Alzheimer’s disease(AD)is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems.Despite extensive research,effective treatments to stop neurod...Alzheimer’s disease(AD)is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems.Despite extensive research,effective treatments to stop neurodegeneration or promote neuronal regeneration in AD remain elusive.Psychoactive substances as modulators of neurophysiological functions,have received increased attention in research.The main psychoactive agents,such as central nervous system depressants and stimulants,cannabinoids,psychedelics,opioids and ketamine,are being explored for their abilities to enhance learning and cognitive performance and potential neurorestorative functions.In this paper,we review the molecular mechanisms and therapeutic potential of psychoactive substances in AD,in the aim to guide future research directions.展开更多
Environmental factors,including chemical/physical pollutants,as well as lifestyle and psychological factors,contribute greatly to the pathways leading to cardiometabolic diseases with a heavy disease burden and econom...Environmental factors,including chemical/physical pollutants,as well as lifestyle and psychological factors,contribute greatly to the pathways leading to cardiometabolic diseases with a heavy disease burden and economic loss.The concept of exposomes provides a novel paradigm for combining all exposure characteristics to evaluate disease risk.A solution-like exposome requires technological support to provide continuous data to monitor vital signs and detect abnormal fluctuations.Wearable devices allow people to conveniently monitor signals during their daily routines.These new technologies empower users to more actively prevent and manage cardiometabolic disease by reviewing risk factors of the disease,especially lifestyle factors,such as sleeping time,screen time,and mental health condition.Devices with multiple sensors can monitor electrocardiography data,oxygen saturation,intraocular pressure,respiratory rate,and heart rate to enhance the exposome study and provide precise suggestions for disease prevention and management.展开更多
基金supported by National Natural Science Foundation of China(82471444,82241032 to G.Z.,82288101 to L.L.)the Academic Promotion Program of Shandong First Medical University(2023ZL001)+4 种基金Taishan Scholars Program of Shandong Province(tsqn202312236)Excellent Youth Fund Project supported by Shandong Provincial Natural Science Foundation(ZR2024YQ040)the Shandong University Youth Innovation Team Development Plan(2023KJ180)the Shandong Postdoctoral Science Foundation(SDBX202302023,SDCX-ZG-202400157),STI2030-Major Projects(2021ZD0200800)Joint Innovation Team for Clinical&Basic Research(202404).
文摘Alzheimer’s disease(AD)is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems.Despite extensive research,effective treatments to stop neurodegeneration or promote neuronal regeneration in AD remain elusive.Psychoactive substances as modulators of neurophysiological functions,have received increased attention in research.The main psychoactive agents,such as central nervous system depressants and stimulants,cannabinoids,psychedelics,opioids and ketamine,are being explored for their abilities to enhance learning and cognitive performance and potential neurorestorative functions.In this paper,we review the molecular mechanisms and therapeutic potential of psychoactive substances in AD,in the aim to guide future research directions.
基金National Natural Science Foundation of China,Grant/Award Number:818725987。
文摘Environmental factors,including chemical/physical pollutants,as well as lifestyle and psychological factors,contribute greatly to the pathways leading to cardiometabolic diseases with a heavy disease burden and economic loss.The concept of exposomes provides a novel paradigm for combining all exposure characteristics to evaluate disease risk.A solution-like exposome requires technological support to provide continuous data to monitor vital signs and detect abnormal fluctuations.Wearable devices allow people to conveniently monitor signals during their daily routines.These new technologies empower users to more actively prevent and manage cardiometabolic disease by reviewing risk factors of the disease,especially lifestyle factors,such as sleeping time,screen time,and mental health condition.Devices with multiple sensors can monitor electrocardiography data,oxygen saturation,intraocular pressure,respiratory rate,and heart rate to enhance the exposome study and provide precise suggestions for disease prevention and management.
