Gas-produced water is an accompanying wastewater in the natural gas extraction process,and it is a potential liquid lithium resource that contains a considerable amount of lithium.This study investigated the feasibili...Gas-produced water is an accompanying wastewater in the natural gas extraction process,and it is a potential liquid lithium resource that contains a considerable amount of lithium.This study investigated the feasibility of using manganese-based ion sieves to adsorb and extract lithium from gas-produced water.And we focused on the applicability of two different granulation methods,extrusion and droplet,in gas-produced water systems.Two types of H_(1.33)Mn_(1.67)O_(4) particles were prepared by the extrusion method(EHMO)and the droplet method(DHMO).The porosity of DHMO was much higher than that of EHMO,and the adsorption performance of DHMO increased with the decrease of binder concentration.DHMO prepared with a binder concentration of 0.14 g·ml^(-1)exhibited the best adsorption performance in gas-produced water,and the Li^(+)adsorption capacity could reach 25.14 mg·g^(-1).In gas-produced water,the adsorption equilibrium of DHMO only took 9 h,and the adsorption process conformed to the Langmuir model and pseudo-second-order kinetic model.The pore diffusion model(PDM)could well describe its adsorption process.Besides,DHMO showed a great selectivity to Li^(+),and the selectivity order of DHMO in gas-produced water was Li^(+)>Ba^(2+)>>Mg^(2+),Ca^(2+),Sr^(2+)>>Na^(+)>>K^(+).After 20 cycles,the Li^(+)adsorption capacity was still higher than 17.30 mg·g^(-1),and the rate of manganese dissolution was less than 1%.展开更多
Objective:To investigate the expression of UCH-L3 and HIF-1αin breast cancer,cancer adjacent tissues and benign lesions and their relationships with the clinicopathological characteristics.Methods:Immunohistochemistr...Objective:To investigate the expression of UCH-L3 and HIF-1αin breast cancer,cancer adjacent tissues and benign lesions and their relationships with the clinicopathological characteristics.Methods:Immunohistochemistry(IHC)method was used to detect the expression of UCH-L3 and HIF-1ɑin 99 cases with breast cancer,38 cases with cancer adjacent tissues and 29 cases with benign lesions.Results:(1)The positive expression rate of UCH-L3 in breast cancer tissue was significantly lower than that in the cancer adjacent tissues,and the expression intensity was significantly weaker than that in cancer adjacent tissues and benign lesion tissue(P<0.05).(2)The basal cell like subtype was significantly lower than that of luminal A subtype(P<0.05).(3)The expression intensity of UCH-L3 in breast cancer was positively correlated with ER and PR expression(P<0.05).(4)The nuclear expression rate of HIF-1αin the breast cancer was significantly higher than that in the cancer adjacent tissues and benign lesions.In luminal typing,the nuclear expression rate of HIF-1αin the HER2 overexpression subtype and basal cell like subtype was significantly higher than that of luminal A and B;The intensity of nuclear expression was positively correlated with Ki-67 expression proportion and histological grade,and negatively correlated with ER and PR protein expression(P<0.05).(5)The rate of HIF-1αcytoplasmic expression in the breast cancer was significantly higher than that in the cancer adjacent tissues.According to the Luminal Type,the basal cell like subtype was significantly lower than that in luminal A/B and HER2 overexpression subtype.The expression intensity was negatively correlated with Ki-67 and histological grade,and positively correlated with ER,PR and UCH-L3 expression intensity(P<0.05).Conclusions:Lost expression of UCH-L3 and overexpression of HIF-1αmight play a role in the oncogenesis and the development of breast cancer.The transformation of HIF-1αfrom cytoplasm into nucleus indicates the malignant evolution of tumor.UCH-L3 and HIF-1αhave certain value in the prognosis evaluation of breast cancer.To increase the expression of UCHL3 and to prevent the migration of HIF-1αfrom cytoplasm to nucleus may be helpful for the prevention and treatment of breast cancer,especially for basal cell like breast cancer.展开更多
