To the Editor:As population aging accelerates,osteoarthritis(OA)has emerged as a major cause of disability among the elderly,significantly increasing the social burden.[1]OA is recognized as a chronic,progressive join...To the Editor:As population aging accelerates,osteoarthritis(OA)has emerged as a major cause of disability among the elderly,significantly increasing the social burden.[1]OA is recognized as a chronic,progressive joint disease resulting from the wear and tear of articular cartilage.This degeneration can lead to histological and structural changes in the joints,ultimately causing comprehensive impairment of joint function.[2]OA features a complex pathological mechanism,making a thorough understanding of its pathogenesis or key signaling pathway molecules essential for effective treatment.展开更多
The aging population has led to a global issue of osteoarthritis(OA),which not only impacts the quality of life for patients but also poses a significant economic burden on society.While biotherapy offers hope for OA ...The aging population has led to a global issue of osteoarthritis(OA),which not only impacts the quality of life for patients but also poses a significant economic burden on society.While biotherapy offers hope for OA treatment,currently available treatments are unable to delay or prevent the onset or progression of OA.Recent studies have shown that as nanoscale bioactive substances that mediate cell communication,exosomes from stem cell sources have led to some breakthroughs in the treatment of OA and have important clinical significance.This paper summarizes the mechanism and function of stem cell exosomes in delaying OA and looks forward to the development prospects and challenges of exosomes.展开更多
基金National Natural Science Funder of China(No.82302758)China Postdoctoral Science Foundation(No.2023M731419)+1 种基金Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2022ZB896)Yangzhou Key Laboratory of Orthopedics(No.YZ2023249)
文摘To the Editor:As population aging accelerates,osteoarthritis(OA)has emerged as a major cause of disability among the elderly,significantly increasing the social burden.[1]OA is recognized as a chronic,progressive joint disease resulting from the wear and tear of articular cartilage.This degeneration can lead to histological and structural changes in the joints,ultimately causing comprehensive impairment of joint function.[2]OA features a complex pathological mechanism,making a thorough understanding of its pathogenesis or key signaling pathway molecules essential for effective treatment.
基金supported by the National Natural Science Foun-dation of China(Grant No.82302758)China Postdoctoral Science Foundation(Grant No.2023M731419)+1 种基金the Jiangsu Funding Pr ogr am for Excellent Postdoctoral Talent(Grant No.2022ZB896)the Yangzhou Key Laboratory of Orthopedics(Grant No.YZ2023249).
文摘The aging population has led to a global issue of osteoarthritis(OA),which not only impacts the quality of life for patients but also poses a significant economic burden on society.While biotherapy offers hope for OA treatment,currently available treatments are unable to delay or prevent the onset or progression of OA.Recent studies have shown that as nanoscale bioactive substances that mediate cell communication,exosomes from stem cell sources have led to some breakthroughs in the treatment of OA and have important clinical significance.This paper summarizes the mechanism and function of stem cell exosomes in delaying OA and looks forward to the development prospects and challenges of exosomes.
