This study aimed to comprehensively examine the association of gallstones,cholecystectomy,and cancer risk.Multivariable logistic regressions were performed to estimate the observational associations of gallstones and ...This study aimed to comprehensively examine the association of gallstones,cholecystectomy,and cancer risk.Multivariable logistic regressions were performed to estimate the observational associations of gallstones and cholecystectomy with cancer risk,using data from a nationwide cohort involving 239799 participants.General and gender-specific two-sample Mendelian randomization(MR)analysis was further conducted to assess the causalities of the observed associations.Observationally,a history of gallstones without cholecystectomy was associated with a high risk of stomach cancer(adjusted odds ratio(aOR)=2.54,95%confidence interval(CI)1.50–4.28),liver and bile duct cancer(aOR=2.46,95%CI 1.17–5.16),kidney cancer(aOR=2.04,95%CI 1.05–3.94),and bladder cancer(aOR=2.23,95%CI 1.01–5.13)in the general population,as well as cervical cancer(aOR=1.69,95%CI 1.12–2.56)in women.Moreover,cholecystectomy was associated with high odds of stomach cancer(aOR=2.41,95%CI 1.29–4.49),colorectal cancer(aOR=1.83,95%CI 1.18–2.85),and cancer of liver and bile duct(aOR=2.58,95%CI 1.11–6.02).MR analysis only supported the causal effect of gallstones on stomach,liver and bile duct,kidney,and bladder cancer.This study added evidence to the causal effect of gallstones on stomach,liver and bile duct,kidney,and bladder cancer,highlighting the importance of cancer screening in individuals with gallstones.展开更多
基金funded by the National Natural Science Foundation of China(Nos.82270859,82370819,and 82088102)the National Key R&D Program of China(No.2023YFC2506700)+1 种基金the Shanghai Municipal Government grant(No.22Y31900300)the Shanghai Clinical Research Center for Metabolic Diseases(No.19MC1910100).
文摘This study aimed to comprehensively examine the association of gallstones,cholecystectomy,and cancer risk.Multivariable logistic regressions were performed to estimate the observational associations of gallstones and cholecystectomy with cancer risk,using data from a nationwide cohort involving 239799 participants.General and gender-specific two-sample Mendelian randomization(MR)analysis was further conducted to assess the causalities of the observed associations.Observationally,a history of gallstones without cholecystectomy was associated with a high risk of stomach cancer(adjusted odds ratio(aOR)=2.54,95%confidence interval(CI)1.50–4.28),liver and bile duct cancer(aOR=2.46,95%CI 1.17–5.16),kidney cancer(aOR=2.04,95%CI 1.05–3.94),and bladder cancer(aOR=2.23,95%CI 1.01–5.13)in the general population,as well as cervical cancer(aOR=1.69,95%CI 1.12–2.56)in women.Moreover,cholecystectomy was associated with high odds of stomach cancer(aOR=2.41,95%CI 1.29–4.49),colorectal cancer(aOR=1.83,95%CI 1.18–2.85),and cancer of liver and bile duct(aOR=2.58,95%CI 1.11–6.02).MR analysis only supported the causal effect of gallstones on stomach,liver and bile duct,kidney,and bladder cancer.This study added evidence to the causal effect of gallstones on stomach,liver and bile duct,kidney,and bladder cancer,highlighting the importance of cancer screening in individuals with gallstones.
