Gestational diabetes mellitus(GDM)is a disease of glucose intolerance that first occurs during pregnancy.Accumulating evidence underlined a link between gut microbiota dysbiosis and GDM,and microbial metabolites repre...Gestational diabetes mellitus(GDM)is a disease of glucose intolerance that first occurs during pregnancy.Accumulating evidence underlined a link between gut microbiota dysbiosis and GDM,and microbial metabolites represent a unique way to explore microbiota-host interactions.However,the associations between changes in the gut microbiota and microbial metabolites and immune homeostasis in the GDM pathogenesis remain largely unclear.In this prospective study,the characteristics of gut microbiota in both first trimester(T1)and second trimester(T2)were investigated in 46 GDM patients and 44 matched controls.We comprehensively profiled the microbial metabolites using non-targeted metabolomics and quantitatively targeted metabolomics,measurements of inflammatory cytokines and biomarkers of intestinal barrier function,and combined with correlation analysis in T2.Gut microbiota dybiosis was observed in GDM patients in both T1 and T2,and was characterised by the enrichment of multiple potentially harmful bacteria,such as UBA1819 and Erysipelatoclostridium.Besides,alterations in the microbiota were accompanied by a disturbance in tryptophan metabolism,mainly manifested as a shift towards the production of more kynurenine and less indole derivatives.Most importantly,correlation network analysis indicated that overgrowth of potential pathogens and tryptophan metabolism disorder were associated with inflammatory imbalance and disrupted epithelial barrier in GDM patients.These findings provide a greater understanding of the pathogenesis and new targets for microecological interventions by mediating tryptophan metabolism in GDM.展开更多
The Beijing 325 m meteorological tower stands as a pivotal research platform for exploring atmospheric boundary layer physics and atmospheric chemistry.With a legacy spanning 45 years,the tower has played a crucial ro...The Beijing 325 m meteorological tower stands as a pivotal research platform for exploring atmospheric boundary layer physics and atmospheric chemistry.With a legacy spanning 45 years,the tower has played a crucial role in unraveling the complexities of urban air pollution,atmospheric processes,and climate change in Beijing,China.This review paper provides a comprehensive overview of the measurements on the tower over the past two decades.Through long-term comprehensive observations,researchers have elucidated the intricate relationships between anthropogenic emissions,meteorological dynamics,and atmospheric composition,shedding light on the drivers of air pollution and its impacts on public health.The vertical measurements on the tower also enable detailed investigations into boundary layer dynamics,turbulent mixing,and pollutant dispersion,providing invaluable data for validating chemical transport models.Key findings from the tower’s research include the identification of positive feedback mechanisms between aerosols and the boundary layer,the characterization of pollutant sources and transport pathways,the determination of fluxes of gaseous and particulate species,and the assessment of the effectiveness of pollution control measures.Additionally,isotopic measurements have provided new insights into the sources and formation processes of particulate matter and reactive nitrogen species.Finally,the paper outlines future directions for tower-based research,emphasizing the need for long-term comprehensive measurements,the development of innovative tower platforms,and integration of emerging technologies.展开更多
Determining accurate pulsar timing model parameters is essential for establishing TT(PT),a realization of Terrestrial Time(TT)based on a pulsar timescale(PT).This study discusses the impact of different data spans on ...Determining accurate pulsar timing model parameters is essential for establishing TT(PT),a realization of Terrestrial Time(TT)based on a pulsar timescale(PT).This study discusses the impact of different data spans on the accuracy of pulsar timing model parameters when determining pulsar timing model parameters.Using observations of PSR J0437-4715,J1909-3744,J1713+0747,and J1744-1134 from the second data release of the International Pulsar Timing Array(IPTA II,Version A),we compare the accuracy of the timing model parameters determined by these observations with different data spans.The results show for PSR J0437-4715,J1713+0747,and J1909-3744,the amplitude fluctuations of rotational frequency remain within 10^(−15),10^(−14),and 10^(−14) Hz,respectively,when the data spans for determining pulsar timing model parameters exceed 13,14,and 6 yr.Additionally,the one-year accuracy of TT(PT)is crucial for its application in timekeeping.By comparing the frequency deviations of TT(PT)relative to TT(BIPM)under both ideal(k_(r))and actual(k_(p))conditions across different data spans,we find that when the data span reaches the duration above,the accuracy of TT(PT)surpasses that of TT(TAI)under ideal conditions,slightly inferior under actual conditions.This suggests with improved observational technologies,the accuracy of TT(PT)can be further enhanced.展开更多
