In recent years,the global incidence of chronic kidney disease caused by popular high-protein diet is on the rise.As a traditional edible and medicinal fungus in Asian countries,Inonotus hispidus has been proved to ha...In recent years,the global incidence of chronic kidney disease caused by popular high-protein diet is on the rise.As a traditional edible and medicinal fungus in Asian countries,Inonotus hispidus has been proved to have a variety of biological activities.In this study,a mouse model of chronic kidney disease was established,and the effect of Inonotus hispidus on chronic kidney disease induced by high protein diet was clarified by the compre-hensive strategy of metabonomics and intestinal microbiota analysis.We found that Inonotus hispidus fermen-tation broth may alleviate renal damage by regulating glycerol phospholipid metabolism and bile acid metabolism,and its fermentation broth can reverse the intestinal microbiota imbalance caused by high-protein diet.In addition,through analysis,it is found that high-protein diet can down-regulate the level of Farnesoid X receptor in the kidney,resulting in lipid accumulation and a series of pathological changes in the kidney.We believe that Inonotus hispidus has the potential to become a new type of safe and effective functional food for the treatment of chronic kidney disease.展开更多
基金funded by the Wuxi Science and Technology Development Fund Project(K20221001)the Fundamental Research Funds for the Central Universities(JUSRP123006 and JUSRP123008).
文摘In recent years,the global incidence of chronic kidney disease caused by popular high-protein diet is on the rise.As a traditional edible and medicinal fungus in Asian countries,Inonotus hispidus has been proved to have a variety of biological activities.In this study,a mouse model of chronic kidney disease was established,and the effect of Inonotus hispidus on chronic kidney disease induced by high protein diet was clarified by the compre-hensive strategy of metabonomics and intestinal microbiota analysis.We found that Inonotus hispidus fermen-tation broth may alleviate renal damage by regulating glycerol phospholipid metabolism and bile acid metabolism,and its fermentation broth can reverse the intestinal microbiota imbalance caused by high-protein diet.In addition,through analysis,it is found that high-protein diet can down-regulate the level of Farnesoid X receptor in the kidney,resulting in lipid accumulation and a series of pathological changes in the kidney.We believe that Inonotus hispidus has the potential to become a new type of safe and effective functional food for the treatment of chronic kidney disease.
