Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for ...Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous system.Howeve r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain circuitry.In addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing mice.In this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse cortex.Time-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local environment.In addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable positions.Furthermore,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural circuits.In conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.展开更多
The sPHENIX experiment is a new generation of large acceptance detectors at the relativistic heavy ion collider at Brookhaven National Laboratory,with scientific goals focusing on probing the strongly interacting Quar...The sPHENIX experiment is a new generation of large acceptance detectors at the relativistic heavy ion collider at Brookhaven National Laboratory,with scientific goals focusing on probing the strongly interacting Quark–Gluon plasma with hard probes of jets,open heavy flavor particles,andγproduction.The EMCal detector,which covers the pseudo-rapidity region of|η|≤1.1,is an essential subsystem of sPHENIX.In this study,we focused on producing and testing EMCal blocks covering a pseudo-rapidity of|η|∈[0.8,1.1].These,in conjunction with the central pseudo-rapidity EMCal blocks,significantly enhance the sPHENIX physics capability of the jet andγparticle measurements.In this paper,the detector module production and testing of sPHENIX W-powder/scintillating fiber(W/ScFi)electromagnetic calorimeter blocks are presented.The selection of the tungsten powder,mold fabrication,QA procedures,and cosmic ray test results are discussed.展开更多
We perform ^(23)Na nuclear magnetic resonance(NMR) and magnetization measurements on an S=1,quasi-2D honeycomb lattice antiferromagnet Na_(3)Ni_(2)BiO_(6).A large positive Curie-Weiss constant of 22.9 K is observed.Th...We perform ^(23)Na nuclear magnetic resonance(NMR) and magnetization measurements on an S=1,quasi-2D honeycomb lattice antiferromagnet Na_(3)Ni_(2)BiO_(6).A large positive Curie-Weiss constant of 22.9 K is observed.The NMR spectra at low fields are consistent with a zigzag magnetic order,indicating a large easy-axis anisotropy.With the field applied along the c*axis,the NMR spectra confirm the existence of a 1/3-magnetization plateau phase between 5.1 T and 7.1 T.The transition from the zigzag order to the 1/3-magnetization plateau phase is also found to be a first-order type.A monotonic decrease of the spin gap is revealed in the 1/3-magnetization plateau phase,which reaches zero at a quantum critical field H_(C)≈8.35 T before entering the fully polarized phase.These data suggest the existence of exchange frustration in the system along with strong ferromagnetic interactions,hosting the possibility for Kitaev physics.Besides,well below the ordered phase,the 1/T_(1) at high fields shows either a level off or an enhancement upon cooling below 3 K,which suggests the existence of low-energy fluctuations.展开更多
Correction to:Nuclear Science and Techniques(2024)35:145 https://doi.org/10.1007/s41365-024-01517-y In this article the author’s name Wan-Bing He was incorrectly written as Wan-Bin He.The original article has been co...Correction to:Nuclear Science and Techniques(2024)35:145 https://doi.org/10.1007/s41365-024-01517-y In this article the author’s name Wan-Bing He was incorrectly written as Wan-Bin He.The original article has been corrected.展开更多
In the background of the low-carbon transformation of the energy structure,the problem of operational uncertainty caused by the high proportion of renewable energy sources and diverse loads in the integrated energy sy...In the background of the low-carbon transformation of the energy structure,the problem of operational uncertainty caused by the high proportion of renewable energy sources and diverse loads in the integrated energy systems(IES)is becoming increasingly obvious.In this case,to promote the low-carbon operation of IES and renewable energy consumption,and to improve the IES anti-interference ability,this paper proposes an IES scheduling strategy that considers CCS-P2G and concentrating solar power(CSP)station.Firstly,CSP station,gas hydrogen doping mode and variable hydrogen doping ratio mode are applied to IES,and combined with CCS-P2G coupling model,the IES low-carbon economic dispatch model is established.Secondly,the stepped carbon trading mechanism is applied,and the sensitivity analysis of IES carbon trading is carried out.Finally,an IES optimal scheduling strategy based on fuzzy opportunity constraints and an IES risk assessment strategy based on CVaR theory are established.The simulation shows that the gas-hydrogen doping model proposed in this paper reduces the operating cost and carbon emission of IES by 1.32%and 7.17%,and improves the carbon benefit by 5.73%;variable hydrogen doping ratio model reduces the operating cost and carbon emission of IES by 3.75%and 1.70%,respectively;CSP stations reduce 19.64%and 38.52%of the operating costs of IES and 1.03%and 1.80%of the carbon emissions of IES respectively compared to equal-capacity photovoltaic and wind turbines;the baseline price of carbon trading of IES and its rate of change jointly affect the carbon emissions of IES;evaluating the anti-interference capability of IES through trapezoidal fuzzy number and weighting coefficients,enabling IES to guarantee operation at the lowest cost.展开更多
Federated learning has emerged as an essential technique of protecting privacy since it allows clients to train models locally without explicitly exchanging sensitive data.Extensive research has been conducted on the ...Federated learning has emerged as an essential technique of protecting privacy since it allows clients to train models locally without explicitly exchanging sensitive data.Extensive research has been conducted on the issue of data heterogeneity in federated learning,but effective model training with severely imbalanced label distributions remains an unexplored area.This paper presents a novel Cluster Federated Learning Algorithm with Intra-cluster Correction(CFIC).First,CFICselects samples fromeach cluster during each round of sampling,ensuring that no single category of data dominates the model training.Second,in addition to updating local models,CFIC adjusts its own parameters based on information shared by other clusters,allowing the final cluster models to better reflect the true nature of the entire dataset.Third,CFIC refines the cluster models into a global model,ensuring that even when label distributions are extremely imbalanced,the negative effects are significantly mitigated,thereby improving the global model’s performance.We conducted extensive experiments on seven datasets and six benchmark algorithms.Theresults show that the CFIC algorithm has a higher generalization ability than the benchmark algorithms.CFIC maintains high accuracy and rapid convergence rates even in a variety of non-independent identically distributed label skew distribution settings.The findings indicate that the proposed algorithm has the potential to become a trustworthy and practical solution for privacy preservation,whichmight be applied to fields such as medical image analysis,autonomous driving technologies,and intelligent educational platforms.展开更多
