The mechanisms of systolic anterior motion(SAM)of the mitral valve in hypertrophic obstructive cardiomyopathy(HOCM)remain unclear.To investigate the angle of attack between blood flow and mitral valve leaflets at pre-...The mechanisms of systolic anterior motion(SAM)of the mitral valve in hypertrophic obstructive cardiomyopathy(HOCM)remain unclear.To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point,patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre-and post-operative 2D vector flow mapping.The comparisons between pre-and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed.It was found that there was no statistically significant difference between pre-and post-operative angles of attack(61.1±t wa o vs.56.2±56.o,p=0.306,n=5).Therefore,we propose that the angle of attack might not play an important role in the initiation of SAM.展开更多
Antisense oligonucleotides(ASOs) hold considerable promise for cancer gene therapy through targeted m RNA degradation.However,their biomedical application is hindered by inefficient delivery and limited visualization ...Antisense oligonucleotides(ASOs) hold considerable promise for cancer gene therapy through targeted m RNA degradation.However,their biomedical application is hindered by inefficient delivery and limited visualization of biodistribution.Herein,we report a novel traceable afterglow nanoparticle platform for PLK1-targeted ASO delivery,representing the first reported integration of autofluorescence-free afterglow imaging with antisense therapeutics to enable non-invasive monitoring.Afterglow nanoparticle was assembled via nanoprecipitation of afterglow molecules(triple-anthracene derivatives) with surfactants,followed by polyethylenimine functionalization to enable ASO loading through electrostatic interactions,resulting in uniform nanoparticles with a favorable size distribution and high loading efficiency.In vitro evaluations revealed efficient cellular uptake,effective lysosomal escape and pronounced PLK1 silencing with substantial m RNA and protein downregulation,leading to marked induction of apoptosis in He La cells compared to free ASO.In vivo afterglow imaging demonstrated preferential tumor accumulation via the enhanced permeability and retention effect,with high signal-to-background ratios.In He La xenograft models,afterglow nanoparticle-mediated ASO delivery induced substantial tumor growth inhibition and widespread apoptosis,without detectable systemic toxicity as indicated by stable body weights and unremarkable organ histology.These findings highlight the potential of afterglow nanoparticles as a versatile platform for imaging-guided gene therapy,providing new avenues for enhanced precision in nucleic acid-based cancer treatments.展开更多
The article "Data-driven soft sensors in blast furnace ironmaking:a survey,"written by Yueyang LUO,Xinmin ZHANG,Manabu KANO,Long DENG,Chunjie YANG,and Zhihuan SONG,was originally published electronically on ...The article "Data-driven soft sensors in blast furnace ironmaking:a survey,"written by Yueyang LUO,Xinmin ZHANG,Manabu KANO,Long DENG,Chunjie YANG,and Zhihuan SONG,was originally published electronically on the publisher's Internet portal on Mar.27,2023 without open access.展开更多
Traumatic brain injury(TBI)constitutes a cluster of disorders resulting from external physical forces that undermine the structure or function of the brain.TBI brings high disability and mortality rates to patients.He...Traumatic brain injury(TBI)constitutes a cluster of disorders resulting from external physical forces that undermine the structure or function of the brain.TBI brings high disability and mortality rates to patients.Hence,the early diagnosis of TBI is of utmost importance.Current approaches mainly encompass computed tomography and magnetic resonance imaging;however,there are still constraints in diagnosing TBI due to limited spatial resolution and long scan durations.Herein,based on the advantages of low imaging background,high signal-to-background ratio,excellent tissue penetration,and high sensitivity of afterglow imaging,we have developed a trianthracene derivative(TA)-based nanoparticle for non-invasive afterglow imaging of TBI.Compared with fluorescence imaging,TA-NPs demonstrate a deeper tissue penetration depth(up to 2.5 cm)and a higher signal-to-noise ratio.After injection via the tail vein,TA-NPs can accumulate in the TBI area within the brain parenchyma and achieve in vivo detection of TBI within a short period(within 1 h),which is beneficial for the early diagnosis of TBI.Additionally,TA-NPs can also accomplish precise afterglow imaging of brain injuries with lower severity.The TA-NPs-based afterglow imaging developed herein will significantly facilitate the early diagnosis of TBI and provide robust evidence for its subsequent treatment.展开更多
The blast furnace is a highly energy-intensive,highly polluting,and extremely complex reactor in the ironmaking process.Soft sensors are a key technology for predicting molten iron quality indices reflecting blast furn...The blast furnace is a highly energy-intensive,highly polluting,and extremely complex reactor in the ironmaking process.Soft sensors are a key technology for predicting molten iron quality indices reflecting blast furnace energy consumption and operation stability,and play an important role in saving energy,reducing emissions,improving product quality,and producing economic benefits.With the advancement of the Internet of Things,big data,and artificial intelligence,data-driven soft sensors in blast furnace ironmaking processes have attracted increasing attention from researchers,but there has been no systematic review of the data-driven soft sensors in the blast furnace ironmaking process.This review covers the state-of-the-art studies of data-driven soft sensors technologies in the blast furnace ironmaking process.Specifically,wefirst conduct a comprehensive overview of various data-driven soft sensor modeling methods(multiscale methods,adaptive methods,deep learning,etc.)used in blast furnace ironmaking.Second,the important applications of data-driven soft sensors in blast furnace ironmaking(silicon content,molten iron temperature,gas utilization rate,etc.)are classified.Finally,the potential challenges and future development trends of data-driven soft sensors in blast furnace ironmaking applications are discussed,including digital twin,multi-source data fusion,and carbon peaking and carbon neutrality.展开更多
