Background:Physical inactivity among adolescents has become a global public health challenge,with over 80%failing to meet the recommendations of the WHO for activity levels.Existing research predominantly examines how...Background:Physical inactivity among adolescents has become a global public health challenge,with over 80%failing to meet the recommendations of the WHO for activity levels.Existing research predominantly examines how physical activity(PA)enhances resilience,while the predictive role of resilience in PA,particularly its interaction with family factors,has received limited attention.This study aimed to examine the associations between resilience and PA among adolescents,focusing on family functioning and gender differences.Methods:In this cross-sectional study,a total of 909 Chinese adolescents(463 males and 446 females,aged 13.30.5 years)completed the±following validated self-report instruments:the Connor-Davidson Resilience Scale with 10 items,the Physical Activity Questionnaire for Older Children,and the Family Adaptability and Cohesion Evaluation Scale II-Chinese version that was used to categorize family functioning into three types(i.e.,lower,balanced,and higher).The generalized linear mixed-effect model(GLMM)was used to determine the contribution of resilience and its interaction with family functioning type on PA after adjusting for age and gender.Results:Males presented significantly higher resilience and PA levels(both p 0.001)as well as better family functioning(p 0.01)than females.Compared with the lower<<functioning group,participants from higher-functioning families showed superior resilience and PA(both p 0.001).<The GLMM analysis revealed a positive relationship between resilience and PA(p 0.001),where the lower functioning<group was significantly weaker than the higher functioning group.Conclusion:Resilience and PA in adolescents vary across gender and family functioning type,with males and adolescents from better-functioning families outperforming their peers.Resilience is a positive predictor of PA in adolescents,with family functioning type being a crucial moderator of such a relationship.展开更多
AIM:To elucidate the distinctive pathobiological behavior between signet ring cell carcinoma (SRC) and mucinous adenocarcinoma of the stomach.METHODS: Based on the histological growth patterns and cell-functional diff...AIM:To elucidate the distinctive pathobiological behavior between signet ring cell carcinoma (SRC) and mucinous adenocarcinoma of the stomach.METHODS: Based on the histological growth patterns and cell-functional differentiation classifications of stomach carcinoma, we conducted a series of comparative studies.All paraffin-embedded and frozen blocks were collected from the files of Cancer Institute of China Medical University. On the basis of histopathological observation, we applied enzymatic and mucous histochemistry, immunohistochemistry,flow cytometry (FCM) and molecular biology to compare these two categories of gastric cancers in terms of the DNA ploidy, proliferative kinetics, the expression of gastric carcinoma associated gene product and instabilities of mitochondrial DNA (mtDNA).RESULTS:Gastric SRC was commonly seen in females below 45 years, mostly presenting diffuse growth and ovary or uterine cervix metastasis. The majority of SRC were absorptive and mucus-producing functional differentiation type (AMPFDT), which growth relied on estrogen. Meanwhile,stomach mucinous adenocarcinomas were mostly observed in males over 50 years, prone to massive growth or nest growth and extensive peritoneal infiltration, showing two categories of cell-functional differentiation types: AMPFDT and mucus-secreting functional differentiation type (MSFDT).Expressions of ER, enzyme c-PDE and 67kDaLN-R in SRC were evidently higher than that in mucinous adenocarcinoma,while expressions of LN, CN-Ⅳ, CD44v6, and PTEN protein were obviously lower in SRC than that in mucinous adenocarcinoma (P<0.05).There was no statistic significance in VEGF, ECD and instabilities of mtDNA (P>0.05) between the above two gastric carcinomas.CONCLUSION: Though SRC and mucinous adenocarcinoma were both characterized by abundant mucus-secretion, they were quite different in morphology, ultrastructure, cell-functional differentiation and protein expression, indicating different mechanisms of carcinogenesis. We concluded that combining histological growth patterns, cell-functional differentiation type with tumor related markers might be significant in early diagnosis and prognosis assessment for SRC and mucinous adenocarcinoma of the stomach.展开更多
