Background: Age is an important prognostic factor for thymoma;however, few studies have specifically focused on age-related survival outcomes in thymoma patients. This study explored the effect of age on the clinicopa...Background: Age is an important prognostic factor for thymoma;however, few studies have specifically focused on age-related survival outcomes in thymoma patients. This study explored the effect of age on the clinicopathological features and survival outcomes of thymoma patients. Methods: We reviewed the clinical data of 1984 chest thymoma patients from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. In accordance with the World Health Organization age brackets, the patients were divided into young (group A, 0 - 44-year-old);middle-aged (group B, 45 - 59-year-old);old (group C, 60 - 74-year-old);and seniors (group D 75 - 84-year-old). Single-factor and multivariate analysis were performed using the Kaplan-Meier method, and a multivariate Cox regression model was generated to assess patient prognosis. Results: In total, 1984 patients were included. The median follow-up time was 156.0 months (range: 0 - 492 months). Group C (60 - 74-year-old) had the most patients (35.1%), and Group D had the fewest patients (12.3%). Among all age groups, the proportion of white people and men with thymoma increased with age, while the proportion of black people and women showed a downward trend. Univariate and multivariate analyses showed that the overall survival rate of thymoma patients was negatively correlated with age. The overall survival times of the four groups were significantly different (p Conclusion: Age is an important prognostic factor for survival in thymoma patients, and younger patients have a survival advantage over older patients.展开更多
The authors regret “The SI for the paper which was published as noted above is not the one which the paper refers to, and only theresponse to the Referees appears. Now the correct file has been provided”.
Luminescent conjugated network polymer is one of the most promising chemo-sensors owing to their good chemical/optical stability and multiple functionalization.Herein,three conjugated network polymers were prepared by...Luminescent conjugated network polymer is one of the most promising chemo-sensors owing to their good chemical/optical stability and multiple functionalization.Herein,three conjugated network polymers were prepared by using aggregation-induced emission active 1,1,2,2-tetrakis(4-formyl-(1,1’-biphenyl))-ethane(TFBE)unit as monomer and hydrazine as linker.Through regulating the synthetical condition,the polyme ric network can form either unifo rm two-dimensional azine-linked nanosheets(ANS),conjugated microporous polymers(A-CMP)or covalent organic frameworks(A-COF).All of these polymers exhibited good stability and high fluorescence quantum efficiency with the quantum yield of6.31%for A-NS,5.26%for A-CMP,and 5.80%for A-COF,as well as fast and selective fluorescence quenching response to 2,4,6-trinitrophenol(TNP).And the best TNP sensing performance with the Stern-Volmer constants(K_(sv))values up to 8×10^(5)L/mol and a detection limit of 0.09μmol/L was obtained for A-NS.The study explores various strategies to construct conjugated polymers with different nanoarchitectures based on the same building block for sensitive detection of explosives.展开更多
Fluorescence probes with strong near-infrared(NIR)emission and water solubility are considered useful visualization tools for localization marking as well as investigating cell migration and transplantation.Here,we de...Fluorescence probes with strong near-infrared(NIR)emission and water solubility are considered useful visualization tools for localization marking as well as investigating cell migration and transplantation.Here,we designed and synthesized a new donor–π–acceptor(D–π–A)fluorogen,2-(4-[(E)-4-(diphenylamino)styryl]phenyl)-3-(4′-[1,2,2-triphenylvinyl]-[1,1′-biphenyl]-4-yl)fumaronitrile(TB-TPE).TB-TPE exhibits twisted intramolecular charge transfer(TICT)and aggregation-induced emission(AIE)in the NIR region,with an emission peak at 714 nm and a fluorescence quantum yield(Qy)of 6.6%in the solid state.By encapsulating TB-TPE with polystyrene–polyethylene glycol(PS-PEG),watersoluble TB-TPE-PS-PEG nanoparticles(TP NPs)are fabricated,which display polymer encapsulationenhanced emission with a Qy of 46.5%due to the strong restriction effect on the TICT process and the destruction of H aggregation for TB-TPE by the polymer matrix.Au-coated Fe_(3)O_(4)(Fe_(3)O_(4)@Au)nanocrystals were then embedded in the TP NPs to form highly fluorescent TB-TPE-Fe_(3)O_(4)-Au-PS-PEG nanoparticles(TFAP NPs)with a Qy of 39.7%.Our demonstration of successful cellular imaging of TP NPs for Hep-G2 cells and multimodality imaging of TFAP NPs in mouse liver tumors indicates that polymer-encapsulated TB-TPE offers great prospects as a multifunctional fluorescence probe for bioimaging.展开更多
The development of conjugated nanomaterials with high sensitivity and super-amplified quenching effect for the detection of nitrophenol explosives is still a great challenge. Herein, we developed conjugated hollow nan...The development of conjugated nanomaterials with high sensitivity and super-amplified quenching effect for the detection of nitrophenol explosives is still a great challenge. Herein, we developed conjugated hollow nanospheres constructed by using aggregation-induced emission(AIE) active 1,3,5-tris(4-formyl-phenyl)benzene(TFPB). The high emission hollow nanospheres with uniform size and admirable dispersiveness exhibited obvious fluorescence quenching response with the addition of nitrophenol explosives owing to the photoinduced electron transfer(PET) from the hollow nanospheres to nitrophenol explosives. The Stern-Volmer constants of hollow spheres for 2,4,6-trinitrophenol(TNP), 4-nitrophenol(NP) and 2,4-dinitrophenol(DNP) can reach 9.67×10^5, 3.14×10^5 and 4.8×10^4 M-1, respectively. Furthermore, the handy test paper coated with hollow nanospheres was prepared and showed a good response toward TNP solutions and vapor. The study provides a novel strategy to construct AIE-active conjugated hollow nanospheres for efficient nitrophenol explosives sensing.展开更多
