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Huge Pelvic GIST Got Good Control after Resistance to Tyrosine Kinase Inhibitors by SIB-IMRT: A Case Report and a Review of Literature
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作者 Duke Chen longhao li 《Journal of Cancer Therapy》 2025年第2期77-85,共9页
Purpose: Gastrointestinal stromal tumor (GIST) has been considered radiation-resistant and data on the radiotherapy for GIST in previous studies are lacking. The purpose of this article is to accumulate more experienc... Purpose: Gastrointestinal stromal tumor (GIST) has been considered radiation-resistant and data on the radiotherapy for GIST in previous studies are lacking. The purpose of this article is to accumulate more experience in the application of radiotherapy for GISTs. Materials and methods: Review our own case material and the relevant English literature. Results: A huge pelvic GIST after resistance to tyrosine kinase inhibitors (TKIs) has been well controlled by simultaneous-integrated boost intensity-modulated radiation therapy (SIB-IMRT). The time from the initial shrinkage of the mass and subsequent stabilization to now was more than 18 months. The patient was palliated from the series of symptoms caused by tumor compression and well tolerated to the adverse reactions by radiotherapy. And the previous studies have shown that GISTs had a certain sensitivity to radiotherapy. Conclusion: SIB-IMRT may provide a new means of achieving objective response and prolonging survival in selected GIST patients. 展开更多
关键词 Gastrointestinal Stromal Tumor Radiotherapy RESISTANCE Tyrosine Kinase Inhibitors
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Fe-N-C氧还原电催化剂的失活机制及延寿策略 被引量:1
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作者 李隆浩 周伟 +3 位作者 谢亮 杨潮伟 孟晓晓 高继慧 《化学进展》 SCIE CAS CSCD 北大核心 2024年第3期376-392,共17页
在质子交换膜燃料电池(PEMFC)中,Fe-N-C催化剂是最有希望替代Pt的非贵金属氧还原(ORR)催化剂。然而目前高活性Fe-N-C催化剂的实际应用仍然受限于其稳定性不足。本文系统总结了Fe-N-C催化剂常见的合成方法(空间限制法和模板法等),概括了... 在质子交换膜燃料电池(PEMFC)中,Fe-N-C催化剂是最有希望替代Pt的非贵金属氧还原(ORR)催化剂。然而目前高活性Fe-N-C催化剂的实际应用仍然受限于其稳定性不足。本文系统总结了Fe-N-C催化剂常见的合成方法(空间限制法和模板法等),概括了用于评估催化剂稳定性的半电池与单电池测试方法,分析了两种测试结果存在差异的原因,阐述了Fe-N-C催化剂的4种失活机理,从构筑稳定的碳载体、构筑稳定的活性位点和避免发生Fenton反应三个角度总结了提升稳定性的方法。最后展望了Fe-N-C催化剂未来的发展方向。 展开更多
关键词 质子交换膜燃料电池 氧还原 Fe-N-C催化剂 稳定性 失活机制 延寿策略
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实体瘤局部免疫治疗的探索与发展现状
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作者 刘娅 李龙浩(综述) 邓红彬(审校) 《中国肿瘤临床》 CAS CSCD 北大核心 2021年第6期317-322,共6页
免疫治疗已被证实为极具前景的晚期恶性实体瘤治疗方式之一。肿瘤所致免疫激活和免疫效应主要来自肿瘤抗原与肿瘤微环境(tumor microenvironment,TME)的相互作用,而肿瘤抗原的免疫原性减弱与免疫应答通路缺陷是产生免疫逃逸的主要原因... 免疫治疗已被证实为极具前景的晚期恶性实体瘤治疗方式之一。肿瘤所致免疫激活和免疫效应主要来自肿瘤抗原与肿瘤微环境(tumor microenvironment,TME)的相互作用,而肿瘤抗原的免疫原性减弱与免疫应答通路缺陷是产生免疫逃逸的主要原因。免疫治疗通过不同途径增强抗原提呈能力,激活免疫应答及改善TME的免疫抑制状态,提高患者生存获益。由于免疫治疗疗效与药物浓度呈正相关,往往较高的治疗剂量才有效,但这对机体将造成不同程度的免疫相关毒性反应及诱导耐药产生。因此,一种新的治疗方式-局部免疫治疗,被探索并取得了早期临床疗效。本文就几种常见的不同类型免疫药物在局部治疗中的作用机制、应用特点及临床发展现状进行综述。 展开更多
关键词 局部免疫治疗 实体瘤 免疫抑制 免疫原性 免疫相关不良反应
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A Primary Study on Mechanical Properties of Heat-Treated Wood via in-situ Synthesis of Calcium Carbonate
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作者 Dianen liang Zhenhao Ding +8 位作者 Qilin Yan Redžo Hasanagić Leila Fathi Zi Yang longhao li Jianbo Wang Houhua Luo Qian Wang Demiao Chu 《Journal of Renewable Materials》 SCIE EI 2023年第1期435-451,共17页
This study aims to improve the value of fast-growing wood and extend the heat-treated wood utilization using inorganic calcium carbonate(CaCO_(3))crystals via an in-situ synthesis method.CaCl_(2)and Na 2CO_(3)solution... This study aims to improve the value of fast-growing wood and extend the heat-treated wood utilization using inorganic calcium carbonate(CaCO_(3))crystals via an in-situ synthesis method.CaCl_(2)and Na 2CO_(3)solutions with a concentration ratio of 1:1 were successively introduced into the thermally modified poplar wood obtained by steam heat treatment(HT)at 200℃for 1.5 and 3 h,resulting in the in-situ synthesis of CaCO_(3)crystals inside the heat-treated wood.The filling effect was best at the concentration of 1.2 mol/L.CaCO_(3)was uniformly distributed in the cell cavities of the heat-treated wood,and some of the crystals were embedded in the fissures of the wood cell walls.The morphology of CaCO_(3)crystals was mainly spherical and rhombic polyhedral.Three main types of CaCO_(3)crystals were calcite,vaterite,and aragonite.The HT of poplar wood at 200℃resulted in degrading the chemical components of the wood cell wall.This degradation led to reduced wood mechanical properties,including the surface hardness(HD),modulus of rupture(MOR),and modulus of elasticity(MOE).After CaCO_(3)was in-situ synthesized in the heat-treated wood,the HD increased by 18.36%and 16.35%,and MOR increased by 14.64%and 8.89%,respectively.Because of the CaCO_(3)synthesization,the char residue of the 200℃heat-treated wood samples increased by 9.31%and the maximum weight loss rate decreased by 19.80%,indicating that the filling with CaCO_(3)cannot only improve the mechanical properties of the heat-treated wood but also effectively enhance its thermal stability. 展开更多
关键词 Heat treatment poplar wood calcium carbonate in-situ synthesis REINFORCEMENT
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