BACKGROUND： Resuscitation after cardiac arrest （CA） with a whole-body ischemia–reperfusion injury causes brain injury and multiple organ dysfunction （MODS）. This study aimed to determine whether mild systemic hy...BACKGROUND： Resuscitation after cardiac arrest （CA） with a whole-body ischemia–reperfusion injury causes brain injury and multiple organ dysfunction （MODS）. This study aimed to determine whether mild systemic hypothermia could decrease multiple organ dysfunctions after resuscitation from cardiac arrest.METHODS： The patients who had been resuscitated after cardiac arrest were reviewed. During the resuscitation they had been assigned to undergo therapeutic hypothermia （target temperature, 32°C to 34°C, measured in the rectum） over a period of 24 to 36 hours or to receive standard treatment with normothermia. Markers of different organ injury were evaluated for the ？ rst 72 hours after recovery of spontaneous circulation （ROSC）.RESULTS： At 72 hours after ROSC, 23 patients in the hypothermia group for whom data were available had favorable neurologic, myocardial, hepatic and pulmonic outcomes as compared with 26 patients in the normothermia group. The values of renal function were not signi？ cantly different between the two groups. However, blood coagulation function was badly injured in the hypothermia group.CONCLUSION： In the patients who have been successfully resuscitated after cardiac arrest, therapeutic mild hypothermia can alleviate dysfunction after resuscitation from cardiac arrest.展开更多
AIM: To investigate the characteristics of the progression of islet β cell function in Chinese latent autoimmune diabetes in adult (LADA) patients with glutamic acid decarboxylase antibody (GAD-Ab) positivity, and to...AIM: To investigate the characteristics of the progression of islet β cell function in Chinese latent autoimmune diabetes in adult (LADA) patients with glutamic acid decarboxylase antibody (GAD-Ab) positivity, and to explore the prognostic factors for β cell function. METHODS: Forty-five LADA patients with GAD-Ab positivity screened from phenotypic type 2 diabetic (T2DM) patients and 45 T2DM patients without GAD-Ab matched as controls were followed-up every 6 mo. Sixteen patients in LADA1 and T2DM1 groups respectively have been followed-up for 6 years, while 29 patients in LADA2 and T2DM2 groups respectively for only 1.5 years. GAD-Ab was determined by radioligand assay, and C-peptides (CP) by radioimmune assay.RESULTS: The percentage of patients whose fasting CP(FCP) decreased more than 50% compared with thebaseline reached to 25.0% at 1.5th year in LADA1 group, and FCP level decreased (395.8±71.5 vs 572.8±72.3 pmol/L, P＜0.05) at 2.5th year and continuously went down to the end of follow-up. No significant changes of the above parameters were found in T2DM1 group. The average decreased percentages of FCP per year in LADA and T2DM patients were 15.8% (4.0-91.0%) and 5.2% (-3.5 to 35.5%, P= 0.000) respectively. The index of GAD-Ab was negatively correlated with the FCP in LADA patients (rs= -0.483, P = 0.000). The decreased percentage of FCP per year in LADA patients were correlated with GAD-Ab index, body mass index (BMI) and age at onset (rs = 0.408, -0.301 and -0.523 respectively, P＜0.05). Moreover, GAD-Ab wasthe only risk factor for predicting βcell failure in LADA patients (B = 1.455, EXP (B) = 4.283, P = 0.023). CONCLUSION: The decreasing rate of islet β cell function in LADA, being highly heterogeneous, is three times that of T2DM patients. The titer of GAD-Ab is an important predictor for the progression of islet β cell function, and age at onset and BMI could also act as the predictors.展开更多
Sinenxan A [2α, 5α, 10β, 14β-tetraacetoxytaxa-4(20), 11-diene, 1] was biotransformed by a filamentous fungus, Aspergillus niger JCM 5546, and an unusual taxatetraene [2α, 5α-acetoxytaxa-4(20), 10(11), 12(18), 13...Sinenxan A [2α, 5α, 10β, 14β-tetraacetoxytaxa-4(20), 11-diene, 1] was biotransformed by a filamentous fungus, Aspergillus niger JCM 5546, and an unusual taxatetraene [2α, 5α-acetoxytaxa-4(20), 10(11), 12(18), 13(14)-tetraene, 2], together with two known products, 10β-deacetyl sinenxan A (3) and 10β, 14β-dideacetyl sinenxan A (4) were produced.展开更多
In this paper, the effect of ionic liquids on the CaCO3 crystal growth has been studied for the first time. The obtained CaCO3 crystals were charactered by the X-ray diffraction and scanning electron micrographs. The ...In this paper, the effect of ionic liquids on the CaCO3 crystal growth has been studied for the first time. The obtained CaCO3 crystals were charactered by the X-ray diffraction and scanning electron micrographs. The results showed that the control ability of ionic liquids for CaCO3 crystals growth was dependent on the counter anion very much.展开更多
基金supported by the National Social Science Fund of China(Grant No.22BTY098)with JJY as Principal Investigator.