The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system.It plays a crucial role in the pathological process of noise-induced hearing loss(NIHL).However,the mechanisms ...The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system.It plays a crucial role in the pathological process of noise-induced hearing loss(NIHL).However,the mechanisms of NLR family pyrin domain containing 3(NLRP3)inflammasome activation in NIHL have not been clearly demonstrated.In this study,miniature pigs were exposed to white noise at 120 dB(A)and auditory brainstem response measurements were used to measure their hearing function.Immunofluorescence staining,confocal laser scanning microscopy,western blot assay,and quantitative reverse transcription-polymerase chain reaction were used to analyze inflammasome-related protein distribution and expression.NLRP3,interleukin-1β,interleukin-18,and cleaved-caspase-1 were highly expressed in the cochlea after 120 dB(A)white noise exposure.Our findings suggest that NLRP3-inflammasomes in the cochlea may be activated after acoustic trauma,which may be an important mechanism of noise-induced hearing loss.展开更多
With the classical statistical and geostatistical methods, the study of the spatial distribution and its in- fluence factors of soil water, salinity and organic matter was carried out for 0-70 cm soil layers in Manas ...With the classical statistical and geostatistical methods, the study of the spatial distribution and its in- fluence factors of soil water, salinity and organic matter was carried out for 0-70 cm soil layers in Manas River watershed. The results showed that the soil moisture data from all soil layers exhibited a normal distribution, with average values of 14.08%-21.55%. Geostatistical analysis revealed that the content of soil moisture had a moder- ate spatial autocorrelation with the ratios of nugget/sill ranging from 0.500 to 0.718, which implies that the spatial pattern of soil moisture is influenced by the combined effects of structural factors and random factors. Remarkable spatial distributions with stripped and mottled features were found for soil moisture in all different soil layers. The landform and crop planting had a relatively big influence on the spatial distribution of soil moisture; total soil salinity was high in east but low in west, and non-salinized soil and lightly salinized soil appeared at the northwest and southwest of the study area. Under the effect of reservoir leakage, the heavily salinized soils are widely distributed in the middle of the study area. The areas of the non-salinized and lightly salinized soils decreased gradually with soil depth increment, which is contrary to the case for saline soils that reached a maximum of 245.67 km2 at the layer of 50-70 cm. The types of soil salinization in Manas River watershed were classified into four classes： the sulfate, chloride-sulfate, sulfate-chloride and chloride. The sulfate salinized soil is most widely distributed in the surface layer. The areas of chloride-sulfate, sulfate-chloride, and chloride salinized soils increased gradually along with the increment of soil depth; the variation range of the average values of soil organic matter content was be- tween 7.48%-11.33%. The ratios of nugget/sill reduced gradually from 0.698 to 0.299 with soil depth increment, which shows that the content of soil organic matter has a moderate spatial autocorrelation. The soil organic matter in all soil layers met normal distribution after logarithmic transformation. The spatial distribution patterns of soil or- ganic matter and soil moisture were similar; the areas with high organic matter contents were mainly distributed in the south of the study area, with the lowest contents in the middle.展开更多
Based on the analyses of environmental proxy data in lake sediments and instrumental records of Xinjiang in northwest China, the Holocene climate and hydrological variability and its environmental responses were studi...Based on the analyses of environmental proxy data in lake sediments and instrumental records of Xinjiang in northwest China, the Holocene climate and hydrological variability and its environmental responses were studied in different time scales and regions. The results showed that the Holocene climate variability had obvious differences between the north and south of Xinjiang. In northern Xinjiang, the Holocene climate was dry in the early period, humid in the middle period, and then changed to dry in the late period. However, the climate transition times were not consistent in different regions. In southern Xin- jiang, although there were many different types of climate change patterns inferred from different catch- ments, the warm and wet climate was recorded in most lake sediments in the middle Holocene. According to comparisons of some millennium scale records in lake sediments, the climate was warm and dry in the past 100 years. It can be concluded the climate showed a trend of aridity in Holocene. Especially in recent 50 years, the lake area has been shrinking rapidly because of the population growth and social economic development, which brings some environmental problems. Lake level and area changes were sensitively affected by the climate variation in geological history of Xinjiang and the lake level will continue to shrink because of the drought climate and strengthened human activities.展开更多
We report in this paper the alignment calibration of the STAR pixel detector(PXL) prototype for the RHIC2013 run and performance study of the full PXL detector installed and commissioned in the RHIC 2014 run. PXL dete...We report in this paper the alignment calibration of the STAR pixel detector(PXL) prototype for the RHIC2013 run and performance study of the full PXL detector installed and commissioned in the RHIC 2014 run. PXL detector is the innermost two silicon layers of the STAR heavy flavor tracker aiming at high-precision reconstruction of secondary decay vertex of heavy flavor particles. To achieve the physics goals, the calibration work was done on the detector with high precision. A histogram-based method was successfully applied for the alignment calibration, and the detector efficiency after alignment was studied using both p t p collision data and cosmic ray data.展开更多
