Lung cancer is one of the most prevalent cancers in the world. A cisplatin-based chemotherapy regimen is commonly used to major patients who have adenocarcinoma. Because of the limited remission rate, many patients ne...Lung cancer is one of the most prevalent cancers in the world. A cisplatin-based chemotherapy regimen is commonly used to major patients who have adenocarcinoma. Because of the limited remission rate, many patients need receive second-line treatment after receiving first-line chemotherapy. Drug screenings carried out currently are mainly from single phase. In consideration of systemic treatment, evaluation of a novel drug candidate from the point of view of first-line and second-line treatment is supposed to be important in the process of drug screening. In this review, we propose a flow of searching for new drugs, which is tailored to accommodate to first-line and second-line treatment in clinic.展开更多
New technologies are in urgent need of unconventional hydrocarbon exploration and development in China.This paper provides a brief introduction and analysis of a new three-dimensional(3D)geomechanical restoration meth...New technologies are in urgent need of unconventional hydrocarbon exploration and development in China.This paper provides a brief introduction and analysis of a new three-dimensional(3D)geomechanical restoration method developed in recent years.After an in-depth discussion on the technical principle and specific characteristics of the fields,we designed a feasible workflow for two oil-gas fields with great unconventional oil-gas resource potentials in China(Weiyuan and Jiulongshan oil-gas fields of Sichuan).After discussing the major challenges and limitations of the new technology,we also suggest its research efforts and future application prospect It is shown that the new technology will be an effective method to facilitate the exploration and development of unconventional oil and gas resources in China.展开更多
Objective： To detect the expressions of FEZ1 and Survivin in small cell lung cancer （SOLO） and poorly differentiated squamous cell carcinoma （PDSCC）, and to approach a theoretical basis for clinical diagnosis and...Objective： To detect the expressions of FEZ1 and Survivin in small cell lung cancer （SOLO） and poorly differentiated squamous cell carcinoma （PDSCC）, and to approach a theoretical basis for clinical diagnosis and treatment. Methods： Immunohistochemical and flow cytometry method were used to detect the expressions of FEZ1 and Survivin. Apoptosis ratio and cell proliferation index in normal lung tissue, SCLC and PDSCC were analyzed. Results： The expressions of FEZ1 and Survivin were significantly different between SCLC and PDSCC （P 〈 0.05）. The apoptosis ratio and proliferation index of normal lung tissue were lower than those of PDSCC and SOLO, with a significant difference （P 〈 0.05）. Conclusion： The expressions of FEZ1 and Survivin are significantly different between SCLC and PDSCC, indicating that detecting the expressions of the two indexes may be helpful for clinical diagnosis.展开更多
As the largest emitter of greenhouse gas(GHG)now,China’s“long-term low greenhouse gas emission development strategies”(LTS)will be important to the success of the Paris climate goals to limit global warming to well...As the largest emitter of greenhouse gas(GHG)now,China’s“long-term low greenhouse gas emission development strategies”(LTS)will be important to the success of the Paris climate goals to limit global warming to well below 2 or 1.5℃by the end of this century.In September 2020,China surprised the international community by announcing carbon neutrality before 2060.展开更多
Post-transplantation cyclophosphamide(PT-Cy)alone or in combination with other immunosuppressive drugs has emerged as a promising strategy in the setting of allogeneic hematopoietic stem cell transplantation.Improved ...Post-transplantation cyclophosphamide(PT-Cy)alone or in combination with other immunosuppressive drugs has emerged as a promising strategy in the setting of allogeneic hematopoietic stem cell transplantation.Improved survival rate was reported in lymphoid malignancies following PT-Cy strategy compared with myeloid disease in non-myeloablative bone marrow transplant setting.Thus,we aimed to evaluate the safety and efficacy of PT-Cy combined with cyclosporine as graft-versus-host disease(GVHD)prophylaxis after myeloablative conditioning and T cell-replete peripheral stem cell transplantation in lymphoid malignancies.This single-arm phase Ⅱ clinical trial(NCT01435447)involving 31 adult patients was conducted from January 2013 to June 2018.The donor-type neutrophil engraftment rate was 100%,and the overall incidence of grade Ⅱ to Ⅳ and grade Ⅲ to Ⅳ acute GVHD was 39%and 24%,respectively.The cumulative incidence rates of chronic GVHD(35%),including moderate to severe forms(10%),were reduced compared with those of the historical group(P=0.03 and P=0.04,respectively).With a median follow-up of 18 months,the estimated 2-year overall and event-free survival was 64.8%(95%confidence interval:47.8%–86.7%)and 58.4%(95%CI:41.9%–81.7%),respectively.The 2-year cumulative incidence rate of relapse was 19.5%(95%CI:9.0%–35.8%),whereas the non-relapse mortality rate was 21.8%(95%CI:11.3%–38.1%).These results demonstrated the feasibility of PT-Cy as GVHD prophylaxis in this clinical setting.This strategy could significantly reduce the incidence of chronic GVHD and its moderate to severe forms but not of acute GVHD and results in similar survival outcomes compared with the historical group.A prospective study with additional patients is warranted to confirm the role of PT-Cy in lymphoid malignancy.展开更多
Children are highly susceptible to influenza and are at high risk for severe cases.Chinese patent medicine(CPM)offers advantages in treating pediatric influenza,but the issue of its improper use is increasingly preval...Children are highly susceptible to influenza and are at high risk for severe cases.Chinese patent medicine(CPM)offers advantages in treating pediatric influenza,but the issue of its improper use is increasingly prevalent in clinical practice.To address this,we adopted a dual leadership approach involving clinical and methodological experts,guided by evidence-based and clinical practice principles.We referred to existing guidelines,consensus statements,and treatment protocols,and designed relevant clinical questions based on the“3 specific”principles:specific CPM,specific disease stages,and specific outcomes.This allowed us to conduct evidencebased evaluations of the efficacy and application of CPMs specifically designed for children or with pediatric dosages.Using the“Checklist for Reporting Clinical Practice Guidelines for Chinese Patent Medicines V1.0”developed by our research team,we formulated recommendations for CPM.Ultimately,13 CPMs were recommended,providing clinicians with references on“how to select medication”and“how to use medication.”展开更多
文摘Lung cancer is one of the most prevalent cancers in the world. A cisplatin-based chemotherapy regimen is commonly used to major patients who have adenocarcinoma. Because of the limited remission rate, many patients need receive second-line treatment after receiving first-line chemotherapy. Drug screenings carried out currently are mainly from single phase. In consideration of systemic treatment, evaluation of a novel drug candidate from the point of view of first-line and second-line treatment is supposed to be important in the process of drug screening. In this review, we propose a flow of searching for new drugs, which is tailored to accommodate to first-line and second-line treatment in clinic.
文摘New technologies are in urgent need of unconventional hydrocarbon exploration and development in China.This paper provides a brief introduction and analysis of a new three-dimensional(3D)geomechanical restoration method developed in recent years.After an in-depth discussion on the technical principle and specific characteristics of the fields,we designed a feasible workflow for two oil-gas fields with great unconventional oil-gas resource potentials in China(Weiyuan and Jiulongshan oil-gas fields of Sichuan).After discussing the major challenges and limitations of the new technology,we also suggest its research efforts and future application prospect It is shown that the new technology will be an effective method to facilitate the exploration and development of unconventional oil and gas resources in China.
基金the Key Technologies R&D Program of Hebei Province (No. 02276103D-11)
文摘Objective： To detect the expressions of FEZ1 and Survivin in small cell lung cancer （SOLO） and poorly differentiated squamous cell carcinoma （PDSCC）, and to approach a theoretical basis for clinical diagnosis and treatment. Methods： Immunohistochemical and flow cytometry method were used to detect the expressions of FEZ1 and Survivin. Apoptosis ratio and cell proliferation index in normal lung tissue, SCLC and PDSCC were analyzed. Results： The expressions of FEZ1 and Survivin were significantly different between SCLC and PDSCC （P 〈 0.05）. The apoptosis ratio and proliferation index of normal lung tissue were lower than those of PDSCC and SOLO, with a significant difference （P 〈 0.05）. Conclusion： The expressions of FEZ1 and Survivin are significantly different between SCLC and PDSCC, indicating that detecting the expressions of the two indexes may be helpful for clinical diagnosis.
