Yinhuo decoction is recorded by Shiduo Chen,a doctor in the Qing Dynasty,in the Dialectical Record.It is mainly used to treat4*"tonsillitis with yin asthenia.^^Its pathogenesis is deficiency of kidney Yin and Yan...Yinhuo decoction is recorded by Shiduo Chen,a doctor in the Qing Dynasty,in the Dialectical Record.It is mainly used to treat4*"tonsillitis with yin asthenia.^^Its pathogenesis is deficiency of kidney Yin and Yang-function insufficiency of kidney Zang,resulting in vacuity heat floating upward.Professor Xiaoyan Wang,the tutor,believes that the general pathogenesis of insomnia is that Vang does not enter Yin.The application of Yinhuo Decoction in clinic to treat insomnia is quite effective.展开更多
Proton exchange membrane water electrolyzers(PEMWEs)are pivotal for efficient hydrogen production due to their high energy efficiency and ability to operate at high current densities,making them ideally suited for int...Proton exchange membrane water electrolyzers(PEMWEs)are pivotal for efficient hydrogen production due to their high energy efficiency and ability to operate at high current densities,making them ideally suited for integration with renewable energy sources.Cobalt(Co)-based nanomaterials,characterized by diverse oxidation states,tunable electronic spin states,and hybrid orbitals,have emerged as promising non-noble metal alternatives to platinum group catalysts for accelerating the anodic oxygen evolution reaction(OER).Based on their inherent properties,this review provides a comprehensive overview of the latest developments in Co-based nanomaterials for acidic OER.The review begins by introducing the operational principles of PEMWEs,the underlying catalytic mechanisms,and the critical design considerations for OER catalysts.It then explores strategies to enhance the activity and stability of Co-based catalysts for acidic OER in PEMWEs,including the incorporation of corrosion-resistant metals or dispersion on acid-resistant supports to increase active surface area and stability;utilization of geometric structural engineering to improve structural integrity and active site efficiency;the optimization of reaction mechanisms to fine-tune catalytic pathways for enhanced stability and performance.The performance degradation mechanisms and metal leaching analysis for Co-based catalysts in PEMWE are also clarified.Finally,this review not only outlines the key challenges associated with Co-based catalysts for acidic OER but also proposes potential strategies to overcome these limitations,offering a roadmap for future advancements and practical implementation of PEMWE technology.展开更多
In recent years,addressing ill-posed problems by leveraging prior knowledge contained in databases on learning techniques has gained much attention.In this paper,we focus on complete three-dimensional(3D)point cloud r...In recent years,addressing ill-posed problems by leveraging prior knowledge contained in databases on learning techniques has gained much attention.In this paper,we focus on complete three-dimensional(3D)point cloud reconstruction based on a single red-green-blue(RGB)image,a task that cannot be approached using classical reconstruction techniques.For this purpose,we used an encoder-decoder framework to encode the RGB information in latent space,and to predict the 3D structure of the considered object from different viewpoints.The individual predictions are combined to yield a common representation that is used in a module combining camera pose estimation and rendering,thereby achieving differentiability with respect to imaging process and the camera pose,and optimization of the two-dimensional prediction error of novel viewpoints.Thus,our method allows end-to-end training and does not require supervision based on additional ground-truth(GT)mask annotations or ground-truth camera pose annotations.Our evaluation of synthetic and real-world data demonstrates the robustness of our approach to appearance changes and self-occlusions,through outperformance of current state-of-the-art methods in terms of accuracy,density,and model completeness.展开更多