Objective Exposure to polycyclic aromatic hydrocarbons(PAHs)or metal(loid)s individually has been associated with neural tube defects(NTDs).However,the impacts of PAH and metal(loid)co-exposure and potential interacti...Objective Exposure to polycyclic aromatic hydrocarbons(PAHs)or metal(loid)s individually has been associated with neural tube defects(NTDs).However,the impacts of PAH and metal(loid)co-exposure and potential interaction effects on NTD risk remain unclear.We conducted a case-control study in China among population with a high prevalence of NTDs to investigate the combined effects of PAH and metal(loid)exposures on the risk of NTD.Methods Cases included 80 women who gave birth to offspring with NTDs,whereas controls were 50 women who delivered infants with no congenital malformations.We analyzed the levels of placental PAHs using gas chromatography and mass spectrometry,PAH-DNA adducts with 32P-post-labeling method,and metal(loid)s with an inductively coupled plasma mass spectrometer.Unconditional logistic regression was employed to estimate the associations between individual exposures and NTDs.Least absolute shrinkage and selection operator(LASSO)penalized regression models were used to select a subset of exposures,while additive interaction models were used to identify interaction effects.Results In the single-exposure models,we found that eight PAHs,PAH-DNA adducts,and 28 metal(loid)s were associated with NTDs.Pyrene,selenium,molybdenum,cadmium,uranium,and rubidium were selected through LASSO regression and were statistically associated with NTDs in the multiple-exposure models.Women with high levels of pyrene and molybdenum or pyrene and selenium exhibited significantly increased risk of having offspring with NTDs,indicating that these combinations may have synergistic effects on the risk of NTDs.Conclusion Our findings suggest that individual PAHs and metal(loid)s,as well as their interactions,may be associated with the risk of NTDs,which warrants further investigation.展开更多
Obesity is a major focus of researchers due to its increasing prevalence and relationship with other diseases,such as cancer and cardiovascular diseases.Probiotics are active microorganisms and have been proven to all...Obesity is a major focus of researchers due to its increasing prevalence and relationship with other diseases,such as cancer and cardiovascular diseases.Probiotics are active microorganisms and have been proven to alleviate obesity by modulating the microbiota.In this study,we found that oral administration of Bifidobacterium adolescentis CCFM8630 to obese mice inhibited high-fat diet(HFD)-induced changes in body weight and adipose tissue and alleviated hepatic oxidative stress.Furthermore,B.adolescentis CCFM8630 treatment primarily affected the relative abundances of the phyla Proteobacteria and Actinobacteria,and thereby decreased the production of lipopolysaccharide(LPS)and the occurrence of LPS related diseases.A high fiber intake increased the abundance of Lactobacillus and the concentrations of short chain fatty acids in obese mice,but these changes were reversed by B.adolescentis CCFM8630 treatment.In addition,targeted metabolomic analysis and microbiota relationship analysis revealed that B.adolescentis CCFM8630 treatment modified the microbiota of obese mice by promoting the conversion of tryptophan(Trp)to xanthurenic acid,kynurenic acid,tryptamine,indole-3-acetic acid,and indole-3-carboxaldehyde;facilitated the expression of interleukin-17A and the aryl hydrocarbon receptor to generate interleukin-22 in the colon;and upregulated the expression of tight junction proteins,thereby strengthening intestinal barriers.In summary,our findings suggest that the intake of B.adolescentis CCFM8630 may alleviate obesity by modulating the gut microbiota and related Trp metabolism.展开更多
This paper introduces an advanced and efficient method for distributed drone-based fruit recognition and localization, tailored to satisfy the precision and security requirements of autonomous agricultural operations....This paper introduces an advanced and efficient method for distributed drone-based fruit recognition and localization, tailored to satisfy the precision and security requirements of autonomous agricultural operations. Our method incorporates depth information to ensure precise localization and utilizes a streamlined detection network centered on the RepVGG module. This module replaces the traditional C2f module, enhancing detection performance while maintaining speed. To bolster the detection of small, distant fruits in complex settings, we integrate Selective Kernel Attention (SKAttention) and a specialized small-target detection layer. This adaptation allows the system to manage difficult conditions, such as variable lighting and obstructive foliage. To reinforce security, the tasks of recognition and localization are distributed among multiple drones, enhancing resilience against tampering and data manipulation. This distribution also optimizes resource allocation through collaborative processing. The model remains lightweight and is optimized for rapid and accurate detection, which is essential for real-time applications. Our proposed system, validated with a D435 depth camera, achieves a mean Average Precision (mAP) of 0.943 and a frame rate of 169 FPS, which represents a significant improvement over the baseline by 0.039 percentage points and 25 FPS, respectively. Additionally, the average localization error is reduced to 0.82 cm, highlighting the model’s high precision. These enhancements render our system highly effective for secure, autonomous fruit-picking operations, effectively addressing significant performance and cybersecurity challenges in agriculture. This approach establishes a foundation for reliable, efficient, and secure distributed fruit-picking applications, facilitating the advancement of autonomous systems in contemporary agricultural practices.展开更多
