Main text Cerebral small vessel disease(CSVD)is a prevalent cer-ebrovascular disease characterized by chronic vascular dysfunction[1],primarily diagnosed using MRI-based markers such as white matter hyperintensities(W...Main text Cerebral small vessel disease(CSVD)is a prevalent cer-ebrovascular disease characterized by chronic vascular dysfunction[1],primarily diagnosed using MRI-based markers such as white matter hyperintensities(WMHs),cerebral microbleeds,perivascular spaces,and lacunes[2].CSVD also involves blood-brain barrier(BBB)dis-ruption,evident with an elevated cerebrospinal fluid(CSF)/serum albumin ratio(also called Albumin Quo-tient,QAlb)[3].Despite these markers reflecting dif-ferent aspects of cerebrovascular disease,its underlying causes are not fully understood.Interestingly,CSVD often coincides with Alzheimer’s disease(AD)pathol-ogy[4].展开更多
基金supported by the National Key Plan for Scientific Research and Development of China(2020YFA0509304 and 2021YFA0805300)the Chinese Academy of Sciences(XDB39000000)+3 种基金the National Natural Science Foundation of China(82030034,32121002,and 81971123)CAMS Innovation Fund for Medical Sciences(2021-I2M-C&T-B-012)the Fundamental Research Funds for the Central Universities(YD9110002027)the Guangzhou Key Research Program on Brain Science(202007030008)。
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)the Fundamental Research Funds for the Central Universities(YD9100002033)+1 种基金the Hefei Comprehensive National Science Center Hefei Brain Projectthe Natural Science Foundation of Anhui Province(2308085QH265)。
基金supported by the National Key Plan for Scientific Research and Development of China(2020YFA0509304 and 2021YFA0805300)the Chinese Academy of Sciences(XDB39000000)+2 种基金the National Natural Sciences Foundation of China(82371418,82030034 and U23A20422)the Fundamental Research Funds for the Central Universities(YD9110002027 and WK9100000057)Postdoctoral Science Foundation of Anhui Province(2023B723).
文摘Main text Cerebral small vessel disease(CSVD)is a prevalent cer-ebrovascular disease characterized by chronic vascular dysfunction[1],primarily diagnosed using MRI-based markers such as white matter hyperintensities(WMHs),cerebral microbleeds,perivascular spaces,and lacunes[2].CSVD also involves blood-brain barrier(BBB)dis-ruption,evident with an elevated cerebrospinal fluid(CSF)/serum albumin ratio(also called Albumin Quo-tient,QAlb)[3].Despite these markers reflecting dif-ferent aspects of cerebrovascular disease,its underlying causes are not fully understood.Interestingly,CSVD often coincides with Alzheimer’s disease(AD)pathol-ogy[4].
