Achieving high-performance perovskite solar modules(pero-SMs)over large areas under ambient conditions remains a significant barrier to the commercialization of perovskite photovoltaics.This challenge arises from the ...Achieving high-performance perovskite solar modules(pero-SMs)over large areas under ambient conditions remains a significant barrier to the commercialization of perovskite photovoltaics.This challenge arises from the strong solvent-perovskite coordination interactions in the hygroscopic perovskite precursor ink,which complicate the control of nucleation-growth kinetics and phase evolution during film formation in the presence of moisture,thereby hindering the formation of high-quality perovskite films.In this work,a“vip-solvent”additive strategy was developed by incorporating N,N-dimethylthioformamide(DMT)into the perovskite precursor ink to effectively modulate the coordination between the solvent and perovskite.It is demonstrated that DMT,structurally similar to the“main-solvent”system(DMF and DMSO),possesses lower coordination ability with Pb2+and forms non-covalent interactions with the primary solvents.These interactions weaken the solvent-perovskite coordination without sacrificing solubility,thereby stabilizing homogeneous nucleation and promoting direct crystallization from the sol-gel phase toα-FAPbI3.As a result,the ambient-printed FAPbI3 films exhibited high quality,with more compact grain stacking,smoother morphology,higher phase purity,and fewer defects.Consequently,the resulting perovskite solar cells(0.062 cm2)and pero-SMs(15.64 cm2)fabricated via blade coating under ambient conditions achieved remarkable power conversion efficiencies(PCEs)of 24.46%and 22.54%,respectively.展开更多
Optic neuropathy is one of the main causes of irreversible blindness in the world,and there is no effective treatment in clinic.Both primary degeneration and secondary degeneration play an important role in the injury...Optic neuropathy is one of the main causes of irreversible blindness in the world,and there is no effective treatment in clinic.Both primary degeneration and secondary degeneration play an important role in the injury caused by optic neuropathy.Partial optic nerve transection(PONT)model can be used to study these two kinds of degeneration simultaneously.However,there is currently no measure that can effectively intervene in both types of injuries concurrently.Here,we constructed an expanded partial optic nerve transection(EPONT)model.Nerve growth factor(NGF)-chitosan locally implanted into the injured area could simultaneously intervene in the secondary and primary degeneration,not only protecting the ventral part of the injured optic nerve,but also promoting the regeneration of the dorsal part.Visual functions,including pupillary light reflex and depth perception,were also well preserved.NGF-chitosan exerted biological effects by enhancing the expression of NGF and tyrosine kinase A(TrkA)in the optic nerve and retinal ganglion cells(RGCs).Furthermore,NGFchitosan played a protective and repairing role by inhibiting the activation of microglia in the ventral area of the injured optic nerve and increasing the expression of mammalian target of rapamycin(mTOR)in RGCs.Our results demonstrate that the local use of NGF-chitosan in the injured area effectively repaired the optic nerve,which provides a new measure for the clinical treatment of optic nerve injury.展开更多
Schwannoma surgeries pose a significant risk of postoperative neurological impairment.While intraoperative neuromonitoring(IONM)has improved surgical outcomes,it offers an indirect assessment of neural structures and ...Schwannoma surgeries pose a significant risk of postoperative neurological impairment.While intraoperative neuromonitoring(IONM)has improved surgical outcomes,it offers an indirect assessment of neural structures and functions.However,during the surgeries,it is not feasible to achieve comprehensive visualization of the nerves.To address this limitation,we introduced a multi-channel flexible microelectrode array(FMEA)characterized by its exceptional resolution,consistent conductivity,and unwavering electrical properties.FMEA conforms precisely to the uneven tumor surface during IONM,capturing detailed spatiotemporal patterns of neural signals.Consequently,neurosurgeons can delineate nerve trajectories on the schwannoma surface with heightened precision and evaluate the functional potential of the residual nerve by analyzing signal amplitudes.For surgical guidance,we developed algorithms enabling real-time intraoperative neuro-mapping.This innovation is poised to refine schwannoma surgical practices,promoting nerve anatomical preservation after surgery and guaranteeing postoperative neural outcomes.展开更多
基金supported by the National Key Research and Development Program of China(Grant No.2022YFB4200302)the National Natural Science Foundation of China(Grant Nos.52325307,52273188,22075194)+1 种基金Department of Science and Technology of Jiangsu Province(No.BE2022023)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Collaborative Innovation Center of Suzhou Nano Science and Technology,and the Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function,Soochow University.
