The purpose of this paper is to analyze the patterns and factors of targeted poverty alleviation strategy in Nujiang Lisu Autonomous Prefecture,a key area from national contiguous special povertystricken areas in Chin...The purpose of this paper is to analyze the patterns and factors of targeted poverty alleviation strategy in Nujiang Lisu Autonomous Prefecture,a key area from national contiguous special povertystricken areas in China.Data collection took place in August 2015,July 2016 and June 2018,a literature search was carried out between March 2018 and May 2018,peer-reviewed publications in English were considered but to keep down the length of the paper and reduce redundancy,not all literature sources we collected are listed as references.The results show that progress of targeted poverty alleviation and development work in Nujiang Prefecture is generally smooth and obvious.Completing the"13 th Five-Year Plan"for poverty alleviation and development on schedule is also full of challenges and still needs a lot of effort.This study analyzes current situation and challenges for carrying out targeted poverty alleviation strategy in Nujiang Lisu Autonomous Prefecture.These contribute to the efficiency and effectiveness in poverty alleviation work in frontier minority area of China.展开更多
文摘目的通过对三氧化二砷的药品不良反应(adverse drug reaction,ADR)信号进行挖掘分析,探讨该药潜在的不良反应,为临床安全合理用药提供参考。方法检索美国食品药品监督管理局不良事件报告系统(FDA Adverse Event Reporting System,FAERS)数据库中1998年第1季度——2023年第2季度有关三氧化二砷的相关数据,利用比值失衡测量法中的报告比值比法以及英国药品和医疗保健产品管理局的综合标准法进行数据挖掘,根据国际人用药品注册技术协调会发布的《国际医学用语词典》的系统器官分类(system organ class,SOC)和首选术语(preferred terms,PT)对数据进行描述和分类。结果共获取三氧化二砷相关的ADR报告2084例,其中男性患者924例,女性841例,≥35岁患者1276例,上报数据主要源于美国(429例,20.59%);严重ADR共1914例,占比91.84%,以导致住院或住院时间延长(711例,34.12%)和死亡为主(296例,14.20%)。共挖掘到358个ADR信号,涉及24种SOC,主要为各类检查(1169例,21.17%)和各类神经系统疾病(361例,6.54%);发生频次较高的ADR以心电图QT间期延长、分化综合征、发热、呼吸困难等PT为主,其中感染性肺炎、白细胞计数降低、疾病进展等PT未被药品说明书收录。信号强度排名靠前的为分化综合征、造血系统肿瘤、白细胞过多等PT,而心肌心包炎、脓毒性栓子、中枢神经系统出血等PT未被说明书收录。结论三氧化二砷会导致极高比例的严重ADR,应对发生频次较高以及未收录在说明书中的ADR予以重视。在使用药物治疗前、治疗中及随访阶段,均应做好相关监测及上报工作,以有效保障患者用药安全。
基金supported by the Yunnan Provincial Department of Education Science Research Fund(Grant No.2019J0199)Third Party Appraisal of“13th Five-Year Plan”on Nujiang Lisu Autonomous Prefecture carried out by the Yunnan Academy of Social Science.
文摘The purpose of this paper is to analyze the patterns and factors of targeted poverty alleviation strategy in Nujiang Lisu Autonomous Prefecture,a key area from national contiguous special povertystricken areas in China.Data collection took place in August 2015,July 2016 and June 2018,a literature search was carried out between March 2018 and May 2018,peer-reviewed publications in English were considered but to keep down the length of the paper and reduce redundancy,not all literature sources we collected are listed as references.The results show that progress of targeted poverty alleviation and development work in Nujiang Prefecture is generally smooth and obvious.Completing the"13 th Five-Year Plan"for poverty alleviation and development on schedule is also full of challenges and still needs a lot of effort.This study analyzes current situation and challenges for carrying out targeted poverty alleviation strategy in Nujiang Lisu Autonomous Prefecture.These contribute to the efficiency and effectiveness in poverty alleviation work in frontier minority area of China.