Solving quaternion kinematical differential equations(QKDE) is one of the most significant problems in the automation, navigation, aerospace and aeronautics literatures. Most existing approaches for this problem neith...Solving quaternion kinematical differential equations(QKDE) is one of the most significant problems in the automation, navigation, aerospace and aeronautics literatures. Most existing approaches for this problem neither preserve the norm of quaternions nor avoid errors accumulated in the sense of long term time. We present explicit symplectic geometric algorithms to deal with the quaternion kinematical differential equation by modelling its time-invariant and time-varying versions with Hamiltonian systems and adopting a three-step strategy. Firstly,a generalized Euler's formula and Cayley-Euler formula are proved and used to construct symplectic single-step transition operators via the centered implicit Euler scheme for autonomous Hamiltonian system. Secondly, the symplecticity, orthogonality and invertibility of the symplectic transition operators are proved rigorously. Finally, the explicit symplectic geometric algorithm for the time-varying quaternion kinematical differential equation, i.e., a non-autonomous and non-linear Hamiltonian system essentially, is designed with the theorems proved. Our novel algorithms have simple structures, linear time complexity and constant space complexity of computation. The correctness and efficiencies of the proposed algorithms are verified and validated via numerical simulations.展开更多
Enderby Land in East Antarctica and its adjacent areas,which are closely related to the Indian Plate in their geological evolution,have become one of the key zones for studies on how the Antarctic continent evolves.Ba...Enderby Land in East Antarctica and its adjacent areas,which are closely related to the Indian Plate in their geological evolution,have become one of the key zones for studies on how the Antarctic continent evolves.Based on the isostasy and flexure theories of the lithosphere and using the CRUST1.0 model as the depth constraint,this paper uses the gravity field model EIGEN-6C4 and topographic data to calculate the isostatic gravity anomalies of Enderby Land and its adjacent areas.Then,the crustal thickness of the study area is calculated,and three comprehensive geophysical interpretation profiles that vertically span the study area are plotted.The results show that the flexural isostatic gravity anomalies in Enderby Land and its adjacent areas are closely related to the regional tectonic setting,and the anomalies in different regions differ substantially,ranging from−50×10^(−5)m/s^(2)to 85×10^(−5)m/s^(2).A zone of high isostatic gravity anomalies(30×10^(−5)−80×10^(−5)m/s^(2))is distributed outside the Cooperation Sea and Queen Maud Land,which may be plate remnants generated by early rifting.Except for the Kerguelen Plateau,which was formed by a hotspot and has a crustal thickness of 15 km,the thickness of the oceanic crust in other parts of the study area changes slightly by approximately 4–9 km,with the thinnest part being in Enderby Basin.The thickness of the inland crust along the coastline increases with the elevation,with the maximum thickness reaching 34 km.The isostatic gravity anomalies corresponding to the zone of high magnetic anomalies along the continental margin of Queen Maud Land are negative and small,with an isostatic adjustment trend indicating Moho surface uplift,and those on the edge of central Enderby Land are near zero,approaching the isostatic state,which may be caused by the magmatism at the early stage of rifting.The continental-oceanic boundary should be close to the contour line of the crustal thickness 10–12 km on the outer edge of the coastline.展开更多
Recently we read the article entitled“Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study”.This was an observational study that reviewed the safety...Recently we read the article entitled“Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study”.This was an observational study that reviewed the safety and efficacy of different cement augmentation modalities for vertebral compression fractures under osteoporotic condition.Overall,this is a valuable study that can provide a reference for clinical practice.On the other hand,we also noticed some points in the article and are willing to share our views.Further studies with a higher level of evidence can add more knowledge regarding relevant concerns.展开更多
The sensitivity of an experiment to detect the Majorana neutrino mass via neutrinoless double-beta decay(0νββ) strongly depends on the rate of background events that can mimic this decay. One major source of this b...The sensitivity of an experiment to detect the Majorana neutrino mass via neutrinoless double-beta decay(0νββ) strongly depends on the rate of background events that can mimic this decay. One major source of this background is the radioactive emissions from the laboratory environment. In our study, we focused on assessing the background contributions from environmental gamma rays, neutrons, and underground muons to the Jinping bolometric demonstration experiment. This experiment uses an array of lithium molybdate crystal bolometers to probe the potential 0νββ decay of the100Mo isotope at the China Jinping Underground Laboratory. We also evaluated the shielding effectiveness of the experimental setup through an attenuation study. Our simulations indicate that the combined background from environmental gamma rays, neutrons, and muons in the relevant100Mo 0νββ Q-value region can be reduced to approximately 0.003 cts/kg/keV/yr.展开更多
We investigate the magnetic ground state of Sm_(3)BWO_(9)with a distorted kagome lattice.A magnetic phase transition is identified at T_(N)=0.75 K from the temperature dependence of specific heat.From 11B nuclear magn...We investigate the magnetic ground state of Sm_(3)BWO_(9)with a distorted kagome lattice.A magnetic phase transition is identified at T_(N)=0.75 K from the temperature dependence of specific heat.From 11B nuclear magnetic resonance measurements,an incommensurate magnetic order is shown by the double-horn type spectra under a c-axis magnetic field,and absence of line splitting is observed for field oriented within the ab-plane,indicating the incommensurate modulation of the internal field strictly along𝑐c-axis.From the spin dynamics,the critical slowing-down behavior is observed in the temperature dependence of 1/T_(1)with𝜇_(μ0)H⊥c-axis,which is completely absent in the case with𝜇_(μ0)H||c-axis.Based on the local symmetry of 11B sites,we analyze the hyperfine coupling tensors and propose two constraints on the possible magnetic structure.The single ion anisotropy should play an important role in determination of contrasting ground states of Sm_(3)BWO_(9) and Pr_(3)BWO_(9).展开更多
Tree ring dating plays an important role in obtaining past climate information.The fundamental study of obtaining tree ring samples in typical climate regions is particularly essential.The optimum distribution of tree...Tree ring dating plays an important role in obtaining past climate information.The fundamental study of obtaining tree ring samples in typical climate regions is particularly essential.The optimum distribution of tree ring sampling sites based on climate information from the Climate Observation Network(ORPOM model) is presented in this article.In this setup,the tree rings in a typical region are used for surface representation,by applying excellent correlation with the climate information as the main principle.Taking the Horqin Sandy Land in the cold and arid region of China as an example,the optimum distribution range of the tree ring sampling sites was obtained through the application of the ORPOM model,which is considered a reasonably practical scheme.展开更多