文摘Achieving high-performance perovskite solar modules(pero-SMs)over large areas under ambient conditions remains a significant barrier to the commercialization of perovskite photovoltaics.This challenge arises from the strong solvent-perovskite coordination interactions in the hygroscopic perovskite precursor ink,which complicate the control of nucleation-growth kinetics and phase evolution during film formation in the presence of moisture,thereby hindering the formation of high-quality perovskite films.In this work,a“vip-solvent”additive strategy was developed by incorporating N,N-dimethylthioformamide(DMT)into the perovskite precursor ink to effectively modulate the coordination between the solvent and perovskite.It is demonstrated that DMT,structurally similar to the“main-solvent”system(DMF and DMSO),possesses lower coordination ability with Pb2+and forms non-covalent interactions with the primary solvents.These interactions weaken the solvent-perovskite coordination without sacrificing solubility,thereby stabilizing homogeneous nucleation and promoting direct crystallization from the sol-gel phase toα-FAPbI3.As a result,the ambient-printed FAPbI3 films exhibited high quality,with more compact grain stacking,smoother morphology,higher phase purity,and fewer defects.Consequently,the resulting perovskite solar cells(0.062 cm2)and pero-SMs(15.64 cm2)fabricated via blade coating under ambient conditions achieved remarkable power conversion efficiencies(PCEs)of 24.46%and 22.54%,respectively.
基金supported by the National Natural Science Foundation of China(82272171,82271403)Beijing Natural Science Foundation(7222004,L234023)。
文摘Optic neuropathy is one of the main causes of irreversible blindness in the world,and there is no effective treatment in clinic.Both primary degeneration and secondary degeneration play an important role in the injury caused by optic neuropathy.Partial optic nerve transection(PONT)model can be used to study these two kinds of degeneration simultaneously.However,there is currently no measure that can effectively intervene in both types of injuries concurrently.Here,we constructed an expanded partial optic nerve transection(EPONT)model.Nerve growth factor(NGF)-chitosan locally implanted into the injured area could simultaneously intervene in the secondary and primary degeneration,not only protecting the ventral part of the injured optic nerve,but also promoting the regeneration of the dorsal part.Visual functions,including pupillary light reflex and depth perception,were also well preserved.NGF-chitosan exerted biological effects by enhancing the expression of NGF and tyrosine kinase A(TrkA)in the optic nerve and retinal ganglion cells(RGCs).Furthermore,NGFchitosan played a protective and repairing role by inhibiting the activation of microglia in the ventral area of the injured optic nerve and increasing the expression of mammalian target of rapamycin(mTOR)in RGCs.Our results demonstrate that the local use of NGF-chitosan in the injured area effectively repaired the optic nerve,which provides a new measure for the clinical treatment of optic nerve injury.
基金supported by the Natural Science Foundation of Beijing Municipality(L234023)National Natural Science Foundation of China(82201170,82027805,82402429)National Key Research and Development Program of China(2022YFF1202301).
文摘Schwannoma surgeries pose a significant risk of postoperative neurological impairment.While intraoperative neuromonitoring(IONM)has improved surgical outcomes,it offers an indirect assessment of neural structures and functions.However,during the surgeries,it is not feasible to achieve comprehensive visualization of the nerves.To address this limitation,we introduced a multi-channel flexible microelectrode array(FMEA)characterized by its exceptional resolution,consistent conductivity,and unwavering electrical properties.FMEA conforms precisely to the uneven tumor surface during IONM,capturing detailed spatiotemporal patterns of neural signals.Consequently,neurosurgeons can delineate nerve trajectories on the schwannoma surface with heightened precision and evaluate the functional potential of the residual nerve by analyzing signal amplitudes.For surgical guidance,we developed algorithms enabling real-time intraoperative neuro-mapping.This innovation is poised to refine schwannoma surgical practices,promoting nerve anatomical preservation after surgery and guaranteeing postoperative neural outcomes.
