Large numbers of microbes can be present in seminal fluid,and there are differences in the semen microbiota between normal and abnormal semen samples.To evaluate the semen microbiota in patients with leukocytospermia,...Large numbers of microbes can be present in seminal fluid,and there are differences in the semen microbiota between normal and abnormal semen samples.To evaluate the semen microbiota in patients with leukocytospermia,87 seminal fluid samples,including 33 samples with a normal seminal leukocyte count and 54 samples with leukocytospermia,were obtained for a cross-sectional analysis.Twenty samples with a normal seminal leukocyte count had normal sperm parameters(Control group),and 13 samples with a normal seminal leukocyte count were from asthenozoospermia patients(Ast group).However,32 samples with leukocytospermia were from asthenozoospermia patients(LA group),and only 22 samples with leukocytospermia had normal sperm parameters(Leu group).The 16S ribosomal RNA(rRNA)gene sequencing method was used to sequence the microbiota in the seminal fluid,and multiple bioinformatics methods were utilized to analyze the data.Finally,the results showed that the worse sperm parameters were observed in the leukocytospermia-related groups.Semen microbiota analysis found that there was increased alpha diversity in the leukocytospermia-related groups.Firmicutes,Proteobacteria,Actinobacteria,and Bacteroidetes were the primary phyla in the seminal fluid.Two microbiota profiles,namely,Lactobacillus-enriched and Streptococcus-enriched groups,were identified in this study.The majority of the samples in the groups with a normal seminal leukocyte count could be categorized as Lactobacillus-enriched,whereas the majority of the leukocytospermia samples could be categorized as Streptococcus-enriched.Our study indicated that males with leukocytospermia have worse sperm parameters and a different semen microbiota composition compared to males with a normal seminal leukocyte count.展开更多
Heavy electron-doped FeSe-derived materials have attracted attention due to their uncommon electronic structures with only‘electron pockets’,and they are different from other iron-based superconductors.Here,we repor...Heavy electron-doped FeSe-derived materials have attracted attention due to their uncommon electronic structures with only‘electron pockets’,and they are different from other iron-based superconductors.Here,we report the crystal structures,superconductivities and normal state properties of two new Li-doped FeSe-based materials,i.e.,Li_(0.15)(C_(3)H_(10)N_(2))_(0.32)FeSe(P-4)and Li_(x)(C_(3)H_(10)N_(2))_(0.32)FeSe(P4/nmm,0.25<x<0.4)with superconducting transition temperatures ranging from 40 K to 46 K.The determined crystal structures reveal a coupling between Li concentration and the orientation of 1,3-diaminopropane molecules within the largely expanded FeSe layers.Superconducting fluctuations appear in the resistivity of the two superconductors and are fitted in terms of the quasi two-dimensional(2 D)Lawrence–Doniach model.The existence of a crossing point and scaling behavior in the T-dependence of diamagnetic response also suggests that the two superconductors belong to the quasi-2 D system.Interestingly,with the increase of temperature,a sign of Hall coefficient(R_(H))reversing from negative to positive is observed at~185 K in both phases,suggesting that‘hole pockets’emerge in these electron-doped FeSe materials.First principle calculations indicate that the increase in FeSe layer distance will lift up a‘hole band’associated with d_(x^(2)-y^(2)) character and increase the hole carriers.Our findings suggest that the increase in two dimensionalities may lead to the sign-reversal Hall resistivity in Li_(x)(C_(3)H_(10)N_(2))_(0.32)FeSe at high temperature.展开更多
Highly regioregular, head-to-tail coupled poly（3-octylesterthiophene） was synthesized by the Pd-catalysed oxidative C--H/C--H coupling polycondensation. The regioregularity of polymer products was confirmed by the 1...Highly regioregular, head-to-tail coupled poly（3-octylesterthiophene） was synthesized by the Pd-catalysed oxidative C--H/C--H coupling polycondensation. The regioregularity of polymer products was confirmed by the 1H-NMR technique. Furthermore, the effects of various reaction factors including polymerization temperature, solvents and catalysts etc. on the yield, molecular weight and structural regioregularity of the resultant polymers were systematically studied. The optical, electrochemical and crystallization properties of the resultant P3OET with different HT regioregularities in solution and film state were studied by UV-Vis and fluorescent spectroscopy, cyclic voltammetry and X-ray diffraction （XRD）, resepectively.展开更多
基金Science and technology innovation fund of Nanjing Forestry University(163040002)Huaian science and technology support program(industry)project(HAG2013024)~~
基金Science and technology innovation fund of Nanjing Forestry University(163040002)Huaian science and technology support program(industry)project(HAG2013024)~~
基金supported by Youth Foundation of National Natural Science Foundation of China(No.81703963 and No.81202807)the Natural Science Foundation of Hunan(No.2018JJ2667 and No.2019JJ40511)the Scientific Research Project of Chinese Traditional Medicine Administration Bureau in Hunan Province(No.201806).