The town of Agura,a typical region in Horqin Sandy Land,was selected as the study area in this paper.Using 12 remote sensing images and climatic data from the past 20 years,the effects of climate change on surface env...The town of Agura,a typical region in Horqin Sandy Land,was selected as the study area in this paper.Using 12 remote sensing images and climatic data from the past 20 years,the effects of climate change on surface environments were analyzed.The impact indices of climatic factors,along with their corresponding ranks,were used to characterize the responses of different types of surface environments to climate change.Results show that in the past 20 years,the surface environments of the study area have been deteriorating.Furthermore,there is a positive relationship between the changes in surface environments and those in climatic factors.Various climatic factors influence surface environments in different ways and at different levels.The most sensitive factor is relative humidity,followed by precipitation and evaporation.Overall,moisture is the key factor that affects the changes in surface environments of arid and semi-arid areas.展开更多
In this paper,approximate nutritional components and amino acid content were determined in muscles of female wild population(WP)with body weight of 2500-3000 g and female cultured population(CP)with body weight of 750...In this paper,approximate nutritional components and amino acid content were determined in muscles of female wild population(WP)with body weight of 2500-3000 g and female cultured population(CP)with body weight of 750-1250 g masu salmon Oncorhynchus masou in the gonadal development stage IV by conventional method.The results showed that there were significantly higher crude protein and significantly lower crude fat in fresh muscle of WP than that in CP(P<0.05),but not significant differences in the contents of moisture and crude ash between WP and CP(P>0.05).Eighteen kinds of amino acids were detected in muscles of WP and CP,with higher total content of amino acids(TAA),essential amino acids(EAA)and four kinds of delicious amino acids(DAA)in WP than those in CP(P<0.05).The amino acid score(AAS)and chemical score(CS)revealed that the first limiting amino acid was tryptophan in two populations,with essential amino acid index(EAAI)of 75.59%in WP and 70.77%in CP.The findings indicated that the amino acid contents in muscles of CP are lower than that of WP,but the amino acid nutritional value evaluation indicators of both populations are very close,and both have high nutritional value.展开更多
Currently,the microwave absorbers usually suffer dreadful electromagnetic wave absorption(EMWA)performance damping at elevated temperature due to impedance mismatching induced by increased conduction loss.Consequently...Currently,the microwave absorbers usually suffer dreadful electromagnetic wave absorption(EMWA)performance damping at elevated temperature due to impedance mismatching induced by increased conduction loss.Consequently,the development of high-performance EMWA materials with good impedance matching and strong loss ability in wide temperature spectrum has emerged as a top priority.Herein,due to the high melting point,good electrical conductivity,excellent environmental stability,EM coupling effect,and abundant interfaces of titanium nitride(TiN)nanotubes,they were designed based on the controlling kinetic diffusion procedure and Ostwald ripening process.Benefiting from boosted heterogeneous interfaces between TiN nanotubes and polydimethylsiloxane(PDMS),enhanced polarization loss relaxations were created,which could not only improve the depletion efficiency of EMWA,but also contribute to the optimized impedance matching at elevated temperature.Therefore,the TiN nanotubes/PDMS composite showed excellent EMWA performances at varied temperature(298-573 K),while achieved an effective absorption bandwidth(EAB)value of 3.23 GHz and a minimum reflection loss(RLmin)value of−44.15 dB at 423 K.This study not only clarifies the relationship between dielectric loss capacity(conduction loss and polarization loss)and temperature,but also breaks new ground for EM absorbers in wide temperature spectrum based on interface engineering.展开更多
An E//B neutral particle analyzer(NPA)has been designed and is under development at Sichuan University and Southwestern Institute of Physics.The main purpose of the E//B NPA is to measure the distribution function of ...An E//B neutral particle analyzer(NPA)has been designed and is under development at Sichuan University and Southwestern Institute of Physics.The main purpose of the E//B NPA is to measure the distribution function of fast ions in the HL-2A/3 tokamak.The E//B NPA contains three main units,i.e.the stripping unit,the analyzing unit and the detection unit.A gas stripping chamber was adopted as the stripping unit.The results of the simulations and beam tests for the stripping chamber are presented.Parallel electric and magnetic fields provided by a NdFeB permanent magnet and two parallel electric plates were designed and constructed for the analyzing unit.The calibration of the magnetic and electric fields was performed using a 50 kV electron cyclotron resonance ion source(ECRIS)platform.The detection unit consists of 32lutetium-yttrium oxyorthosilicate(LYSO)detector modules arranged in two rows.The response functions ofα,hydrogen ions(H^(+),H_(2)^(+)and H_(3)^(+))andγfor a detector module were measured with^(241)Am,^(137)Cs and^(152)Eu sources together with the 50 kV ECRIS platform.The overall results indicate that the designed E//B NPA device is capable of measuring the intensity of neutral hydrogen and deuteron atoms with energy higher than 20 keV.展开更多
基金supported by the National Natural Science Foundation of China,No.31970906(to WLei)the Natural Science Foundation of Guangdong Province,No.2020A1515011079(to WLei)+4 种基金Key Technologies R&D Program of Guangdong Province,No.2018B030332001(to GC)Science and Technology Projects of Guangzhou,No.202206060002(to GC)the Youth Science Program of the National Natural Science Foundation of China,No.32100793(to ZX)the Pearl River Innovation and Entrepreneurship Team,No.2021ZT09 Y552Yi-Liang Liu Endowment Fund from Jinan University Education Development Foundation。
文摘Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous system.Howeve r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain circuitry.In addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing mice.In this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse cortex.Time-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local environment.In addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable positions.Furthermore,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural circuits.In conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.