The moisture content(MC)of municipal sludge is the key factor affecting sludge treatment and disposal technologies,while the vast majority of existing measurement methods are off-line and time-consuming.To realize rap...The moisture content(MC)of municipal sludge is the key factor affecting sludge treatment and disposal technologies,while the vast majority of existing measurement methods are off-line and time-consuming.To realize rapid online detection for the MC of sludge,a detection method based on the microwave reflection principle is proposed:experiments are carried out and the MC computation model of the sludge is derived using the resonant frequency and the permittivity(e').The results reveal that the detection accuracy of granular sludge with a thickness of 10 mm is higher.The theoretical model between the MC and the real part of e'is developed,and the relationship between the resonant frequency and e'is expressed by a cubic polynomial.The average error and the root mean square error(RMSE)of sludge are 2.06%and 2.49%,respectively.The prediction model for the MC of sludge is also given,and the determination coefficient and RMSE are 0.981 and 2.06%,respectively.展开更多
The invention of pottery played a crucial role in human history,promoting human settlement and the transition to an agricultural society[1,2].Pottery first emerged in East Asia during the Late Pleistocene/Paleolithic ...The invention of pottery played a crucial role in human history,promoting human settlement and the transition to an agricultural society[1,2].Pottery first emerged in East Asia during the Late Pleistocene/Paleolithic across a diverse range of environmental settings,becoming more widespread with the climatic warming of the Holocene/Neolithic[3].The relatively cold Mongolian Plateau was a key region for early human adaptation.展开更多
基金The authors would like to acknowledge the research support from Natural Science Foundation of Fujian Province of China(Grant No.2017J01009)Fundamental Research Funds for the Central Universities(Grant No.20720180004)National Heart,Lung and Blood Institute grants R01 HL089269,and National Sciences Foundation of China(Grant No.11672001,81571691).
文摘The mechanisms of systolic anterior motion(SAM)of the mitral valve in hypertrophic obstructive cardiomyopathy(HOCM)remain unclear.To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point,patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre-and post-operative 2D vector flow mapping.The comparisons between pre-and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed.It was found that there was no statistically significant difference between pre-and post-operative angles of attack(61.1±t wa o vs.56.2±56.o,p=0.306,n=5).Therefore,we propose that the angle of attack might not play an important role in the initiation of SAM.
基金supported by the National Key R&D Program of China (2024YFA1209404)the National Natural Science Foundation of China (U21A20287,22234003,21890744)+2 种基金the Zhejiang Provincial Natural Science Foundation (LQN 25C100009)the Ningbo Natural Science Foundation (2023J395)the China Postdoctoral Science Foundation (2024M762445)。
文摘Antisense oligonucleotides(ASOs) hold considerable promise for cancer gene therapy through targeted m RNA degradation.However,their biomedical application is hindered by inefficient delivery and limited visualization of biodistribution.Herein,we report a novel traceable afterglow nanoparticle platform for PLK1-targeted ASO delivery,representing the first reported integration of autofluorescence-free afterglow imaging with antisense therapeutics to enable non-invasive monitoring.Afterglow nanoparticle was assembled via nanoprecipitation of afterglow molecules(triple-anthracene derivatives) with surfactants,followed by polyethylenimine functionalization to enable ASO loading through electrostatic interactions,resulting in uniform nanoparticles with a favorable size distribution and high loading efficiency.In vitro evaluations revealed efficient cellular uptake,effective lysosomal escape and pronounced PLK1 silencing with substantial m RNA and protein downregulation,leading to marked induction of apoptosis in He La cells compared to free ASO.In vivo afterglow imaging demonstrated preferential tumor accumulation via the enhanced permeability and retention effect,with high signal-to-background ratios.In He La xenograft models,afterglow nanoparticle-mediated ASO delivery induced substantial tumor growth inhibition and widespread apoptosis,without detectable systemic toxicity as indicated by stable body weights and unremarkable organ histology.These findings highlight the potential of afterglow nanoparticles as a versatile platform for imaging-guided gene therapy,providing new avenues for enhanced precision in nucleic acid-based cancer treatments.
文摘The article "Data-driven soft sensors in blast furnace ironmaking:a survey,"written by Yueyang LUO,Xinmin ZHANG,Manabu KANO,Long DENG,Chunjie YANG,and Zhihuan SONG,was originally published electronically on the publisher's Internet portal on Mar.27,2023 without open access.
