This study investigated the expression characteristics and clinical significance of gamma-aminobutyric acid A(GABAA)receptor subunit gamma1(GABRG1)in glioma by integrating cancer and normal tissue data from multiple d...This study investigated the expression characteristics and clinical significance of gamma-aminobutyric acid A(GABAA)receptor subunit gamma1(GABRG1)in glioma by integrating cancer and normal tissue data from multiple databases and combining them with experimental evidence.The research revealed that GABRG1 exhibited low expression levels in glioma,and its low expression was closely associated with unfavorable clinical outcomes.Furthermore,a prognostic model with strong decision-making ability was constructed using multivariate Cox regression analysis,incorporating age,isocitric dehydrogenase(IDH)mutation status,O6-methylguanine-DNA methyltransferase(MGMT)methylation status,World Health Organization(WHO)grade,and GABRG1 expression.Additionally,GABRG1 might be associated with the expression of tumor-associated macrophages and was significantly linked to immune regulatory processes.This study provided a new target for immunotherapy in glioma and offered a novel indicator for predicting and evaluating the clinical prognosis of patients.展开更多
目的探讨经皮椎体成形术(PVP)中分期注射法对于脊柱病变治疗的安全性及有效性。方法回顾性分析228例患者,443节手术椎体,根据手术方法的不同将患者分为两组:A组(采用分期注射法)和B组(无分期注射法),所有患者随访12个月,随访过程中采用...目的探讨经皮椎体成形术(PVP)中分期注射法对于脊柱病变治疗的安全性及有效性。方法回顾性分析228例患者,443节手术椎体,根据手术方法的不同将患者分为两组:A组(采用分期注射法)和B组(无分期注射法),所有患者随访12个月,随访过程中采用视觉模拟评分(VAS)及Oswestry功能障碍指数(ODI)评价临床疗效,采用统计学方法对随访数据进行统计学分析。结果所有患者顺利完成手术,A组患者每节椎体骨水泥注入量平均(4.75±0.85) m L,B组患者骨水泥注入量平均(4.23±1.16) m L,A组患者81节椎体(23.9%)发生骨水泥渗漏,B组患者36节椎体(34.6%)发生骨水泥渗漏,骨水泥渗漏周围组织,未引起明显不适。对随访数据进行统计学分析显示,A组术后1 d和1个月VAS及ODI评分优于B组,差异有统计学意义,但是A组与B组术后6和12个月VAS及ODI评分差异无统计学意义。结论 PVP是治疗椎体病变安全有效的方法,为达到解剖学上的修复,从而最大程度恢复脊柱稳定性,缓解症状,在PVP中采用分期注射法是一种安全及有效的手术方法。展开更多
基金Supported by the National Natural Science Foundation of China(82271340,82071368)the Outstanding Youth Funding of Harbin Medical University(HYD2020JQ0016)the Horizontal Subject(86010900)。
文摘This study investigated the expression characteristics and clinical significance of gamma-aminobutyric acid A(GABAA)receptor subunit gamma1(GABRG1)in glioma by integrating cancer and normal tissue data from multiple databases and combining them with experimental evidence.The research revealed that GABRG1 exhibited low expression levels in glioma,and its low expression was closely associated with unfavorable clinical outcomes.Furthermore,a prognostic model with strong decision-making ability was constructed using multivariate Cox regression analysis,incorporating age,isocitric dehydrogenase(IDH)mutation status,O6-methylguanine-DNA methyltransferase(MGMT)methylation status,World Health Organization(WHO)grade,and GABRG1 expression.Additionally,GABRG1 might be associated with the expression of tumor-associated macrophages and was significantly linked to immune regulatory processes.This study provided a new target for immunotherapy in glioma and offered a novel indicator for predicting and evaluating the clinical prognosis of patients.
文摘目的探讨经皮椎体成形术(PVP)中分期注射法对于脊柱病变治疗的安全性及有效性。方法回顾性分析228例患者,443节手术椎体,根据手术方法的不同将患者分为两组:A组(采用分期注射法)和B组(无分期注射法),所有患者随访12个月,随访过程中采用视觉模拟评分(VAS)及Oswestry功能障碍指数(ODI)评价临床疗效,采用统计学方法对随访数据进行统计学分析。结果所有患者顺利完成手术,A组患者每节椎体骨水泥注入量平均(4.75±0.85) m L,B组患者骨水泥注入量平均(4.23±1.16) m L,A组患者81节椎体(23.9%)发生骨水泥渗漏,B组患者36节椎体(34.6%)发生骨水泥渗漏,骨水泥渗漏周围组织,未引起明显不适。对随访数据进行统计学分析显示,A组术后1 d和1个月VAS及ODI评分优于B组,差异有统计学意义,但是A组与B组术后6和12个月VAS及ODI评分差异无统计学意义。结论 PVP是治疗椎体病变安全有效的方法,为达到解剖学上的修复,从而最大程度恢复脊柱稳定性,缓解症状,在PVP中采用分期注射法是一种安全及有效的手术方法。