基金supported by the National Key R&D Program from the Ministry of Science and Technology of China(Nos.2019YFE0114300 and 2022YFA1604900)the National Natural Science Foundation of China(No.11905036)+1 种基金the STCSM(No.23590780100)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB34030200)。
文摘The sPHENIX experiment is a new generation of large acceptance detectors at the relativistic heavy ion collider at Brookhaven National Laboratory,with scientific goals focusing on probing the strongly interacting Quark–Gluon plasma with hard probes of jets,open heavy flavor particles,andγproduction.The EMCal detector,which covers the pseudo-rapidity region of|η|≤1.1,is an essential subsystem of sPHENIX.In this study,we focused on producing and testing EMCal blocks covering a pseudo-rapidity of|η|∈[0.8,1.1].These,in conjunction with the central pseudo-rapidity EMCal blocks,significantly enhance the sPHENIX physics capability of the jet andγparticle measurements.In this paper,the detector module production and testing of sPHENIX W-powder/scintillating fiber(W/ScFi)electromagnetic calorimeter blocks are presented.The selection of the tungsten powder,mold fabrication,QA procedures,and cosmic ray test results are discussed.
基金Project supported by the National Key R&D Program of China (Grant Nos. 2023YFA1406500, 2022YFA1402700, and 2021YFA1400400)the National Natural Science Foundation of China (Grant Nos. 12134020, 12374156, 12104503,12061131004, 12225407, and 12074174)。
文摘We perform ^(23)Na nuclear magnetic resonance(NMR) and magnetization measurements on an S=1,quasi-2D honeycomb lattice antiferromagnet Na_(3)Ni_(2)BiO_(6).A large positive Curie-Weiss constant of 22.9 K is observed.The NMR spectra at low fields are consistent with a zigzag magnetic order,indicating a large easy-axis anisotropy.With the field applied along the c*axis,the NMR spectra confirm the existence of a 1/3-magnetization plateau phase between 5.1 T and 7.1 T.The transition from the zigzag order to the 1/3-magnetization plateau phase is also found to be a first-order type.A monotonic decrease of the spin gap is revealed in the 1/3-magnetization plateau phase,which reaches zero at a quantum critical field H_(C)≈8.35 T before entering the fully polarized phase.These data suggest the existence of exchange frustration in the system along with strong ferromagnetic interactions,hosting the possibility for Kitaev physics.Besides,well below the ordered phase,the 1/T_(1) at high fields shows either a level off or an enhancement upon cooling below 3 K,which suggests the existence of low-energy fluctuations.
文摘Correction to:Nuclear Science and Techniques(2024)35:145 https://doi.org/10.1007/s41365-024-01517-y In this article the author’s name Wan-Bing He was incorrectly written as Wan-Bin He.The original article has been corrected.
基金State Grid Gansu Electric Power Company Science and Technology Program(Grant No.W24FZ2730008)National Natural Science Foundation of China(Grant No.51767017).
文摘In the background of the low-carbon transformation of the energy structure,the problem of operational uncertainty caused by the high proportion of renewable energy sources and diverse loads in the integrated energy systems(IES)is becoming increasingly obvious.In this case,to promote the low-carbon operation of IES and renewable energy consumption,and to improve the IES anti-interference ability,this paper proposes an IES scheduling strategy that considers CCS-P2G and concentrating solar power(CSP)station.Firstly,CSP station,gas hydrogen doping mode and variable hydrogen doping ratio mode are applied to IES,and combined with CCS-P2G coupling model,the IES low-carbon economic dispatch model is established.Secondly,the stepped carbon trading mechanism is applied,and the sensitivity analysis of IES carbon trading is carried out.Finally,an IES optimal scheduling strategy based on fuzzy opportunity constraints and an IES risk assessment strategy based on CVaR theory are established.The simulation shows that the gas-hydrogen doping model proposed in this paper reduces the operating cost and carbon emission of IES by 1.32%and 7.17%,and improves the carbon benefit by 5.73%;variable hydrogen doping ratio model reduces the operating cost and carbon emission of IES by 3.75%and 1.70%,respectively;CSP stations reduce 19.64%and 38.52%of the operating costs of IES and 1.03%and 1.80%of the carbon emissions of IES respectively compared to equal-capacity photovoltaic and wind turbines;the baseline price of carbon trading of IES and its rate of change jointly affect the carbon emissions of IES;evaluating the anti-interference capability of IES through trapezoidal fuzzy number and weighting coefficients,enabling IES to guarantee operation at the lowest cost.
基金supported by National Natural Science Foundation of China under Grant(No.62277043)Science and Technology Research Project of Chongqing Education Commission under Grant(No.KJZD-K202300515).
