Precisely quantifying the strength of the proximal femur and accurately assessing hip fracture risk would enablethose at high risk to be identified so that preventive interventions could be taken.Development of better...Precisely quantifying the strength of the proximal femur and accurately assessing hip fracture risk would enablethose at high risk to be identified so that preventive interventions could be taken.Development of better measures offemoral strength using the clinically available information is an important research and clinical direction.The purposes ofthis study were:to develop subject-specific QCT image-based finite element models to predict the strength of proximalfemur,with considering non-linear elasto-plasticity and heterogeneity of bone tissues,and association with proper bonefailure criteria;and to quantify the relationship between femoral strength predicted from finite element analysis(FEA)andbone mineral density(BMD),material distribution,and geometric parameters.展开更多
Pathologic fracture is caused by bone diseases,which is common in middle-aged and elderly adults.Compromised bone strength is the leading contributor to this type of fracture.Therefore,accurately quantifying bone stre...Pathologic fracture is caused by bone diseases,which is common in middle-aged and elderly adults.Compromised bone strength is the leading contributor to this type of fracture.Therefore,accurately quantifying bone strength could help clinicians assess individualized fracture risk and develop therapeutic interventions.Orthopedic clinical imaging including dual X-ray absorptiometry(DXA),computed tomography(CT),and magnetic resonance imaging(MRI)has been an important tool to obtain radiology images of bone,which could be further used for noninvasive assessment of bone strength and related fracture risk.With the development of biomechanics and computer technology,the combination of finite element analysis with orthopedic imaging is the most advanced method for noninvasive prediction of bone strength in clinics.In this review,an overview is provided for the commonly noninvasive methods based on the radiology images(i.e.,DXA,CT,and MRI)to predict bone strength,which may improve the understanding of the relationship between orthopedic clinical imaging and biomechanics.展开更多
基金supported by The HongKong Polytechnic University Research Grants(No.1-BB81)grants from National Natural Science Foundation of China,Nos.10872078 and 10832012
文摘Precisely quantifying the strength of the proximal femur and accurately assessing hip fracture risk would enablethose at high risk to be identified so that preventive interventions could be taken.Development of better measures offemoral strength using the clinically available information is an important research and clinical direction.The purposes ofthis study were:to develop subject-specific QCT image-based finite element models to predict the strength of proximalfemur,with considering non-linear elasto-plasticity and heterogeneity of bone tissues,and association with proper bonefailure criteria;and to quantify the relationship between femoral strength predicted from finite element analysis(FEA)andbone mineral density(BMD),material distribution,and geometric parameters.
基金This work was supported by the National Natural Science Foundation of China(Nos.11872095,11702110)the Natural Science Foundation of Jilin Province(No.20200201260JC).
文摘Pathologic fracture is caused by bone diseases,which is common in middle-aged and elderly adults.Compromised bone strength is the leading contributor to this type of fracture.Therefore,accurately quantifying bone strength could help clinicians assess individualized fracture risk and develop therapeutic interventions.Orthopedic clinical imaging including dual X-ray absorptiometry(DXA),computed tomography(CT),and magnetic resonance imaging(MRI)has been an important tool to obtain radiology images of bone,which could be further used for noninvasive assessment of bone strength and related fracture risk.With the development of biomechanics and computer technology,the combination of finite element analysis with orthopedic imaging is the most advanced method for noninvasive prediction of bone strength in clinics.In this review,an overview is provided for the commonly noninvasive methods based on the radiology images(i.e.,DXA,CT,and MRI)to predict bone strength,which may improve the understanding of the relationship between orthopedic clinical imaging and biomechanics.
