Heart failure(HF)has emerged as one of the foremost global health threats due to its intricate pathophysiological mechanisms and multifactorial etiology.Adeno-sine triphosphate(ATP)-induced cell death represents a nov...Heart failure(HF)has emerged as one of the foremost global health threats due to its intricate pathophysiological mechanisms and multifactorial etiology.Adeno-sine triphosphate(ATP)-induced cell death represents a novel form of regulated cell deaths,marked by cellular energy depletion and metabolic dysregulation stemming from excessive ATP accumulation,identifying its uniqueness compared to other cell death processes modalities such as programmed cell death and necrosis.Growing evidence suggests that ATP-induced cell death(AICD)is predominantly governed by various biological pathways,including energy meta-bolism,redox homeostasis and intracellular calcium equilibrium.Recent research has shown that AICD is crucial in HF induced by pathological conditions like myocardial infarction,ischemia-reperfusion injury,and chemotherapy.Thus,it is essential to investigate the function of AICD in the pathogenesis of HF,as this may provide a foundation for the development of targeted therapies and novel treatment strategies.This review synthesizes current advancements in under-standing the link between AICD and HF,while further elucidating its invol-vement in cardiac remodeling and HF progression.展开更多
The implicit partition algorithm used to solve fluid–structure coupling problems has high accuracy,but it requires a long computation time.In this paper,a semi-implicit fluid–structure coupling algorithm based on mo...The implicit partition algorithm used to solve fluid–structure coupling problems has high accuracy,but it requires a long computation time.In this paper,a semi-implicit fluid–structure coupling algorithm based on modal force prediction-correction is proposed to improve the computational efficiency.In the pre-processing stage,the fluid domain is assumed to be a pseudo-elastic solid and merged with the solid domain to form a holistic system,and the normalized modal information of the holistic system is calculated and stored.During the sub-step cycle,the modal superposition method is used to obtain the response of the holistic system with the predicted modal force as the load,so that the deformation of the structure and the updating of the fluid mesh can be achieved simultaneously.After solving the Reynolds-averaged Navier-Stokes equations in the fluid domain,the predicted modal force is corrected and a new sub-step cycle is started until the converged result is obtained.In this method,the computation of the fluid equations and the updating of the dynamic mesh are done implicitly,while the deformation of the structure is done explicitly.Two numerical cases,vortex induced oscillation of an elastic beam and fluid–structure interaction of a final stage blade,are used to verify the efficiency and accuracy of the proposed algorithm.The results show that the proposed method achieves the same accuracy as the implicit method while the computational time is reduced.In the case of the vortex-induced oscillation problem,the computational time can be reduced to 18.6%.In the case of the final stage blade vibration,the computational time can be reduced to 53.8%.展开更多
A mixed organic（4-phenylbutylamine, 4-PBA） and inorganic（cesium, Cs） cations are used to deposit quasi-two-dimensional layered perovskites. This layered perovskites exhibit good film coverage as twodimensional per...A mixed organic（4-phenylbutylamine, 4-PBA） and inorganic（cesium, Cs） cations are used to deposit quasi-two-dimensional layered perovskites. This layered perovskites exhibit good film coverage as twodimensional perovskites and high emission performance close to three-dimensional organic–inorganic hybrid perovskites. Light-emitting diodes（LEDs） are fabricated by using solution process based on the quasi-two-dimensional layered perovskites. The perovskite LEDs exhibit a sky-blue emission with electroluminescence peak at 491 nm and a low turn on voltage at 2.9 V. The maximum external quantum efficiency reaches 0.015% at brightness of 186 cd/m^2.展开更多
For unacceptable computational efficiency and accuracy on the probabilistic analysis of multi-component system with multi-failure modes,this paper proposed multi-extremum response surface method(MERSM).MERSM model was...For unacceptable computational efficiency and accuracy on the probabilistic analysis of multi-component system with multi-failure modes,this paper proposed multi-extremum response surface method(MERSM).MERSM model was established based on quadratic polynomial function by taking extremum response surface model as the sub-model of multi-response surface method.The dynamic probabilistic analysis of an aeroengine turbine blisk with two components,and their reliability of deformation and stress failures was obtained,based on thermal-structural coupling technique,by considering the nonlinearity of material parameters and the transients of gas flow,gas temperature and rotational speed.The results show that the comprehensive reliability of structure is 0.9904 when the allowable deformations and stresses of blade and disk are 4.78×10–3 m and 1.41×109 Pa,and 1.64×10–3 m and 1.04×109 Pa,respectively.Besides,gas temperature and rotating speed severely influence the comprehensive reliability of system.Through the comparison of methods,it is shown that the MERSM holds higher computational precision and speed in the probabilistic analysis of turbine blisk,and MERSM computational precision satisfies the requirement of engineering design.The efforts of this study address the difficulties on transients and multiple models coupling for the dynamic probabilistic analysis of multi-component system with multi-failure modes.展开更多
