We report the manipulation of ferromagnetism in magnetic semiconductor Ba(Zn,Mn,Cu)_(2)As_(2)through chemical pressure.The substitutions of Sr for Ba and Sb for As introduce positive and negative chemical pressures,re...We report the manipulation of ferromagnetism in magnetic semiconductor Ba(Zn,Mn,Cu)_(2)As_(2)through chemical pressure.The substitutions of Sr for Ba and Sb for As introduce positive and negative chemical pressures,respectively;neither Sr doping nor Sb doping change the tetragonal crystal structure.Based on Ba(Zn_(0.75)Mn_(0.125)Cu_(0.125))_(2)As_(2)with T_(C)~34 K,10%Sr/Ba substitutions significantly improve T_(C)by~15%to 39 K,whereas 10%Sb/As substitutions substantially reduce TCby~47%to 18 K.The AC magnetic susceptibility measurements indicate that Sr-doped and Sb-doped samples evolve into a spin glass state below the spin freezing temperature Tf.Electrical transport measurements demonstrate that Sr-doped specimens retain semiconducting behavior;additionally,they display a significant negative magnetoresistance effect under applied magnetic fields and the magnetoresistance reaches~-19%at 8 T.展开更多
We report the successful synthesis and characterization of a novel 1111-type magnetic semiconductor(Ba_(1−x)Na_(x))F(Zn_(1−x)Mn_(x))Sb(0.05≤x≤0.175)with tetragonal ZrSiCuAs-type structure,which is isostructural to t...We report the successful synthesis and characterization of a novel 1111-type magnetic semiconductor(Ba_(1−x)Na_(x))F(Zn_(1−x)Mn_(x))Sb(0.05≤x≤0.175)with tetragonal ZrSiCuAs-type structure,which is isostructural to the layered iron-based superconductor La(O,F)FeAs.Na substitutions for Ba and Mn substitutions for Zn introduce carriers and local magnetic moments,respectively.Ferromagnetic interaction is formed when Na and Mn are codoped,demonstrating that local magnetic moments are mediated by carriers.Iso-thermal magnetization shows that the coercive field is as large as-12000 Oe,which is also reflected in the large split between the temperature-dependent magnetization in zero-field-cooling and field-cooling condition.AC susceptibility under zero field demonstrates that samples evolve into spin-glass state below spin freezing temperature T_(f).The measurements of temperature-dependent resistivity indicate that(Ba_(1−x)Na_(x))F(Zn_(1−x)Mn_(x))Sb exhibits semiconducting behaviour.展开更多
We have successfully synthesized a novel diluted magnetic semiconductor(Ca_(1−2x)K_(2x))(Zn_(1−x)Mn_(x))_(2)As_(2) with decoupled charge and spin doping.The substitutions of(Ca^(2+),K^(+))and(Zn^(2+),Mn^(2+))in the pa...We have successfully synthesized a novel diluted magnetic semiconductor(Ca_(1−2x)K_(2x))(Zn_(1−x)Mn_(x))_(2)As_(2) with decoupled charge and spin doping.The substitutions of(Ca^(2+),K^(+))and(Zn^(2+),Mn^(2+))in the parent compound CaZn_(2)As_(2)(space group P m1(No.164))introduce carriers and magnetic moments,respectively.Doping only Mn into CaZn_(2)As_(2) does not induce any type of long range magnetic ordering.The ferromagnetic ordering arise can only when K^(+)and Mn^(2+)are simultaneously doped.The res-ulted maximum Curie temperature reaches~7 K,and the corresponding coercive field is~60 Oe.The transport measurements confirm that samples with K and Mn co-doping still behave like a semiconductor.展开更多
We report the successful fabrication of a new 1111-type bulk magnetic semiconductor(La,Ba)(Zn,Mn)SbO through the solid solution of(La,Ba)and(Zn,Mn)in the parent compound LaZnSbO.The polycrystalline samples(La,Ba)(Zn,M...We report the successful fabrication of a new 1111-type bulk magnetic semiconductor(La,Ba)(Zn,Mn)SbO through the solid solution of(La,Ba)and(Zn,Mn)in the parent compound LaZnSbO.The polycrystalline samples(La,Ba)(Zn,Mn)SbO crystallize into ZrCuSiAs-type tetragonal structure,which has the same structure as iron-based superconductor LaFeAsO_(1-δ).The DC magnetization measurements indicate the existence of spin-glass ordering,and the coercive field is up to~11500 Oe(1 Oe=79.5775 A·m^(-1)).The AC magnetic susceptibility further determines that the samples evolve into a conventional spin-glass ordering state below the spin freezing temperature T_(f).In addition,the negative magnetoresistance(MR≡[ρ(H)-ρ(0)]/ρ(0))reaches-88%under 9 T.展开更多
Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biologic...Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration.展开更多
基金supported by the National Key Research and Development Program of China(Grant Nos.2022YFA1402701 and 2022YFA1403202)the National Natural Science Foundation of China(Grant No.12074333)the Key Research and Development Program of Zhejiang Province,China(Grant No.2021C01002)。
文摘We report the manipulation of ferromagnetism in magnetic semiconductor Ba(Zn,Mn,Cu)_(2)As_(2)through chemical pressure.The substitutions of Sr for Ba and Sb for As introduce positive and negative chemical pressures,respectively;neither Sr doping nor Sb doping change the tetragonal crystal structure.Based on Ba(Zn_(0.75)Mn_(0.125)Cu_(0.125))_(2)As_(2)with T_(C)~34 K,10%Sr/Ba substitutions significantly improve T_(C)by~15%to 39 K,whereas 10%Sb/As substitutions substantially reduce TCby~47%to 18 K.The AC magnetic susceptibility measurements indicate that Sr-doped and Sb-doped samples evolve into a spin glass state below the spin freezing temperature Tf.Electrical transport measurements demonstrate that Sr-doped specimens retain semiconducting behavior;additionally,they display a significant negative magnetoresistance effect under applied magnetic fields and the magnetoresistance reaches~-19%at 8 T.
