: The cardiometabolic risk score was lower in adolescents meeting the MVPA recommendation and with less time spent in SB in comparison to the high-SB & Inactive group(p < 0.05). However, no difference in cardiometabolic risk score was established between High-SB or Low-SB groups in inactive adolescents. It is important to note that CRF was the only variable that showed a significant modification(higher)when children were compared from the category of physically inactive with "active" but not from high-to low-SB.Conclusion: Being physically active is the most significant and protective outcome in adolescents to reduce cardiometabolic risk. Lower SB does not exhibit a significant and extra beneficial difference.展开更多
Objectives To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin-1(ISM1)and obesity-related phenotypes in a population of Spanish children and to investigate ...Objectives To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin-1(ISM1)and obesity-related phenotypes in a population of Spanish children and to investigate the plausible molecular alterations behind the alteration of the serum levels of this protein in children with obesity.Methods The study population is a sub-cohort of the PUBMEP research project,consisting of a cross-sectional population of 119 pubertal children with overweight(17 boys,19 girls),obesity(20 boys,25 girls),and normal weight(17 boys,21 girls).All subjects were classified into experimental groups according to their sex,obesity,and insulin resistance(IR)status.They were counted anthropometry,glucose and lipid metabolism,inflammation and cardiovascular biomarkers as well as isthmin-1(ISM1)serum levels.This population was intended as a discovery population to elucidate the relationship between obesity and ISM1 levels in children.Furthermore,the study population had blood whole-genome DNA methylation examined,allowing deepening into the obesity–ISM1 molecular relationship.Results Higher serum ISM1 levels were observed in boys with obesity than in normal weight(P=0.004)and overweight(P=0.007)boys.ISM1 serum levels were positively associated with body mass index(BMI)Z-score(P=0.005)and fat mass(P=0.058)and negatively associated with myeloperoxidase(MPO)(P=0.043)in boys.Although we did not find associations between ISM1 serum levels and metabolic outcomes in girls,which may indicate a putative sexual dimorphism,fat mass was positively associated in all children,including boys and girls(P=0.011).DNA methylation levels in two-enhancer-related CpG sites of ISM1(cg03304641 and cg14269097)were associated with serum levels of ISM1 in children.Conclusions ISM1 is associated with obesity in boys at the pubertal stage,elucidating how this protein might be of special relevance as a new biomarker of obesity in children.Further studies including a longitudinal design during puberty are needed.展开更多
Background Preschoolers and young children are vulnerable to psychosocial and behavioral disorders linked to lifestyle factors such as screen time and sleep disturbances.Our study examines the relationship between scr...Background Preschoolers and young children are vulnerable to psychosocial and behavioral disorders linked to lifestyle factors such as screen time and sleep disturbances.Our study examines the relationship between screen time and adherence to recommendations with children's behavioral and emotional difficulties,with a focus on the role of sleep duration.Methods Cross-sectional analyses were conducted within the multicenter prospective Childhood Obesity Risk Assessment Longitudinal Study(CORALS),which included 1420 children aged 3-6 years.Screen time(hours/day)and adherence to recommendations(≤2 hours/day)were assessed.Behavioral and emotional difficulties were measured via the strengths and difficulties questionnaire.Multivariable linear and logistic regression models were used to estimate associations between screen time(continuous and dichotomous)and strengths and difficulties questionnaire scores,adjusting for potential confounders.We also tested the moderating effect of sleep and conducted isotemporal substitution analyses replacing screen time with sleep duration.Results Higher screen time was associated with higher total strengths and difficulties questionnaire scores[β95%confidence interval(CI),0.35(0.10,0.61)],emotional symptoms[0.10(0.01,0.19)],conduct problems[0.10(0.01,0.18)],and greater odds of exceeding the 16-point strengths and difficulties questionnaire cutofffor behavioral and emotional difficulties[odds ratio(OR)(95%CI),1.21(1.04,1.41)].Children who adhered to screen time recommendations had lower strengths and difficulties questionnaire total scores[β(95%CI),-0.64(-1.19,-0.10)]and odds of experiencing behavioral and emotional difficulties[OR(95%CI),0.67(0.47,0.95)].Sleep duration moderated the screen time–strengths and difficulties questionnaire association(P=0.020).The isotemporal substitution of screen time for sleep duration was associated with lower strengths and difficulties questionnaire scores across all subscales,except for prosocial behavior.Conclusions Higher screen time was associated with greater emotional and behavioral difficulties,whereas adherence to screen time recommendations and adequate sleep duration were inversely associated.Managing screen time and promoting sleep are crucial for children's well-being.展开更多
基金supported by the European Community Sixth RTD Framework Programme (contract FOOD-CT-2005-007034)supported by the Spanish Ministry of Economy and Competitiveness (Grants RYC-2010-05957 and RYC-2011-09011)+3 种基金the Spanish Ministry of Health: Maternal, Child Health and Development Network (Grants RD08/0072 and RD16/0022)the Fondo Europeo de Desarrollo Regional (MICINN-FEDER)the University of Granada, Plan Propio de Investigacion 2016, Excellence actions:Units of ExcellenceUnit of Excellence on Exercise and Health (UCEES)
文摘Purpose: This study aims to compare adolescents' cardiometabolic risk score through an integrative classification of physical activity(PA),which involves the combination of moderate-to-vigorous physical activity(MVPA) and sedentary behavior(SB).Methods: A cross-sectional study derived from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study database(2006-2008) was conducted in adolescents(n = 548; boys, 47.3%; 14.7 ± 1.2 years) from 10 European cities. MVPA and SB were objectively measured using accelerometry. Adolescents were divided into 4 categories according to MVPA(meeting or not meeting the international recommendations) and the median of SB time(above or below sex-and age-specific median) as follows: High-SB & Inactive, Low-SB & Inactive,High-SB & Active, and Low-SB & Active. A clustered cardiometabolic risk score was computed using the homeostatic model assessment, systolic blood pressure, triglycerides, total cholesterol/high-density lipoprotein cholesterol, sum 4 skinfolds, and cardiorespiratory fitness(CRF).Analyses of covariance were performed to discern differences on cardiometabolic risk scores among PA categories and each health component.Results: The cardiometabolic risk score was lower in adolescents meeting the MVPA recommendation and with less time spent in SB in comparison to the high-SB & Inactive group(p < 0.05). However, no difference in cardiometabolic risk score was established between High-SB or Low-SB groups in inactive adolescents. It is important to note that CRF was the only variable that showed a significant modification(higher)when children were compared from the category of physically inactive with "active" but not from high-to low-SB.Conclusion: Being physically active is the most significant and protective outcome in adolescents to reduce cardiometabolic risk. Lower SB does not exhibit a significant and extra beneficial difference.
