To study the energy evolution and failure characteristics of saturated sandstone under unloading conditions,rock unloading tests under different stress paths were conducted.The energy evolution mechanism of the unload...To study the energy evolution and failure characteristics of saturated sandstone under unloading conditions,rock unloading tests under different stress paths were conducted.The energy evolution mechanism of the unloading failure of saturated sandstone was systematically explored from the perspectives of the stress path,the initial confining pressure,and the energy conversion rate.The results show that(1)before the peak stress,the elastic energy increases with an increase in deviatoric stress,while the dissipated energy slowly increases first.After the peak stress,the elastic energy decreases with the decrease of deviatoric stress,and the dissipated energy suddenly increases.The energy release intensity during rock failure is positively correlated with the axial stress.(2)When the initial confining pressure is below a certain threshold,the stress path is the main factor influencing the total energy difference.When the axial stress remains constant and the confining pressure is unloading,the total energy is more sensitive to changes in the confining pressure.When the axial stress remains constant,the compressive deformation ability of the rock cannot be significantly improved by the increase in the initial confining pressure.The initial confining pressure is positively correlated with the rock's energy storage limit.(3)The initial confining pressure increases the energy conversion rate of the rock;the initial confining pressure is positively correlated with the energy conversion rate;and the energy conversion rate has a high confining pressure effect.The increase in the axial stress has a much greater impact on the elastic energy than the confining pressure.(4)When the deviatoric stress is small,the confining pressure mainly plays a protective role.Compared with the case of triaxial compression paths,the rock damage is more severe under unloading paths,and compared with the case of constant axial stress,the rock damage is more severe under increasing axial stress.展开更多
Acute lung injury(ALI)is a significant complication of sepsis,characterized by high morbidity,mortality,and poor prognosis.Neutrophils,as critical intrinsic immune cells in the lung,play a fundamental role in the deve...Acute lung injury(ALI)is a significant complication of sepsis,characterized by high morbidity,mortality,and poor prognosis.Neutrophils,as critical intrinsic immune cells in the lung,play a fundamental role in the development and progression of ALI.During ALI,neutrophils generate neutrophil extracellular traps(NETs),and excessive NETs can intensify inflammatory injury.Research indicates that Taohe Chengqi decoction(THCQD)can ameliorate sepsis-induced lung inflammation and modulate immune function.This study aimed to investigate the mechanisms by which THCQD improves ALI and its relationship with NETs in sepsis patients,seeking to provide novel perspectives and interventions for clinical treatment.The findings demonstrate that THCQD enhanced survival rates and reduced lung injury in the cecum ligation and puncture(CLP)-induced ALI mouse model.Furthermore,THCQD diminished neutrophil and macrophage infiltration,inflammatory responses,and the production of pro-inflammatory cytokines,including interleukin-1β(IL-1β),IL-6,and tumor necrosis factorα(TNF-α).Notably,subsequent experiments confirmed that THCQD inhibits NET formation both in vivo and in vitro.Moreover,THCQD significantly decreased the expression of peptidyl arginine deiminase 4(PAD4)protein,and molecular docking predicted that certain active compounds in THCQD could bind tightly to PAD4.PAD4 overexpression partially reversed THCQD’s inhibitory effects on PAD4.These findings strongly indicate that THCQD mitigates CLP-induced ALI by inhibiting PAD4-mediated NETs.展开更多
Semiconductor nanowires coupled to a superconductor provide a powerful testbed for quantum device physics such as Majorana zero modes and gate-tunable hybrid qubits.The performance of these quantum devices heavily rel...Semiconductor nanowires coupled to a superconductor provide a powerful testbed for quantum device physics such as Majorana zero modes and gate-tunable hybrid qubits.The performance of these quantum devices heavily relies on the quality of the induced superconducting gap.A hard gap.展开更多