文摘Federated learning has emerged as an essential technique of protecting privacy since it allows clients to train models locally without explicitly exchanging sensitive data.Extensive research has been conducted on the issue of data heterogeneity in federated learning,but effective model training with severely imbalanced label distributions remains an unexplored area.This paper presents a novel Cluster Federated Learning Algorithm with Intra-cluster Correction(CFIC).First,CFICselects samples fromeach cluster during each round of sampling,ensuring that no single category of data dominates the model training.Second,in addition to updating local models,CFIC adjusts its own parameters based on information shared by other clusters,allowing the final cluster models to better reflect the true nature of the entire dataset.Third,CFIC refines the cluster models into a global model,ensuring that even when label distributions are extremely imbalanced,the negative effects are significantly mitigated,thereby improving the global model’s performance.We conducted extensive experiments on seven datasets and six benchmark algorithms.Theresults show that the CFIC algorithm has a higher generalization ability than the benchmark algorithms.CFIC maintains high accuracy and rapid convergence rates even in a variety of non-independent identically distributed label skew distribution settings.The findings indicate that the proposed algorithm has the potential to become a trustworthy and practical solution for privacy preservation,whichmight be applied to fields such as medical image analysis,autonomous driving technologies,and intelligent educational platforms.
基金supported by the National Key Research and Development Program of China, No.2020YFC2005200(to WWG and WJH)the National Nature Science Foundation of China, Nos.81770992(to NS and WJH), 81970897(to WWG)+1 种基金Health and Family Planning System Research Project of Shenzhen Municipality, No.SZXJ2018079(to YYY)Shenzhen Sanming Project, No.SZSM201612076(to YYY)
文摘The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system.It plays a crucial role in the pathological process of noise-induced hearing loss(NIHL).However,the mechanisms of NLR family pyrin domain containing 3(NLRP3)inflammasome activation in NIHL have not been clearly demonstrated.In this study,miniature pigs were exposed to white noise at 120 dB(A)and auditory brainstem response measurements were used to measure their hearing function.Immunofluorescence staining,confocal laser scanning microscopy,western blot assay,and quantitative reverse transcription-polymerase chain reaction were used to analyze inflammasome-related protein distribution and expression.NLRP3,interleukin-1β,interleukin-18,and cleaved-caspase-1 were highly expressed in the cochlea after 120 dB(A)white noise exposure.Our findings suggest that NLRP3-inflammasomes in the cochlea may be activated after acoustic trauma,which may be an important mechanism of noise-induced hearing loss.
基金funded by the National Basic Research Program of China(2009CB825101)the National Natural Science Foundation of China(41071139)
文摘With the classical statistical and geostatistical methods, the study of the spatial distribution and its in- fluence factors of soil water, salinity and organic matter was carried out for 0-70 cm soil layers in Manas River watershed. The results showed that the soil moisture data from all soil layers exhibited a normal distribution, with average values of 14.08%-21.55%. Geostatistical analysis revealed that the content of soil moisture had a moder- ate spatial autocorrelation with the ratios of nugget/sill ranging from 0.500 to 0.718, which implies that the spatial pattern of soil moisture is influenced by the combined effects of structural factors and random factors. Remarkable spatial distributions with stripped and mottled features were found for soil moisture in all different soil layers. The landform and crop planting had a relatively big influence on the spatial distribution of soil moisture; total soil salinity was high in east but low in west, and non-salinized soil and lightly salinized soil appeared at the northwest and southwest of the study area. Under the effect of reservoir leakage, the heavily salinized soils are widely distributed in the middle of the study area. The areas of the non-salinized and lightly salinized soils decreased gradually with soil depth increment, which is contrary to the case for saline soils that reached a maximum of 245.67 km2 at the layer of 50-70 cm. The types of soil salinization in Manas River watershed were classified into four classes： the sulfate, chloride-sulfate, sulfate-chloride and chloride. The sulfate salinized soil is most widely distributed in the surface layer. The areas of chloride-sulfate, sulfate-chloride, and chloride salinized soils increased gradually along with the increment of soil depth; the variation range of the average values of soil organic matter content was be- tween 7.48%-11.33%. The ratios of nugget/sill reduced gradually from 0.698 to 0.299 with soil depth increment, which shows that the content of soil organic matter has a moderate spatial autocorrelation. The soil organic matter in all soil layers met normal distribution after logarithmic transformation. The spatial distribution patterns of soil or- ganic matter and soil moisture were similar; the areas with high organic matter contents were mainly distributed in the south of the study area, with the lowest contents in the middle.
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KZCX2-EW-308)the National Basic Research Program of China (2006FY110600)the National Natural Science Foundation of China (41071139 and 40971117)
文摘Based on the analyses of environmental proxy data in lake sediments and instrumental records of Xinjiang in northwest China, the Holocene climate and hydrological variability and its environmental responses were studied in different time scales and regions. The results showed that the Holocene climate variability had obvious differences between the north and south of Xinjiang. In northern Xinjiang, the Holocene climate was dry in the early period, humid in the middle period, and then changed to dry in the late period. However, the climate transition times were not consistent in different regions. In southern Xin- jiang, although there were many different types of climate change patterns inferred from different catch- ments, the warm and wet climate was recorded in most lake sediments in the middle Holocene. According to comparisons of some millennium scale records in lake sediments, the climate was warm and dry in the past 100 years. It can be concluded the climate showed a trend of aridity in Holocene. Especially in recent 50 years, the lake area has been shrinking rapidly because of the population growth and social economic development, which brings some environmental problems. Lake level and area changes were sensitively affected by the climate variation in geological history of Xinjiang and the lake level will continue to shrink because of the drought climate and strengthened human activities.
基金supported in part by the National Natural Science Foundation of China(No.11421505)the Major State Basic Research Development Program in China(No.2014CB845400)
文摘We report in this paper the alignment calibration of the STAR pixel detector(PXL) prototype for the RHIC2013 run and performance study of the full PXL detector installed and commissioned in the RHIC 2014 run. PXL detector is the innermost two silicon layers of the STAR heavy flavor tracker aiming at high-precision reconstruction of secondary decay vertex of heavy flavor particles. To achieve the physics goals, the calibration work was done on the detector with high precision. A histogram-based method was successfully applied for the alignment calibration, and the detector efficiency after alignment was studied using both p t p collision data and cosmic ray data.