In this paper, the artificial neural network(ANN) model was used to evaluate the degree of intensive urban land use in Nanjing City, China. The construction and application of the ANN model took into account the compr...In this paper, the artificial neural network(ANN) model was used to evaluate the degree of intensive urban land use in Nanjing City, China. The construction and application of the ANN model took into account the comprehensive, spatial and complex nature of urban land use. Through a preliminary calculation of the degree of intensive land use of the sample area, representative sample area selection and using the back propagation neural network model to train, the intensive land use level of each evaluation unit is finally determined in the study area. Results show that the method can effectively correct the errors caused by the limitations of the model itself and the determination of the ideal value and weights when the multifactor comprehensive evaluation is used alone. The ANN model can make the evaluation results more objective and practical. The evaluation results show a tendency of decreasing land use intensity from the core urban area to the periphery and the industrial functional area has relatively low land use intensity compared with other functional areas. Based on the evaluation results, some suggestions are put forward, such as transforming the mode of urban spatial expansion, strengthening the integration and potential exploitation of the land in the urban built-up area, and strengthening the control of the construction intensity of protected areas.展开更多
Flutter is a self-sustained vibration which could create serious damage to compressor blades.Improving the efficiency and accuracy of Fluid-Structure Interaction(FSI)method is crucial to flutter analysis.An efficient ...Flutter is a self-sustained vibration which could create serious damage to compressor blades.Improving the efficiency and accuracy of Fluid-Structure Interaction(FSI)method is crucial to flutter analysis.An efficient FSI method which combines a fast mesh deformation technology and Double-Passage Shape Correction(DPSC)method is proposed to predict blades flutter under traveling wave modes.Firstly,regarding the fluid domain as a pseudo elastic solid,the flow mesh deformation and blade vibration response can be quickly obtained by solving the governing equations of the holistic system composed of blade and pseudo elastic solid.Then,by storing and updating the Fourier coefficients on the circumferential boundary,the phase-lagged boundary condition is introduced into the computational domain.Finally,the aerodynamic stability for the blades of an axial compressor under various Inter-Blade Phase Angle(IBPA)is analyzed.The results show that the proposed method can effectively predict the characteristics of aerodynamic damping,aerodynamic force and blade displacement.And a conceptual model is proposed to describe the motion behavior of the shock wave.Compared with the multi-passage method,the proposed method obtains almost the same unstable IBPA interval and the blade displacement error is less than 3.4%.But the calculation time is significantly shortened especially in small IBPA cases.展开更多
为保障复杂装备技术状态管理的有效集成和多方协同,实现技术状态管理业务数据的双重有序管控,提出基于领域系统(domain system,DS)的建模架构和设计方法。通过引入基于模式的系统工程(pattern-based system engineering,PBSE)框架,构建...为保障复杂装备技术状态管理的有效集成和多方协同,实现技术状态管理业务数据的双重有序管控,提出基于领域系统(domain system,DS)的建模架构和设计方法。通过引入基于模式的系统工程(pattern-based system engineering,PBSE)框架,构建基于DS的复杂装备技术状态管理基本架构,设计DS元模型、DS模型、DS模式的建模方法,将国防部体系架构元模型(Department of Defense Architecture framework metamodel,DM2)进行复杂装备技术状态管理领域化重组为DS元模型,并通过领域元数据映射为DS模型,使其有序组织为适用于具体装备技术状态管理的DS模式。为验证所提方法的有效性,以运载火箭结构系统多视图物料清单(X bill of material,XBOM)为案例,开展基于DS的技术状态管理应用。结果表明,所提方法可为其技术状态管理提供兼具建模的一致性和可追溯性的实施方案,为复杂装备技术状态管理的领域模型配置提供指导性思路。展开更多
基金Supported by Science and Technology Department of Yunnan Province-Kunming Medical University,Kunming Medical Joint Special Project-Surface Project,No.202401AY070001-164Yunnan Provincial Clinical Research Center Cardiovascular Diseases-New Technology Research for Development Project for Diagnosis and Treatment Cardiovascular Diseases,No.202102AA310002the Key Technology Research and Device Development Project for Innovative Diagnosis and Treatment of Structural Heart Disease in the Southwest Plateau Region,No.202302AA310045.