基金supported by the National Natural Science Foundation of China(71690243,71722003,72174105,72025401,71974108,71703167,and 51861135102)。
文摘As the largest emitter of greenhouse gas(GHG)now,China’s“long-term low greenhouse gas emission development strategies”(LTS)will be important to the success of the Paris climate goals to limit global warming to well below 2 or 1.5℃by the end of this century.In September 2020,China surprised the international community by announcing carbon neutrality before 2060.
基金supported by the National Natural Science Foundation of China(No.81770187)the National Key Research and Development Plan of China(No.2017YFA0104500).
文摘Post-transplantation cyclophosphamide(PT-Cy)alone or in combination with other immunosuppressive drugs has emerged as a promising strategy in the setting of allogeneic hematopoietic stem cell transplantation.Improved survival rate was reported in lymphoid malignancies following PT-Cy strategy compared with myeloid disease in non-myeloablative bone marrow transplant setting.Thus,we aimed to evaluate the safety and efficacy of PT-Cy combined with cyclosporine as graft-versus-host disease(GVHD)prophylaxis after myeloablative conditioning and T cell-replete peripheral stem cell transplantation in lymphoid malignancies.This single-arm phase Ⅱ clinical trial(NCT01435447)involving 31 adult patients was conducted from January 2013 to June 2018.The donor-type neutrophil engraftment rate was 100%,and the overall incidence of grade Ⅱ to Ⅳ and grade Ⅲ to Ⅳ acute GVHD was 39%and 24%,respectively.The cumulative incidence rates of chronic GVHD(35%),including moderate to severe forms(10%),were reduced compared with those of the historical group(P=0.03 and P=0.04,respectively).With a median follow-up of 18 months,the estimated 2-year overall and event-free survival was 64.8%(95%confidence interval:47.8%–86.7%)and 58.4%(95%CI:41.9%–81.7%),respectively.The 2-year cumulative incidence rate of relapse was 19.5%(95%CI:9.0%–35.8%),whereas the non-relapse mortality rate was 21.8%(95%CI:11.3%–38.1%).These results demonstrated the feasibility of PT-Cy as GVHD prophylaxis in this clinical setting.This strategy could significantly reduce the incidence of chronic GVHD and its moderate to severe forms but not of acute GVHD and results in similar survival outcomes compared with the historical group.A prospective study with additional patients is warranted to confirm the role of PT-Cy in lymphoid malignancy.
基金funded by the National Natural Science Foundation of China(No.82105053)China Academy of Chinese Medical Sciences Key Collaborative Project of Innovation Fund(No.CI2022C004-01,No.CI2021A05505)+1 种基金Central Public Welfare Research Institute Basic Scientific Research Fund(No.ZZ14-YQ-039)Young Qihuang Scholars Program of the National Administration of Traditional Chinese Medicine(Z0841).
文摘Children are highly susceptible to influenza and are at high risk for severe cases.Chinese patent medicine(CPM)offers advantages in treating pediatric influenza,but the issue of its improper use is increasingly prevalent in clinical practice.To address this,we adopted a dual leadership approach involving clinical and methodological experts,guided by evidence-based and clinical practice principles.We referred to existing guidelines,consensus statements,and treatment protocols,and designed relevant clinical questions based on the“3 specific”principles:specific CPM,specific disease stages,and specific outcomes.This allowed us to conduct evidencebased evaluations of the efficacy and application of CPMs specifically designed for children or with pediatric dosages.Using the“Checklist for Reporting Clinical Practice Guidelines for Chinese Patent Medicines V1.0”developed by our research team,we formulated recommendations for CPM.Ultimately,13 CPMs were recommended,providing clinicians with references on“how to select medication”and“how to use medication.”