基金supported by the Fundamental Research Funds for the Central Universities of China(ZXH2012H005)supported in part by the National Natural Science Foundation of China(61201085,51402356,51506216)+1 种基金the Joint Fund of National Natural Science Foundation of China and Civil Aviation Administration of China(U1633101)the Joint Fund of the Natural Science Foundation of Tianjin(15JCQNJC42800)
文摘Solving quaternion kinematical differential equations(QKDE) is one of the most significant problems in the automation, navigation, aerospace and aeronautics literatures. Most existing approaches for this problem neither preserve the norm of quaternions nor avoid errors accumulated in the sense of long term time. We present explicit symplectic geometric algorithms to deal with the quaternion kinematical differential equation by modelling its time-invariant and time-varying versions with Hamiltonian systems and adopting a three-step strategy. Firstly,a generalized Euler's formula and Cayley-Euler formula are proved and used to construct symplectic single-step transition operators via the centered implicit Euler scheme for autonomous Hamiltonian system. Secondly, the symplecticity, orthogonality and invertibility of the symplectic transition operators are proved rigorously. Finally, the explicit symplectic geometric algorithm for the time-varying quaternion kinematical differential equation, i.e., a non-autonomous and non-linear Hamiltonian system essentially, is designed with the theorems proved. Our novel algorithms have simple structures, linear time complexity and constant space complexity of computation. The correctness and efficiencies of the proposed algorithms are verified and validated via numerical simulations.
基金The National Natural Science Foundation of China under contract No.42006198the Open Fund of the Key Laboratory of Marine Geology and Environment,Chinese Academy of Sciences under contract No.MGE2020KG02.
文摘Enderby Land in East Antarctica and its adjacent areas,which are closely related to the Indian Plate in their geological evolution,have become one of the key zones for studies on how the Antarctic continent evolves.Based on the isostasy and flexure theories of the lithosphere and using the CRUST1.0 model as the depth constraint,this paper uses the gravity field model EIGEN-6C4 and topographic data to calculate the isostatic gravity anomalies of Enderby Land and its adjacent areas.Then,the crustal thickness of the study area is calculated,and three comprehensive geophysical interpretation profiles that vertically span the study area are plotted.The results show that the flexural isostatic gravity anomalies in Enderby Land and its adjacent areas are closely related to the regional tectonic setting,and the anomalies in different regions differ substantially,ranging from−50×10^(−5)m/s^(2)to 85×10^(−5)m/s^(2).A zone of high isostatic gravity anomalies(30×10^(−5)−80×10^(−5)m/s^(2))is distributed outside the Cooperation Sea and Queen Maud Land,which may be plate remnants generated by early rifting.Except for the Kerguelen Plateau,which was formed by a hotspot and has a crustal thickness of 15 km,the thickness of the oceanic crust in other parts of the study area changes slightly by approximately 4–9 km,with the thinnest part being in Enderby Basin.The thickness of the inland crust along the coastline increases with the elevation,with the maximum thickness reaching 34 km.The isostatic gravity anomalies corresponding to the zone of high magnetic anomalies along the continental margin of Queen Maud Land are negative and small,with an isostatic adjustment trend indicating Moho surface uplift,and those on the edge of central Enderby Land are near zero,approaching the isostatic state,which may be caused by the magmatism at the early stage of rifting.The continental-oceanic boundary should be close to the contour line of the crustal thickness 10–12 km on the outer edge of the coastline.
文摘Recently we read the article entitled“Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study”.This was an observational study that reviewed the safety and efficacy of different cement augmentation modalities for vertebral compression fractures under osteoporotic condition.Overall,this is a valuable study that can provide a reference for clinical practice.On the other hand,we also noticed some points in the article and are willing to share our views.Further studies with a higher level of evidence can add more knowledge regarding relevant concerns.
基金supported in part by the State Key Research Development Program in China(Nos.2022YFA1604702 and 2022YFA1604900)the National Natural Science Foundation of China(No.12025501)Strategic Priority Research Program of Chinese Academy of Science(No.XDB34030200).
文摘The sensitivity of an experiment to detect the Majorana neutrino mass via neutrinoless double-beta decay(0νββ) strongly depends on the rate of background events that can mimic this decay. One major source of this background is the radioactive emissions from the laboratory environment. In our study, we focused on assessing the background contributions from environmental gamma rays, neutrons, and underground muons to the Jinping bolometric demonstration experiment. This experiment uses an array of lithium molybdate crystal bolometers to probe the potential 0νββ decay of the100Mo isotope at the China Jinping Underground Laboratory. We also evaluated the shielding effectiveness of the experimental setup through an attenuation study. Our simulations indicate that the combined background from environmental gamma rays, neutrons, and muons in the relevant100Mo 0νββ Q-value region can be reduced to approximately 0.003 cts/kg/keV/yr.
基金supported by the National Natural Science Foundation of China (Grants No.11874057,11874158,U1732273,and 21927814)the High Magnetic Field Laboratory of Anhui Province
文摘We investigate the magnetic ground state of Sm_(3)BWO_(9)with a distorted kagome lattice.A magnetic phase transition is identified at T_(N)=0.75 K from the temperature dependence of specific heat.From 11B nuclear magnetic resonance measurements,an incommensurate magnetic order is shown by the double-horn type spectra under a c-axis magnetic field,and absence of line splitting is observed for field oriented within the ab-plane,indicating the incommensurate modulation of the internal field strictly along𝑐c-axis.From the spin dynamics,the critical slowing-down behavior is observed in the temperature dependence of 1/T_(1)with𝜇_(μ0)H⊥c-axis,which is completely absent in the case with𝜇_(μ0)H||c-axis.Based on the local symmetry of 11B sites,we analyze the hyperfine coupling tensors and propose two constraints on the possible magnetic structure.The single ion anisotropy should play an important role in determination of contrasting ground states of Sm_(3)BWO_(9) and Pr_(3)BWO_(9).