基金The work was supported by the Key R&D Program of Zhejiang Province,China(2021C01002)NSF of China(No.12074333).
文摘We report the successful synthesis and characterization of a novel 1111-type magnetic semiconductor(Ba_(1−x)Na_(x))F(Zn_(1−x)Mn_(x))Sb(0.05≤x≤0.175)with tetragonal ZrSiCuAs-type structure,which is isostructural to the layered iron-based superconductor La(O,F)FeAs.Na substitutions for Ba and Mn substitutions for Zn introduce carriers and local magnetic moments,respectively.Ferromagnetic interaction is formed when Na and Mn are codoped,demonstrating that local magnetic moments are mediated by carriers.Iso-thermal magnetization shows that the coercive field is as large as-12000 Oe,which is also reflected in the large split between the temperature-dependent magnetization in zero-field-cooling and field-cooling condition.AC susceptibility under zero field demonstrates that samples evolve into spin-glass state below spin freezing temperature T_(f).The measurements of temperature-dependent resistivity indicate that(Ba_(1−x)Na_(x))F(Zn_(1−x)Mn_(x))Sb exhibits semiconducting behaviour.
基金supported by the Key R&D Program of Zhejiang Province, China (2021C01002)NSF of China (No. 12074333)。
文摘We have successfully synthesized a novel diluted magnetic semiconductor(Ca_(1−2x)K_(2x))(Zn_(1−x)Mn_(x))_(2)As_(2) with decoupled charge and spin doping.The substitutions of(Ca^(2+),K^(+))and(Zn^(2+),Mn^(2+))in the parent compound CaZn_(2)As_(2)(space group P m1(No.164))introduce carriers and magnetic moments,respectively.Doping only Mn into CaZn_(2)As_(2) does not induce any type of long range magnetic ordering.The ferromagnetic ordering arise can only when K^(+)and Mn^(2+)are simultaneously doped.The res-ulted maximum Curie temperature reaches~7 K,and the corresponding coercive field is~60 Oe.The transport measurements confirm that samples with K and Mn co-doping still behave like a semiconductor.
基金Project supported by the National Key Research and Development Program of China (Grant Nos.2022YFA1402701 and 2022YFA1403202)the National Natural Science Foundation of China (Grant No.12074333)the Key Research and Development Program of Zhejiang Province,China (Grant No.2021C01002)。
文摘We report the successful fabrication of a new 1111-type bulk magnetic semiconductor(La,Ba)(Zn,Mn)SbO through the solid solution of(La,Ba)and(Zn,Mn)in the parent compound LaZnSbO.The polycrystalline samples(La,Ba)(Zn,Mn)SbO crystallize into ZrCuSiAs-type tetragonal structure,which has the same structure as iron-based superconductor LaFeAsO_(1-δ).The DC magnetization measurements indicate the existence of spin-glass ordering,and the coercive field is up to~11500 Oe(1 Oe=79.5775 A·m^(-1)).The AC magnetic susceptibility further determines that the samples evolve into a conventional spin-glass ordering state below the spin freezing temperature T_(f).In addition,the negative magnetoresistance(MR≡[ρ(H)-ρ(0)]/ρ(0))reaches-88%under 9 T.
基金supported by the Natural Key Research and Development Program(No:2021YFA1101604)the key Research and Development program of Hubei province(2022BCA028)the international cooperation project of China Manned Space Program,and program for Tongji Hospital Academic Frontier Youth Team(2019A20)。
文摘Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration.
