Cell fate determination as a fundamental question in cell biology has been extensively studied at different regulatory levels for many years.However,the mechanisms of multilevel regulation of cell fate determination r...Cell fate determination as a fundamental question in cell biology has been extensively studied at different regulatory levels for many years.However,the mechanisms of multilevel regulation of cell fate determination remain unclear.Recently,we have proposed an Epigenome-Metabolome-Epigenome(E-M-E)signaling cascade model to describe the cross-over cooperation during mouse somatic cell reprogramming.In this review,we summarize the broad roles of E-M-E signaling cascade in different cell biological processes,including cell differentiation and dedifferentiation,cell specialization,cell proliferation,and cell pathologic processes.Precise E-M-E signaling cascades are critical in these cell biological processes,and it is of worth to explore each step of E-M-E signaling cascade.E-M-E signaling cascade model sheds light on and may open a window to explore the mechanisms of multilevel regulation of cell biological processes.展开更多
The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction...The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction(SCR)has the potential to achieve ultra-low NO_(x) emissions,several challenges remain,including the accurate prediction of ammonia(NH_(3))storage mass and the co-control of the two-stage SCR.The first step in this study involved the establishment of a rapid control prototype platform to facilitate the development and validation of a two-stage SCR control strategy.Secondly,an initial method for predicting the NH_(3) storage based on the mass conservation law was proposed,which was subsequently improved by filling and emptying experiments.The third step involved the development of a two-stage SCR co-control strategy,including obtaining the steady-state NH_(3) storage target value,dynamic correction for NH_(3) storage target value,regulation of NH_(3) storage,and control of the close-coupled SCR urea injector state.Finally,the two-stage SCR urea injection control strategy was certified under the world harmonized transient cycle(WHTC).The results demonstrate that the composite value of engine outlet NO_(x) emissions under cold and hot start WHTC cycles is 13 g/(kW·h).Meanwhile,the composite value of tailpipe NO_(x) emissions under cold and hot start WHTC cycles is 0.065 g/(kW·h),representing only 14%of the EU VI limit value of 0.46 g/(kW·h).Thus,the findings demonstrate that integrating an accurate NH_(3) storage prediction method with the two-stage SCR co-control function is crucial for heavy-duty diesel engines to achieve ultra-low NO_(x) emissions.展开更多
Sutures,as necessary medical devices for postoperative treatment,are no longer merely supportive but are required to have advanced functions to promote repair.Here,we report an absorbable self-powered electrical stimu...Sutures,as necessary medical devices for postoperative treatment,are no longer merely supportive but are required to have advanced functions to promote repair.Here,we report an absorbable self-powered electrical stimulation suture.The suture is composed entirely of absorbable materials(magnesium,polylactic acid,and polycaprolactone)and can be used in vivo for incision closure and repair.The suture has the capacity to generate spontaneous electrical stimulation in response to body movement,allowing for accelerated tissue reconstruction.An in vivo muscle incision repair model demonstrated that the wound healing rate under treatment with this suture was 1.6 times faster than that of commercial sutures,proving its postoperative therapeutic capability.展开更多
Metabolites play important roles in numerous cell biology processes,such as cell proliferation,differentiation,stress response,and cell death[1].Recently,lactate and lactate-derived lysine residue lactylation(Kla)have...Metabolites play important roles in numerous cell biology processes,such as cell proliferation,differentiation,stress response,and cell death[1].Recently,lactate and lactate-derived lysine residue lactylation(Kla)have emerged as newly discovered epigenetic modifications that play critical roles in various physiological and pathological processes.In the history of lactate research,we can categorize the studies into three mile stones(Fig.S1 online).展开更多
