Mixed polyanion phosphate Na_(4)Fe_(3)(PO_(4))_(2)P_(2)O_(7)(NFPP)is regarded as the most promising cathode material for sodium-ion batteries(SIBs),due to its high structural stability and low-cost environmental frien...Mixed polyanion phosphate Na_(4)Fe_(3)(PO_(4))_(2)P_(2)O_(7)(NFPP)is regarded as the most promising cathode material for sodium-ion batteries(SIBs),due to its high structural stability and low-cost environmental friendliness.However,its intrinsic low conductivity and sluggish Na^(+)diffusion restricted the fast-charge and low-temperature sodium storage.Herein,an NFPP composite encapsulated by in-situ pyrolytic carbon and coupled with expanded graphite(NFPP@C/EG)was constructed via a sol-gel method followed by a ballmill procedure.Due to the dual-carbon modified strategy,this NFPP@C/EG only enhanced the electronic conductivity,but also endowed more channels for Na^(+)diffusion.As cathode for SIBs,the optimized NFPP(M-NFPP@C/EG)delivers excellent rate capability(capacity of~80.5 mAh/g at 50 C)and outstanding cycling stability(11000 cycles at 50 C with capacity retention of 89.85%).Additionally,cyclic voltammetry(CV)confirmed that its sodium storage behavior is pseudocapacitance-controlled,with in-situ electrochemical impedance spectroscopy(EIS)further elucidating improvements in electrode reaction kinetics.At lower temperatures(0℃),M-NFPP@C/EG demonstrated exceptional cycling performance(8800 cycles at 10 C with capacity retention of 95.81%).Moreover,pouch cells also exhibited excellent stability.This research demonstrates the feasibility of a dual carbon modification strategy in enhancing NFPP and proposes a low-cost,high-rate,and ultra-stable cathode material for SIBs.展开更多
Background and aims:Methane has shown protective effects against ischemia and reperfusion injury(IRI)in the liver,but the mechanism underlying these beneficial effects is unclear.To investigate the hypothesis that ita...Background and aims:Methane has shown protective effects against ischemia and reperfusion injury(IRI)in the liver,but the mechanism underlying these beneficial effects is unclear.To investigate the hypothesis that itaconate facilitates in methane-induced Nrf2 pathway activation to mitigate liver IRI.Methods:An oxygen and glucose derivation(OGD)model using RAW 264.7 cells and a liver IRI model in mice were established.Methane's beneficial effects were assessed through hematoxylin and eosin(HE)staining,Suzuki's score,serum alanine transferase level,superoxide dismutase(SOD)level,malondialdehyde(MDA)level,and cell viability.The relative expression levels of Nrf2,its downstream molecules and some inflammatory factors were detected via western blotting.Itaconate levels were analyzed using liquid chromatography.RAW 264.7 cells were transfected with short hairpin RNA targeting mouse aconitate decarboxylase 1(Acod1)mRNA for itaconate downregulation.Results:Methane significantly alleviated liver IRI,as shown by the significant reduction in Suzuki's scores and alanine transferase(ALT)levels in vivo.Methane treatment significantly increased MTT and SOD levels and decreased MDA levels in the OGD injury model in vitro.Methane also increased the total and nuclear Nrf2 expression levels,activated downstream molecules including heme oxygenase-1(HO-1),NQO1 and affected the production of inflammatory cytokines such as IL-10,IL-1β,and IL-12.Itaconate levels were significantly elevated after methane treatment compared with the OGD injury group.The protective effects of methane were abolished after itaconate downregulation through Acod1 knockdown.Conclusions:Methane alleviates liver IRI through itaconate/Nrf2 pathway activation,with itaconate being critical for methane's beneficial effects.展开更多
基金supported by the National Key Research and Development Program of China(No.2022YFB2502000)the National Natural Science Foundation of China(Nos.U21A20332,51771076,U21A200970,52301266)the Science and Technology Planning Project of Guangzhou(No.2024A04J3332)。
文摘Mixed polyanion phosphate Na_(4)Fe_(3)(PO_(4))_(2)P_(2)O_(7)(NFPP)is regarded as the most promising cathode material for sodium-ion batteries(SIBs),due to its high structural stability and low-cost environmental friendliness.However,its intrinsic low conductivity and sluggish Na^(+)diffusion restricted the fast-charge and low-temperature sodium storage.Herein,an NFPP composite encapsulated by in-situ pyrolytic carbon and coupled with expanded graphite(NFPP@C/EG)was constructed via a sol-gel method followed by a ballmill procedure.Due to the dual-carbon modified strategy,this NFPP@C/EG only enhanced the electronic conductivity,but also endowed more channels for Na^(+)diffusion.As cathode for SIBs,the optimized NFPP(M-NFPP@C/EG)delivers excellent rate capability(capacity of~80.5 mAh/g at 50 C)and outstanding cycling stability(11000 cycles at 50 C with capacity retention of 89.85%).Additionally,cyclic voltammetry(CV)confirmed that its sodium storage behavior is pseudocapacitance-controlled,with in-situ electrochemical impedance spectroscopy(EIS)further elucidating improvements in electrode reaction kinetics.At lower temperatures(0℃),M-NFPP@C/EG demonstrated exceptional cycling performance(8800 cycles at 10 C with capacity retention of 95.81%).Moreover,pouch cells also exhibited excellent stability.This research demonstrates the feasibility of a dual carbon modification strategy in enhancing NFPP and proposes a low-cost,high-rate,and ultra-stable cathode material for SIBs.
基金funded by National Natural Science Foundation of China(82000587,82202382)the Beijing Municipal Natural Science Foundation(7242135)。
文摘Background and aims:Methane has shown protective effects against ischemia and reperfusion injury(IRI)in the liver,but the mechanism underlying these beneficial effects is unclear.To investigate the hypothesis that itaconate facilitates in methane-induced Nrf2 pathway activation to mitigate liver IRI.Methods:An oxygen and glucose derivation(OGD)model using RAW 264.7 cells and a liver IRI model in mice were established.Methane's beneficial effects were assessed through hematoxylin and eosin(HE)staining,Suzuki's score,serum alanine transferase level,superoxide dismutase(SOD)level,malondialdehyde(MDA)level,and cell viability.The relative expression levels of Nrf2,its downstream molecules and some inflammatory factors were detected via western blotting.Itaconate levels were analyzed using liquid chromatography.RAW 264.7 cells were transfected with short hairpin RNA targeting mouse aconitate decarboxylase 1(Acod1)mRNA for itaconate downregulation.Results:Methane significantly alleviated liver IRI,as shown by the significant reduction in Suzuki's scores and alanine transferase(ALT)levels in vivo.Methane treatment significantly increased MTT and SOD levels and decreased MDA levels in the OGD injury model in vitro.Methane also increased the total and nuclear Nrf2 expression levels,activated downstream molecules including heme oxygenase-1(HO-1),NQO1 and affected the production of inflammatory cytokines such as IL-10,IL-1β,and IL-12.Itaconate levels were significantly elevated after methane treatment compared with the OGD injury group.The protective effects of methane were abolished after itaconate downregulation through Acod1 knockdown.Conclusions:Methane alleviates liver IRI through itaconate/Nrf2 pathway activation,with itaconate being critical for methane's beneficial effects.