Low-temperature selective catalytic reduction(SCR)is important for the elimination of NOfrom stationary sources.In the present study,the loading of Ce and W onα-Fe_(2)O_(3)was achieved through the integration of sing...Low-temperature selective catalytic reduction(SCR)is important for the elimination of NOfrom stationary sources.In the present study,the loading of Ce and W onα-Fe_(2)O_(3)was achieved through the integration of single-mode microwave and incipient wetness impregnation(IWI)methods.The scanning electron microscopy(SEM)and transmission electron microscopy(TEM)images reveal that the structure ofα-Fe_(2)O_(3)is spindle-like,and the structure remains unchanged after the introduction of Ce and/or W.The results of NH-SCR investigation demonstrate that NOconversion over Ce-W/α-Fe_(2)O_(3)is more than85%at 300℃,which is much higher than that over Ce/a-Fe_(2)O_(3)andα-Fe_(2)O_(3),Our studies illustrate that the addition of Ce can significantly increase the amount of surface oxygen vacancies as well as sites of moderate basicity.On the other hand,the addition of W can obviously decrease the amount of basic sites and increase the number of Br?nsted acid sites.The synergistic effect of Ce and W addition on balancing acidity/basicity properties accounts for the high activity of CeW/α-Fe_(2)O_(3)for NOremoval at low temperatures.The study provides insight into the relationship between acidity/basicity properties and catalytic performance of Ce-W/α-Fe_(2)O_(3)catalysts,which is beneficial to the design of high-performance NH-SCR catalyst for NOremoval at low temperatures.展开更多
A general,facile and eco-friendly iron catalysis enables oxidation of unstrained tertiary aromatic alcohols to ketones through C-C bond cleavage even with H_(2)O_(2) as the oxidant.Notably,this transformation can tole...A general,facile and eco-friendly iron catalysis enables oxidation of unstrained tertiary aromatic alcohols to ketones through C-C bond cleavage even with H_(2)O_(2) as the oxidant.Notably,this transformation can tolerate oxidation-labile functional groups.The robustness of this method is further demonstrated on the late-stage oxidation of complex bioactive molecules.展开更多
Electrocatalytic water splitting has been identified as a potential candidate for producing clean hydrogen energy with zero carbon emission.However,the sluggish kinetics of oxygen evolution reaction on the anode side ...Electrocatalytic water splitting has been identified as a potential candidate for producing clean hydrogen energy with zero carbon emission.However,the sluggish kinetics of oxygen evolution reaction on the anode side of the watersplitting device significantly hinders its practical applications.Generally,the efficiency of oxygen evolution processes depends greatly on the availability of cost‐effective catalysts with high activity and selectivity.In recent years,extensive theoretical and experimental studies have demonstrated that cobalt(Co)‐based nanomaterials,especially low‐dimensional Co‐based nanomaterials with a huge specific surface area and abundant unsaturated active sites,have emerged as versatile electrocatalysts for oxygen evolution reactions,and thus,great progress has been made in the rational design and synthesis of Co‐based nanomaterials for electrocatalytic oxygen evolution reactions.Considering the remarkable progress in this area,in this timely review,we highlight the most recent developments in Co‐based nanomaterials relating to their dimensional control,defect regulation(conductivity),electronic structure regulation,and so forth.Furthermore,a brief conclusion about recent progress achieved in oxygen evolution on Co‐based nanomaterials,as well as an outlook on future research challenges,is given.展开更多
Objective The aim of this study was to investigate the clinical efficacy of neoadjuvant chemotherapy(NACT) and the prognostic factors for advanced epithelial ovarian cancer(EOC).Methods We enrolled 241 patients with s...Objective The aim of this study was to investigate the clinical efficacy of neoadjuvant chemotherapy(NACT) and the prognostic factors for advanced epithelial ovarian cancer(EOC).Methods We enrolled 241 patients with stage III and IV EOC who were diagnosed at the Yunnan Cancer Hospital between October 2006 and December 2015.The observation(NACT-IDS) group(n = 119) received 1–3 courses of platinum-based NACT,followed by interval debulking surgery(IDS) and 6–8 courses of postoperative chemotherapy.The control group underwent primary debulking surgery(PDS)(n = 122) followed by 6–8 courses of postoperative chemotherapy.We analyzed the general conditions of the operations and the survival of both groups.Results Operating time,intraoperative blood loss and postoperative hospitalization were significantly lower in the NACT-IDS group(P < 0.05).The rate of optimal cytoreductive surgery was significantly higher in the NACT-IDS group(P < 0.05).A visible residual lesion was observed in 49(41.18%) and 48(40%) cases in the NACT-IDS and PDS groups,respectively,which were not significantly different(P > 0.05).The percentage of International Federation of Gynecology and Obstetrics(FIGO) stage IV tumors and the recurrence rates were significantly higher in the NACT-IDS group(P < 0.05).The mortality rates were 45.19%(47/104) and 35.19%(38/108) in the NACT-IDS and PDS groups,respectively(P > 0.05).Progression-free survival was 23.75 ± 9.98 and 23.57 ± 12.25 months in the NACT-IDS and PDS groups,respectively(P > 0.05).Overall survival(OS) was 31.11 ± 15.66 and 29.63 ± 18.00 months in the NACTIDS and PDS groups,respectively(P > 0.05).Optimal cytoreductive surgery with or without residual lesion was an independent influencing factor for advanced EOC in multivariate analysis.OS of patients treated with ≥8 courses of chemotherapy was significantly longer than those treated with < 8 courses.Conclusion NACT could improve the intra-and postoperative conditions in advanced EOC patients.Although the percentage of FIGO stage IV cancer was significantly higher in the NACT-IDS group,the prognosis was similar in both the NACT-IDS and PDS groups,suggesting that NACT improves the clinical outcome of advanced EOC.Optimal cytoreductive surgery with no residual lesion is a long-term protective factor in advanced EOC.At least 8 courses of chemotherapy overall or ≥ 6 courses postoperatively improves the OS.展开更多
In this paper, we study the existence of standIng waves of the coupled nonlinear Schrodinger equations. The proofs of which rely on the Lyapunov-Schmidt methods and contraction mapping principle are due to F. Weinstei...In this paper, we study the existence of standIng waves of the coupled nonlinear Schrodinger equations. The proofs of which rely on the Lyapunov-Schmidt methods and contraction mapping principle are due to F. Weinstein in .展开更多
The genus Cathyalia Ragonot, 1888 and three species C. fulvella Ragonot, 1888, C. okinawana Yamanaka, 2003 and C. pallicostella Roesler ＆ Küppers, 1981 are newly recorded from China. A key and photographs of adu...The genus Cathyalia Ragonot, 1888 and three species C. fulvella Ragonot, 1888, C. okinawana Yamanaka, 2003 and C. pallicostella Roesler ＆ Küppers, 1981 are newly recorded from China. A key and photographs of adults and genitalia of the three species are provided.展开更多
Tinnitus refers to the abnormal sound hallucinations in the ear or inside the skull when the patient lacks outside sound.In recent years,the incidence of tinnitus is increasing gradually,which seriously affects the qu...Tinnitus refers to the abnormal sound hallucinations in the ear or inside the skull when the patient lacks outside sound.In recent years,the incidence of tinnitus is increasing gradually,which seriously affects the quality of life of patients.Reducing tinnitus symptoms is one of the main purposes of clinical treatment.Professor Xiaoyan Wang applied the monism of Qi,combined with the dialectics of the six channels and the therapeutic effect was remarkable.展开更多
The impacts of substituting dietary soybean meal(SBM)with yellow mealworm meal(YMM)were investigated during a 56-day feeding trial on growth,antioxidant capacity,immunity,intestinal morphology,and intestinal microbiot...The impacts of substituting dietary soybean meal(SBM)with yellow mealworm meal(YMM)were investigated during a 56-day feeding trial on growth,antioxidant capacity,immunity,intestinal morphology,and intestinal microbiota of grass carp.A total of 750 grass carp were divided into 5 groups(3 replications per group and 50 fish per replication)with different levels of YMM:SBM(control group),H25,H50,H75,and H100,for 8 weeks.The results showed that dietary YMM significantly increased final body weight(FW),weight gain(WG),and protein efficiency ratio(PER)in H25 group(P<0.05);however,complete substitution showed the opposite trend(P<0.05 for FW and WG).The liver antioxidant capacity was improved,manifested by enhanced superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GPx)activities,glutathione(GSH)content and up-regulated antioxidant-related genes mediated by the Keap1-Nrf2 signaling pathway in the H25 group(P<0.05).However,in the H100 group oxidative stress occurred in parallel with impairment of hepatic function.Intestinal inflammation was aggravated in the H100 group as evidenced by the up-regulated pro-inflammatory gene expression mediated by the NF-κB pathway(P<0.05).Additionally,the activity of intestinal digestive enzymes for the grass carp was significantly reduced and accompanied with intestinal mucosal barrier dysfunction in the H100 group(P<0.05).In summary,replacement of SBM with 25%YMM showed positive influences on growth,antioxidant capacity,immunity,and intestinal health.Conversely,complete replacement of SBM with YMM triggered oxidative stress,caused liver function disorder,and impaired intestinal health in grass carp.展开更多