Pluripotent stem cells(PSCs)possess the ability to proliferate indefinitely,self-renew,and differentiate into three germ layers.These pluripotent characteristics allow PSCs to be used to treat many incurable diseases,...Pluripotent stem cells(PSCs)possess the ability to proliferate indefinitely,self-renew,and differentiate into three germ layers.These pluripotent characteristics allow PSCs to be used to treat many incurable diseases,such as spinal cord injury with the embryonic stem cells(ESCs)-derived oligodendrocyte progenitor cells,and dry age-related macular degeneration(AMD)with the ESCs-derived retinal pigment epithelium,and have great application value in clinical regenerative medicine.展开更多
Synchronous function of an ion-exchange polymer and carbon nanotube(CNT)leads to a splendid unipolar-stroke motion and superior actuation performance,in yarn artificial muscles.The ionic polymer proposed in this surve...Synchronous function of an ion-exchange polymer and carbon nanotube(CNT)leads to a splendid unipolar-stroke motion and superior actuation performance,in yarn artificial muscles.The ionic polymer proposed in this survey alters the zero potential to create a unipolar muscle(monotonical-stroke)behavior.This study is a great paradigm shift toward application of versatile systems and abundant,but highly functional materials for rehabilitation and healing purposes.展开更多
基金financially supported by the National Key Research and Development Program of China (2017YFA0106300)the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030505)+6 种基金the National Natural Science Foundation projects of China (2017YFA0102900, 2019YFA09004500, 2017YFC1001602, 2016YFA0100300, 2018YFA0107100)the National Natural Science Foundation projects of China (92157202, 32025010, 31801168, 31900614, 31970709, 81901275, 32070729, 32100619, 32170747)the Key Research Program of Frontier Sciences, CAS (QYZDB-SSW-SMC001)International Cooperation Program (154144KYSB20200006)Guangdong Province Science and Technology Program (2020B1212060052, 2018A030313825, 2018GZR110103002, 2020A1515011200, 2020A1515010919, 2020A1515011410, 2021A1515012513)Guangzhou Science and Technology Program (201807010067, 202002030277, 202102021250, 202102020827, 202102080066), Open Research Program of Key Laboratory of Regenerative Biology, CAS (KLRB201907, KLRB202014)CAS Youth Innovation Promotion Association (to Y. W. and K. C.)
文摘Cell fate determination as a fundamental question in cell biology has been extensively studied at different regulatory levels for many years.However,the mechanisms of multilevel regulation of cell fate determination remain unclear.Recently,we have proposed an Epigenome-Metabolome-Epigenome(E-M-E)signaling cascade model to describe the cross-over cooperation during mouse somatic cell reprogramming.In this review,we summarize the broad roles of E-M-E signaling cascade in different cell biological processes,including cell differentiation and dedifferentiation,cell specialization,cell proliferation,and cell pathologic processes.Precise E-M-E signaling cascades are critical in these cell biological processes,and it is of worth to explore each step of E-M-E signaling cascade.E-M-E signaling cascade model sheds light on and may open a window to explore the mechanisms of multilevel regulation of cell biological processes.
基金supported by the National Natural Science Foundation of China(No.51921004).
文摘The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction(SCR)has the potential to achieve ultra-low NO_(x) emissions,several challenges remain,including the accurate prediction of ammonia(NH_(3))storage mass and the co-control of the two-stage SCR.The first step in this study involved the establishment of a rapid control prototype platform to facilitate the development and validation of a two-stage SCR control strategy.Secondly,an initial method for predicting the NH_(3) storage based on the mass conservation law was proposed,which was subsequently improved by filling and emptying experiments.The third step involved the development of a two-stage SCR co-control strategy,including obtaining the steady-state NH_(3) storage target value,dynamic correction for NH_(3) storage target value,regulation of NH_(3) storage,and control of the close-coupled SCR urea injector state.Finally,the two-stage SCR urea injection control strategy was certified under the world harmonized transient cycle(WHTC).The results demonstrate that the composite value of engine outlet NO_(x) emissions under cold and hot start WHTC cycles is 13 g/(kW·h).Meanwhile,the composite value of tailpipe NO_(x) emissions under cold and hot start WHTC cycles is 0.065 g/(kW·h),representing only 14%of the EU VI limit value of 0.46 g/(kW·h).Thus,the findings demonstrate that integrating an accurate NH_(3) storage prediction method with the two-stage SCR co-control function is crucial for heavy-duty diesel engines to achieve ultra-low NO_(x) emissions.
