Objective: to explore the effect of micro-current stimulation on activation or inhibition of relevant signal pathways (MAPK, Wnt/β-catenin, NF-κB) in LDH model rats. Methods: a total of 180 healthy adult SD rats, ha...Objective: to explore the effect of micro-current stimulation on activation or inhibition of relevant signal pathways (MAPK, Wnt/β-catenin, NF-κB) in LDH model rats. Methods: a total of 180 healthy adult SD rats, half male and half female, weighing 250-280g, were selected for modeling. After successful modeling, NPCs cells of intervertebral disc were divided into stimulation group and non-stimulation group according to the intervention of low-frequency electronic pulse current stimulation. The contents of MAPK, Wnt/β-catenin, NF-κB signal pathway and LDH-related characteristic indicators in the two groups of rats were compared. Results: the relative expressions of p-p38MAPK, p-ERK1, p-ERK2 and p-JNK in the stimulation group were significantly lower than those in the non-stimulation group (p 0.05). The mechanical stimulation pain threshold of the stimulation group was significantly higher than that of the non-stimulation group, and the content of IL-1β and TNF-α was significantly lower than that of the non-stimulation group (P 0.05). There was no significant difference in IL-6 between the two groups. Conclusion: microcurrent stimulation can reduce the relative expression of p-p38MAPK, p-ERK1, p-ERK2, p-JNK protein in rat dorsal root ganglion, suggesting that it can inhibit ERK signaling pathway in rats with lumbar disc herniation.展开更多
When speaking of Shanghai’s bars, what comes to people’s minds first must be Hengshan Street, a road known for its variety of bars. For many people, Hengshan Street is a landmark. On this street, bars in bold and un...When speaking of Shanghai’s bars, what comes to people’s minds first must be Hengshan Street, a road known for its variety of bars. For many people, Hengshan Street is a landmark. On this street, bars in bold and unrestrained styles appeal to visitors. In fact, the whole street is a large open bar: the hurly-burly of "Hello" permeates every corner of the street; the resonant singing of "Rainbow Potato" echoes in the night sky; the rock’n roll of "Full House" fascinates passers-by with the wildness of John Lennon;展开更多
Under the background of quality-oriented education, teachers should have a deep understanding of the goals of English teaching in senior high schools in the new era, and teach English knowledge from different angles a...Under the background of quality-oriented education, teachers should have a deep understanding of the goals of English teaching in senior high schools in the new era, and teach English knowledge from different angles according to the actual situation of the students in the classes they teach, so as to cultivate students' abilities in an all-round way and make them become innovative and high-quality talents to meet the needs of social development, which is very beneficial to their future growth and development. This paper mainly discusses the innovative strategies of high school English teaching in the new era.展开更多
Background MicroRNAs （miRNAs） control gene expression by destabilizing target transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human diseases, including schizoph...Background MicroRNAs （miRNAs） control gene expression by destabilizing target transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human diseases, including schizophrenia. However, the effects on miRNA expression in response to antipsychotic treatment in peripheral circulation have not been thoroughly examined. Methods Using quantitative real-time PCR （qRT-PCR）, We quantified the expression of seven candidate miRNAs in plasma samples of 40 first-episode schizophrenics before and after antipsychotic treatment. The patients were all treated with risperidone and achieved remission in 1 year. Results Compared with the baseline, the expression levels of miR-365 and miR-520c-3p were significantly down- regulated after 1 year of risperidone treatment （P 〈0.001）. There were no significant correlations between the clinical symptoms and the expression levels of these two miRNAs （P 〉0.05）. Conclusions This study analyzed possible circulating miRNAs in response to antipsychotic monotherapy for schizophrenia, the further mechanism need to be confirmed.展开更多
文摘Objective: to explore the effect of micro-current stimulation on activation or inhibition of relevant signal pathways (MAPK, Wnt/β-catenin, NF-κB) in LDH model rats. Methods: a total of 180 healthy adult SD rats, half male and half female, weighing 250-280g, were selected for modeling. After successful modeling, NPCs cells of intervertebral disc were divided into stimulation group and non-stimulation group according to the intervention of low-frequency electronic pulse current stimulation. The contents of MAPK, Wnt/β-catenin, NF-κB signal pathway and LDH-related characteristic indicators in the two groups of rats were compared. Results: the relative expressions of p-p38MAPK, p-ERK1, p-ERK2 and p-JNK in the stimulation group were significantly lower than those in the non-stimulation group (p 0.05). The mechanical stimulation pain threshold of the stimulation group was significantly higher than that of the non-stimulation group, and the content of IL-1β and TNF-α was significantly lower than that of the non-stimulation group (P 0.05). There was no significant difference in IL-6 between the two groups. Conclusion: microcurrent stimulation can reduce the relative expression of p-p38MAPK, p-ERK1, p-ERK2, p-JNK protein in rat dorsal root ganglion, suggesting that it can inhibit ERK signaling pathway in rats with lumbar disc herniation.
文摘When speaking of Shanghai’s bars, what comes to people’s minds first must be Hengshan Street, a road known for its variety of bars. For many people, Hengshan Street is a landmark. On this street, bars in bold and unrestrained styles appeal to visitors. In fact, the whole street is a large open bar: the hurly-burly of "Hello" permeates every corner of the street; the resonant singing of "Rainbow Potato" echoes in the night sky; the rock’n roll of "Full House" fascinates passers-by with the wildness of John Lennon;
文摘Under the background of quality-oriented education, teachers should have a deep understanding of the goals of English teaching in senior high schools in the new era, and teach English knowledge from different angles according to the actual situation of the students in the classes they teach, so as to cultivate students' abilities in an all-round way and make them become innovative and high-quality talents to meet the needs of social development, which is very beneficial to their future growth and development. This paper mainly discusses the innovative strategies of high school English teaching in the new era.
文摘Background MicroRNAs （miRNAs） control gene expression by destabilizing target transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human diseases, including schizophrenia. However, the effects on miRNA expression in response to antipsychotic treatment in peripheral circulation have not been thoroughly examined. Methods Using quantitative real-time PCR （qRT-PCR）, We quantified the expression of seven candidate miRNAs in plasma samples of 40 first-episode schizophrenics before and after antipsychotic treatment. The patients were all treated with risperidone and achieved remission in 1 year. Results Compared with the baseline, the expression levels of miR-365 and miR-520c-3p were significantly down- regulated after 1 year of risperidone treatment （P 〈0.001）. There were no significant correlations between the clinical symptoms and the expression levels of these two miRNAs （P 〉0.05）. Conclusions This study analyzed possible circulating miRNAs in response to antipsychotic monotherapy for schizophrenia, the further mechanism need to be confirmed.