文摘Large numbers of microbes can be present in seminal fluid,and there are differences in the semen microbiota between normal and abnormal semen samples.To evaluate the semen microbiota in patients with leukocytospermia,87 seminal fluid samples,including 33 samples with a normal seminal leukocyte count and 54 samples with leukocytospermia,were obtained for a cross-sectional analysis.Twenty samples with a normal seminal leukocyte count had normal sperm parameters(Control group),and 13 samples with a normal seminal leukocyte count were from asthenozoospermia patients(Ast group).However,32 samples with leukocytospermia were from asthenozoospermia patients(LA group),and only 22 samples with leukocytospermia had normal sperm parameters(Leu group).The 16S ribosomal RNA(rRNA)gene sequencing method was used to sequence the microbiota in the seminal fluid,and multiple bioinformatics methods were utilized to analyze the data.Finally,the results showed that the worse sperm parameters were observed in the leukocytospermia-related groups.Semen microbiota analysis found that there was increased alpha diversity in the leukocytospermia-related groups.Firmicutes,Proteobacteria,Actinobacteria,and Bacteroidetes were the primary phyla in the seminal fluid.Two microbiota profiles,namely,Lactobacillus-enriched and Streptococcus-enriched groups,were identified in this study.The majority of the samples in the groups with a normal seminal leukocyte count could be categorized as Lactobacillus-enriched,whereas the majority of the leukocytospermia samples could be categorized as Streptococcus-enriched.Our study indicated that males with leukocytospermia have worse sperm parameters and a different semen microbiota composition compared to males with a normal seminal leukocyte count.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51472266,51532010,91422303,and 51772323)the National Key Research and Development Program of China(Grant No.2016YFA0300301)the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(Grant No.QYZDJ-SSW-SLH013)
文摘Heavy electron-doped FeSe-derived materials have attracted attention due to their uncommon electronic structures with only‘electron pockets’,and they are different from other iron-based superconductors.Here,we report the crystal structures,superconductivities and normal state properties of two new Li-doped FeSe-based materials,i.e.,Li_(0.15)(C_(3)H_(10)N_(2))_(0.32)FeSe(P-4)and Li_(x)(C_(3)H_(10)N_(2))_(0.32)FeSe(P4/nmm,0.25<x<0.4)with superconducting transition temperatures ranging from 40 K to 46 K.The determined crystal structures reveal a coupling between Li concentration and the orientation of 1,3-diaminopropane molecules within the largely expanded FeSe layers.Superconducting fluctuations appear in the resistivity of the two superconductors and are fitted in terms of the quasi two-dimensional(2 D)Lawrence–Doniach model.The existence of a crossing point and scaling behavior in the T-dependence of diamagnetic response also suggests that the two superconductors belong to the quasi-2 D system.Interestingly,with the increase of temperature,a sign of Hall coefficient(R_(H))reversing from negative to positive is observed at~185 K in both phases,suggesting that‘hole pockets’emerge in these electron-doped FeSe materials.First principle calculations indicate that the increase in FeSe layer distance will lift up a‘hole band’associated with d_(x^(2)-y^(2)) character and increase the hole carriers.Our findings suggest that the increase in two dimensionalities may lead to the sign-reversal Hall resistivity in Li_(x)(C_(3)H_(10)N_(2))_(0.32)FeSe at high temperature.
基金financially supported by the National Natural Science Foundation of China(Nos.21604063 and 51373122)China Postdoctoral Science Foundation(No.2016M591392)
文摘Highly regioregular, head-to-tail coupled poly（3-octylesterthiophene） was synthesized by the Pd-catalysed oxidative C--H/C--H coupling polycondensation. The regioregularity of polymer products was confirmed by the 1H-NMR technique. Furthermore, the effects of various reaction factors including polymerization temperature, solvents and catalysts etc. on the yield, molecular weight and structural regioregularity of the resultant polymers were systematically studied. The optical, electrochemical and crystallization properties of the resultant P3OET with different HT regioregularities in solution and film state were studied by UV-Vis and fluorescent spectroscopy, cyclic voltammetry and X-ray diffraction （XRD）, resepectively.
