The active ingredient(a.i.)glyphosate is frequently detected in waterways at relatively high concentrations,posing a risk to aquatic organisms including freshwater mussels,North America’s most endangered animal group...The active ingredient(a.i.)glyphosate is frequently detected in waterways at relatively high concentrations,posing a risk to aquatic organisms including freshwater mussels,North America’s most endangered animal group.This research aims to evaluate for the first time the effect of a glyphosate-based herbicide on a freshwater mussel(Unionid)using a battery of biomarkers.Themussel Elliptio complanata was exposed for 21 days to CreditR Xtreme(at 0,50,100,and 150μg/L a.i.of glyphosate).An integrated biomarker response(IBRv2)was used to visualize the overall impact of each glyphosate-based herbicide concentration on mussels’health conditions.The biomarker results showed that glyphosate(used at 100μg/L and 150μg/L)induced lipid peroxidation in the gills and digestive gland and inhibited acetylcholinesterase in the foot and gills,indicating oxidative damage and neurotoxicity.Other biomarkerswere influenced at the lowest concentration of glyphosate tested(50μg/L):lipids(decrease),triglycerides(increase)and,to a lesser extent,vitellogenin(decrease).For the latter biomarkers,the sexeswere not affected similarly,and theywere only sensitive at 50μg/L,only females showed a trend toward a decrease for vitellogenin and a decrease for lipids.Using IBRv2,we found a clear discrimination between concentrations,and the index values increased with glyphosate concentration,attesting to the deterioration in biomarker-defined mussel health when exposed to Credit® Xtreme at realistic glyphosate concentrations in agricultural rivers.This study shows that glyphosate-based herbicides can alter neurological function,induce oxidative damage,and selectively modify the E.complanata metabolism at relatively low concentrations.展开更多
基金funded by Environment and Climate Change Canada(Fonds pour dommages a l’environnement)under a grant given to L.Vandelac and L.Parentthe Fondation UQAM(2020 to 2022)+2 种基金the Collectif de recherche Ecosante sur les pesticides,les politiques et les alternatives(CREPPA)the Natural Sciences and Engineering Research Council of Canada(NSERC)under a grant given to M.Boily(No.RGPIN-2016–05142)the Centre de recherche en ecotoxicologie du Quebec(EcotoQ) and the Centre interdisciplinaire de recherche en operationnalisation du developpement durable(CIRODD)for scholarships attributed to Y.Nombre.
文摘The active ingredient(a.i.)glyphosate is frequently detected in waterways at relatively high concentrations,posing a risk to aquatic organisms including freshwater mussels,North America’s most endangered animal group.This research aims to evaluate for the first time the effect of a glyphosate-based herbicide on a freshwater mussel(Unionid)using a battery of biomarkers.Themussel Elliptio complanata was exposed for 21 days to CreditR Xtreme(at 0,50,100,and 150μg/L a.i.of glyphosate).An integrated biomarker response(IBRv2)was used to visualize the overall impact of each glyphosate-based herbicide concentration on mussels’health conditions.The biomarker results showed that glyphosate(used at 100μg/L and 150μg/L)induced lipid peroxidation in the gills and digestive gland and inhibited acetylcholinesterase in the foot and gills,indicating oxidative damage and neurotoxicity.Other biomarkerswere influenced at the lowest concentration of glyphosate tested(50μg/L):lipids(decrease),triglycerides(increase)and,to a lesser extent,vitellogenin(decrease).For the latter biomarkers,the sexeswere not affected similarly,and theywere only sensitive at 50μg/L,only females showed a trend toward a decrease for vitellogenin and a decrease for lipids.Using IBRv2,we found a clear discrimination between concentrations,and the index values increased with glyphosate concentration,attesting to the deterioration in biomarker-defined mussel health when exposed to Credit® Xtreme at realistic glyphosate concentrations in agricultural rivers.This study shows that glyphosate-based herbicides can alter neurological function,induce oxidative damage,and selectively modify the E.complanata metabolism at relatively low concentrations.