One major challenge of using DNA nanostructures for cellular and in vivo applications is their insufficiently structural integrity that stems from the non-covalent base pairing and stacking in complex cellular and phy...One major challenge of using DNA nanostructures for cellular and in vivo applications is their insufficiently structural integrity that stems from the non-covalent base pairing and stacking in complex cellular and physiological environment. The establishment of covalent bonds in DNA nanostructures can link individual strands more stably and therefore should improve the performance of DNA nanostructures in different scenarios where structural integrity is required. Here, we developed a convenient and effective method for constructing covalently stabilized DNA nanostructures by chemically inserting photo-crosslinker(^(CNV)K) in DNA sequences. These covalently linked DNA nanostructures were found to be more resistant to external interference, such as low cation concentrations and unspecific displacement on cell membranes. We also demonstrated that our strategy could improve the efficiency of cell surface receptor-mediated labeling and function regulations in living cells, which sheds light on broadening the biomedical applications of DNA nanostructures.展开更多
Drugs sharing similar therapeutic function may not bind to the same group of targets.However,their targets may be involved in similar pathway profiles which are associated with certain pathological process.In this stu...Drugs sharing similar therapeutic function may not bind to the same group of targets.However,their targets may be involved in similar pathway profiles which are associated with certain pathological process.In this study,pathway fingerprint was introduced to indicate the profile of significant pathways being influenced by the targets of drugs.Then drug−drug network was further constructed based on significant similarity of pathway fingerprints.In this way,the functions of a drug may be hinted by the enriched therapeutic functions of its neighboring drugs.In the test of 911 FDA approved drugs with more than one known target,471 drugs could be connected into networks.760 significant associations of drug−therapeutic function were generated,among which around 60%of them were supported by scientific literatures or ATC codes of drug functional classification.Therefore,pathway fingerprints may be useful to further study on the potential function of known drugs,or the unknown function of new drugs.展开更多
Lonicerae Japonicae Flos is a significant food and traditional Chinese medicine,known as plant antibiotics.It has rich chemical constituents and significant pharmacological effects.The antitumor activity of Lonicerae ...Lonicerae Japonicae Flos is a significant food and traditional Chinese medicine,known as plant antibiotics.It has rich chemical constituents and significant pharmacological effects.The antitumor activity of Lonicerae Japonicae Flos has been clarified,but the study on its spectrum-effect relationship has not been reported.The compounds responsible for its antitumor activity are still unknown.In this study,processed products of Lonicerae Japonicae Flos at different temperatures were taken as experimental materials,and SMMC-7721,A549,andMGC80-3 cells were tested.The orthogonal partial least squares regressionmethod was used to analyze the common compounds in different processed products and the antitumor activity.The results show that processed products have a stronger inhibitory effect on A549 cells and MGC80-3 cells than SMMC-7721 cells.Compounds such as secologanic acid,isochlorogenic acid A,serotonin,and chlorogenic acid play an important role in their antitumor effects.展开更多
With the progress and development of the times,education informatization has become the primary content to promote the progress of education.However,with the rapid advancement of technology,many problems have arisen i...With the progress and development of the times,education informatization has become the primary content to promote the progress of education.However,with the rapid advancement of technology,many problems have arisen in the integration of online education and information technology.From a practical point of view,advanced information technology should be fully integrated with school education activities to promote education reform and development,and students will definitely obtain a better learning experience.This study aimed to introduce a classroom teaching effect monitoring and evaluation system that incorporates artificial intelligence.In view of the background conditions for the development of this system,reforming measures and specific implementation methods for the integration of information technology and online classroom education are proposed.展开更多
文摘Yinhuo decoction is recorded by Shiduo Chen,a doctor in the Qing Dynasty,in the Dialectical Record.It is mainly used to treat4*"tonsillitis with yin asthenia.^^Its pathogenesis is deficiency of kidney Yin and Yang-function insufficiency of kidney Zang,resulting in vacuity heat floating upward.Professor Xiaoyan Wang,the tutor,believes that the general pathogenesis of insomnia is that Vang does not enter Yin.The application of Yinhuo Decoction in clinic to treat insomnia is quite effective.