文摘Heart failure(HF)has emerged as one of the foremost global health threats due to its intricate pathophysiological mechanisms and multifactorial etiology.Adeno-sine triphosphate(ATP)-induced cell death represents a novel form of regulated cell deaths,marked by cellular energy depletion and metabolic dysregulation stemming from excessive ATP accumulation,identifying its uniqueness compared to other cell death processes modalities such as programmed cell death and necrosis.Growing evidence suggests that ATP-induced cell death(AICD)is predominantly governed by various biological pathways,including energy meta-bolism,redox homeostasis and intracellular calcium equilibrium.Recent research has shown that AICD is crucial in HF induced by pathological conditions like myocardial infarction,ischemia-reperfusion injury,and chemotherapy.Thus,it is essential to investigate the function of AICD in the pathogenesis of HF,as this may provide a foundation for the development of targeted therapies and novel treatment strategies.This review synthesizes current advancements in under-standing the link between AICD and HF,while further elucidating its invol-vement in cardiac remodeling and HF progression.
基金support of the National Natural Science Foundation of China(No.51675406)the Basic Research Project Group,China(No.514010106-205)。
文摘The implicit partition algorithm used to solve fluid–structure coupling problems has high accuracy,but it requires a long computation time.In this paper,a semi-implicit fluid–structure coupling algorithm based on modal force prediction-correction is proposed to improve the computational efficiency.In the pre-processing stage,the fluid domain is assumed to be a pseudo-elastic solid and merged with the solid domain to form a holistic system,and the normalized modal information of the holistic system is calculated and stored.During the sub-step cycle,the modal superposition method is used to obtain the response of the holistic system with the predicted modal force as the load,so that the deformation of the structure and the updating of the fluid mesh can be achieved simultaneously.After solving the Reynolds-averaged Navier-Stokes equations in the fluid domain,the predicted modal force is corrected and a new sub-step cycle is started until the converged result is obtained.In this method,the computation of the fluid equations and the updating of the dynamic mesh are done implicitly,while the deformation of the structure is done explicitly.Two numerical cases,vortex induced oscillation of an elastic beam and fluid–structure interaction of a final stage blade,are used to verify the efficiency and accuracy of the proposed algorithm.The results show that the proposed method achieves the same accuracy as the implicit method while the computational time is reduced.In the case of the vortex-induced oscillation problem,the computational time can be reduced to 18.6%.In the case of the final stage blade vibration,the computational time can be reduced to 53.8%.
基金financially supported by the National Basic Research Program of China-Fundamental Studies of Perovskite Solar Cells (No. 2015CB932200)the Natural Science Foundation of [6_TD$IF]Jiangsu Province, China (Nos. BK20131413, BK20140952, BM2012010)+3 种基金the National Natural Science Foundation of China (Nos. 11474164, 61405091)the National 973 Program of China (No. 2015CB654901)the Jiangsu Specially-Appointed Professor programthe Synergetic Innovation Center for Organic Electronics and Information Displays
文摘A mixed organic（4-phenylbutylamine, 4-PBA） and inorganic（cesium, Cs） cations are used to deposit quasi-two-dimensional layered perovskites. This layered perovskites exhibit good film coverage as twodimensional perovskites and high emission performance close to three-dimensional organic–inorganic hybrid perovskites. Light-emitting diodes（LEDs） are fabricated by using solution process based on the quasi-two-dimensional layered perovskites. The perovskite LEDs exhibit a sky-blue emission with electroluminescence peak at 491 nm and a low turn on voltage at 2.9 V. The maximum external quantum efficiency reaches 0.015% at brightness of 186 cd/m^2.