Joint time–frequency analysis is an emerging method for interpreting the underlying physics in fuel cells,batteries,and supercapacitors.To increase the reliability of time–frequency analysis,a theoretical correlatio...Joint time–frequency analysis is an emerging method for interpreting the underlying physics in fuel cells,batteries,and supercapacitors.To increase the reliability of time–frequency analysis,a theoretical correlation between frequency-domain stationary analysis and time-domain transient analysis is urgently required.The present work formularizes a thorough model reduction of fractional impedance spectra for electrochemical energy devices involving not only the model reduction from fractional-order models to integer-order models and from high-to low-order RC circuits but also insight into the evolution of the characteristic time constants during the whole reduction process.The following work has been carried out:(i)the model-reduction theory is addressed for typical Warburg elements and RC circuits based on the continued fraction expansion theory and the response error minimization technique,respectively;(ii)the order effect on the model reduction of typical Warburg elements is quantitatively evaluated by time–frequency analysis;(iii)the results of time–frequency analysis are confirmed to be useful to determine the reduction order in terms of the kinetic information needed to be captured;and(iv)the results of time–frequency analysis are validated for the model reduction of fractional impedance spectra for lithium-ion batteries,supercapacitors,and solid oxide fuel cells.In turn,the numerical validation has demonstrated the powerful function of the joint time–frequency analysis.The thorough model reduction of fractional impedance spectra addressed in the present work not only clarifies the relationship between time-domain transient analysis and frequency-domain stationary analysis but also enhances the reliability of the joint time–frequency analysis for electrochemical energy devices.展开更多
The unpowered high-speed vehicle experiences a significant coupling between the disciplines of aerodynamics and control due to its characteristics of high flight speed and extensive maneuverability within large airspa...The unpowered high-speed vehicle experiences a significant coupling between the disciplines of aerodynamics and control due to its characteristics of high flight speed and extensive maneuverability within large airspace.The conventional aircraft conceptual design process follows a sequential design approach,and there is an artificial separation between the disciplines of aerodynamics and control,neglecting the coupling effects arising from their interaction.As a result,this design process often requires extensive iterations over long periods when applied to high-speed vehicles,and may not be able to effectively achieve the desired design objectives.To enhance the overall performance and design efficiency of high-speed vehicles,this study integrates the concept of Active Control Technology(ACT)from modern aircraft into the philosophy of aerodynamic/control integrated optimization.Two integrated optimization strategies,with differences in coupling granularity,have been developed.Subsequently,these strategies are put into action on a biconical vehicle that operates at Mach 5.The results reveal that the comprehensive performance of the synthesis optimal model derived from the aerodynamic/control integrated optimization strategy is improved by 31.76%and 28.29%respectively compared to the base model under high-speed conditions,demonstrating the feasibility and effectiveness of the method and optimization strategies employed.Moreover,in comparison to the single-stage strategy,the multi-stage strategy takes into deeper consideration the impact of control capacity.As a result,the control performance of the synthesis opti-mal model derived from the multi-stage strategy improves by 13.99%,whereas the single-stage strategy only achieves a 5.79%improvement.This method enables a fruitful interaction between aerodynamic configuration design and control system design,leading to enhanced overall performance and design efficiency.Furthermore,it improves the controllability of high-speed vehicles,mitigating the risk of mission failure resulting from an ineffective control system.展开更多
The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm infections.Phytochemical-based nanoplatform is a promising emerging approach for treatment...The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm infections.Phytochemical-based nanoplatform is a promising emerging approach for treatment of biofilm infection.However,their therapeutic efficacy was restricted by the low drug loading capacity and lack of selectivity.Herein,we constructed a surface charge adaptive phytochemical-based nanoparticle with high isoliquiritigenin(ISL)loading content for effective treatment of MRSA biofilm.A dimeric ISL prodrug(ISL-G2)bearing a lipase responsive ester bond was synthesized,and then encapsulated into the amphiphilic quaternized oligochitosan.The obtained ISL-G2loaded NPs possessed positively charged surface,which allowed cis-aconityl-D-tyrosine(CA-Tyr)binding via electrostatic interaction to obtain ISL-G2@TMDCOS-Tyr NPs.The NPs maintained their negatively charged surface,thus prolonging the blood circulation time.In response to low pH in the biofilms,the fast removal of CA-Tyr led to a shift in their surface charge from negative to positive,which enhanced the accumulation and penetration of NPs in the biofilms.Sequentially,the pH-triggered release of D-tyrosine dispersed the biofilm and lipase-triggered released of ISL effectively kill biofilm MRSA.An in vivo study was performed on a MRSA biofilm infected wound model.This phytochemical-based system led to~2log CFU(>99%)reduction of biofilm MRSA as compared to untreated wound(P<0.001)with negligible biotoxicity in mice.This phytochemical dimer nanoplatform shows great potential for long-term treatment of resistant bacterial infections.展开更多