基金financially supported by the National Natural Science Foundation of China(82301331)。
文摘Sutures,as necessary medical devices for postoperative treatment,are no longer merely supportive but are required to have advanced functions to promote repair.Here,we report an absorbable self-powered electrical stimulation suture.The suture is composed entirely of absorbable materials(magnesium,polylactic acid,and polycaprolactone)and can be used in vivo for incision closure and repair.The suture has the capacity to generate spontaneous electrical stimulation in response to body movement,allowing for accelerated tissue reconstruction.An in vivo muscle incision repair model demonstrated that the wound healing rate under treatment with this suture was 1.6 times faster than that of commercial sutures,proving its postoperative therapeutic capability.
基金supported by the National Natural Science Foundation of China(92157202,32025010,32241002,92254301,32261160376,31970709,32070729,32100619,32170747,32322022,32370782,32371007,32300608,and 32300620)the National Key Research and Development Program of China(2022YFA1103800,2022YFE0210100,and 2019YFA0904500)+9 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB0480000)the Key Research Program,CAS(ZDBS-ZRKJZ-TLC003)the International Cooperation Program,CAS(154144KYSB20200006)the CAS Project for Young Scientists in Basic Research(YSBR-075)the Guangdong Provincial Science and Technology Program(2023B1111050005,2023A1515030231,2022A1515110493,2020B1212060052,2021A1515012513,2021B1515020096,2022A1515012616,and 2022A1515110951)the Guangzhou Science and Technology Program(202102021037,202102020827,202102080066,and 202206060002)the Open Research Program of Key Laboratory of Regenerative Biology,CAS(KLRB202106,KLRB202107,and KLRB202203)the CAS Youth Innovation Promotion Association(Y2021097 and 2021355)NSFC/RGC Joint Grant Scheme(N_CUHK 428/22)the Open Research Funds from the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital(202301-203)。
文摘Metabolites play important roles in numerous cell biology processes,such as cell proliferation,differentiation,stress response,and cell death[1].Recently,lactate and lactate-derived lysine residue lactylation(Kla)have emerged as newly discovered epigenetic modifications that play critical roles in various physiological and pathological processes.In the history of lactate research,we can categorize the studies into three mile stones(Fig.S1 online).
基金supported by the National Key Research and Development Program of China(2024YFA0916400)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000)+5 种基金the National Natural Science Foundation of China(32025010,32488301,92254301,92357302,92157202,32241002,32261160376,32322022,and 32471358)Major Project of Guangzhou National Laboratory(GZNL2024A03006 and GZNL2024B01003)the Key Research Program,CAS(ZDBS-ZRKJZ-TLC003,YSBR-075 and 188GJHZ2024048GC)Guangdong Province Science and Technology Program(2023B0303000023,2023B1111050005,2023B1212060050,2023B1212120009,2024B1515040020,and 2024A1515010782)Guangzhou Science and Technology Program(202206060002 and 2025A04J7110)Health@InnoHK funding support from the Innovation Technology Commission of the Hong Kong SAR,and Major Research Project(GIBHMRP25-01)Basic Research Project of Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences.
文摘Pluripotent stem cells(PSCs)possess the ability to proliferate indefinitely,self-renew,and differentiate into three germ layers.These pluripotent characteristics allow PSCs to be used to treat many incurable diseases,such as spinal cord injury with the embryonic stem cells(ESCs)-derived oligodendrocyte progenitor cells,and dry age-related macular degeneration(AMD)with the ESCs-derived retinal pigment epithelium,and have great application value in clinical regenerative medicine.
文摘Synchronous function of an ion-exchange polymer and carbon nanotube(CNT)leads to a splendid unipolar-stroke motion and superior actuation performance,in yarn artificial muscles.The ionic polymer proposed in this survey alters the zero potential to create a unipolar muscle(monotonical-stroke)behavior.This study is a great paradigm shift toward application of versatile systems and abundant,but highly functional materials for rehabilitation and healing purposes.