基金supported by National Key R&D Program of China(2021YFC2902603)Shanghai Pujiang Program(2019PJD011)。
文摘Gas-produced water is an accompanying wastewater in the natural gas extraction process,and it is a potential liquid lithium resource that contains a considerable amount of lithium.This study investigated the feasibility of using manganese-based ion sieves to adsorb and extract lithium from gas-produced water.And we focused on the applicability of two different granulation methods,extrusion and droplet,in gas-produced water systems.Two types of H_(1.33)Mn_(1.67)O_(4) particles were prepared by the extrusion method(EHMO)and the droplet method(DHMO).The porosity of DHMO was much higher than that of EHMO,and the adsorption performance of DHMO increased with the decrease of binder concentration.DHMO prepared with a binder concentration of 0.14 g·ml^(-1)exhibited the best adsorption performance in gas-produced water,and the Li^(+)adsorption capacity could reach 25.14 mg·g^(-1).In gas-produced water,the adsorption equilibrium of DHMO only took 9 h,and the adsorption process conformed to the Langmuir model and pseudo-second-order kinetic model.The pore diffusion model(PDM)could well describe its adsorption process.Besides,DHMO showed a great selectivity to Li^(+),and the selectivity order of DHMO in gas-produced water was Li^(+)>Ba^(2+)>>Mg^(2+),Ca^(2+),Sr^(2+)>>Na^(+)>>K^(+).After 20 cycles,the Li^(+)adsorption capacity was still higher than 17.30 mg·g^(-1),and the rate of manganese dissolution was less than 1%.
基金National natural science foundation of China(No.81360395)。
文摘Objective:To investigate the expression of UCH-L3 and HIF-1αin breast cancer,cancer adjacent tissues and benign lesions and their relationships with the clinicopathological characteristics.Methods:Immunohistochemistry(IHC)method was used to detect the expression of UCH-L3 and HIF-1ɑin 99 cases with breast cancer,38 cases with cancer adjacent tissues and 29 cases with benign lesions.Results:(1)The positive expression rate of UCH-L3 in breast cancer tissue was significantly lower than that in the cancer adjacent tissues,and the expression intensity was significantly weaker than that in cancer adjacent tissues and benign lesion tissue(P<0.05).(2)The basal cell like subtype was significantly lower than that of luminal A subtype(P<0.05).(3)The expression intensity of UCH-L3 in breast cancer was positively correlated with ER and PR expression(P<0.05).(4)The nuclear expression rate of HIF-1αin the breast cancer was significantly higher than that in the cancer adjacent tissues and benign lesions.In luminal typing,the nuclear expression rate of HIF-1αin the HER2 overexpression subtype and basal cell like subtype was significantly higher than that of luminal A and B;The intensity of nuclear expression was positively correlated with Ki-67 expression proportion and histological grade,and negatively correlated with ER and PR protein expression(P<0.05).(5)The rate of HIF-1αcytoplasmic expression in the breast cancer was significantly higher than that in the cancer adjacent tissues.According to the Luminal Type,the basal cell like subtype was significantly lower than that in luminal A/B and HER2 overexpression subtype.The expression intensity was negatively correlated with Ki-67 and histological grade,and positively correlated with ER,PR and UCH-L3 expression intensity(P<0.05).Conclusions:Lost expression of UCH-L3 and overexpression of HIF-1αmight play a role in the oncogenesis and the development of breast cancer.The transformation of HIF-1αfrom cytoplasm into nucleus indicates the malignant evolution of tumor.UCH-L3 and HIF-1αhave certain value in the prognosis evaluation of breast cancer.To increase the expression of UCHL3 and to prevent the migration of HIF-1αfrom cytoplasm to nucleus may be helpful for the prevention and treatment of breast cancer,especially for basal cell like breast cancer.