文摘Background:Physical inactivity among adolescents has become a global public health challenge,with over 80%failing to meet the recommendations of the WHO for activity levels.Existing research predominantly examines how physical activity(PA)enhances resilience,while the predictive role of resilience in PA,particularly its interaction with family factors,has received limited attention.This study aimed to examine the associations between resilience and PA among adolescents,focusing on family functioning and gender differences.Methods:In this cross-sectional study,a total of 909 Chinese adolescents(463 males and 446 females,aged 13.30.5 years)completed the±following validated self-report instruments:the Connor-Davidson Resilience Scale with 10 items,the Physical Activity Questionnaire for Older Children,and the Family Adaptability and Cohesion Evaluation Scale II-Chinese version that was used to categorize family functioning into three types(i.e.,lower,balanced,and higher).The generalized linear mixed-effect model(GLMM)was used to determine the contribution of resilience and its interaction with family functioning type on PA after adjusting for age and gender.Results:Males presented significantly higher resilience and PA levels(both p 0.001)as well as better family functioning(p 0.01)than females.Compared with the lower<<functioning group,participants from higher-functioning families showed superior resilience and PA(both p 0.001).<The GLMM analysis revealed a positive relationship between resilience and PA(p 0.001),where the lower functioning<group was significantly weaker than the higher functioning group.Conclusion:Resilience and PA in adolescents vary across gender and family functioning type,with males and adolescents from better-functioning families outperforming their peers.Resilience is a positive predictor of PA in adolescents,with family functioning type being a crucial moderator of such a relationship.
基金Supported by the National Natural Science Foundation of China,No.30070845 and No.30371607
文摘AIM:To elucidate the distinctive pathobiological behavior between signet ring cell carcinoma (SRC) and mucinous adenocarcinoma of the stomach.METHODS: Based on the histological growth patterns and cell-functional differentiation classifications of stomach carcinoma, we conducted a series of comparative studies.All paraffin-embedded and frozen blocks were collected from the files of Cancer Institute of China Medical University. On the basis of histopathological observation, we applied enzymatic and mucous histochemistry, immunohistochemistry,flow cytometry (FCM) and molecular biology to compare these two categories of gastric cancers in terms of the DNA ploidy, proliferative kinetics, the expression of gastric carcinoma associated gene product and instabilities of mitochondrial DNA (mtDNA).RESULTS:Gastric SRC was commonly seen in females below 45 years, mostly presenting diffuse growth and ovary or uterine cervix metastasis. The majority of SRC were absorptive and mucus-producing functional differentiation type (AMPFDT), which growth relied on estrogen. Meanwhile,stomach mucinous adenocarcinomas were mostly observed in males over 50 years, prone to massive growth or nest growth and extensive peritoneal infiltration, showing two categories of cell-functional differentiation types: AMPFDT and mucus-secreting functional differentiation type (MSFDT).Expressions of ER, enzyme c-PDE and 67kDaLN-R in SRC were evidently higher than that in mucinous adenocarcinoma,while expressions of LN, CN-Ⅳ, CD44v6, and PTEN protein were obviously lower in SRC than that in mucinous adenocarcinoma (P<0.05).There was no statistic significance in VEGF, ECD and instabilities of mtDNA (P>0.05) between the above two gastric carcinomas.CONCLUSION: Though SRC and mucinous adenocarcinoma were both characterized by abundant mucus-secretion, they were quite different in morphology, ultrastructure, cell-functional differentiation and protein expression, indicating different mechanisms of carcinogenesis. We concluded that combining histological growth patterns, cell-functional differentiation type with tumor related markers might be significant in early diagnosis and prognosis assessment for SRC and mucinous adenocarcinoma of the stomach.