Perovskite nanocrystal(PNC)solids are promising materials for optoelectronic applications.Recent studies have shown that exciton diffusion in PNC solids occurs via alternate exciton hopping(EH)and photon recycling(PR)...Perovskite nanocrystal(PNC)solids are promising materials for optoelectronic applications.Recent studies have shown that exciton diffusion in PNC solids occurs via alternate exciton hopping(EH)and photon recycling(PR).The energy disorder induced by the size distribution is a common factor in PNC solids,and the impact of this energy disorder on the exciton diffusion remains unclear.Here,we investigated the exciton diffusion in CsPbBr3 NC solids with a Gaussian size distribution of 11.2±6.8 nm via steady and time-resolved photoluminescence(PL)spectroscopy with multiple detection bands in transmission mode.Our results indicated that exciton diffusion was controlled by a downhill transfer among the different energy sites through the disordered energy landscape,as confirmed by the accompanying low-temperature PL analysis.A detailed examination revealed that the acceptor distribution in tandem with the reabsorption coefficient determined the contribution of EH and PR to exciton transfer between different energy sites.Consequently,the exciton diffusion mechanism varied in PNC solids of different thicknesses:in a thin solid with a thickness of several hundred nanometers,the exciton transfer was dominated by efficient EH and PR from the high-energy sites to the lower-energy sites;in a few-micrometer-thick solid,transfer from the medium-energy sites toward the lower-energy sites also became prominent and occurred mainly through PR.These findings enhance the understanding of the vital role that the acceptor distribution plays in the exciton diffusion process in PNC solids,providing important insights for optoelectronic applications based on PNC solids.Our work also exploits the use of commonly available tools for in-depth exciton diffusion studies,which reveals the interior diffusion information that is usually hidden in surface sensitive PL imaging methods.展开更多
文摘Background: Age is an important prognostic factor for thymoma;however, few studies have specifically focused on age-related survival outcomes in thymoma patients. This study explored the effect of age on the clinicopathological features and survival outcomes of thymoma patients. Methods: We reviewed the clinical data of 1984 chest thymoma patients from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. In accordance with the World Health Organization age brackets, the patients were divided into young (group A, 0 - 44-year-old);middle-aged (group B, 45 - 59-year-old);old (group C, 60 - 74-year-old);and seniors (group D 75 - 84-year-old). Single-factor and multivariate analysis were performed using the Kaplan-Meier method, and a multivariate Cox regression model was generated to assess patient prognosis. Results: In total, 1984 patients were included. The median follow-up time was 156.0 months (range: 0 - 492 months). Group C (60 - 74-year-old) had the most patients (35.1%), and Group D had the fewest patients (12.3%). Among all age groups, the proportion of white people and men with thymoma increased with age, while the proportion of black people and women showed a downward trend. Univariate and multivariate analyses showed that the overall survival rate of thymoma patients was negatively correlated with age. The overall survival times of the four groups were significantly different (p Conclusion: Age is an important prognostic factor for survival in thymoma patients, and younger patients have a survival advantage over older patients.
文摘The authors regret “The SI for the paper which was published as noted above is not the one which the paper refers to, and only theresponse to the Referees appears. Now the correct file has been provided”.
基金financially supported by the National Natural Science Foundation of China(Nos.21835001,51773080,21674041)Program for Changbaishan Scholars of Jilin Provinceby the"Talents Cultivation Program"of Jilin University。
文摘Luminescent conjugated network polymer is one of the most promising chemo-sensors owing to their good chemical/optical stability and multiple functionalization.Herein,three conjugated network polymers were prepared by using aggregation-induced emission active 1,1,2,2-tetrakis(4-formyl-(1,1’-biphenyl))-ethane(TFBE)unit as monomer and hydrazine as linker.Through regulating the synthetical condition,the polyme ric network can form either unifo rm two-dimensional azine-linked nanosheets(ANS),conjugated microporous polymers(A-CMP)or covalent organic frameworks(A-COF).All of these polymers exhibited good stability and high fluorescence quantum efficiency with the quantum yield of6.31%for A-NS,5.26%for A-CMP,and 5.80%for A-COF,as well as fast and selective fluorescence quenching response to 2,4,6-trinitrophenol(TNP).And the best TNP sensing performance with the Stern-Volmer constants(K_(sv))values up to 8×10^(5)L/mol and a detection limit of 0.09μmol/L was obtained for A-NS.The study explores various strategies to construct conjugated polymers with different nanoarchitectures based on the same building block for sensitive detection of explosives.