基金supported by the Plan Nacional de Investigación Científca,Desarrollo e Innovación Tecnológica(I+D+I)Instituto de Salud Carlos III-Health Research Funding(FONDOS FEDER)(PI051968,PI1102042 and PI1600871)Maria C.Rico is funded by Redes temáticas de Investigación cooperativa RETIC(Red SAMID RD12/0026/0015)and the Mapfre Foundation.
文摘Objectives To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin-1(ISM1)and obesity-related phenotypes in a population of Spanish children and to investigate the plausible molecular alterations behind the alteration of the serum levels of this protein in children with obesity.Methods The study population is a sub-cohort of the PUBMEP research project,consisting of a cross-sectional population of 119 pubertal children with overweight(17 boys,19 girls),obesity(20 boys,25 girls),and normal weight(17 boys,21 girls).All subjects were classified into experimental groups according to their sex,obesity,and insulin resistance(IR)status.They were counted anthropometry,glucose and lipid metabolism,inflammation and cardiovascular biomarkers as well as isthmin-1(ISM1)serum levels.This population was intended as a discovery population to elucidate the relationship between obesity and ISM1 levels in children.Furthermore,the study population had blood whole-genome DNA methylation examined,allowing deepening into the obesity–ISM1 molecular relationship.Results Higher serum ISM1 levels were observed in boys with obesity than in normal weight(P=0.004)and overweight(P=0.007)boys.ISM1 serum levels were positively associated with body mass index(BMI)Z-score(P=0.005)and fat mass(P=0.058)and negatively associated with myeloperoxidase(MPO)(P=0.043)in boys.Although we did not find associations between ISM1 serum levels and metabolic outcomes in girls,which may indicate a putative sexual dimorphism,fat mass was positively associated in all children,including boys and girls(P=0.011).DNA methylation levels in two-enhancer-related CpG sites of ISM1(cg03304641 and cg14269097)were associated with serum levels of ISM1 in children.Conclusions ISM1 is associated with obesity in boys at the pubertal stage,elucidating how this protein might be of special relevance as a new biomarker of obesity in children.Further studies including a longitudinal design during puberty are needed.
基金Instituto Danone,Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición,Generalitat Valenciana,PROMETEO 21/2021Dolores Corella,Instituto de Salud Carlos III,PI24/00711,Nancy Babio。
文摘Background Preschoolers and young children are vulnerable to psychosocial and behavioral disorders linked to lifestyle factors such as screen time and sleep disturbances.Our study examines the relationship between screen time and adherence to recommendations with children's behavioral and emotional difficulties,with a focus on the role of sleep duration.Methods Cross-sectional analyses were conducted within the multicenter prospective Childhood Obesity Risk Assessment Longitudinal Study(CORALS),which included 1420 children aged 3-6 years.Screen time(hours/day)and adherence to recommendations(≤2 hours/day)were assessed.Behavioral and emotional difficulties were measured via the strengths and difficulties questionnaire.Multivariable linear and logistic regression models were used to estimate associations between screen time(continuous and dichotomous)and strengths and difficulties questionnaire scores,adjusting for potential confounders.We also tested the moderating effect of sleep and conducted isotemporal substitution analyses replacing screen time with sleep duration.Results Higher screen time was associated with higher total strengths and difficulties questionnaire scores[β95%confidence interval(CI),0.35(0.10,0.61)],emotional symptoms[0.10(0.01,0.19)],conduct problems[0.10(0.01,0.18)],and greater odds of exceeding the 16-point strengths and difficulties questionnaire cutofffor behavioral and emotional difficulties[odds ratio(OR)(95%CI),1.21(1.04,1.41)].Children who adhered to screen time recommendations had lower strengths and difficulties questionnaire total scores[β(95%CI),-0.64(-1.19,-0.10)]and odds of experiencing behavioral and emotional difficulties[OR(95%CI),0.67(0.47,0.95)].Sleep duration moderated the screen time–strengths and difficulties questionnaire association(P=0.020).The isotemporal substitution of screen time for sleep duration was associated with lower strengths and difficulties questionnaire scores across all subscales,except for prosocial behavior.Conclusions Higher screen time was associated with greater emotional and behavioral difficulties,whereas adherence to screen time recommendations and adequate sleep duration were inversely associated.Managing screen time and promoting sleep are crucial for children's well-being.
