A laser texturing technique herein can endow bare aluminum alloy surface with regular dimple-pattern array and thus generates a case hardening.After STA treatment,these laser-textured samples become superhydrophobic.T...A laser texturing technique herein can endow bare aluminum alloy surface with regular dimple-pattern array and thus generates a case hardening.After STA treatment,these laser-textured samples become superhydrophobic.The surface wettability of the laser-textured samples can be regulated by controlling the dimple-pattern dimensions during the laser processing.It is noteworthy that a fluorescence method is utilized to record the zones on the superhydrophobic surface penetrated by small enough water molecules.Compared with a general method of the Cassie-Baxter theoretical calculation,this fluorescence method intuitively exhibits the air trapping ability of the superhydrophobic surface.Furthermore,the laser-textured superhydrophobic samples have a notable hysteresis phenomenon at the initial period of UMT friction because the air cushion trapped within superhydrophobic samples have strong repellency against water droplets on the hydrophilic steel ball.Additionally,such samples display strong mechanical stability in comparison with bare aluminum alloy because of the presence of case hardening on the surface of the laser patterns.The research results above provide a valuable reference for designing a surface with different wettability,which may inspire practical applications in the fields of fluid transport,droplet manipulation,water harvesting and microfluidic devices.展开更多
Hydrogel has been widely used in the research of bionic articular cartilage due to their similarity in structure and functional properties to natural articular cartilage.In this research,polyvinyl alcohol and betaine ...Hydrogel has been widely used in the research of bionic articular cartilage due to their similarity in structure and functional properties to natural articular cartilage.In this research,polyvinyl alcohol and betaine monomer were used as raw materials to prepare a high-strength double-network hydrogel by a combination of ultraviolet(UV)irradiation and freeze–thaw methods.The structure of samples was characterized by Fourier transform infrared spectroscopy and X-ray diff raction,and the morphology of the samples was characterized by scanning electron microscope and three-dimensional white light interferometer.In addition,we also studied the swelling ratio,water content,mechanical properties and tribological properties of the samples.We found that the addition of betaine monomer and the UV irradiation time had a positive eff ect on the mechanical properties and tribological properties of the samples.展开更多
Poly (vinyl alcohol) hydrogel has been perceived as a promising replacement for articular cartilage due to its superior water-absorption ability and excellent biocompatibility, but its mechanical properties are still ...Poly (vinyl alcohol) hydrogel has been perceived as a promising replacement for articular cartilage due to its superior water-absorption ability and excellent biocompatibility, but its mechanical properties are still insufficient. In this study, the poly (vinyl alcohol)/sodium tetraborate triple-network (PVA/SB TN) hydrogel was developed by repeated freeze–thaw method. Scanning electron microscopy images demonstrated that the structure of as-prepared hydrogels was three-dimensional porous network structure similar to that of natural articular cartilage. Compared to the pure PVA hydrogel, the mechanical performance of the PVA/SB TN hydrogels were improved by 116% and 461% in tensile and compressive strengths, respectively. This was mainly because that the complexation reaction between the PVA and SB strengthened the stability of the hydrogel network. Notably, the biotribological performance of PVA hydrogel has also been improved significantly. Even at high load, the friction coefficient of the PVA/SB TN hydrogel was both very low in calf serum or deionized water. This PVA/SB TN hydrogel with good mechanical property and low friction has high application potential in cartilage repair.展开更多
ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia.However,the neural mechanisms underlying this association are unknown.Given that ZNF804A upregulates the expression of COMT,we hypothesi...ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia.However,the neural mechanisms underlying this association are unknown.Given that ZNF804A upregulates the expression of COMT,we hypothesized that ZNF804 A may influence brain activity by interacting with COMT.Here,we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants.Amplitudes of low-frequency fluctuations(ALFFs)were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680.The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 x COMT rs4680 interaction,manifesting as a U-shaped modulation,presumably by dopamine signaling.Significant main effects were also found.These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT,and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia.展开更多