基金financially supported by the National Natural Science Foundation of China(22172063)the Young Taishan Scholars Program(tsqn201812080)+2 种基金the China Scholarship Council(CSC)for scholarship support(202008130132)the Independent Cultivation Program of Innovation Team of Ji’nan City(2021GXRC052)funding from CERCA Programme/Generalitat de Catalunya。
文摘Proton exchange membrane water electrolyzers(PEMWEs)are pivotal for efficient hydrogen production due to their high energy efficiency and ability to operate at high current densities,making them ideally suited for integration with renewable energy sources.Cobalt(Co)-based nanomaterials,characterized by diverse oxidation states,tunable electronic spin states,and hybrid orbitals,have emerged as promising non-noble metal alternatives to platinum group catalysts for accelerating the anodic oxygen evolution reaction(OER).Based on their inherent properties,this review provides a comprehensive overview of the latest developments in Co-based nanomaterials for acidic OER.The review begins by introducing the operational principles of PEMWEs,the underlying catalytic mechanisms,and the critical design considerations for OER catalysts.It then explores strategies to enhance the activity and stability of Co-based catalysts for acidic OER in PEMWEs,including the incorporation of corrosion-resistant metals or dispersion on acid-resistant supports to increase active surface area and stability;utilization of geometric structural engineering to improve structural integrity and active site efficiency;the optimization of reaction mechanisms to fine-tune catalytic pathways for enhanced stability and performance.The performance degradation mechanisms and metal leaching analysis for Co-based catalysts in PEMWE are also clarified.Finally,this review not only outlines the key challenges associated with Co-based catalysts for acidic OER but also proposes potential strategies to overcome these limitations,offering a roadmap for future advancements and practical implementation of PEMWE technology.
基金Supported by National Natural Science Foundation of China(Grant No.51935003).
文摘In recent years,addressing ill-posed problems by leveraging prior knowledge contained in databases on learning techniques has gained much attention.In this paper,we focus on complete three-dimensional(3D)point cloud reconstruction based on a single red-green-blue(RGB)image,a task that cannot be approached using classical reconstruction techniques.For this purpose,we used an encoder-decoder framework to encode the RGB information in latent space,and to predict the 3D structure of the considered object from different viewpoints.The individual predictions are combined to yield a common representation that is used in a module combining camera pose estimation and rendering,thereby achieving differentiability with respect to imaging process and the camera pose,and optimization of the two-dimensional prediction error of novel viewpoints.Thus,our method allows end-to-end training and does not require supervision based on additional ground-truth(GT)mask annotations or ground-truth camera pose annotations.Our evaluation of synthetic and real-world data demonstrates the robustness of our approach to appearance changes and self-occlusions,through outperformance of current state-of-the-art methods in terms of accuracy,density,and model completeness.
基金Project supported by the National Natural Science Foundation of China(21703037,22108037)the Natural Science Foundation of Fujian(2018J10691)。
文摘Low-temperature selective catalytic reduction(SCR)is important for the elimination of NOfrom stationary sources.In the present study,the loading of Ce and W onα-Fe_(2)O_(3)was achieved through the integration of single-mode microwave and incipient wetness impregnation(IWI)methods.The scanning electron microscopy(SEM)and transmission electron microscopy(TEM)images reveal that the structure ofα-Fe_(2)O_(3)is spindle-like,and the structure remains unchanged after the introduction of Ce and/or W.The results of NH-SCR investigation demonstrate that NOconversion over Ce-W/α-Fe_(2)O_(3)is more than85%at 300℃,which is much higher than that over Ce/a-Fe_(2)O_(3)andα-Fe_(2)O_(3),Our studies illustrate that the addition of Ce can significantly increase the amount of surface oxygen vacancies as well as sites of moderate basicity.On the other hand,the addition of W can obviously decrease the amount of basic sites and increase the number of Br?nsted acid sites.The synergistic effect of Ce and W addition on balancing acidity/basicity properties accounts for the high activity of CeW/α-Fe_(2)O_(3)for NOremoval at low temperatures.The study provides insight into the relationship between acidity/basicity properties and catalytic performance of Ce-W/α-Fe_(2)O_(3)catalysts,which is beneficial to the design of high-performance NH-SCR catalyst for NOremoval at low temperatures.