Objective This study aimed to understand the real-life experiences of Tibetans in China with dysfunction in the process of accepting assistive device services and to provide a reference for service quality improvement...Objective This study aimed to understand the real-life experiences of Tibetans in China with dysfunction in the process of accepting assistive device services and to provide a reference for service quality improvement and policy formulation.Methods Semi-structured personal interviews were used to collect data.Ten Tibetans with dysfunction representing three categories of different economic level areas in Lhasa,Xizang were selected to participate in the study by purposive sampling method from September to December 2021.The data were analyzed using Colaizzi’s seven-step method.Results The results present three themes and seven sub-themes:identification of tangible benefits from assistive devices(enhancing self-care ability for persons with dysfunction,assisting family members with caregiving and promoting harmonious family relationships),problems and burdens(difficulty in accessing professional services and cumbersome processes,not knowing how to use it correctly,psychological burden:fear of falling and stigmatization),and needs and expectations(providing social support to reduce the cost of use,enhancing the accessibility of barrier-free facilities at the grassroots level and improving the environment for the use of assistive devices).Conclusion A proper understanding of the problems and challenges faced by Tibetans with dysfunction in the process of accepting assistive device services,focusing on the real-life experiences of people with functional impairment,and proposing targeted suggestions for improving and optimizing the user experience can provide reference and basis for future intervention studies and related policy formulation.展开更多
The influence of Na2 SO4 on the formation of ZnO whiskers was investigated in this paper. ZnO whiskers with aspect ratios of up to 50 were synthesized by dissolving ε-Zn（OH）2 precursor in NaOH/Na2SO4 solution at ro...The influence of Na2 SO4 on the formation of ZnO whiskers was investigated in this paper. ZnO whiskers with aspect ratios of up to 50 were synthesized by dissolving ε-Zn（OH）2 precursor in NaOH/Na2SO4 solution at room temperature, followed by aging of the resulting solution at 140 ℃ for 6 h. Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy analyses revealed that SO4^2- ions were primarily adsorbed on the （1 00） plane of the ZnO whiskers via an outer-sphere com- plex configuration （O-H……O）, thereby promoting the one-dimensional growth of ZnO whiskers along the c-axis.展开更多
基金Anhui Natural Science Foundation Youth Program,Grant/Award Number:2208085QE142National Natural Science Foundations of China,Grant/Award Numbers:52004003,52304073Opening Foundation of Anhui Province Key Laboratory of Building Structure and Underground Engineering,Grant/Award Number:KLBSUE-2022-04。
文摘To study the energy evolution and failure characteristics of saturated sandstone under unloading conditions,rock unloading tests under different stress paths were conducted.The energy evolution mechanism of the unloading failure of saturated sandstone was systematically explored from the perspectives of the stress path,the initial confining pressure,and the energy conversion rate.The results show that(1)before the peak stress,the elastic energy increases with an increase in deviatoric stress,while the dissipated energy slowly increases first.After the peak stress,the elastic energy decreases with the decrease of deviatoric stress,and the dissipated energy suddenly increases.The energy release intensity during rock failure is positively correlated with the axial stress.(2)When the initial confining pressure is below a certain threshold,the stress path is the main factor influencing the total energy difference.When the axial stress remains constant and the confining pressure is unloading,the total energy is more sensitive to changes in the confining pressure.When the axial stress remains constant,the compressive deformation ability of the rock cannot be significantly improved by the increase in the initial confining pressure.The initial confining pressure is positively correlated with the rock's energy storage limit.(3)The initial confining pressure increases the energy conversion rate of the rock;the initial confining pressure is positively correlated with the energy conversion rate;and the energy conversion rate has a high confining pressure effect.The increase in the axial stress has a much greater impact on the elastic energy than the confining pressure.(4)When the deviatoric stress is small,the confining pressure mainly plays a protective role.Compared with the case of triaxial compression paths,the rock damage is more severe under unloading paths,and compared with the case of constant axial stress,the rock damage is more severe under increasing axial stress.
基金supporteded by the National Natural ScienceFoundation of China(Nos.82374183,82405092,82204991,82274246,and 82374341)the Planned Science TechnologyProjectofGuangzhouCity(Nos.2023A03J0419and2023A03J0420)+3 种基金the General Project of Natural Science Foundationof Guangdong Province(No.2023A1515011090)Hong KongScholars Program 2024(No.XJ2024005)the Basic and AppliedBasic Research Foundation of Guangdong Province(No.2021A151510809)the Project of Administration of TraditionalChinese Medicine of Guangdong Province of China(No.20223013).