Lubricin in synovial fluid is the primary boundary lubricant for articular cartilage.Its excellent boundary lubricating capability comes from its unique bottlebrush structure.In this study,a biomimetic polymer contain...Lubricin in synovial fluid is the primary boundary lubricant for articular cartilage.Its excellent boundary lubricating capability comes from its unique bottlebrush structure.In this study,a biomimetic polymer containing 2-hydroxyethyl acrylate and 2-methacryloyloxyethyl phosphorylcholine(MPC)was synthesized.This polymer is structurally similar to lubricin and achieves a water-trapping capacity similar to that of lubricin through the design of the pMPC moiety.Atomic force microscopy(AFM)imaging indicates that changes in the molecular chain length and concentration lead to different self-assembled polymer structures.The lateral force between the AFM probe and silicon surface covered by the polymer demonstrates that the self-assembled structure of polymer molecules on the surface affects its boundary lubrication ability.When polymers are adsorbed onto the surface of articular cartilage to replace natural lubricin,the system exhibits extremely low friction(~0.028)under boundary film-liquid mixed lubrication conditions,which is close to the coefficient of friction(COF,~0.024)of natural lubricin under the same conditions.The study of this biomimetic polymer provides a strategy for lubricating damaged cartilage during the initial stages of osteoarthritis development.展开更多
Background and Objectives:In recent years,with the improvement of people's living standards and changes in dietary patterns,dietary knowledge and food preference have been playing an increasingly crucial role in h...Background and Objectives:In recent years,with the improvement of people's living standards and changes in dietary patterns,dietary knowledge and food preference have been playing an increasingly crucial role in health.The aim of our study was to examine the relationship between dietary knowledge,food preference,and long-short term health status among Chinese adults aged 18-70.Methods and Study Design:This study employed crosssectional data from the 2015 China Health and Nutrition Survey obtained from 4822 adults.We utilized selfassessed health status as an indicator of long-term health status and utilized sickness in the last four weeks as a measure of short-term health status.Taking advantage of ordered probit regression,long-term health status was regressed on all predictors,while the binary logistic regression was used to analyze the factors influencing shortterm health status.The propensity score matching is employed to account for potential selection bias in analysis,thereby increasing the robustness and credibility of results.Results:The analysis revealed that dietary knowledge and food preference can improve an individual’s long-term health status significantly.However,there is no evidence to show that short-term health status is affected by food preference.Furthermore,dietary knowledge is negatively associated with short-term health status.Conclusions:These findings highlight the importance of dietary education and healthy eating habits in improving the long-term health status of Chinese adults.The study suggests implications for public health strategies aimed at enhancing the health and well-being of Chinese adults.展开更多
Malware is emerging day by day.To evade detection,many malware obfuscation techniques have emerged.Dynamicmalware detectionmethods based on data flow graphs have attracted much attention since they can deal with the o...Malware is emerging day by day.To evade detection,many malware obfuscation techniques have emerged.Dynamicmalware detectionmethods based on data flow graphs have attracted much attention since they can deal with the obfuscation problem to a certain extent.Many malware classification methods based on data flow graphs have been proposed.Some of them are based on userdefined features or graph similarity of data flow graphs.Graph neural networks have also recently been used to implement malware classification recently.This paper provides an overview of current data flow graph-based malware classification methods.Their respective advantages and disadvantages are summarized as well.In addition,the future trend of the data flow graph-based malware classification method is analyzed,which is of great significance for promoting the development of malware detection technology.展开更多
基金supported by the National Natural Science Foundation of China under grant Nos.51975296&51575278the Advanced Composite Materials Key Laboratory Fund under grant No.614290402091702the Funding for Excellent PhD Training Program。
文摘A laser texturing technique herein can endow bare aluminum alloy surface with regular dimple-pattern array and thus generates a case hardening.After STA treatment,these laser-textured samples become superhydrophobic.The surface wettability of the laser-textured samples can be regulated by controlling the dimple-pattern dimensions during the laser processing.It is noteworthy that a fluorescence method is utilized to record the zones on the superhydrophobic surface penetrated by small enough water molecules.Compared with a general method of the Cassie-Baxter theoretical calculation,this fluorescence method intuitively exhibits the air trapping ability of the superhydrophobic surface.Furthermore,the laser-textured superhydrophobic samples have a notable hysteresis phenomenon at the initial period of UMT friction because the air cushion trapped within superhydrophobic samples have strong repellency against water droplets on the hydrophilic steel ball.Additionally,such samples display strong mechanical stability in comparison with bare aluminum alloy because of the presence of case hardening on the surface of the laser patterns.The research results above provide a valuable reference for designing a surface with different wettability,which may inspire practical applications in the fields of fluid transport,droplet manipulation,water harvesting and microfluidic devices.