Objective The study aimed to investigate the impact of rare earth elements(REEs)exposure on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)by analyzing samples from spouses.Methods A total of 141 ...Objective The study aimed to investigate the impact of rare earth elements(REEs)exposure on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)by analyzing samples from spouses.Methods A total of 141 couples were included.Blood and follicular fluid from the wives and semen plasma from the husbands,were analyzed for REEs using inductively coupled plasma mass spectrometry(ICP-MS).Spearman's correlation coefficients and the Mann–Whitney U test were used to assess correlations and compare REE concentrations among three types of samples,respectively.Logistic models were utilized to estimate the individual REE effect on IVF-ET outcomes,while BKMR and WQS models explored the mixture of REE interaction effects on IVF-ET outcomes.Results Higher La concentration in semen(median 0.089 ng/mL,P=0.03)was associated with a lower fertilization rate.However,this effect was not observed after artificial selection intervention through intracytoplasmic sperm injection(ICSI)(P=0.27).In semen,the REEs mixture did not exhibit any significant association with clinical pregnancy.Conclusion Our study revealed a potential association between high La exposure in semen and a decline in fertilization rate,but not clinical pregnancy rate.This is the first to report REEs concentrations in follicular fluid with La,Ce,Pr,and Nd found at significantly lower concentrations than in serum,suggesting that these four REEs may not accumulate in the female reproductive system.However,at the current exposure levels,mixed REEs exposure did not exhibit reproductive toxicity.展开更多
1.Introduction Functional constipation(FC),encompassing normal-transmission constipation(NTC),slow-transmission constipation(STC),obstructed defecation constipation,and mixed constipation(MC),is a common gastrointesti...1.Introduction Functional constipation(FC),encompassing normal-transmission constipation(NTC),slow-transmission constipation(STC),obstructed defecation constipation,and mixed constipation(MC),is a common gastrointestinal disorder characterized by difficulty in bowel movements and dry stools.展开更多
Background: Recent obstetrical practice tends to avoid the use of manual uterine fundal pressure (MUFP);however, data showed that MUFP is actually employed. We here attempted 1) to determine the obstetricians’ attitu...Background: Recent obstetrical practice tends to avoid the use of manual uterine fundal pressure (MUFP);however, data showed that MUFP is actually employed. We here attempted 1) to determine the obstetricians’ attitudes towards MUFP via questionnaire, and 2) to examine whether MUFP shortens the 2nd stage of labor, with the latter tested as a pilot study. Methods: A questionnaire-based study was carried out (n = 122) at meetings of Obstetrics on May 5, 2017. Then, we conducted a pilot case-control study from August 23 to September 6, 2020. Participants (n = 29) were divided into two groups;women who did and did not want MUFP;i.e., MUFP (n = 14) vs. (Non-MUFP) group (n = 15). Results: Of 122 doctors, 99.18% (121/122) used MUFP at cesarean section. 95.90% (117/122) of institutions used MUFP in spontaneous delivery. 95.08% (116/122) obstetricians considered MUFP effective and helpful. 85.24% (104/122) considered that MUFP should be employed after station +3. In the case control study, MUFP vs. Non-MUFP group showed the second-stage-duration of 58.5 (50.25 - 71.25) vs. 48 (39 - 59) minutes, without statistical significance (P = 0.101). However, importantly, MUFP, compared with Non-MUFP group, showed a significantly shorter duration from head visible on introitus (apparition) to delivery;i.e., 21.26 ± 7.32 vs. 30.13 ± 10.61 minutes (P = 0.014). Conclusions: MUFP is still used widely and MUFP shortened the duration of head apparition to delivery time. Larger-sample studies are needed to confirm the efficacy and safety of MUFP.展开更多
The refined management of university finances primarily involves optimizing management methods and continuously improving financial management levels.This process helps enhance fund utilization efficiency,optimize res...The refined management of university finances primarily involves optimizing management methods and continuously improving financial management levels.This process helps enhance fund utilization efficiency,optimize resource allocation,ensure the rational use of educational funds,and provide solid financial support for the development of teaching,research,and other university undertakings.This paper explores the application of refined management in university financial management.展开更多
Sequential indicator simulation is a commonly used method for discrete variable simulation in 3D geological modeling and a widely used stochastic simulation method, which can be used not only for continuous variable s...Sequential indicator simulation is a commonly used method for discrete variable simulation in 3D geological modeling and a widely used stochastic simulation method, which can be used not only for continuous variable simulation but also for discrete variable simulation. In this paper, the X Oilfield in the western South China Sea is taken as an example to compare the sequential indicator simulation method and the Indicator Kriging interpolation method. The results of the final comparison show that the results of the lithofacies model established by the Indicator Kriging deterministic interpolation method are overly smooth, and its coincidence rate with the geological statistical results is not high, thus cannot well reflect the heterogeneity of the underground reservoir, while the simulation results of the lithofacies model established by the sequential indicator stochastic simulation method can fit well with the statistical law of the well, which has eliminated the smoothing effect of Kriging interpolation, thus can better reflect the heterogeneity of the underground reservoir. Therefore, the sequential indicator simulation is more suitable for the characterization of sand bodies and the study of reservoir heterogeneity.展开更多