基金supported by the National Natural Science Foundation of China (Grant No. 50869005)
文摘Tree ring dating plays an important role in obtaining past climate information.The fundamental study of obtaining tree ring samples in typical climate regions is particularly essential.The optimum distribution of tree ring sampling sites based on climate information from the Climate Observation Network(ORPOM model) is presented in this article.In this setup,the tree rings in a typical region are used for surface representation,by applying excellent correlation with the climate information as the main principle.Taking the Horqin Sandy Land in the cold and arid region of China as an example,the optimum distribution range of the tree ring sampling sites was obtained through the application of the ORPOM model,which is considered a reasonably practical scheme.
基金supported by the National Natural Science Foundation of China (Grant No. 50869005 and 50669002)the National Natural Science Foundation of China (Grant No. 50869005)supported by the National Natural Science Foundation of China (Grant No. 50669002)
文摘The town of Agura,a typical region in Horqin Sandy Land,was selected as the study area in this paper.Using 12 remote sensing images and climatic data from the past 20 years,the effects of climate change on surface environments were analyzed.The impact indices of climatic factors,along with their corresponding ranks,were used to characterize the responses of different types of surface environments to climate change.Results show that in the past 20 years,the surface environments of the study area have been deteriorating.Furthermore,there is a positive relationship between the changes in surface environments and those in climatic factors.Various climatic factors influence surface environments in different ways and at different levels.The most sensitive factor is relative humidity,followed by precipitation and evaporation.Overall,moisture is the key factor that affects the changes in surface environments of arid and semi-arid areas.
基金the Project of Beijing Sturgeon-Salmon and Trout Innovation Team(BAIC08-2019).
文摘In this paper,approximate nutritional components and amino acid content were determined in muscles of female wild population(WP)with body weight of 2500-3000 g and female cultured population(CP)with body weight of 750-1250 g masu salmon Oncorhynchus masou in the gonadal development stage IV by conventional method.The results showed that there were significantly higher crude protein and significantly lower crude fat in fresh muscle of WP than that in CP(P<0.05),but not significant differences in the contents of moisture and crude ash between WP and CP(P>0.05).Eighteen kinds of amino acids were detected in muscles of WP and CP,with higher total content of amino acids(TAA),essential amino acids(EAA)and four kinds of delicious amino acids(DAA)in WP than those in CP(P<0.05).The amino acid score(AAS)and chemical score(CS)revealed that the first limiting amino acid was tryptophan in two populations,with essential amino acid index(EAAI)of 75.59%in WP and 70.77%in CP.The findings indicated that the amino acid contents in muscles of CP are lower than that of WP,but the amino acid nutritional value evaluation indicators of both populations are very close,and both have high nutritional value.
基金the National Nature Science Foundation of China(No.22305066).
文摘Currently,the microwave absorbers usually suffer dreadful electromagnetic wave absorption(EMWA)performance damping at elevated temperature due to impedance mismatching induced by increased conduction loss.Consequently,the development of high-performance EMWA materials with good impedance matching and strong loss ability in wide temperature spectrum has emerged as a top priority.Herein,due to the high melting point,good electrical conductivity,excellent environmental stability,EM coupling effect,and abundant interfaces of titanium nitride(TiN)nanotubes,they were designed based on the controlling kinetic diffusion procedure and Ostwald ripening process.Benefiting from boosted heterogeneous interfaces between TiN nanotubes and polydimethylsiloxane(PDMS),enhanced polarization loss relaxations were created,which could not only improve the depletion efficiency of EMWA,but also contribute to the optimized impedance matching at elevated temperature.Therefore,the TiN nanotubes/PDMS composite showed excellent EMWA performances at varied temperature(298-573 K),while achieved an effective absorption bandwidth(EAB)value of 3.23 GHz and a minimum reflection loss(RLmin)value of−44.15 dB at 423 K.This study not only clarifies the relationship between dielectric loss capacity(conduction loss and polarization loss)and temperature,but also breaks new ground for EM absorbers in wide temperature spectrum based on interface engineering.
基金supported by the National Magnetic Confinement Fusion Energy R&D Program of China(No.2018YFE0310200)National Natural Science Foundation of China(Nos.11705242,11805138 and 12175156)the Fundamental Research Funds for the Central Universities in China(Nos.YJ201820 and YJ201954)。
文摘An E//B neutral particle analyzer(NPA)has been designed and is under development at Sichuan University and Southwestern Institute of Physics.The main purpose of the E//B NPA is to measure the distribution function of fast ions in the HL-2A/3 tokamak.The E//B NPA contains three main units,i.e.the stripping unit,the analyzing unit and the detection unit.A gas stripping chamber was adopted as the stripping unit.The results of the simulations and beam tests for the stripping chamber are presented.Parallel electric and magnetic fields provided by a NdFeB permanent magnet and two parallel electric plates were designed and constructed for the analyzing unit.The calibration of the magnetic and electric fields was performed using a 50 kV electron cyclotron resonance ion source(ECRIS)platform.The detection unit consists of 32lutetium-yttrium oxyorthosilicate(LYSO)detector modules arranged in two rows.The response functions ofα,hydrogen ions(H^(+),H_(2)^(+)and H_(3)^(+))andγfor a detector module were measured with^(241)Am,^(137)Cs and^(152)Eu sources together with the 50 kV ECRIS platform.The overall results indicate that the designed E//B NPA device is capable of measuring the intensity of neutral hydrogen and deuteron atoms with energy higher than 20 keV.