基金the Natural Science Foundation of China(No.21776139)the“Qing Lan Project”Young and Middle-aged Academic Leaders of Jiangsu Provincial Colleges and Universities,and the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘A general,facile and eco-friendly iron catalysis enables oxidation of unstrained tertiary aromatic alcohols to ketones through C-C bond cleavage even with H_(2)O_(2) as the oxidant.Notably,this transformation can tolerate oxidation-labile functional groups.The robustness of this method is further demonstrated on the late-stage oxidation of complex bioactive molecules.
基金National Natural Science Foundation of China,Grant/Award Number:22172063Young Taishan Scholars Program,Grant/Award Number:tsqn201812080+1 种基金China Scholarship Council(CSC),Grant/Award Number:202008130132Independent Cultivation Program of Innovation Team of Ji'nan City,Grant/Award Number:2021GXRC052。
文摘Electrocatalytic water splitting has been identified as a potential candidate for producing clean hydrogen energy with zero carbon emission.However,the sluggish kinetics of oxygen evolution reaction on the anode side of the watersplitting device significantly hinders its practical applications.Generally,the efficiency of oxygen evolution processes depends greatly on the availability of cost‐effective catalysts with high activity and selectivity.In recent years,extensive theoretical and experimental studies have demonstrated that cobalt(Co)‐based nanomaterials,especially low‐dimensional Co‐based nanomaterials with a huge specific surface area and abundant unsaturated active sites,have emerged as versatile electrocatalysts for oxygen evolution reactions,and thus,great progress has been made in the rational design and synthesis of Co‐based nanomaterials for electrocatalytic oxygen evolution reactions.Considering the remarkable progress in this area,in this timely review,we highlight the most recent developments in Co‐based nanomaterials relating to their dimensional control,defect regulation(conductivity),electronic structure regulation,and so forth.Furthermore,a brief conclusion about recent progress achieved in oxygen evolution on Co‐based nanomaterials,as well as an outlook on future research challenges,is given.
文摘Objective The aim of this study was to investigate the clinical efficacy of neoadjuvant chemotherapy(NACT) and the prognostic factors for advanced epithelial ovarian cancer(EOC).Methods We enrolled 241 patients with stage III and IV EOC who were diagnosed at the Yunnan Cancer Hospital between October 2006 and December 2015.The observation(NACT-IDS) group(n = 119) received 1–3 courses of platinum-based NACT,followed by interval debulking surgery(IDS) and 6–8 courses of postoperative chemotherapy.The control group underwent primary debulking surgery(PDS)(n = 122) followed by 6–8 courses of postoperative chemotherapy.We analyzed the general conditions of the operations and the survival of both groups.Results Operating time,intraoperative blood loss and postoperative hospitalization were significantly lower in the NACT-IDS group(P < 0.05).The rate of optimal cytoreductive surgery was significantly higher in the NACT-IDS group(P < 0.05).A visible residual lesion was observed in 49(41.18%) and 48(40%) cases in the NACT-IDS and PDS groups,respectively,which were not significantly different(P > 0.05).The percentage of International Federation of Gynecology and Obstetrics(FIGO) stage IV tumors and the recurrence rates were significantly higher in the NACT-IDS group(P < 0.05).The mortality rates were 45.19%(47/104) and 35.19%(38/108) in the NACT-IDS and PDS groups,respectively(P > 0.05).Progression-free survival was 23.75 ± 9.98 and 23.57 ± 12.25 months in the NACT-IDS and PDS groups,respectively(P > 0.05).Overall survival(OS) was 31.11 ± 15.66 and 29.63 ± 18.00 months in the NACTIDS and PDS groups,respectively(P > 0.05).Optimal cytoreductive surgery with or without residual lesion was an independent influencing factor for advanced EOC in multivariate analysis.OS of patients treated with ≥8 courses of chemotherapy was significantly longer than those treated with < 8 courses.Conclusion NACT could improve the intra-and postoperative conditions in advanced EOC patients.Although the percentage of FIGO stage IV cancer was significantly higher in the NACT-IDS group,the prognosis was similar in both the NACT-IDS and PDS groups,suggesting that NACT improves the clinical outcome of advanced EOC.Optimal cytoreductive surgery with no residual lesion is a long-term protective factor in advanced EOC.At least 8 courses of chemotherapy overall or ≥ 6 courses postoperatively improves the OS.
