There are multiple contaminants in practical wastewater;and the photodegradation of mixed pollutants is a challenge in the field of photocatalysis.Herein,we design a mesoporous 2D/2D TiO_(2)(B)-BiOBr heterojunction ph...There are multiple contaminants in practical wastewater;and the photodegradation of mixed pollutants is a challenge in the field of photocatalysis.Herein,we design a mesoporous 2D/2D TiO_(2)(B)-BiOBr heterojunction photocatalyst for the photodegradation of mixed pollutants.Such a coupling structure results in an enhancement in the disconnection of photoexcited carriers,and the increase of absorption and reaction sites.The 2D/2D TiO_(2)(B)-BiOBr demonstrates outstanding photocatalytic activity for photodegrading rhodamine B(RhB),methyl orange(MO),tetracycline hydrochloride(TCH),and bisphenol A(BPA)simultaneously under visible light,which is 4.7,1.4,23 and 16.4 times as high as that of original BiOBr,respectively.Our work represents a possible solution to devise promising and efficient photocatalysts for the treatment of practical wastewater in the near future.展开更多
Cellular senescence is an irreversible form of cell cycle arrest that provides a barrier to neoplastic transformation. The integrity of the Rb （Retinoblastoma） pathway is necessary for the formation of the senescenc...Cellular senescence is an irreversible form of cell cycle arrest that provides a barrier to neoplastic transformation. The integrity of the Rb （Retinoblastoma） pathway is necessary for the formation of the senescence-associated heterochromatin foci （SAHF） that offers a molecular basis for the stability of the senescent state. Surprisingly, although high mobility group A2 protein （HMGA2） can promote tumorigenesis and inhibit Rb function in tumor cells, high-level expression of HMGA2 is sufficient to induce SAHF formation in primary cells. It therefore becomes significant to determine whether Rb protein is necessary in HMGA2-induced SAHF formation. In this study, we established the cellular senescence and SAHF assembly W138 cell model by ectopic expression of HMGA2, in which typical senescent markers were seen, including notable upregulation of p53, p21 and p16, and elevated SA-[3-galactosidase staining together with downregulation of E2F target genes. We then showed that the Rb pathway inhibitor E7 protein was able to partly abolish the ability of SAHF formation alter HMGA2 expression in W138 cells, indicating that Rb is a crucial factor for HMGA2-induced SAHF formation. However. Rb depletion did not completely rescue the cell growth arrest induced by HMGA2, suggesting that Rb is not an exclusive pathway for HMGA2-induced senescence in W138 cells.展开更多
Document Frequency(DF)is reported to be a simple yet quite effective measure for feature selection in text classification,which is a key step in processing big textual data collections.The calculation is based on how ...Document Frequency(DF)is reported to be a simple yet quite effective measure for feature selection in text classification,which is a key step in processing big textual data collections.The calculation is based on how many documents in a collection contain a feature,which can be a word,a phrase,a n-gram,or a specially derived attribute.It is an unsupervised and class independent metric.Features of the same DF value may have quite different distribution over different categories,and thus have different discriminative power over categories.For example,in a binary classification problem,if feature A only appears in one category,but feature B,which has the same DF value as feature A,is evenly distributed in both categories.Then,feature A is obviously more effective than feature B for classification.To overcome this weakness of the original document frequency feature selection metric,we,therefore,propose a class based document frequency strategy to further refine the original DF to some extent.Extensive experiments on three text classification datasets demonstrate the effectiveness of the proposed measures.Using Class Based Document Frequency to Select展开更多
Female primary pelvic retroperitoneal tumours(PPRTs)refer to a heterogeneous group of tumours originating from the retroperitoneal space of the female pelvis,located predominantly or entirely within the true pelvis.Th...Female primary pelvic retroperitoneal tumours(PPRTs)refer to a heterogeneous group of tumours originating from the retroperitoneal space of the female pelvis,located predominantly or entirely within the true pelvis.This group excludes metastatic tumours,bone-derived tumours,extragastrointestinal stromal tumours,broad ligament myomas,endometriosis,tumours originating from the lymphoreticular system and tumours originating from pelvic visceral organs(such as those of the female reproductive tract,intestines and urinary system).PPRTs,also known as pelvic extraperitoneal tumours,have an incidence rate of less than 0.01%.The upper boundary of the pelvic retroperitoneal space is defined by a line consisting of the superior border of the symphysis pubis,the pubic tubercle and the superior border of the sacral promontory,whereas the inferior boundary extends to the pelvic diaphragm or below.Most female PPRTs are diagnosed during reproductive age,with approximately 80%of the tumours being benign.1 The management of PPRTs poses challenges for general clinicians due to their limited clinical experience,which leads to a high rate of missed cases and misdiagnoses.Compared with abdominal retroperitoneal tumours,the anatomical structure of PPRTs is deeper and more complex,resulting in greater surgical difficulty.展开更多
基金funding support from the National Science Foundation of China(NO.220413201)。
文摘There are multiple contaminants in practical wastewater;and the photodegradation of mixed pollutants is a challenge in the field of photocatalysis.Herein,we design a mesoporous 2D/2D TiO_(2)(B)-BiOBr heterojunction photocatalyst for the photodegradation of mixed pollutants.Such a coupling structure results in an enhancement in the disconnection of photoexcited carriers,and the increase of absorption and reaction sites.The 2D/2D TiO_(2)(B)-BiOBr demonstrates outstanding photocatalytic activity for photodegrading rhodamine B(RhB),methyl orange(MO),tetracycline hydrochloride(TCH),and bisphenol A(BPA)simultaneously under visible light,which is 4.7,1.4,23 and 16.4 times as high as that of original BiOBr,respectively.Our work represents a possible solution to devise promising and efficient photocatalysts for the treatment of practical wastewater in the near future.