基金supported by the National Natural Science Foundation of China(32272332,32021005)the Fundamental Research Funds for the Central Universities(JUSRP622020,JUSRP22006,and JUSRP51501)+2 种基金the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu ProvinceTop Talent Support Program for Young and Middle-aged People of Wuxi Health Committee(bj2020111)Appropriate Technology Promotion Project of Wuxi Municipal Health Commission(FYTG202006)。
文摘Gestational diabetes mellitus(GDM)is a disease of glucose intolerance that first occurs during pregnancy.Accumulating evidence underlined a link between gut microbiota dysbiosis and GDM,and microbial metabolites represent a unique way to explore microbiota-host interactions.However,the associations between changes in the gut microbiota and microbial metabolites and immune homeostasis in the GDM pathogenesis remain largely unclear.In this prospective study,the characteristics of gut microbiota in both first trimester(T1)and second trimester(T2)were investigated in 46 GDM patients and 44 matched controls.We comprehensively profiled the microbial metabolites using non-targeted metabolomics and quantitatively targeted metabolomics,measurements of inflammatory cytokines and biomarkers of intestinal barrier function,and combined with correlation analysis in T2.Gut microbiota dybiosis was observed in GDM patients in both T1 and T2,and was characterised by the enrichment of multiple potentially harmful bacteria,such as UBA1819 and Erysipelatoclostridium.Besides,alterations in the microbiota were accompanied by a disturbance in tryptophan metabolism,mainly manifested as a shift towards the production of more kynurenine and less indole derivatives.Most importantly,correlation network analysis indicated that overgrowth of potential pathogens and tryptophan metabolism disorder were associated with inflammatory imbalance and disrupted epithelial barrier in GDM patients.These findings provide a greater understanding of the pathogenesis and new targets for microecological interventions by mediating tryptophan metabolism in GDM.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0760200)the National Natural Science Foundation of China(Grant Nos.42330605 and 42377101).
文摘The Beijing 325 m meteorological tower stands as a pivotal research platform for exploring atmospheric boundary layer physics and atmospheric chemistry.With a legacy spanning 45 years,the tower has played a crucial role in unraveling the complexities of urban air pollution,atmospheric processes,and climate change in Beijing,China.This review paper provides a comprehensive overview of the measurements on the tower over the past two decades.Through long-term comprehensive observations,researchers have elucidated the intricate relationships between anthropogenic emissions,meteorological dynamics,and atmospheric composition,shedding light on the drivers of air pollution and its impacts on public health.The vertical measurements on the tower also enable detailed investigations into boundary layer dynamics,turbulent mixing,and pollutant dispersion,providing invaluable data for validating chemical transport models.Key findings from the tower’s research include the identification of positive feedback mechanisms between aerosols and the boundary layer,the characterization of pollutant sources and transport pathways,the determination of fluxes of gaseous and particulate species,and the assessment of the effectiveness of pollution control measures.Additionally,isotopic measurements have provided new insights into the sources and formation processes of particulate matter and reactive nitrogen species.Finally,the paper outlines future directions for tower-based research,emphasizing the need for long-term comprehensive measurements,the development of innovative tower platforms,and integration of emerging technologies.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(grant No.XDA0350502)the National SKA Program of China(No.2020SKA0120103)the National Natural Science Foundation of China(No.U1831130).
文摘Determining accurate pulsar timing model parameters is essential for establishing TT(PT),a realization of Terrestrial Time(TT)based on a pulsar timescale(PT).This study discusses the impact of different data spans on the accuracy of pulsar timing model parameters when determining pulsar timing model parameters.Using observations of PSR J0437-4715,J1909-3744,J1713+0747,and J1744-1134 from the second data release of the International Pulsar Timing Array(IPTA II,Version A),we compare the accuracy of the timing model parameters determined by these observations with different data spans.The results show for PSR J0437-4715,J1713+0747,and J1909-3744,the amplitude fluctuations of rotational frequency remain within 10^(−15),10^(−14),and 10^(−14) Hz,respectively,when the data spans for determining pulsar timing model parameters exceed 13,14,and 6 yr.Additionally,the one-year accuracy of TT(PT)is crucial for its application in timekeeping.By comparing the frequency deviations of TT(PT)relative to TT(BIPM)under both ideal(k_(r))and actual(k_(p))conditions across different data spans,we find that when the data span reaches the duration above,the accuracy of TT(PT)surpasses that of TT(TAI)under ideal conditions,slightly inferior under actual conditions.This suggests with improved observational technologies,the accuracy of TT(PT)can be further enhanced.
基金supported by the National Key Research and Development Program,Ministry of Science and Technology of the People's Republic of China(Grant No.2021YFC2701001)the National Natural Science Foundation of China(Grant No.81973056).