基金Projects (51275138,51605016) supported by the National Natural Science Foundation of ChinaProject (12531109) supported by the Science Foundation of Heilongjiang Provincial Department of Education,ChinaProject supported by Research Start-up Funding of Fudan University,China
文摘For unacceptable computational efficiency and accuracy on the probabilistic analysis of multi-component system with multi-failure modes,this paper proposed multi-extremum response surface method(MERSM).MERSM model was established based on quadratic polynomial function by taking extremum response surface model as the sub-model of multi-response surface method.The dynamic probabilistic analysis of an aeroengine turbine blisk with two components,and their reliability of deformation and stress failures was obtained,based on thermal-structural coupling technique,by considering the nonlinearity of material parameters and the transients of gas flow,gas temperature and rotational speed.The results show that the comprehensive reliability of structure is 0.9904 when the allowable deformations and stresses of blade and disk are 4.78×10–3 m and 1.41×109 Pa,and 1.64×10–3 m and 1.04×109 Pa,respectively.Besides,gas temperature and rotating speed severely influence the comprehensive reliability of system.Through the comparison of methods,it is shown that the MERSM holds higher computational precision and speed in the probabilistic analysis of turbine blisk,and MERSM computational precision satisfies the requirement of engineering design.The efforts of this study address the difficulties on transients and multiple models coupling for the dynamic probabilistic analysis of multi-component system with multi-failure modes.
基金Under the auspices of Special Financial Grant and General Financial Grant from the China Postdoctoral Science Foundation(No.2015T80127,2014M561040)National Natural Science Foundation of China(No.41371172,41401171,41471143)A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.164320H101)
文摘In this paper, the artificial neural network(ANN) model was used to evaluate the degree of intensive urban land use in Nanjing City, China. The construction and application of the ANN model took into account the comprehensive, spatial and complex nature of urban land use. Through a preliminary calculation of the degree of intensive land use of the sample area, representative sample area selection and using the back propagation neural network model to train, the intensive land use level of each evaluation unit is finally determined in the study area. Results show that the method can effectively correct the errors caused by the limitations of the model itself and the determination of the ideal value and weights when the multifactor comprehensive evaluation is used alone. The ANN model can make the evaluation results more objective and practical. The evaluation results show a tendency of decreasing land use intensity from the core urban area to the periphery and the industrial functional area has relatively low land use intensity compared with other functional areas. Based on the evaluation results, some suggestions are put forward, such as transforming the mode of urban spatial expansion, strengthening the integration and potential exploitation of the land in the urban built-up area, and strengthening the control of the construction intensity of protected areas.
基金The authors would like to acknowledge the support of the National Natural Science Foundation of China(No.51675406)the Basic Research Project Group,China(No.514010106-205).
文摘Flutter is a self-sustained vibration which could create serious damage to compressor blades.Improving the efficiency and accuracy of Fluid-Structure Interaction(FSI)method is crucial to flutter analysis.An efficient FSI method which combines a fast mesh deformation technology and Double-Passage Shape Correction(DPSC)method is proposed to predict blades flutter under traveling wave modes.Firstly,regarding the fluid domain as a pseudo elastic solid,the flow mesh deformation and blade vibration response can be quickly obtained by solving the governing equations of the holistic system composed of blade and pseudo elastic solid.Then,by storing and updating the Fourier coefficients on the circumferential boundary,the phase-lagged boundary condition is introduced into the computational domain.Finally,the aerodynamic stability for the blades of an axial compressor under various Inter-Blade Phase Angle(IBPA)is analyzed.The results show that the proposed method can effectively predict the characteristics of aerodynamic damping,aerodynamic force and blade displacement.And a conceptual model is proposed to describe the motion behavior of the shock wave.Compared with the multi-passage method,the proposed method obtains almost the same unstable IBPA interval and the blade displacement error is less than 3.4%.But the calculation time is significantly shortened especially in small IBPA cases.
文摘为保障复杂装备技术状态管理的有效集成和多方协同,实现技术状态管理业务数据的双重有序管控,提出基于领域系统(domain system,DS)的建模架构和设计方法。通过引入基于模式的系统工程(pattern-based system engineering,PBSE)框架,构建基于DS的复杂装备技术状态管理基本架构,设计DS元模型、DS模型、DS模式的建模方法,将国防部体系架构元模型(Department of Defense Architecture framework metamodel,DM2)进行复杂装备技术状态管理领域化重组为DS元模型,并通过领域元数据映射为DS模型,使其有序组织为适用于具体装备技术状态管理的DS模式。为验证所提方法的有效性,以运载火箭结构系统多视图物料清单(X bill of material,XBOM)为案例,开展基于DS的技术状态管理应用。结果表明,所提方法可为其技术状态管理提供兼具建模的一致性和可追溯性的实施方案,为复杂装备技术状态管理的领域模型配置提供指导性思路。