文摘Acute lung injury(ALI)is a significant complication of sepsis,characterized by high morbidity,mortality,and poor prognosis.Neutrophils,as critical intrinsic immune cells in the lung,play a fundamental role in the development and progression of ALI.During ALI,neutrophils generate neutrophil extracellular traps(NETs),and excessive NETs can intensify inflammatory injury.Research indicates that Taohe Chengqi decoction(THCQD)can ameliorate sepsis-induced lung inflammation and modulate immune function.This study aimed to investigate the mechanisms by which THCQD improves ALI and its relationship with NETs in sepsis patients,seeking to provide novel perspectives and interventions for clinical treatment.The findings demonstrate that THCQD enhanced survival rates and reduced lung injury in the cecum ligation and puncture(CLP)-induced ALI mouse model.Furthermore,THCQD diminished neutrophil and macrophage infiltration,inflammatory responses,and the production of pro-inflammatory cytokines,including interleukin-1β(IL-1β),IL-6,and tumor necrosis factorα(TNF-α).Notably,subsequent experiments confirmed that THCQD inhibits NET formation both in vivo and in vitro.Moreover,THCQD significantly decreased the expression of peptidyl arginine deiminase 4(PAD4)protein,and molecular docking predicted that certain active compounds in THCQD could bind tightly to PAD4.PAD4 overexpression partially reversed THCQD’s inhibitory effects on PAD4.These findings strongly indicate that THCQD mitigates CLP-induced ALI by inhibiting PAD4-mediated NETs.
基金supported by Tsinghua University Initiative Scientific Research Programthe National Natural Science Foundation of China(Grant No.92065206)+1 种基金the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302400)the support from National Postdoctoral Researcher Program of China(Grant No.GZC20231368)。
文摘Semiconductor nanowires coupled to a superconductor provide a powerful testbed for quantum device physics such as Majorana zero modes and gate-tunable hybrid qubits.The performance of these quantum devices heavily relies on the quality of the induced superconducting gap.A hard gap.
基金This research was funded by The National Key Research and Development Program of China(No.2020YFC2005900)The Key Research and Development Program Jointly Implemented by Sichuan and Chongqing(No.cstc2020jscx-cylhX002).
文摘Objective This study aimed to understand the real-life experiences of Tibetans in China with dysfunction in the process of accepting assistive device services and to provide a reference for service quality improvement and policy formulation.Methods Semi-structured personal interviews were used to collect data.Ten Tibetans with dysfunction representing three categories of different economic level areas in Lhasa,Xizang were selected to participate in the study by purposive sampling method from September to December 2021.The data were analyzed using Colaizzi’s seven-step method.Results The results present three themes and seven sub-themes:identification of tangible benefits from assistive devices(enhancing self-care ability for persons with dysfunction,assisting family members with caregiving and promoting harmonious family relationships),problems and burdens(difficulty in accessing professional services and cumbersome processes,not knowing how to use it correctly,psychological burden:fear of falling and stigmatization),and needs and expectations(providing social support to reduce the cost of use,enhancing the accessibility of barrier-free facilities at the grassroots level and improving the environment for the use of assistive devices).Conclusion A proper understanding of the problems and challenges faced by Tibetans with dysfunction in the process of accepting assistive device services,focusing on the real-life experiences of people with functional impairment,and proposing targeted suggestions for improving and optimizing the user experience can provide reference and basis for future intervention studies and related policy formulation.
基金supported by the National Natural Science Foundation of China(Nos.51174125,51234003,and 51374138)
文摘The influence of Na2 SO4 on the formation of ZnO whiskers was investigated in this paper. ZnO whiskers with aspect ratios of up to 50 were synthesized by dissolving ε-Zn（OH）2 precursor in NaOH/Na2SO4 solution at room temperature, followed by aging of the resulting solution at 140 ℃ for 6 h. Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy analyses revealed that SO4^2- ions were primarily adsorbed on the （1 00） plane of the ZnO whiskers via an outer-sphere com- plex configuration （O-H……O）, thereby promoting the one-dimensional growth of ZnO whiskers along the c-axis.
