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Genetic Analysis of Android Malware
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作者 linna wang 《Journal of Electronic Research and Application》 2025年第4期163-169,共7页
With the proliferation of Android malware,the issue of traceability in malware analysis has emerged as a significant problem that requires exploration.By establishing links between newly discovered,unreported malware ... With the proliferation of Android malware,the issue of traceability in malware analysis has emerged as a significant problem that requires exploration.By establishing links between newly discovered,unreported malware and prior knowledge from existing malware data pools,security analysts can gain a better understanding of the evolution process of malware and its underlying reasons.However,in real-world scenarios,analyzing the traceability of malware can be complex and time-consuming due to the large volume of existing malware data,requiring extensive manual analysis.Furthermore,the results obtained from such analysis often lack explanation.Therefore,there is a pressing need to develop a comprehensive automated malware tracking system that can provide detailed insights into the tracking and evolution process of malware and offer strong explanatory capabilities.In this paper,we propose a knowledge graph-based approach that uses partial API call graphs comprising semantic and behavioral features to reveal the traceability relations among malware and provide explainable results for these relations.Our approach is implemented on a dataset of over 20,000 malware samples labeled with family information,spanning a time period of 10 years.To address the challenges associated with the complexity of analysis,we leverage prior knowledge from existing malware research and a branch pruning method on call graphs to reduce computational complexity and enhance the precision of explanations when determining traceability relations. 展开更多
关键词 Malware gene traceability Malware analysis ANDROID
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The complete mitochondrial genome of the hybrid grouper Epinephelus moara(♀)×Epinephelus tukula(♂), and phylogenetic analysis in subfamily Epinephelinae
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作者 Zhentong Li Yongsheng Tian +6 位作者 Meiling Cheng linna wang Jingjing Zhang Yuping Wu Zunfang Pang Wenhui Ma Jieming Zhai 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2020年第12期65-75,共11页
The mitochondrial genome(mitogenome)of hybrid grouper Epinephelus moara(♀)×Epinephelus tukula(♂),a new hybrid progeny,can provide valuable information for analyzing phylogeny and molecular evolution.In this stu... The mitochondrial genome(mitogenome)of hybrid grouper Epinephelus moara(♀)×Epinephelus tukula(♂),a new hybrid progeny,can provide valuable information for analyzing phylogeny and molecular evolution.In this study,the mitogenome was analyzed using PCR amplification and sequenced,then the phylogenetic relationship of E.moara(♀)×E.tukula(♂)and 35 other species were constructed using Maximum Likelihood and NeighborJoining methods with the nucleotide sequences of 13 conserved protein-coding genes(PCGs).The complete mitogenome of E.moara(♀)×E.tukula(♂)was 16695 bp in length,which contained 13 PCGs,2 rRNA genes,22 tRNA genes,a replication origin and a control region.The composition and order of these genes were consistent with most other vertebrates.Of the 13 PCGs,12 PCGs were encoded on the heavy strand,and ND6 was encoded on the light strand.The mitogenome of the E.moara(♀)×E.tukula(♂)had a higher AT nucleotide content,a positive AT-skew and a negative GC-skew.All protein initiation codons were ATG,except for COX and ND4(GTG),ATP6(CTG),and ND3(ATA).ND2,COXII,ND3,ND4 and Cytb had T as the terminating codon,COXIII’s termination codon was TA,and the remaining PCGs of that were TAA.All tRNA genes,except for the lacking DHU-arm of tRNASer(AGN),were predicted to form a typical cloverleaf secondary structure.In addition,sequence similarity analysis(99%identity)and phylogenetic analysis(100%bootstrap value)indicated that the mitochondrial genome was maternally inherited.This study provides mitogenome data for studying genetic,phylogenetic relationships and breeding of grouper. 展开更多
关键词 Epinephelus moara(♀)×Epinephelus tukula(♂) Epinephelus moara Epinephelus tukula mitochondrial genome PHYLOGENY
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青少年特发性膜性肾病的临床和病理特点及其转归影响因素
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作者 王琳娜 郭存霞 +7 位作者 苗艳 田素革 乔东鸽 阎磊 刘冰 朱清 邵凤民 陈香美 《中华肾病研究电子杂志》 2022年第4期181-190,共10页
目的分析青少年特发性膜性肾病(IMN)的临床和病理特征、治疗及预后。方法回顾性分析2011年1月1日至2018年4月30日在解放军总医院肾脏病科经肾活检确诊的164例13~24岁青少年IMN患者的基本资料、实验室检查、肾活检病理、治疗方案等资料... 目的分析青少年特发性膜性肾病(IMN)的临床和病理特征、治疗及预后。方法回顾性分析2011年1月1日至2018年4月30日在解放军总医院肾脏病科经肾活检确诊的164例13~24岁青少年IMN患者的基本资料、实验室检查、肾活检病理、治疗方案等资料。患者分为少年组(13~18岁)60例,青年组(19~24岁)104例,以肾活检时间为起点随访6~24个月,分析不同药物治疗的有效性及预后。结果患者的男女比例约为1.6∶1;少年组的血尿发生率(P=0.002)和eGFR(P=0.002)高于青年组,而IgA(P=0.017)和IgG(P=0.050)水平则低于青年组。两组的临床表现均以肾病综合征为主,肾脏病理以膜性肾病Ⅱ期最多见。少年组和青年组的血清磷脂酶A2受体(PLA2R)抗体阳性率分别为44.4%和40%。平均随访时间8.5(6,24)月,两组使用他克莫司和(或)糖皮质激素治疗IMN的总缓解率均为75%。少年组和青年组的24个月总缓解率分别为85.7%和96%(χ^(2)=1.303,P=0.254),而24个月完全缓解率则分别为61.5%和79.2%(χ^(2)=1.329,P=0.254)。少年组及青年组均无患者进展至终末期肾病(ESRD)。单因素Cox回归分析显示,血尿和低IgG血症(<4.0 g/L)预示IMN患者较低的24个月总缓解率。多因素Cox回归分析发现,血尿(HR=0.345,95%CI:0.035~0.188,P=0.005)和IgG<4.0 g/L(HR=0.278,95%CI:0.034~0.434,P=0.023)均为24个月总缓解率的独立危险因素,而且IgG<4.0 g/L(HR=3.538,95%CI:1.193~10.499,P=0.028)还是24个月完全缓解率的独立危险因素。接受者操作特征(ROC)曲线下面积(AUC)也证实,IgG<3.48 g/L(AUC=0.765,特异性69.4%,灵敏度88.7%,P=0.001)是预测24个月不缓解的最佳临界点。结论少年组IMN患者的临床表现较青年组严重;随访24个月时青少年IMN患者的转归良好;血尿和低IgG血症是青少年IMN缓解率的独立危险因素。 展开更多
关键词 膜性肾病 青少年 临床病理 治疗 预后
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