基金supported by the grants from the National Natural Science Foundation of China(Nos.31100998 and 31050015)the Fundamental Research Funds for the Central Universities(No.11SSXT132)
文摘Cellular senescence is an irreversible form of cell cycle arrest that provides a barrier to neoplastic transformation. The integrity of the Rb （Retinoblastoma） pathway is necessary for the formation of the senescence-associated heterochromatin foci （SAHF） that offers a molecular basis for the stability of the senescent state. Surprisingly, although high mobility group A2 protein （HMGA2） can promote tumorigenesis and inhibit Rb function in tumor cells, high-level expression of HMGA2 is sufficient to induce SAHF formation in primary cells. It therefore becomes significant to determine whether Rb protein is necessary in HMGA2-induced SAHF formation. In this study, we established the cellular senescence and SAHF assembly W138 cell model by ectopic expression of HMGA2, in which typical senescent markers were seen, including notable upregulation of p53, p21 and p16, and elevated SA-[3-galactosidase staining together with downregulation of E2F target genes. We then showed that the Rb pathway inhibitor E7 protein was able to partly abolish the ability of SAHF formation alter HMGA2 expression in W138 cells, indicating that Rb is a crucial factor for HMGA2-induced SAHF formation. However. Rb depletion did not completely rescue the cell growth arrest induced by HMGA2, suggesting that Rb is not an exclusive pathway for HMGA2-induced senescence in W138 cells.
文摘Document Frequency(DF)is reported to be a simple yet quite effective measure for feature selection in text classification,which is a key step in processing big textual data collections.The calculation is based on how many documents in a collection contain a feature,which can be a word,a phrase,a n-gram,or a specially derived attribute.It is an unsupervised and class independent metric.Features of the same DF value may have quite different distribution over different categories,and thus have different discriminative power over categories.For example,in a binary classification problem,if feature A only appears in one category,but feature B,which has the same DF value as feature A,is evenly distributed in both categories.Then,feature A is obviously more effective than feature B for classification.To overcome this weakness of the original document frequency feature selection metric,we,therefore,propose a class based document frequency strategy to further refine the original DF to some extent.Extensive experiments on three text classification datasets demonstrate the effectiveness of the proposed measures.Using Class Based Document Frequency to Select
基金supported by the Henan Provincial Health Commission Key Project of Science and Technology Research (SBGJ202302074)the Henan Provincial Key Support Discipline Project for 2024-Gynaecological and Obstetric Surgery。
文摘Female primary pelvic retroperitoneal tumours(PPRTs)refer to a heterogeneous group of tumours originating from the retroperitoneal space of the female pelvis,located predominantly or entirely within the true pelvis.This group excludes metastatic tumours,bone-derived tumours,extragastrointestinal stromal tumours,broad ligament myomas,endometriosis,tumours originating from the lymphoreticular system and tumours originating from pelvic visceral organs(such as those of the female reproductive tract,intestines and urinary system).PPRTs,also known as pelvic extraperitoneal tumours,have an incidence rate of less than 0.01%.The upper boundary of the pelvic retroperitoneal space is defined by a line consisting of the superior border of the symphysis pubis,the pubic tubercle and the superior border of the sacral promontory,whereas the inferior boundary extends to the pelvic diaphragm or below.Most female PPRTs are diagnosed during reproductive age,with approximately 80%of the tumours being benign.1 The management of PPRTs poses challenges for general clinicians due to their limited clinical experience,which leads to a high rate of missed cases and misdiagnoses.Compared with abdominal retroperitoneal tumours,the anatomical structure of PPRTs is deeper and more complex,resulting in greater surgical difficulty.