基金supported by Zhejiang Provincial Natural Science Foundation(LQN25C100009)Ningbo Natural Science Foundation(2023J261,2023J395)the Shenzhen Science and Technology Program(JCYJ20210324140205013).
文摘Traumatic brain injury(TBI)constitutes a cluster of disorders resulting from external physical forces that undermine the structure or function of the brain.TBI brings high disability and mortality rates to patients.Hence,the early diagnosis of TBI is of utmost importance.Current approaches mainly encompass computed tomography and magnetic resonance imaging;however,there are still constraints in diagnosing TBI due to limited spatial resolution and long scan durations.Herein,based on the advantages of low imaging background,high signal-to-background ratio,excellent tissue penetration,and high sensitivity of afterglow imaging,we have developed a trianthracene derivative(TA)-based nanoparticle for non-invasive afterglow imaging of TBI.Compared with fluorescence imaging,TA-NPs demonstrate a deeper tissue penetration depth(up to 2.5 cm)and a higher signal-to-noise ratio.After injection via the tail vein,TA-NPs can accumulate in the TBI area within the brain parenchyma and achieve in vivo detection of TBI within a short period(within 1 h),which is beneficial for the early diagnosis of TBI.Additionally,TA-NPs can also accomplish precise afterglow imaging of brain injuries with lower severity.The TA-NPs-based afterglow imaging developed herein will significantly facilitate the early diagnosis of TBI and provide robust evidence for its subsequent treatment.
基金Project supported by the National Natural Science Founda-tion of China(Nos.62003301,61933013,and 61833014)the Natural Science Foundation of Zhejiang Province,China(No.LQ21F030018)the Open Research Project of the State Key Laboratory of Industrial Control Technology,Zhejiang Univer-sity,China(Nos.ICT2022B30 and ICT2022B08)。
文摘The blast furnace is a highly energy-intensive,highly polluting,and extremely complex reactor in the ironmaking process.Soft sensors are a key technology for predicting molten iron quality indices reflecting blast furnace energy consumption and operation stability,and play an important role in saving energy,reducing emissions,improving product quality,and producing economic benefits.With the advancement of the Internet of Things,big data,and artificial intelligence,data-driven soft sensors in blast furnace ironmaking processes have attracted increasing attention from researchers,but there has been no systematic review of the data-driven soft sensors in the blast furnace ironmaking process.This review covers the state-of-the-art studies of data-driven soft sensors technologies in the blast furnace ironmaking process.Specifically,wefirst conduct a comprehensive overview of various data-driven soft sensor modeling methods(multiscale methods,adaptive methods,deep learning,etc.)used in blast furnace ironmaking.Second,the important applications of data-driven soft sensors in blast furnace ironmaking(silicon content,molten iron temperature,gas utilization rate,etc.)are classified.Finally,the potential challenges and future development trends of data-driven soft sensors in blast furnace ironmaking applications are discussed,including digital twin,multi-source data fusion,and carbon peaking and carbon neutrality.
基金the financial support from the Science and Technology Innovation Leading Talent Project of Special Support Plan For High-Level Talents of Zhejiang Province(Grant No.201R52056)Zhejiang Provincial Natural Science Foundation(Grant Nos.LZ23E080001,LR19E060001)+1 种基金Major Science and Technology Projects of Jinhua City(Grant No.2022-1-014)Jiangsu Province International Cooperative Research Project(Grant No.BZ2021008).
文摘The moisture content(MC)of municipal sludge is the key factor affecting sludge treatment and disposal technologies,while the vast majority of existing measurement methods are off-line and time-consuming.To realize rapid online detection for the MC of sludge,a detection method based on the microwave reflection principle is proposed:experiments are carried out and the MC computation model of the sludge is derived using the resonant frequency and the permittivity(e').The results reveal that the detection accuracy of granular sludge with a thickness of 10 mm is higher.The theoretical model between the MC and the real part of e'is developed,and the relationship between the resonant frequency and e'is expressed by a cubic polynomial.The average error and the root mean square error(RMSE)of sludge are 2.06%and 2.49%,respectively.The prediction model for the MC of sludge is also given,and the determination coefficient and RMSE are 0.981 and 2.06%,respectively.
基金supported by the National Natural Science Foundation of China(41972192 and 42301094)the Project Entrusted by the Local Government of Nei Mongol(33222021001)+1 种基金Fundamental Research Funds for the Central Universities(590122095)a scholarship from the China Scholarship Council(202306400035).
文摘The invention of pottery played a crucial role in human history,promoting human settlement and the transition to an agricultural society[1,2].Pottery first emerged in East Asia during the Late Pleistocene/Paleolithic across a diverse range of environmental settings,becoming more widespread with the climatic warming of the Holocene/Neolithic[3].The relatively cold Mongolian Plateau was a key region for early human adaptation.