基金supported by the USST Cultivation Project for General Programm (No. 14XPM02)
文摘In this paper, we study the existence of standIng waves of the coupled nonlinear Schrodinger equations. The proofs of which rely on the Lyapunov-Schmidt methods and contraction mapping principle are due to F. Weinstein in .
基金supported by the National Natural Science Foundation of China(31172141)partly funded by the Basic Scientific Research Project of Henan Academy of Agricultural Sciences(2016ZC40,2017ZC39)
文摘The genus Cathyalia Ragonot, 1888 and three species C. fulvella Ragonot, 1888, C. okinawana Yamanaka, 2003 and C. pallicostella Roesler ＆ Küppers, 1981 are newly recorded from China. A key and photographs of adults and genitalia of the three species are provided.
文摘Tinnitus refers to the abnormal sound hallucinations in the ear or inside the skull when the patient lacks outside sound.In recent years,the incidence of tinnitus is increasing gradually,which seriously affects the quality of life of patients.Reducing tinnitus symptoms is one of the main purposes of clinical treatment.Professor Xiaoyan Wang applied the monism of Qi,combined with the dialectics of the six channels and the therapeutic effect was remarkable.
基金funded by New Protein Source and High Efficiency Feed for Aquaculture Animals(Grant No.2019YFD0900200)National Natural Science Foundation of China(Grant No.32172985)Major Scientifc and Technological Projects of Hunan(Grant No.2024QK3001).
文摘The impacts of substituting dietary soybean meal(SBM)with yellow mealworm meal(YMM)were investigated during a 56-day feeding trial on growth,antioxidant capacity,immunity,intestinal morphology,and intestinal microbiota of grass carp.A total of 750 grass carp were divided into 5 groups(3 replications per group and 50 fish per replication)with different levels of YMM:SBM(control group),H25,H50,H75,and H100,for 8 weeks.The results showed that dietary YMM significantly increased final body weight(FW),weight gain(WG),and protein efficiency ratio(PER)in H25 group(P<0.05);however,complete substitution showed the opposite trend(P<0.05 for FW and WG).The liver antioxidant capacity was improved,manifested by enhanced superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GPx)activities,glutathione(GSH)content and up-regulated antioxidant-related genes mediated by the Keap1-Nrf2 signaling pathway in the H25 group(P<0.05).However,in the H100 group oxidative stress occurred in parallel with impairment of hepatic function.Intestinal inflammation was aggravated in the H100 group as evidenced by the up-regulated pro-inflammatory gene expression mediated by the NF-κB pathway(P<0.05).Additionally,the activity of intestinal digestive enzymes for the grass carp was significantly reduced and accompanied with intestinal mucosal barrier dysfunction in the H100 group(P<0.05).In summary,replacement of SBM with 25%YMM showed positive influences on growth,antioxidant capacity,immunity,and intestinal health.Conversely,complete replacement of SBM with YMM triggered oxidative stress,caused liver function disorder,and impaired intestinal health in grass carp.
