Despite great advancements in organic mixed ionic-electronic conductors(OMIECs),their applications remain predominantly restricted to three-electrode organic electro-chemical transistors(OECTs),which rely on an additi...Despite great advancements in organic mixed ionic-electronic conductors(OMIECs),their applications remain predominantly restricted to three-electrode organic electro-chemical transistors(OECTs),which rely on an additional electrolyte layer to balance ionic and electronic transport,resulting in indirect coupling of charge carriers.While direct coupling has the potential to greatly simplify device architectures,it remains underexplored in OMIECs due to the inherent imbalance between electronic and ionic conductivities.In this study,we introduce a straightforward approach to achieve balanced OMIECs and employ them as channel materials in two-electrode organic electrochemical memristors.These devices provide clear evidence of direct coupling between electronic and ionic carriers and exhibit exceptional performance in synaptic device applications.Our findings offer new insights into charge carrier transport mechanisms in OMIECs and establish organic electrochemical memristors as a promising new class of organic electronic devices for next-generation neuromorphic applications.展开更多
In vitro characterization experiments revealed the formations of 3-(trans-2’-aminocyclopropyl)alanine((3-Acp)Ala)and 3-(trans-2’-nitrocyclopropyl)alanine((3-Ncp)Ala)are originated via two homologous proteins,BelK an...In vitro characterization experiments revealed the formations of 3-(trans-2’-aminocyclopropyl)alanine((3-Acp)Ala)and 3-(trans-2’-nitrocyclopropyl)alanine((3-Ncp)Ala)are originated via two homologous proteins,BelK and HrmI,which regioselectively catalyze the N𝜀-oxygenation of l-lysine.The two enzymes belong to the emerg-ing heme-oxygenase-like diiron oxidase and oxygenase(HDO)superfamily and the catalytic center of BelK is validated by homology modeling and site-directed mutations.Based on the in vitro characterization,the biosyn-thetic pathways of(3-Acp)Ala and(3-Ncp)Ala are proposed.展开更多
基金supported by the National Natural Science Foundation of China(4020969,62405044,and 52173156)Fund by Science Research Project of Hebei Education Department(HY2024050011)+1 种基金Natural Science Foundation of Sichuan Province(25NSFSC1287)Foundation of Yanshan University(1050030 and 8190299).
文摘Despite great advancements in organic mixed ionic-electronic conductors(OMIECs),their applications remain predominantly restricted to three-electrode organic electro-chemical transistors(OECTs),which rely on an additional electrolyte layer to balance ionic and electronic transport,resulting in indirect coupling of charge carriers.While direct coupling has the potential to greatly simplify device architectures,it remains underexplored in OMIECs due to the inherent imbalance between electronic and ionic conductivities.In this study,we introduce a straightforward approach to achieve balanced OMIECs and employ them as channel materials in two-electrode organic electrochemical memristors.These devices provide clear evidence of direct coupling between electronic and ionic carriers and exhibit exceptional performance in synaptic device applications.Our findings offer new insights into charge carrier transport mechanisms in OMIECs and establish organic electrochemical memristors as a promising new class of organic electronic devices for next-generation neuromorphic applications.
基金supported by the National Key R&D Program of China(2019YFA0905700)the National Natural Science Foundation of China(21907057,32070060)+3 种基金the Shan-dong Provincial Natural Science Foundation,China(ZR2019JQ11,ZR2019ZD18)the Natural Science Foundation of Jiangsu Province,China(BK20190201)the 111 project(B16030),the Youth Interdisci-plinary Innovative Research Group(2020QNQT009)the Future Plan for Young Scholars,and the Fundamental Research Funds(2019GN032)of Shandong University.
文摘In vitro characterization experiments revealed the formations of 3-(trans-2’-aminocyclopropyl)alanine((3-Acp)Ala)and 3-(trans-2’-nitrocyclopropyl)alanine((3-Ncp)Ala)are originated via two homologous proteins,BelK and HrmI,which regioselectively catalyze the N𝜀-oxygenation of l-lysine.The two enzymes belong to the emerg-ing heme-oxygenase-like diiron oxidase and oxygenase(HDO)superfamily and the catalytic center of BelK is validated by homology modeling and site-directed mutations.Based on the in vitro characterization,the biosyn-thetic pathways of(3-Acp)Ala and(3-Ncp)Ala are proposed.