文摘Objective Exposure to polycyclic aromatic hydrocarbons(PAHs)or metal(loid)s individually has been associated with neural tube defects(NTDs).However,the impacts of PAH and metal(loid)co-exposure and potential interaction effects on NTD risk remain unclear.We conducted a case-control study in China among population with a high prevalence of NTDs to investigate the combined effects of PAH and metal(loid)exposures on the risk of NTD.Methods Cases included 80 women who gave birth to offspring with NTDs,whereas controls were 50 women who delivered infants with no congenital malformations.We analyzed the levels of placental PAHs using gas chromatography and mass spectrometry,PAH-DNA adducts with 32P-post-labeling method,and metal(loid)s with an inductively coupled plasma mass spectrometer.Unconditional logistic regression was employed to estimate the associations between individual exposures and NTDs.Least absolute shrinkage and selection operator(LASSO)penalized regression models were used to select a subset of exposures,while additive interaction models were used to identify interaction effects.Results In the single-exposure models,we found that eight PAHs,PAH-DNA adducts,and 28 metal(loid)s were associated with NTDs.Pyrene,selenium,molybdenum,cadmium,uranium,and rubidium were selected through LASSO regression and were statistically associated with NTDs in the multiple-exposure models.Women with high levels of pyrene and molybdenum or pyrene and selenium exhibited significantly increased risk of having offspring with NTDs,indicating that these combinations may have synergistic effects on the risk of NTDs.Conclusion Our findings suggest that individual PAHs and metal(loid)s,as well as their interactions,may be associated with the risk of NTDs,which warrants further investigation.
基金supported by the National Natural Science Foundation of China(32272332,32021005,31820103010)the Fundamental Research Funds for the Central Universities(JUSRP622020,JUSRP22006,JUSRP51501)the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province.
文摘Obesity is a major focus of researchers due to its increasing prevalence and relationship with other diseases,such as cancer and cardiovascular diseases.Probiotics are active microorganisms and have been proven to alleviate obesity by modulating the microbiota.In this study,we found that oral administration of Bifidobacterium adolescentis CCFM8630 to obese mice inhibited high-fat diet(HFD)-induced changes in body weight and adipose tissue and alleviated hepatic oxidative stress.Furthermore,B.adolescentis CCFM8630 treatment primarily affected the relative abundances of the phyla Proteobacteria and Actinobacteria,and thereby decreased the production of lipopolysaccharide(LPS)and the occurrence of LPS related diseases.A high fiber intake increased the abundance of Lactobacillus and the concentrations of short chain fatty acids in obese mice,but these changes were reversed by B.adolescentis CCFM8630 treatment.In addition,targeted metabolomic analysis and microbiota relationship analysis revealed that B.adolescentis CCFM8630 treatment modified the microbiota of obese mice by promoting the conversion of tryptophan(Trp)to xanthurenic acid,kynurenic acid,tryptamine,indole-3-acetic acid,and indole-3-carboxaldehyde;facilitated the expression of interleukin-17A and the aryl hydrocarbon receptor to generate interleukin-22 in the colon;and upregulated the expression of tight junction proteins,thereby strengthening intestinal barriers.In summary,our findings suggest that the intake of B.adolescentis CCFM8630 may alleviate obesity by modulating the gut microbiota and related Trp metabolism.
基金supported by Guangdong Province Rural Science and Technology Commissioner Project,Zen Tea Reliable Traceability and Intelligent Planting Key Technology Research and Development,Promotion and Application(KTP20210199)Special Project of Guangdong Provincial Education Department,Research on Abnormal Behavior Recognition Technology of Pregnant Sows Based onGraph Convolution(2021ZDZX1091)+2 种基金Guangdong Basic and Applied Basic Research Foundation under Grant 2023A1515110729Shenzhen Science and Technology Program under Grant 20231128093642002the Research Foundation of Shenzhen Polytechnic University under Grant 6023312007K.
文摘This paper introduces an advanced and efficient method for distributed drone-based fruit recognition and localization, tailored to satisfy the precision and security requirements of autonomous agricultural operations. Our method incorporates depth information to ensure precise localization and utilizes a streamlined detection network centered on the RepVGG module. This module replaces the traditional C2f module, enhancing detection performance while maintaining speed. To bolster the detection of small, distant fruits in complex settings, we integrate Selective Kernel Attention (SKAttention) and a specialized small-target detection layer. This adaptation allows the system to manage difficult conditions, such as variable lighting and obstructive foliage. To reinforce security, the tasks of recognition and localization are distributed among multiple drones, enhancing resilience against tampering and data manipulation. This distribution also optimizes resource allocation through collaborative processing. The model remains lightweight and is optimized for rapid and accurate detection, which is essential for real-time applications. Our proposed system, validated with a D435 depth camera, achieves a mean Average Precision (mAP) of 0.943 and a frame rate of 169 FPS, which represents a significant improvement over the baseline by 0.039 percentage points and 25 FPS, respectively. Additionally, the average localization error is reduced to 0.82 cm, highlighting the model’s high precision. These enhancements render our system highly effective for secure, autonomous fruit-picking operations, effectively addressing significant performance and cybersecurity challenges in agriculture. This approach establishes a foundation for reliable, efficient, and secure distributed fruit-picking applications, facilitating the advancement of autonomous systems in contemporary agricultural practices.