基金supported by National Natural Science Foundation of China(Grant No.51975296)Jiangsu Key Laboratory of Advanced Micro/Nano Materials and Technologies.
文摘Hydrogel has been widely used in the research of bionic articular cartilage due to their similarity in structure and functional properties to natural articular cartilage.In this research,polyvinyl alcohol and betaine monomer were used as raw materials to prepare a high-strength double-network hydrogel by a combination of ultraviolet(UV)irradiation and freeze–thaw methods.The structure of samples was characterized by Fourier transform infrared spectroscopy and X-ray diff raction,and the morphology of the samples was characterized by scanning electron microscope and three-dimensional white light interferometer.In addition,we also studied the swelling ratio,water content,mechanical properties and tribological properties of the samples.We found that the addition of betaine monomer and the UV irradiation time had a positive eff ect on the mechanical properties and tribological properties of the samples.
基金supported by National Natural Science Foundation of China(Grant No.51975296)Jiangsu Key Laboratory of Advanced Micro/Nano Materials and Technologies.
文摘Poly (vinyl alcohol) hydrogel has been perceived as a promising replacement for articular cartilage due to its superior water-absorption ability and excellent biocompatibility, but its mechanical properties are still insufficient. In this study, the poly (vinyl alcohol)/sodium tetraborate triple-network (PVA/SB TN) hydrogel was developed by repeated freeze–thaw method. Scanning electron microscopy images demonstrated that the structure of as-prepared hydrogels was three-dimensional porous network structure similar to that of natural articular cartilage. Compared to the pure PVA hydrogel, the mechanical performance of the PVA/SB TN hydrogels were improved by 116% and 461% in tensile and compressive strengths, respectively. This was mainly because that the complexation reaction between the PVA and SB strengthened the stability of the hydrogel network. Notably, the biotribological performance of PVA hydrogel has also been improved significantly. Even at high load, the friction coefficient of the PVA/SB TN hydrogel was both very low in calf serum or deionized water. This PVA/SB TN hydrogel with good mechanical property and low friction has high application potential in cartilage repair.
基金supported by the National Basic Research Development Program of China (2016YFC0906400, 2016YFC1306900 and 2016YFC0904300)the National Natural Science Foundation of China (81571311 and 81571331)+4 种基金the National Science Fund for Distinguished Young Scholars of China (81725005)the National High Tech Development Project (863 Project) of China (2015AA020513)the Science and Technology Project of Liaoning Province, China (2015225018)the Educational Foundation (Pandeng Scholarship) of Liaoning Province, Chinathe support of Department of Radiology and Psychiatry, First Affiliated Hospital of China Medical University
文摘ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia.However,the neural mechanisms underlying this association are unknown.Given that ZNF804A upregulates the expression of COMT,we hypothesized that ZNF804 A may influence brain activity by interacting with COMT.Here,we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants.Amplitudes of low-frequency fluctuations(ALFFs)were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680.The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 x COMT rs4680 interaction,manifesting as a U-shaped modulation,presumably by dopamine signaling.Significant main effects were also found.These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT,and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia.
基金supported by the National Natural Science Foundation of China(Nos.51975296 and 51711530228)the Jiangsu Key Laboratory of Advanced Micro/Nano Materials and Technologies.
