Multiple myeloma(MM)is the second most common hematological tumor.It is characterized by high drug resistance,easy recurrence,and poor prognosis,and remains incurable.Various models or scoring modalities can be used t...Multiple myeloma(MM)is the second most common hematological tumor.It is characterized by high drug resistance,easy recurrence,and poor prognosis,and remains incurable.Various models or scoring modalities can be used to predict the survival prognosis of MM patients;however,these predictions are still not accurate enough.We have previously found that scorings related to bone marrow microenvironment metabolism can improve predictive efficacy.展开更多
Internal tandem duplication of FMs-like tyrosine kinase 3(FLT3-ITD)is one of the most common genetic alterations in human acute myeloid leukemia(AML)and confers a poor prognosis for the disease.1 Though several FLT3 i...Internal tandem duplication of FMs-like tyrosine kinase 3(FLT3-ITD)is one of the most common genetic alterations in human acute myeloid leukemia(AML)and confers a poor prognosis for the disease.1 Though several FLT3 inhibitors have been approved in AML,their clinical benefits are still unsatisfactory due to primary refractory and drug resistance.Therefore,it may be crucial to develop novel therapeutics forFLT3-ITD+AML.展开更多
基金the Sun Yat-sen University Hundred Talents Program(China)(No.PT19200101)Natural Science Foundation of Guangdong Province,China(No.2022A1515010290)+4 种基金Guangdong Province Science and Technology Planning Project of China(No.2020A1414010033)Guangzhou Science and Technology Planning Project of China(No.202102020430)YL was supported,in part,by Sun Yat-sen University Start-up Funding(China)(No.201603)H-XL was supported by the National Natural Science Foundation of China(No.81773103)the Natural Science Foundation of Guangdong Province,China(No.2017A030313617).
文摘Multiple myeloma(MM)is the second most common hematological tumor.It is characterized by high drug resistance,easy recurrence,and poor prognosis,and remains incurable.Various models or scoring modalities can be used to predict the survival prognosis of MM patients;however,these predictions are still not accurate enough.We have previously found that scorings related to bone marrow microenvironment metabolism can improve predictive efficacy.
基金This project was supported by grants from Theme-based Research Scheme of the Research Grants Council(Hongkong)(No.T12-707/20-N,A.Y.H.Leung.)National Natural Science Foundation of China(No.32000569,B.L.He)GuangDong Basic and Applied Basic Research Foundation,China(No.2019A1515110281,B.L.He).
文摘Internal tandem duplication of FMs-like tyrosine kinase 3(FLT3-ITD)is one of the most common genetic alterations in human acute myeloid leukemia(AML)and confers a poor prognosis for the disease.1 Though several FLT3 inhibitors have been approved in AML,their clinical benefits are still unsatisfactory due to primary refractory and drug resistance.Therefore,it may be crucial to develop novel therapeutics forFLT3-ITD+AML.