基金support from the National Science Foundation of China(22078190)the National Key R&D Plan of China(2020YFB1505802).
文摘Joint time–frequency analysis is an emerging method for interpreting the underlying physics in fuel cells,batteries,and supercapacitors.To increase the reliability of time–frequency analysis,a theoretical correlation between frequency-domain stationary analysis and time-domain transient analysis is urgently required.The present work formularizes a thorough model reduction of fractional impedance spectra for electrochemical energy devices involving not only the model reduction from fractional-order models to integer-order models and from high-to low-order RC circuits but also insight into the evolution of the characteristic time constants during the whole reduction process.The following work has been carried out:(i)the model-reduction theory is addressed for typical Warburg elements and RC circuits based on the continued fraction expansion theory and the response error minimization technique,respectively;(ii)the order effect on the model reduction of typical Warburg elements is quantitatively evaluated by time–frequency analysis;(iii)the results of time–frequency analysis are confirmed to be useful to determine the reduction order in terms of the kinetic information needed to be captured;and(iv)the results of time–frequency analysis are validated for the model reduction of fractional impedance spectra for lithium-ion batteries,supercapacitors,and solid oxide fuel cells.In turn,the numerical validation has demonstrated the powerful function of the joint time–frequency analysis.The thorough model reduction of fractional impedance spectra addressed in the present work not only clarifies the relationship between time-domain transient analysis and frequency-domain stationary analysis but also enhances the reliability of the joint time–frequency analysis for electrochemical energy devices.
基金supported by the National Natural Science Foundation of China(Nos.92371201,52192633)the Natural Science Foundation of Shaanxi Province(No.2022JC-03)Chinese Aeronautical Foundation(No.ASFC-20220019070002)。
文摘The unpowered high-speed vehicle experiences a significant coupling between the disciplines of aerodynamics and control due to its characteristics of high flight speed and extensive maneuverability within large airspace.The conventional aircraft conceptual design process follows a sequential design approach,and there is an artificial separation between the disciplines of aerodynamics and control,neglecting the coupling effects arising from their interaction.As a result,this design process often requires extensive iterations over long periods when applied to high-speed vehicles,and may not be able to effectively achieve the desired design objectives.To enhance the overall performance and design efficiency of high-speed vehicles,this study integrates the concept of Active Control Technology(ACT)from modern aircraft into the philosophy of aerodynamic/control integrated optimization.Two integrated optimization strategies,with differences in coupling granularity,have been developed.Subsequently,these strategies are put into action on a biconical vehicle that operates at Mach 5.The results reveal that the comprehensive performance of the synthesis optimal model derived from the aerodynamic/control integrated optimization strategy is improved by 31.76%and 28.29%respectively compared to the base model under high-speed conditions,demonstrating the feasibility and effectiveness of the method and optimization strategies employed.Moreover,in comparison to the single-stage strategy,the multi-stage strategy takes into deeper consideration the impact of control capacity.As a result,the control performance of the synthesis opti-mal model derived from the multi-stage strategy improves by 13.99%,whereas the single-stage strategy only achieves a 5.79%improvement.This method enables a fruitful interaction between aerodynamic configuration design and control system design,leading to enhanced overall performance and design efficiency.Furthermore,it improves the controllability of high-speed vehicles,mitigating the risk of mission failure resulting from an ineffective control system.
基金supported by the National Natural Science Foundation of China(No.3210190403)the Natural Science Foundation of Heilongjiang Province(No.YQ2022C016)+2 种基金the China Postdoctoral Science Foundation(2022T150104and 2020M670877)the Postdoctoral Science Foundation of Heilongjiang Province(LBH-TZ2104 and LBH-Z20039)the China Agriculture Research System of MOF and MARA(No.CARS-35)。
文摘The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm infections.Phytochemical-based nanoplatform is a promising emerging approach for treatment of biofilm infection.However,their therapeutic efficacy was restricted by the low drug loading capacity and lack of selectivity.Herein,we constructed a surface charge adaptive phytochemical-based nanoparticle with high isoliquiritigenin(ISL)loading content for effective treatment of MRSA biofilm.A dimeric ISL prodrug(ISL-G2)bearing a lipase responsive ester bond was synthesized,and then encapsulated into the amphiphilic quaternized oligochitosan.The obtained ISL-G2loaded NPs possessed positively charged surface,which allowed cis-aconityl-D-tyrosine(CA-Tyr)binding via electrostatic interaction to obtain ISL-G2@TMDCOS-Tyr NPs.The NPs maintained their negatively charged surface,thus prolonging the blood circulation time.In response to low pH in the biofilms,the fast removal of CA-Tyr led to a shift in their surface charge from negative to positive,which enhanced the accumulation and penetration of NPs in the biofilms.Sequentially,the pH-triggered release of D-tyrosine dispersed the biofilm and lipase-triggered released of ISL effectively kill biofilm MRSA.An in vivo study was performed on a MRSA biofilm infected wound model.This phytochemical-based system led to~2log CFU(>99%)reduction of biofilm MRSA as compared to untreated wound(P<0.001)with negligible biotoxicity in mice.This phytochemical dimer nanoplatform shows great potential for long-term treatment of resistant bacterial infections.
