Bacterial infections cause severe health conditions,resulting in a significant economic burden for the public health system.Although natural phytochemicals are considered promising anti-bacterial agents,they suffer fr...Bacterial infections cause severe health conditions,resulting in a significant economic burden for the public health system.Although natural phytochemicals are considered promising anti-bacterial agents,they suffer from several limitations,such as poor water solubility and low bioavailability in vivo,severely restricting their wide application.Herein,we constructed a near-infrared(NIR)-responsive carrier-free berberine hydrochloride(BH,phytochemicals)/indocyanine green(ICG,photosensitizer)nanoparticles(BI NPs)for synergistic antibacterial of an infected wound.Through electrostatic interaction andπ-πstacking,the hydrophobic BH and amphiphilic ICG are initially self-assembled to generate carrier-free nanoparticles.The obtained BI NPs demonstrated NIR-responsive drug release behavior and better photothermal conversion efficiency of up to 36%.In addition,BI NPs stimulated by NIR laser exhibited remarkable antibacterial activity,which realized the synergistic antibacterial treatment and promoted infected wound healing.In summary,the current research results provided a candidate strategy for self-assembling new BI NPs to treat bacterial infections synergistically.展开更多
基金supported by the National Key Research&Development Program of China(2019YFE0113600)the National Natural Science Foundation of China(NSFC 81971734,32071323,32271410)+1 种基金the Science and Technology Projects in Fujian Province(2022FX1,2023Y4008)the Program for Innovative Research Team in Science,Scientific Research Funds of Huaqiao University(21BS113)is gratefully acknowledged.
文摘Bacterial infections cause severe health conditions,resulting in a significant economic burden for the public health system.Although natural phytochemicals are considered promising anti-bacterial agents,they suffer from several limitations,such as poor water solubility and low bioavailability in vivo,severely restricting their wide application.Herein,we constructed a near-infrared(NIR)-responsive carrier-free berberine hydrochloride(BH,phytochemicals)/indocyanine green(ICG,photosensitizer)nanoparticles(BI NPs)for synergistic antibacterial of an infected wound.Through electrostatic interaction andπ-πstacking,the hydrophobic BH and amphiphilic ICG are initially self-assembled to generate carrier-free nanoparticles.The obtained BI NPs demonstrated NIR-responsive drug release behavior and better photothermal conversion efficiency of up to 36%.In addition,BI NPs stimulated by NIR laser exhibited remarkable antibacterial activity,which realized the synergistic antibacterial treatment and promoted infected wound healing.In summary,the current research results provided a candidate strategy for self-assembling new BI NPs to treat bacterial infections synergistically.