基金supported by the National Key Research and Development Program of China (2021YFA0909400)the National Natural Science Foundation of China (21974087, 81974315)+6 种基金Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (20181709)Shanghai Rising-Star Program (20QA1405800)the General Projects of China Postdoctoral Fund (2021M692104)Innovative Research Team of High-Level Local Universities in Shanghaifaculty start-up funding support from the Institute of Molecular Medicine of Shanghai Jiao Tong UniversityRecruitment Program of Global Youth Experts of China。
文摘One major challenge of using DNA nanostructures for cellular and in vivo applications is their insufficiently structural integrity that stems from the non-covalent base pairing and stacking in complex cellular and physiological environment. The establishment of covalent bonds in DNA nanostructures can link individual strands more stably and therefore should improve the performance of DNA nanostructures in different scenarios where structural integrity is required. Here, we developed a convenient and effective method for constructing covalently stabilized DNA nanostructures by chemically inserting photo-crosslinker(^(CNV)K) in DNA sequences. These covalently linked DNA nanostructures were found to be more resistant to external interference, such as low cation concentrations and unspecific displacement on cell membranes. We also demonstrated that our strategy could improve the efficiency of cell surface receptor-mediated labeling and function regulations in living cells, which sheds light on broadening the biomedical applications of DNA nanostructures.
基金the National Natural Science Foundation of China(Grant No.30900832)Open Project Program Foundation of Key Laboratory of Liver and Kidney Diseases(Shanghai University of Traditional Chinese Medicine)+2 种基金Ministry of Education Program for New Century Excellent Talents in Universities(NCET-08-0399)“Shu Guang”Project by Shanghai Municipal Education Commission and Shanghai Education Development Foundation(07SG22)grants from the Ministry of Science and Technology of China(No.2012ZX10005001).
文摘Drugs sharing similar therapeutic function may not bind to the same group of targets.However,their targets may be involved in similar pathway profiles which are associated with certain pathological process.In this study,pathway fingerprint was introduced to indicate the profile of significant pathways being influenced by the targets of drugs.Then drug−drug network was further constructed based on significant similarity of pathway fingerprints.In this way,the functions of a drug may be hinted by the enriched therapeutic functions of its neighboring drugs.In the test of 911 FDA approved drugs with more than one known target,471 drugs could be connected into networks.760 significant associations of drug−therapeutic function were generated,among which around 60%of them were supported by scientific literatures or ATC codes of drug functional classification.Therefore,pathway fingerprints may be useful to further study on the potential function of known drugs,or the unknown function of new drugs.
基金supported by the Scientific and Technological Research Project of Henan Province(grant no.242102310549)the Key Research and Development Programme of Henan Province(grant no.231111312700)+2 种基金the National Natural Science Foundation of China(grant no.82104329)theNational Key Research andDevelopment Programme of China(grant no.2017YFC1702800)the special funds for starting scientific research of Henan University of Chinese Medicine(grant no.00104311-2021-1-41).
文摘Lonicerae Japonicae Flos is a significant food and traditional Chinese medicine,known as plant antibiotics.It has rich chemical constituents and significant pharmacological effects.The antitumor activity of Lonicerae Japonicae Flos has been clarified,but the study on its spectrum-effect relationship has not been reported.The compounds responsible for its antitumor activity are still unknown.In this study,processed products of Lonicerae Japonicae Flos at different temperatures were taken as experimental materials,and SMMC-7721,A549,andMGC80-3 cells were tested.The orthogonal partial least squares regressionmethod was used to analyze the common compounds in different processed products and the antitumor activity.The results show that processed products have a stronger inhibitory effect on A549 cells and MGC80-3 cells than SMMC-7721 cells.Compounds such as secologanic acid,isochlorogenic acid A,serotonin,and chlorogenic acid play an important role in their antitumor effects.
文摘With the progress and development of the times,education informatization has become the primary content to promote the progress of education.However,with the rapid advancement of technology,many problems have arisen in the integration of online education and information technology.From a practical point of view,advanced information technology should be fully integrated with school education activities to promote education reform and development,and students will definitely obtain a better learning experience.This study aimed to introduce a classroom teaching effect monitoring and evaluation system that incorporates artificial intelligence.In view of the background conditions for the development of this system,reforming measures and specific implementation methods for the integration of information technology and online classroom education are proposed.