基金supported by the National Natural Science Foundation of China(nos.21835001,51773080,and 21674041)Program for Changbaishan Scholars of Jilin Province,and the“Talents Cultivation Program”of Jilin University。
文摘Fluorescence probes with strong near-infrared(NIR)emission and water solubility are considered useful visualization tools for localization marking as well as investigating cell migration and transplantation.Here,we designed and synthesized a new donor–π–acceptor(D–π–A)fluorogen,2-(4-[(E)-4-(diphenylamino)styryl]phenyl)-3-(4′-[1,2,2-triphenylvinyl]-[1,1′-biphenyl]-4-yl)fumaronitrile(TB-TPE).TB-TPE exhibits twisted intramolecular charge transfer(TICT)and aggregation-induced emission(AIE)in the NIR region,with an emission peak at 714 nm and a fluorescence quantum yield(Qy)of 6.6%in the solid state.By encapsulating TB-TPE with polystyrene–polyethylene glycol(PS-PEG),watersoluble TB-TPE-PS-PEG nanoparticles(TP NPs)are fabricated,which display polymer encapsulationenhanced emission with a Qy of 46.5%due to the strong restriction effect on the TICT process and the destruction of H aggregation for TB-TPE by the polymer matrix.Au-coated Fe_(3)O_(4)(Fe_(3)O_(4)@Au)nanocrystals were then embedded in the TP NPs to form highly fluorescent TB-TPE-Fe_(3)O_(4)-Au-PS-PEG nanoparticles(TFAP NPs)with a Qy of 39.7%.Our demonstration of successful cellular imaging of TP NPs for Hep-G2 cells and multimodality imaging of TFAP NPs in mouse liver tumors indicates that polymer-encapsulated TB-TPE offers great prospects as a multifunctional fluorescence probe for bioimaging.
基金the National Natural Science Foundation of China(21835001,51773080,21674041,51573068,21221063)Program for Changbaishan Scholars of Jilin Province,Jilin Province Project(20160101305JC)the“Talents Cultivation Program”of Jilin University.
文摘The development of conjugated nanomaterials with high sensitivity and super-amplified quenching effect for the detection of nitrophenol explosives is still a great challenge. Herein, we developed conjugated hollow nanospheres constructed by using aggregation-induced emission(AIE) active 1,3,5-tris(4-formyl-phenyl)benzene(TFPB). The high emission hollow nanospheres with uniform size and admirable dispersiveness exhibited obvious fluorescence quenching response with the addition of nitrophenol explosives owing to the photoinduced electron transfer(PET) from the hollow nanospheres to nitrophenol explosives. The Stern-Volmer constants of hollow spheres for 2,4,6-trinitrophenol(TNP), 4-nitrophenol(NP) and 2,4-dinitrophenol(DNP) can reach 9.67×10^5, 3.14×10^5 and 4.8×10^4 M-1, respectively. Furthermore, the handy test paper coated with hollow nanospheres was prepared and showed a good response toward TNP solutions and vapor. The study provides a novel strategy to construct AIE-active conjugated hollow nanospheres for efficient nitrophenol explosives sensing.
基金financially supported by Shenzhen Fundamental Research Program(JCYJ20200109142425294)the National Natural Science Foundation of China(62034009 and 62104266)the Shenzhen Science and Technology Innovation Program(2022A006)。
文摘Perovskite nanocrystal(PNC)solids are promising materials for optoelectronic applications.Recent studies have shown that exciton diffusion in PNC solids occurs via alternate exciton hopping(EH)and photon recycling(PR).The energy disorder induced by the size distribution is a common factor in PNC solids,and the impact of this energy disorder on the exciton diffusion remains unclear.Here,we investigated the exciton diffusion in CsPbBr3 NC solids with a Gaussian size distribution of 11.2±6.8 nm via steady and time-resolved photoluminescence(PL)spectroscopy with multiple detection bands in transmission mode.Our results indicated that exciton diffusion was controlled by a downhill transfer among the different energy sites through the disordered energy landscape,as confirmed by the accompanying low-temperature PL analysis.A detailed examination revealed that the acceptor distribution in tandem with the reabsorption coefficient determined the contribution of EH and PR to exciton transfer between different energy sites.Consequently,the exciton diffusion mechanism varied in PNC solids of different thicknesses:in a thin solid with a thickness of several hundred nanometers,the exciton transfer was dominated by efficient EH and PR from the high-energy sites to the lower-energy sites;in a few-micrometer-thick solid,transfer from the medium-energy sites toward the lower-energy sites also became prominent and occurred mainly through PR.These findings enhance the understanding of the vital role that the acceptor distribution plays in the exciton diffusion process in PNC solids,providing important insights for optoelectronic applications based on PNC solids.Our work also exploits the use of commonly available tools for in-depth exciton diffusion studies,which reveals the interior diffusion information that is usually hidden in surface sensitive PL imaging methods.
