Using the meteorological data of 50 stations in Jilin Province from 1961 to 2016, the demographic and economic data, and geographical information of all counties and cities aims to conduct the risk zoning of cold wave...Using the meteorological data of 50 stations in Jilin Province from 1961 to 2016, the demographic and economic data, and geographical information of all counties and cities aims to conduct the risk zoning of cold wave disasters in Jilin Province. The results show that, since 1961, the average number of cold wave occurrences per year in Jilin Province is 8.3 days, of which the highest number of occurrences occurred in February, followed by December and January, and the spring cold wave occurred mostly in March. From the map of cold-sea disaster risk zoning in Jilin Province, due to factors such as topography and land use distribution, the west and east of Jilin Province have a certain resilience to the disasters caused by cold waves, and the risk of disasters is low. The distribution of agricultural facilities and large areas of farmland in the central region are extremely sensitive to cold wave disasters and have a high risk of disasters. Areas with high risk of cold wave are mainly concentrated in Siping City, Changchun City, Liaoyuan City, Jilin City, northern Tonghua City and most of Baishan City. Areas with low cold wave risk are mainly concentrated in most of Baicheng City, most of Songyuan City and Yanbian Prefecture. And other places are moderately risky areas of cold waves.展开更多
To assess the efficacy and safety of L-oxiracetam,a novel nootropic agent,in improving cognition in patients with TBI,we performed a multicentre,double-blind,randomized controlled trial in China.Participants aged 18 t...To assess the efficacy and safety of L-oxiracetam,a novel nootropic agent,in improving cognition in patients with TBI,we performed a multicentre,double-blind,randomized controlled trial in China.Participants aged 18 to 75 years with TBI(Glasgow Coma Scale score of 10 to 15)were recruited from 51 hospitals from 2019 to 2024.Patients were randomly assigned to Loxiracetam,4 g/day,oxiracetam 6 g/day,or placebo in 2:2:1.The primary outcome was the change in the Loewenstein Occupational Therapy Cognitive Assessment(LOTCA)score from baseline to 90 days post treatment.Secondary outcomes included changes in additional cognitive evaluations,neurological function,activities of daily living(ADL),and adverse events(AEs).The trial was approved by the China National Medical Products Administration(2016L03521),and registered at Clinicaltrials.gov(NCT04205565)and Chinadrugtrials.org.cn(CTR20192539).Five hundred and ninety patients were included(mean age(SD),50.9(14.5);421 males).The least squares(LS)mean of LOTCA change from baseline to 90 days post treatment was 20.45(95%confidence interval[CI]17.23,23.66)in the L-oxiracetam group,15.90(95%CI 12.71,19.10)in the oxiracetam group,and 11.47(95%CI 7.75,15.20)in the placebo group(P value<0.05 for all groups).The LS mean difference of the L-oxiracetam was significantly higher than the placebo group(8.97,95%CI 5.69,12.26;P<0.001;Cohen’s d=0.48[95%CI:0.26,0.69])and the oxiracetam group(4.54,95%CI 1.85,7.23).Secondary efficacy outcomes did not differ between the L-oxiracetam and oxiracetam groups.The proportion of serious AEs did not differ among the three groups.L-oxiracetam could improve cognitive function in patients with mild-to-moderate TBI.L-oxiracetam might be more efficacious than oxiracetam.No significant safety concerns were reported.Despite limitations such as loss to followup,the findings of this study provide important evidence for the clinical management of cognitive dysfunction following TBI.Future studies in real-world clinical settings are warranted to further substantiate the efficacy of L-oxiracetam and oxiracetam.展开更多
文摘Using the meteorological data of 50 stations in Jilin Province from 1961 to 2016, the demographic and economic data, and geographical information of all counties and cities aims to conduct the risk zoning of cold wave disasters in Jilin Province. The results show that, since 1961, the average number of cold wave occurrences per year in Jilin Province is 8.3 days, of which the highest number of occurrences occurred in February, followed by December and January, and the spring cold wave occurred mostly in March. From the map of cold-sea disaster risk zoning in Jilin Province, due to factors such as topography and land use distribution, the west and east of Jilin Province have a certain resilience to the disasters caused by cold waves, and the risk of disasters is low. The distribution of agricultural facilities and large areas of farmland in the central region are extremely sensitive to cold wave disasters and have a high risk of disasters. Areas with high risk of cold wave are mainly concentrated in Siping City, Changchun City, Liaoyuan City, Jilin City, northern Tonghua City and most of Baishan City. Areas with low cold wave risk are mainly concentrated in most of Baicheng City, most of Songyuan City and Yanbian Prefecture. And other places are moderately risky areas of cold waves.
文摘To assess the efficacy and safety of L-oxiracetam,a novel nootropic agent,in improving cognition in patients with TBI,we performed a multicentre,double-blind,randomized controlled trial in China.Participants aged 18 to 75 years with TBI(Glasgow Coma Scale score of 10 to 15)were recruited from 51 hospitals from 2019 to 2024.Patients were randomly assigned to Loxiracetam,4 g/day,oxiracetam 6 g/day,or placebo in 2:2:1.The primary outcome was the change in the Loewenstein Occupational Therapy Cognitive Assessment(LOTCA)score from baseline to 90 days post treatment.Secondary outcomes included changes in additional cognitive evaluations,neurological function,activities of daily living(ADL),and adverse events(AEs).The trial was approved by the China National Medical Products Administration(2016L03521),and registered at Clinicaltrials.gov(NCT04205565)and Chinadrugtrials.org.cn(CTR20192539).Five hundred and ninety patients were included(mean age(SD),50.9(14.5);421 males).The least squares(LS)mean of LOTCA change from baseline to 90 days post treatment was 20.45(95%confidence interval[CI]17.23,23.66)in the L-oxiracetam group,15.90(95%CI 12.71,19.10)in the oxiracetam group,and 11.47(95%CI 7.75,15.20)in the placebo group(P value<0.05 for all groups).The LS mean difference of the L-oxiracetam was significantly higher than the placebo group(8.97,95%CI 5.69,12.26;P<0.001;Cohen’s d=0.48[95%CI:0.26,0.69])and the oxiracetam group(4.54,95%CI 1.85,7.23).Secondary efficacy outcomes did not differ between the L-oxiracetam and oxiracetam groups.The proportion of serious AEs did not differ among the three groups.L-oxiracetam could improve cognitive function in patients with mild-to-moderate TBI.L-oxiracetam might be more efficacious than oxiracetam.No significant safety concerns were reported.Despite limitations such as loss to followup,the findings of this study provide important evidence for the clinical management of cognitive dysfunction following TBI.Future studies in real-world clinical settings are warranted to further substantiate the efficacy of L-oxiracetam and oxiracetam.