基金supported by the National Key Research and Development Program of China(2022YFC2702900 and 2021YFC2701103)National Natural Science Foundation of China(82171654)。
文摘Objective The study aimed to investigate the impact of rare earth elements(REEs)exposure on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)by analyzing samples from spouses.Methods A total of 141 couples were included.Blood and follicular fluid from the wives and semen plasma from the husbands,were analyzed for REEs using inductively coupled plasma mass spectrometry(ICP-MS).Spearman's correlation coefficients and the Mann–Whitney U test were used to assess correlations and compare REE concentrations among three types of samples,respectively.Logistic models were utilized to estimate the individual REE effect on IVF-ET outcomes,while BKMR and WQS models explored the mixture of REE interaction effects on IVF-ET outcomes.Results Higher La concentration in semen(median 0.089 ng/mL,P=0.03)was associated with a lower fertilization rate.However,this effect was not observed after artificial selection intervention through intracytoplasmic sperm injection(ICSI)(P=0.27).In semen,the REEs mixture did not exhibit any significant association with clinical pregnancy.Conclusion Our study revealed a potential association between high La exposure in semen and a decline in fertilization rate,but not clinical pregnancy rate.This is the first to report REEs concentrations in follicular fluid with La,Ce,Pr,and Nd found at significantly lower concentrations than in serum,suggesting that these four REEs may not accumulate in the female reproductive system.However,at the current exposure levels,mixed REEs exposure did not exhibit reproductive toxicity.
基金supported by the Major Program of the National Natural Science Foundation of China(32394051)。
文摘1.Introduction Functional constipation(FC),encompassing normal-transmission constipation(NTC),slow-transmission constipation(STC),obstructed defecation constipation,and mixed constipation(MC),is a common gastrointestinal disorder characterized by difficulty in bowel movements and dry stools.
文摘Background: Recent obstetrical practice tends to avoid the use of manual uterine fundal pressure (MUFP);however, data showed that MUFP is actually employed. We here attempted 1) to determine the obstetricians’ attitudes towards MUFP via questionnaire, and 2) to examine whether MUFP shortens the 2nd stage of labor, with the latter tested as a pilot study. Methods: A questionnaire-based study was carried out (n = 122) at meetings of Obstetrics on May 5, 2017. Then, we conducted a pilot case-control study from August 23 to September 6, 2020. Participants (n = 29) were divided into two groups;women who did and did not want MUFP;i.e., MUFP (n = 14) vs. (Non-MUFP) group (n = 15). Results: Of 122 doctors, 99.18% (121/122) used MUFP at cesarean section. 95.90% (117/122) of institutions used MUFP in spontaneous delivery. 95.08% (116/122) obstetricians considered MUFP effective and helpful. 85.24% (104/122) considered that MUFP should be employed after station +3. In the case control study, MUFP vs. Non-MUFP group showed the second-stage-duration of 58.5 (50.25 - 71.25) vs. 48 (39 - 59) minutes, without statistical significance (P = 0.101). However, importantly, MUFP, compared with Non-MUFP group, showed a significantly shorter duration from head visible on introitus (apparition) to delivery;i.e., 21.26 ± 7.32 vs. 30.13 ± 10.61 minutes (P = 0.014). Conclusions: MUFP is still used widely and MUFP shortened the duration of head apparition to delivery time. Larger-sample studies are needed to confirm the efficacy and safety of MUFP.
文摘The refined management of university finances primarily involves optimizing management methods and continuously improving financial management levels.This process helps enhance fund utilization efficiency,optimize resource allocation,ensure the rational use of educational funds,and provide solid financial support for the development of teaching,research,and other university undertakings.This paper explores the application of refined management in university financial management.
文摘Sequential indicator simulation is a commonly used method for discrete variable simulation in 3D geological modeling and a widely used stochastic simulation method, which can be used not only for continuous variable simulation but also for discrete variable simulation. In this paper, the X Oilfield in the western South China Sea is taken as an example to compare the sequential indicator simulation method and the Indicator Kriging interpolation method. The results of the final comparison show that the results of the lithofacies model established by the Indicator Kriging deterministic interpolation method are overly smooth, and its coincidence rate with the geological statistical results is not high, thus cannot well reflect the heterogeneity of the underground reservoir, while the simulation results of the lithofacies model established by the sequential indicator stochastic simulation method can fit well with the statistical law of the well, which has eliminated the smoothing effect of Kriging interpolation, thus can better reflect the heterogeneity of the underground reservoir. Therefore, the sequential indicator simulation is more suitable for the characterization of sand bodies and the study of reservoir heterogeneity.