文摘Lubricin in synovial fluid is the primary boundary lubricant for articular cartilage.Its excellent boundary lubricating capability comes from its unique bottlebrush structure.In this study,a biomimetic polymer containing 2-hydroxyethyl acrylate and 2-methacryloyloxyethyl phosphorylcholine(MPC)was synthesized.This polymer is structurally similar to lubricin and achieves a water-trapping capacity similar to that of lubricin through the design of the pMPC moiety.Atomic force microscopy(AFM)imaging indicates that changes in the molecular chain length and concentration lead to different self-assembled polymer structures.The lateral force between the AFM probe and silicon surface covered by the polymer demonstrates that the self-assembled structure of polymer molecules on the surface affects its boundary lubrication ability.When polymers are adsorbed onto the surface of articular cartilage to replace natural lubricin,the system exhibits extremely low friction(~0.028)under boundary film-liquid mixed lubrication conditions,which is close to the coefficient of friction(COF,~0.024)of natural lubricin under the same conditions.The study of this biomimetic polymer provides a strategy for lubricating damaged cartilage during the initial stages of osteoarthritis development.
基金supported in part by the National Natural Science Foundation of China under Grant[61773018]Fundamental Research Fund of Zhengzhou University of Light Industry(No.23XJCYJ078)+8 种基金in part by the Scientific Research Foundation of the Higher Education Institutions of Henan Province of China under Grant[23A110003]funding from the National Institute for Health(NIH),the Eunice Kennedy Shriver National Institute of Child Health and Human Development(NICHD)for R01 HD30880 and R01 HD38700National Institute on Aging(NIA)for R01 AG065357National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK)for R01 DK104371 and P30 DK056350National Heart,Lung,and Blood Institute(NHLBI)for R01 HL108427the NIH Fogarty grant D43 TW009077the Carolina Population Center for P2C HD050924 and P30 AG066615 since 1989the China-Japan Friendship Hospital,Ministry of Health for support for CHNS 2009,Chinese National Human Genome Center at Shanghai since 2009Beijing Municipal Center for Disease Prevention and Control since 2011.
文摘Background and Objectives:In recent years,with the improvement of people's living standards and changes in dietary patterns,dietary knowledge and food preference have been playing an increasingly crucial role in health.The aim of our study was to examine the relationship between dietary knowledge,food preference,and long-short term health status among Chinese adults aged 18-70.Methods and Study Design:This study employed crosssectional data from the 2015 China Health and Nutrition Survey obtained from 4822 adults.We utilized selfassessed health status as an indicator of long-term health status and utilized sickness in the last four weeks as a measure of short-term health status.Taking advantage of ordered probit regression,long-term health status was regressed on all predictors,while the binary logistic regression was used to analyze the factors influencing shortterm health status.The propensity score matching is employed to account for potential selection bias in analysis,thereby increasing the robustness and credibility of results.Results:The analysis revealed that dietary knowledge and food preference can improve an individual’s long-term health status significantly.However,there is no evidence to show that short-term health status is affected by food preference.Furthermore,dietary knowledge is negatively associated with short-term health status.Conclusions:These findings highlight the importance of dietary education and healthy eating habits in improving the long-term health status of Chinese adults.The study suggests implications for public health strategies aimed at enhancing the health and well-being of Chinese adults.
文摘Malware is emerging day by day.To evade detection,many malware obfuscation techniques have emerged.Dynamicmalware detectionmethods based on data flow graphs have attracted much attention since they can deal with the obfuscation problem to a certain extent.Many malware classification methods based on data flow graphs have been proposed.Some of them are based on userdefined features or graph similarity of data flow graphs.Graph neural networks have also recently been used to implement malware classification recently.This paper provides an overview of current data flow graph-based malware classification methods.Their respective advantages and disadvantages are summarized as well.In addition,the future trend of the data flow graph-based malware classification method is analyzed,which is of great significance for promoting the development of malware detection technology.
