Ascites is the pathologic accumulation of fluid within the peritoneal cavity.Because many diseases can cause ascites,in particular cirrhosis,samples of ascitic fluid are commonly analyzed in order to develop a differe...Ascites is the pathologic accumulation of fluid within the peritoneal cavity.Because many diseases can cause ascites,in particular cirrhosis,samples of ascitic fluid are commonly analyzed in order to develop a differential diagnosis.The concept of transudate versus exudate,as determined by total protein measurements,is outdated and the use of serumascites albumin gradient as an indicator of portal hypertension is more accurate.Lactate dehydrogenase (LDH),vascular endothelial growth factor (VEGF),and other tumor markers can be helpful in distinguishing between malignant and benign conditions.Glucose and adenosine deaminase levels may support a diagnosis of tuberculous disease,and amylase level may indicate a diagnosis of pancreatitis.Given the specificity and sensitivity of laboratory results,accurate diagnosis should be based on both laboratory data and clinical iudgment.展开更多
First,I would like to congratulate the authors,Huang LL,Xia HH and Zhu SL,on the overall great work done in preparing the review article'Ascitic Fluid Analysis in the Differential Diagnosis of Ascites:Focus on Cir...First,I would like to congratulate the authors,Huang LL,Xia HH and Zhu SL,on the overall great work done in preparing the review article'Ascitic Fluid Analysis in the Differential Diagnosis of Ascites:Focus on Cirrhotic Ascites'.1 However,there seems to be an error in the description of diagnosis of spontaneous bacterial peritonitis(SBP).The authors state"SBP is defined by the presence of neutrophil cells greater than or equal to 250/mL or a positive bacterial culture in the ascitic fluid without evidence of an abdominal source."The issue here is the fact that the authors make the presence of neutrophil cells greater than or equal to 250/mL for diagnoses of SBP an option(by using the conjunction term'or')and not a condition,whereas it is proven by evidence in the literature that it is a prerequisite.展开更多
基金This project was sponsored in part by grants from the National Natural Science Foundation of China(#81072044)the Guangdong Natural Science Foundation(#S2011010004653)
文摘Ascites is the pathologic accumulation of fluid within the peritoneal cavity.Because many diseases can cause ascites,in particular cirrhosis,samples of ascitic fluid are commonly analyzed in order to develop a differential diagnosis.The concept of transudate versus exudate,as determined by total protein measurements,is outdated and the use of serumascites albumin gradient as an indicator of portal hypertension is more accurate.Lactate dehydrogenase (LDH),vascular endothelial growth factor (VEGF),and other tumor markers can be helpful in distinguishing between malignant and benign conditions.Glucose and adenosine deaminase levels may support a diagnosis of tuberculous disease,and amylase level may indicate a diagnosis of pancreatitis.Given the specificity and sensitivity of laboratory results,accurate diagnosis should be based on both laboratory data and clinical iudgment.
文摘First,I would like to congratulate the authors,Huang LL,Xia HH and Zhu SL,on the overall great work done in preparing the review article'Ascitic Fluid Analysis in the Differential Diagnosis of Ascites:Focus on Cirrhotic Ascites'.1 However,there seems to be an error in the description of diagnosis of spontaneous bacterial peritonitis(SBP).The authors state"SBP is defined by the presence of neutrophil cells greater than or equal to 250/mL or a positive bacterial culture in the ascitic fluid without evidence of an abdominal source."The issue here is the fact that the authors make the presence of neutrophil cells greater than or equal to 250/mL for diagnoses of SBP an option(by using the conjunction term'or')and not a condition,whereas it is proven by evidence in the literature that it is a prerequisite.