文摘BACKGROUND： Resuscitation after cardiac arrest （CA） with a whole-body ischemia–reperfusion injury causes brain injury and multiple organ dysfunction （MODS）. This study aimed to determine whether mild systemic hypothermia could decrease multiple organ dysfunctions after resuscitation from cardiac arrest.METHODS： The patients who had been resuscitated after cardiac arrest were reviewed. During the resuscitation they had been assigned to undergo therapeutic hypothermia （target temperature, 32°C to 34°C, measured in the rectum） over a period of 24 to 36 hours or to receive standard treatment with normothermia. Markers of different organ injury were evaluated for the ？ rst 72 hours after recovery of spontaneous circulation （ROSC）.RESULTS： At 72 hours after ROSC, 23 patients in the hypothermia group for whom data were available had favorable neurologic, myocardial, hepatic and pulmonic outcomes as compared with 26 patients in the normothermia group. The values of renal function were not signi？ cantly different between the two groups. However, blood coagulation function was badly injured in the hypothermia group.CONCLUSION： In the patients who have been successfully resuscitated after cardiac arrest, therapeutic mild hypothermia can alleviate dysfunction after resuscitation from cardiac arrest.
基金Supported by the National Natural Science Foundation of China,No. 39370343 the National Ministry of Health Youth Talents Foundation, No. Q9420 the Hunan Health Bureau Key Scientific Funds, No. 9736, 2001-Z04
文摘AIM: To investigate the characteristics of the progression of islet β cell function in Chinese latent autoimmune diabetes in adult (LADA) patients with glutamic acid decarboxylase antibody (GAD-Ab) positivity, and to explore the prognostic factors for β cell function. METHODS: Forty-five LADA patients with GAD-Ab positivity screened from phenotypic type 2 diabetic (T2DM) patients and 45 T2DM patients without GAD-Ab matched as controls were followed-up every 6 mo. Sixteen patients in LADA1 and T2DM1 groups respectively have been followed-up for 6 years, while 29 patients in LADA2 and T2DM2 groups respectively for only 1.5 years. GAD-Ab was determined by radioligand assay, and C-peptides (CP) by radioimmune assay.RESULTS: The percentage of patients whose fasting CP(FCP) decreased more than 50% compared with thebaseline reached to 25.0% at 1.5th year in LADA1 group, and FCP level decreased (395.8±71.5 vs 572.8±72.3 pmol/L, P＜0.05) at 2.5th year and continuously went down to the end of follow-up. No significant changes of the above parameters were found in T2DM1 group. The average decreased percentages of FCP per year in LADA and T2DM patients were 15.8% (4.0-91.0%) and 5.2% (-3.5 to 35.5%, P= 0.000) respectively. The index of GAD-Ab was negatively correlated with the FCP in LADA patients (rs= -0.483, P = 0.000). The decreased percentage of FCP per year in LADA patients were correlated with GAD-Ab index, body mass index (BMI) and age at onset (rs = 0.408, -0.301 and -0.523 respectively, P＜0.05). Moreover, GAD-Ab wasthe only risk factor for predicting βcell failure in LADA patients (B = 1.455, EXP (B) = 4.283, P = 0.023). CONCLUSION: The decreasing rate of islet β cell function in LADA, being highly heterogeneous, is three times that of T2DM patients. The titer of GAD-Ab is an important predictor for the progression of islet β cell function, and age at onset and BMI could also act as the predictors.
基金supported by the National Natural Science Foundation of China(Project No.30100230)the Japan Society for the Promotion of Science(Project No.1300127).
文摘Sinenxan A [2α, 5α, 10β, 14β-tetraacetoxytaxa-4(20), 11-diene, 1] was biotransformed by a filamentous fungus, Aspergillus niger JCM 5546, and an unusual taxatetraene [2α, 5α-acetoxytaxa-4(20), 10(11), 12(18), 13(14)-tetraene, 2], together with two known products, 10β-deacetyl sinenxan A (3) and 10β, 14β-dideacetyl sinenxan A (4) were produced.
文摘In this paper, the effect of ionic liquids on the CaCO3 crystal growth has been studied for the first time. The obtained CaCO3 crystals were charactered by the X-ray diffraction and scanning electron micrographs. The results showed that the control ability of ionic liquids for CaCO3 crystals growth was dependent on the counter anion very much.
