该研究旨在评估1990-2016年间中国和日本因高钠摄入量导致的脑卒中死亡率的长期趋势。研究人员从全球疾病负担(global burden of disease,GBD)2016中获得死亡率数据,并采用年龄段队列方法进行分析。年龄标准化死亡率数据显示,与高钠摄...该研究旨在评估1990-2016年间中国和日本因高钠摄入量导致的脑卒中死亡率的长期趋势。研究人员从全球疾病负担(global burden of disease,GBD)2016中获得死亡率数据,并采用年龄段队列方法进行分析。年龄标准化死亡率数据显示,与高钠摄入相关的脑卒中死亡率呈下降趋势。中国男性和中国女性每年的净降低率分别为-3.1%和-5.0%;而日本男性和日本女性分别为-4.6%和-5.7%。展开更多
尚未有前瞻性多种族队列对抗高血压药物类别和动脉硬化进展的相关性进行研究。该研究所有受试者基线均患高血压,定义为血压≥140/90 mm Hg（1mm Hg=0.133kPa）或服用降压药物治疗。在5个时间点评估药物的服用情况和血压水平。通过超声...尚未有前瞻性多种族队列对抗高血压药物类别和动脉硬化进展的相关性进行研究。该研究所有受试者基线均患高血压,定义为血压≥140/90 mm Hg（1mm Hg=0.133kPa）或服用降压药物治疗。在5个时间点评估药物的服用情况和血压水平。通过超声在基线时和平均随访（9.4±0.5）年后测定右颈总动脉的杨氏弹性模量和扩张系数。展开更多
Context: Abundant evidence links overweight and obesity with impaired health. However, controversies persist as to whether overweight and obesity have additional impact on cardiovascular outcomes independent of their ...Context: Abundant evidence links overweight and obesity with impaired health. However, controversies persist as to whether overweight and obesity have additional impact on cardiovascular outcomes independent of their strong associations with established coronary risk factors, eg, high blood pressure and high cholesterol level. Objective: To assess the relation of midlife body mass index with morbidity and mortality outcomes in older age among individuals without and with other major risk factors at baseline. Design: Chicago Heart Association Detection Project in Industry study, a prospective study with baseline(1967- 1973) cardiovascular risk classified as low risk(blood pressure ≤ 120/≤ 80 mm Hg, serum total cholesterol level < 200 mg/dL[5.2 mmol/L], and not currently smoking); moderate risk(nonsmoking and systolic blood pressure 121- 139 mm Hg, diastolic blood pressure 81- 89 mm Hg, and/or total cholesterol level 200- 239 mg/dL[5.2- 6.2 mmol/L]); or having any 1, any 2, or all 3 of the following risk factors: blood pressure ≥ 140/90 mm Hg, total cholesterol level ≥ 240 mg/dL(6.2 mmol/L), and current cigarette smoking. Body mass index was classified as normal weight(18.5- 24.9), overweight(25.0- 29.9), or obese(≥ 30). Mean follow-up was 32 years. Setting and Participants: Participants were 17 643 men and women aged 31 through 64 years, recruited from Chicago-area companies or organizations and free of coronary heart disease(CHD), diabetes, or major electrocardiographic abnormalities at baseline. Main Outcome Measures: Hospitalization and mortality from CHD, cardiovascular disease, or diabetes, beginning at age 65 years. Results: In multivariable analyses that included adjustment for systolic blood pressure and total cholesterol level, the odds ratio(95% confidence interval) for CHD death for obese participants compared with those of normal weight in the same risk category was 1.43(0.33- 6.25) for low risk and 2.07(1.29- 3.31) for moderate risk; for CHD hospitalization, the corresponding results were 4.25(1.57- 11.5) for low risk and 2.04(1.29- 3.24) for moderate risk. Results were similar for other risk groups and for cardiovascular disease, but stronger for diabetes(eg, low risk: 11.0[2.21- 54.5] for mortality and 7.84[3.95- 15.6] for hospitalization). Conclusion: For individuals with no cardiovascular risk factors as well as for those with 1 or more risk factors, those who are obese in middle age have a higher risk of hospitalization and mortality from CHD, cardiovascular disease, and diabetes in older age than those who are normal weight.展开更多
文摘该研究旨在评估1990-2016年间中国和日本因高钠摄入量导致的脑卒中死亡率的长期趋势。研究人员从全球疾病负担(global burden of disease,GBD)2016中获得死亡率数据,并采用年龄段队列方法进行分析。年龄标准化死亡率数据显示,与高钠摄入相关的脑卒中死亡率呈下降趋势。中国男性和中国女性每年的净降低率分别为-3.1%和-5.0%;而日本男性和日本女性分别为-4.6%和-5.7%。
文摘尚未有前瞻性多种族队列对抗高血压药物类别和动脉硬化进展的相关性进行研究。该研究所有受试者基线均患高血压,定义为血压≥140/90 mm Hg（1mm Hg=0.133kPa）或服用降压药物治疗。在5个时间点评估药物的服用情况和血压水平。通过超声在基线时和平均随访（9.4±0.5）年后测定右颈总动脉的杨氏弹性模量和扩张系数。
文摘Context: Abundant evidence links overweight and obesity with impaired health. However, controversies persist as to whether overweight and obesity have additional impact on cardiovascular outcomes independent of their strong associations with established coronary risk factors, eg, high blood pressure and high cholesterol level. Objective: To assess the relation of midlife body mass index with morbidity and mortality outcomes in older age among individuals without and with other major risk factors at baseline. Design: Chicago Heart Association Detection Project in Industry study, a prospective study with baseline(1967- 1973) cardiovascular risk classified as low risk(blood pressure ≤ 120/≤ 80 mm Hg, serum total cholesterol level < 200 mg/dL[5.2 mmol/L], and not currently smoking); moderate risk(nonsmoking and systolic blood pressure 121- 139 mm Hg, diastolic blood pressure 81- 89 mm Hg, and/or total cholesterol level 200- 239 mg/dL[5.2- 6.2 mmol/L]); or having any 1, any 2, or all 3 of the following risk factors: blood pressure ≥ 140/90 mm Hg, total cholesterol level ≥ 240 mg/dL(6.2 mmol/L), and current cigarette smoking. Body mass index was classified as normal weight(18.5- 24.9), overweight(25.0- 29.9), or obese(≥ 30). Mean follow-up was 32 years. Setting and Participants: Participants were 17 643 men and women aged 31 through 64 years, recruited from Chicago-area companies or organizations and free of coronary heart disease(CHD), diabetes, or major electrocardiographic abnormalities at baseline. Main Outcome Measures: Hospitalization and mortality from CHD, cardiovascular disease, or diabetes, beginning at age 65 years. Results: In multivariable analyses that included adjustment for systolic blood pressure and total cholesterol level, the odds ratio(95% confidence interval) for CHD death for obese participants compared with those of normal weight in the same risk category was 1.43(0.33- 6.25) for low risk and 2.07(1.29- 3.31) for moderate risk; for CHD hospitalization, the corresponding results were 4.25(1.57- 11.5) for low risk and 2.04(1.29- 3.24) for moderate risk. Results were similar for other risk groups and for cardiovascular disease, but stronger for diabetes(eg, low risk: 11.0[2.21- 54.5] for mortality and 7.84[3.95- 15.6] for hospitalization). Conclusion: For individuals with no cardiovascular risk factors as well as for those with 1 or more risk factors, those who are obese in middle age have a higher risk of hospitalization and mortality from CHD, cardiovascular disease, and diabetes in older age than those who are normal weight.
